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Article
October 1914

THE SPECIFICITY OF CHOLESTERIN WITH SYPHILITIC SERUMS AND OF CHOLESTERIN-REINFORCED HEART ANTIGEN IN THE WASSERMANN REACTION

Author Affiliations

BOSTON

From the Medical Clinic of the Peter Bent Brigham Hospital, Boston, Henry A. Christian, Physician-in-Chief.

Arch Intern Med (Chic). 1914;XIV(4):563-588. doi:10.1001/archinte.1914.00070160113009
Abstract

PART I  The intention of the first part of this paper is to present evidence of the safety with non-syphilitic serums and the specificity with syphilitic serums of the cholesterin heart antigen in the Wassermann reaction. The second part of the paper demonstrates that this specificity is due to cholesterin. No attempt will be made to discuss the reasons for this specificity. The work is treated largely from the technical point of view, and thus assumes a general knowledge of the principles and even of the technic of the reaction on the part of the reader.This paper is based on one thousand Wassermann reactions which were done on the serums of eight hundred different persons, and in addition on eighty-seven Wassermann reactions on the spinal fluid of the same persons. All of these cases have been under observation in this hospital. Since, here, the Wassermann reaction is

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