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Article
November 1914

SPECIFIC HYPERLEUKOCYTOSIS: STUDIES IN TYPHOID IMMUNIZATION. IV

Author Affiliations
BERKELEY, CAL.
From the Hearst Laboratory of Pathology and Bacteriology, University of California.
Arch Intern Med (Chic). 1914;XIV(5):662-670. doi:10.1001/archinte.1914.00070170055004
Abstract

We have already briefly described the specific and extreme grade of hyperleukocytosis that follows the intravenous injection of living typhoid bacilli in rabbits that have been immunized against this microorganism.1 In the present communication we wish to consider more fully the detail and mechanism of this phenomenon and its analog in other types of protein immunization.

The importance of the polymorphonuclear leukocytes in both natural and acquired immunity against bacteria has been well and advisedly emphasized by Metchnikoff and his pupils.2 The observations on the importance of leukocytes in immunity have dealt, however, with the qualitative rather than the quantitative response of these cells to the infecting agent. Our work, we believe, points out the existence and importance of a quantitative leukocyte response in cases in which recovery from an acute infection occurs abruptly.

The injection of apparently any foreign protein substance in normal animals

References
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Gay, F. P., and Claypole, E. J.:  Specific and Extreme Hyperleukocytosis following the Injection of Bacillus Typhosus in Immunized Rabbits ,  Jour. Am. Med. Assn. , 1913, lx, 1950Crossref
2.
 A Further Note on Specific Hyperleukocystosis in Immunized Animals ,  Proc. Soc. Exper. Biol. and Med. , 1913, xi, 47.
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Metchnikoff :  L'immunité dans les maladies infectieuses , Paris, Masson & Cie, 1901.
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Sacconaghi :  Leucocitosi; organi ; leucopoietici; immunita, Morgagni , Milan, 1905, xlvii, 282.
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Simonds and Baldauf :  The Relation of the Opsonic Index to the Leukopenia and the Leukocytosis Following Injections of Heated Bacterial Cultures ,  Jour. Infec. Dis. , 1909, vi, 38.Crossref
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Gay, F. P., and Claypole, E. J.:  An Experimental Study of Methods of Prophylactic Immunization Against Typhoid Fever. Studies in Typhoid Immunization V ,  The Archives Int. Med. , p. 671 this issue.
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Gay, F. P., and Claypole, E. J.:  The "Typhoid Carrier" State in Rabbits as a Method of Determining the Comparative Immunizing Value of Preparations of the Typhoid Bacillus. Studies in Typhoid Immunization, I ,  The Archives Int. Med. , 1913, xii, 613.Crossref
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Hektoen :  The Mechanism of Recovery in Pneumonia ,  Jour. Am. Med. Assn. , 1914, lxii, 254.Crossref
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Hamburger :  Zur Vakzinebehandlung der kindlichen Gonorrhoe ,  Deutsch. med. Wchnschr. , 1914, xl, 759.Crossref
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