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Article
December 1914

THE EFFECT OF STRYCHNIN, CAFFEIN, ATROPIN AND CAMPHOR ON THE RESPIRATION AND RESPIRATORY METABOLISM IN NORMAL HUMAN SUBJECTS

Author Affiliations

BOSTON

From the Medical Service, Massachusetts General Hospital.

Arch Intern Med (Chic). 1914;XIV(6):897-910. doi:10.1001/archinte.1914.00070180130010
Abstract

The effects which drugs may, conceivably, have on respiration are of four varieties.

  1. They may either stimulate or depress the respiratory center.

  2. They may alter respiration indirectly by increasing or decreasing metabolism.

  3. They may alter the general character of breathing, rapid and shallow or slow and deep, or thoracic or abdominal by producing changes in the mechanical conditions within the chest or abdomen, by acting on the circulation, the abdominal viscera or the thoracic or abdominal musculatures.

  4. They also may alter respiration by acting as bronchoconstrictors or dilators, and hence altering the dead space in the chest, which necessitates a compensatory change in the ventilation.

The data which must be obtained in studying these various actions are: the carbon dioxid elimination and the oxygen absorption, which give the metabolism ; the carbon dioxid tension of the alveolar air and the ventilation of the lungs, which give

References
1.
Edsall, D. L.:  The Clinical Study of Respiration, Med. Communications ,  Mass. Med. Soc. , 1912, xxiii, 19.
2.
Haldane, J. S., and Priestley, J. G.:  The Regulation of Lung Ventilation ,  Jour. Physiol. , 1905, xxxii, 224.
3.
Hasselbalch, K. A.:  Neutralitätsregulation und Reizbarkeit des Atemzentrums in ihren Wirkung auf die Köhlensaurespannung des Blutes ,  Biochem. Ztschr. , 1912, xlvi, 403.
4.
Loewy, A.:  Zur Kentniss der Erregbarkeit des Athemcentrums ,  Arch. f. d. ges. Physiol. , 1890, xlvii, 601.Crossref
5.
Wood, H. C., and Cerna, D.:  The Effect of Drugs and Other Agencies upon the Respiratory Movements ,  Jour. Physiol. , 1892, xiii, 870.
6.
Impens :  Les analeptiques de la respiration ,  Arch. de pharmacodynam , 1899, vi, 149.
7.
Biberfeld :  Zur Wirkungsweise des Strychnins auf das Athmungscentrum ,  Arch. f. d. ges. Physiol. , 1904, ciii, 266.Crossref
8.
Dreser, H.:  Ueber die Wirkung einiger Derivate des Morphins auf die Athmung ,  Arch. f. d. ges. Physiol. , 1898, lxxii, 485.Crossref
9.
Cushny, A. R.:  On the Pharmacology of the Respiratory Center ,  Jour. Pharm. and Exper. Therap. , 1913, iv, 363.
10.
Benedict, F. G.:  Ein Universalrespirationsapparat ,  Deutsch. Arch. f. klin. Med. , 1912, cvii, 156.
11.
Krogh, A., and Lindhrad, J.:  The Volume of the Dead Space in Breathing ,  Jour. Physiol. , 1913, xlvii, 30.
12.
Boothby, W. M., and Peabody, F. W.:  A Comparison of Methods for Obtaining Alveolar Air ,  The Archives Int. Med. , 1914, xiii, 497.Crossref
13.
Parkinson, J., and Rowlands, R. A.:  Strychnin in Heart Failure ,  Quart. Jour. Med. , 1913, vii, 42.
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