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Increased urea in the blood was first demonstrated in 1823 by Prevost and Dumas,1 while working with nephrectomized animals. Bostock,2 in 1829, noticed an increase in the blood urea of certain albuminuries. Richard Bright3 with his co-workers—Prout, Babbington, and Christison (1836)—confirmed this observation and recognized it to be of clinical importance in nephritis. Babbington and Christison also made estimations of urea in body fluids.
Following the qualitative demonstration of blood urea, quantitative determinations were attempted by both French and German clinicians. Picard4 (1856) was the first to determine that the amount of blood urea varies with the nitrogen intake.
Interest in the subject abated about this time, and for a period of forty years the references in the literature were infrequent. Schöndorf5 (1899) revived the subject by an examination of the previous work, adding to it his own more accurate results, which confirmed the
SCHWARTZ H, McGILL C. BLOOD UREA DETERMINATIONS IN 211 CASES. Arch Intern Med (Chic). 1916;XVII(1):42–77. doi:10.1001/archinte.1916.00080070060005
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