Isoniazid-Monoresistant Tuberculosis in the United States, 1993 to 2003 | Infectious Diseases | JAMA Internal Medicine | JAMA Network
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1.
Centers for Disease Control and Prevention, National action plan to combat multidrug-resistant tuberculosis.  MMWR Recomm Rep 1992;41 ((RR-11)) 5- 48Google Scholar
2.
Centers for Disease Control and Prevention, Reported tuberculosis in the United States, 2005.  Atlanta, GA US Dept of Health and Human Services2006;
3.
Francis  J Curry National Tuberculosis Center.  Drug-resistant tuberculosis: a survival guide for clinicians. http://www.nationaltbcenter.edu. Accessed July 7, 2008Google Scholar
4.
Scior  TMeneses Morales  IGarcés Eisele  SJDomeyer  DLaufer  S Antitubercular isoniazid and drug resistance of Mycobacterium tuberculosis: a review.  Arch Pharm (Weinheim) 2002;335 (11-12) 511- 525PubMedGoogle ScholarCrossref
5.
Bloch  ABOnorato  IMIhle  WWHadler  JLHayden  CHSnider  DE  Jr The need for epidemic intelligence.  Public Health Rep 1996;111 (1) 26- 31PubMedGoogle Scholar
6.
American Thoracic Society, CDC; Infectious Diseases Society of America. Treatment of tuberculosis [published correction appears in MMWR Recomm Rep. 2005;53(51):1203].  MMWR Recomm Rep 2003;52 ((RR-11)) 1- 77Google Scholar
7.
Sterling  TRBethel  JGoldberg  SWeinfurter  PYun  LHorsburgh  CRTuberculosis Epidemiologic Studies Consortium, The scope and impact of treatment of latent tuberculosis infection in the United States and Canada.  Am J Respir Crit Care Med 2006;173 (8) 927- 931PubMedGoogle ScholarCrossref
8.
Moore  MOnorato  IMMcCray  ECastro  K Trends in drug-resistant tuberculosis in the United States, 1993-1996.  JAMA 1997;278 (10) 833- 837PubMedGoogle ScholarCrossref
9.
Forssbohm  MLoddenkemper  RRieder  HL Isoniazid resistance among tuberculosis patients by birth cohort in Germany.  Int J Tuberc Lung Dis 2003;7 (10) 973- 979PubMedGoogle Scholar
10.
Centers for Disease Control and Prevention (CDC), National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Prevention and control of tuberculosis in correctional and detention facilities: recommendations from CDC: endorsed by the Advisory Council for the Elimination of Tuberculosis, the National Commission on Correctional Health Care, and the American Correctional Association.  MMWR Recomm Rep 2006;55 ((RR-9)) 1- 44Google Scholar
11.
Escalante  PGraviss  EAGriffith  DEMusser  JMAwe  RJ Treatment of isoniazid-resistant tuberculosis in southeastern Texas.  Chest 2001;119 (6) 1730- 1736PubMedGoogle ScholarCrossref
12.
Institute of Medicine, Ending Neglect: The Elimination of Tuberculosis in the United States.  Washington, DC National Academy Press2000;
Original Investigation
October 13, 2008

Isoniazid-Monoresistant Tuberculosis in the United States, 1993 to 2003

Author Affiliations

Author Affiliations: Division of Tuberculosis Elimination, Centers for Disease Control and Prevention (Ms Hoopes and Drs Harrington, Ijaz, and Armstrong), and Northrop Grumman Information Technology, Atlanta, Georgia (Mr Kammerer); and The Ohio State University College of Medicine, Columbus (Ms Hoopes).

Arch Intern Med. 2008;168(18):1984-1992. doi:10.1001/archinte.168.18.1984
Abstract

Background  Seven percent of tuberculosis (TB) cases reported to the US National Tuberculosis Surveillance System in 2005 had Mycobacterium tuberculosis isolates with resistance to at least isoniazid.

Methods  We undertook this study to describe demographic characteristics, risk factor information, and treatment outcomes for persons with isoniazid-monoresistant (resistant to isoniazid and susceptible to rifampin, pyrazinamide, and ethambutol hydrochloride) TB compared with persons with TB susceptible to all first-line anti-TB drugs.

Results  The numbers of isoniazid-monoresistant TB cases increased from 303 (4.1%) in 1993 to 351 (4.2%) in 2005. In our multivariate analysis of all TB cases reported from 1993 to 2003, the races/ethnicities of patients with isoniazid-monoresistant TB were significantly more likely to be US-born Asian/Pacific Islander (adjusted odds ratio [aOR], 1.9; 95% confidence interval [CI], 1.4-2.6), foreign-born Asian/Pacific Islander (1.8; 1.4-2.1), foreign-born black non-Hispanic (1.4; 1.1-1.7), or US-born Hispanic (1.3; 1.1-1.5). Isoniazid monoresistance was also associated with failure to complete therapy within 1 year (aOR, 1.7; 95% CI, 1.5-1.8), a history of TB (1.5; 1.3-1.7), and correctional facility residence (1.5; 1.2-1.7).

Conclusions  Isoniazid-monoresistant TB did not decline from January 1, 1993, through December 31, 2005, despite national downward trends observed in overall TB cases and in multidrug-resistant TB cases. Physicians must ensure completion of treatment for patients taking isoniazid as part of their TB or latent TB infection therapy. In addition, physicians should maintain heightened vigilance for isoniazid resistance when evaluating certain at-risk populations for TB and latent TB infection.

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