Carratalà et al test the hypothesis that the use of a 3-step critical pathway would be as safe as, and more effective than, usual care in reducing the duration of intravenous antibiotic therapy and length of stay in hospitalized patients with community-acquired pneumonia (CAP). Sharpe provides an Invited Commentary about the implementation of a 3-step critical pathway.
Kerr et al developed a tightly linked clinical action measure designed to encourage appropriate medical management and a marker of potential overtreatment, designed to monitor overly aggressive treatment of hypertension in the face of low diastolic blood pressure. In an 2261, Handberg discusses what impact guidelines have on measures of performance.
Within the Get With The Guidelines–Resuscitation registry, Chan and coauthors identified 42 957 patients who were successfully resuscitated from an in-hospital cardiac arrest. They developed a simple prediction tool for favorable neurological survival in patients successfully resuscitated from an in-hospital cardiac arrest using multivariate logistic regression. Also see the 2279.
Gutierrez and colleagues report the findings of their meta-analysis to evaluate if statin therapy is equally effective in decreasing recurrent cardiovascular events in women and men. In an invited commentary, Taylor expands on the issue.
Prasad et al discuss the diagnosis and treatment of pulmonary embolism, with a focus on anticoagulation.