Lodi et al evaluated the effectiveness of short-term combination antiretroviral therapy at the time of HIV seroconversion in achieving long-term immunologic control in 259 patients. See the editor’s note by Katz and the original investigation by Jarzebowski et al.
Chatterjee et al determine performance and improvement on measures of patientreported hospital experience among safety-net hospitals compared with non– safety-net hospitals. In an Editorial, Neuhausen and Katz discuss value-based purchasing and safety-net hospitals
Reichlin et al develop and validate an algorithm for rapid rule-out and rule-in of acute myocardial infarction using high-sensitivity cardiac troponin T baseline levels and absolute changes within 1 hour. Newby provides a commentary.
In a retrospective cohort study of the first nonsurgical admission of 289 310 patients admitted from the emergency department or the outpatient clinic to 118 Veterans Affairs acute care hospitals, Chen and coauthors described hospital intensive care unit admitting patterns for medical patients after accounting for severity of illness on admission. See invited commentary by Seymour and Kahn.
Lalmohamed and coauthors evaluate timing of acute myocardial infarction in patients undergoing total hip or knee replacement surgery compared with matched controls. See invited commentary by Wallace.
Jarzebowski and coauthors compared 282 human immunodeficiency virus (HIV)- 1–infected men diagnosed as having incident primary or secondary syphilis with 1233 syphilis-free men to examine the impact of early syphilis on plasma HIV-1 RNA levels and CD4 cell counts. See invited commentary by Vermund and a brief report by Lodi.
Friedman et al evaluate the relationship between use of photosensitizing drugs used for treatment of hypertension and development of lip cancer in 712 lip cancer cases and 22 904 controls. See editor’s note by Katz.
Samukawa and coauthors report a new case of 1-bromopropane–induced neurotoxicity.