Grøntved and coauthors examined the association of weight training with risk of type 2 diabetes mellitus in US men and assessed the influence of combining weight training and aerobic exercise in a prospective cohort study of 32 002 men from the Health Professionals Follow-up Study. See also the editorial by Katz and the review article by Sluik et al.
Elzi and coworkers analyzed treatment-naive adults with HIV infection. The end points were the choice of the initial antiretroviral regimen as well as virologic suppression, the increase in CD4 cell counts from baseline, and treatment modification within 12 months after starting treatment. See the invited commentary by Kuritzkes.
To examine the association of delirium with long-term cognitive trajectories in older adults with Alzheimer disease (AD), Gross and colleagues evaluated prospectively collected data from a nested cohort of 263 hospitalized patients with AD. The rate of cognitive deterioration was contrasted using random-effects regression models. An invited critique by Ely and Vasilevskis accompanies this article.
Willis et al evaluate the association between midlife fitness and the development of chronic disease during a 26-year follow-up in 18 670 healthy individuals.
Sluik and coauthors conducted a prospective cohort study and meta-analysis of existing studies to investigate the association between physical activity and mortality in individuals with diabetes mellitus. See the editorial by Katz and original investigation by Hu.
Using electronic databases, bibliographies, and clinical trial registries, McBrien and colleagues determined the effectiveness and safety of treating blood pressure to intensive targets compared with standard targets in patients with type 2 diabetes mellitus. They assessed risk differences for mortality, myocardial infarction, and stroke. See invited commentary by Sarafidis and Bakris.