State “right-to-try” laws that purport to allow patients to be treated with unapproved drugs or devices seem likely to be futile.
This Viewpoint describe the case of the commercial withdrawal of tositumomab as a cautionary tale of the weaknesses in our current drug-approval system.
This open-label, multicenter, noninferiority, randomized trial reports that β-lactam monotherapy delays clinical stability for patients with pneumonia. See also the Invited Commentary by Fine.
This survey study revealed that the local planning and improvement efforts of hospital leaders are strongly influenced by health care quality measures.
Wang et al identify current patterns of antibiotic use and explore the reasons for inappropriate prescription in primary health care settings in China.
This quantitative assessment estimates that US adults have approximately 14 million major medical conditions that are attributable to smoking. See also the Invited Commentary by Schroeder.
This disproportionality analysis demonstrates that dopamine receptor agonists can cause impulse control disorders. See also the Invited Commentaries by Weiss and Pontone and Gagne.
This study found that few drug labels contained or referenced convincing evidence of clinical utility of biomarker testing, whereas many made recommendations based on biomarker test results. See also the Invited Commentary by Burke.
This randomized clinical trial reports that buprenorphine taper is less efficacious than ongoing maintenance treatment in patients dependent on prescription opioids in primary care.
This retrospective cohort study found that diabetes treatment with metformin reduced subsequent treatment intensification, without differences in rates of adverse clinical events. See also the Invited Commentary by Segal and Maruthur.
The Women’s Health Study is a nationwide cohort of US women free of cardiovascular disease, cancer, or other major illness at baseline from 1992 to 1995. A total of 27 542 women aged 45 to 79 years with complete ascertainment of plasma lipids and other risk factors were followed for a median of 10 years.
This observational cohort study suggests that maintenance treatment with methadone or buprenorphine for opioid use disorders may be an important strategy to prevent the spread of hepatitis C virus (HCV) infection among young injection drug users.
In a large retrospective cohort study, patients with COPD treated with noninvasive ventilation at the time of hospitalization had lower inpatient mortality, shorter length of stay, and lower costs compared with those treated with invasive mechanical ventilation .
This Special Communication reviews the evidence and describes best practices in conversations about serious illness care goals, concluding that such communication is an intervention that should be systematically integrated into our clinical care structures and processes.
This special communication concludes that there is currently no role for carotid imaging in patients without a history of carotid-territory stroke or transient ischemic attack.
This Special Communication proposes inclusive shared savings, an alternative method to control medical costs that retains physicians’ incentives for providing lower-cost but otherwise equivalent interventions through the shared savings model and extends the shared savings to patients.
This Special Communication argues for low-dose computed tomography screening for lung cancer in Medicare beneficiaries.
This Special Communication argues that low-dose CT screening for lung cancer in Medicare recipients should not be implemented until more and better evidence has been collected that the benefits outweigh the risks.
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