David S. Black, PhD, MPH; Gillian A. O’Reilly, BS; Richard Olmstead, PhD; et al.
JAMA Intern Med. 2015;175(4):494-501. doi:10.1001/jamainternmed.2014.8081
This randomized clinical trial with 2 parallel groups finds that the use of a community-accessible mindfulness meditation program resulted in improvements in sleep quality at immediate postintervention, which was superior to a highly structured sleep hygiene education program. See the Invited Commentary by Spira.
Robert A. Schnoll, PhD; Patricia M. Goelz, MPH; Anna Veluz-Wilkins, MA; et al.
JAMA Intern Med. 2015;175(4):504-511. doi:10.1001/jamainternmed.2014.8313
This randomized clinical trial finds that use of the nicotine patch for 24 weeks is safe, although efficacy does not extend beyond that point.
Health Care Reform
Tammy T. Hshieh, MD; Jirong Yue, MD; Esther Oh, MD; et al.
JAMA Intern Med. 2015;175(4):512-520. doi:10.1001/jamainternmed.2014.7779
This meta-analysis finds that multicomponent nonpharmacological delirium prevention interventions are effective in reducing delirium incidence and preventing falls, with a trend toward decreasing length of stay and avoiding institutionalization. See the Invited Commentary by Greysen.
Lauren E. Ferrante, MD; Margaret A. Pisani, MD, MPH; Terrence E. Murphy, PhD; et al.
JAMA Intern Med. 2015;175(4):523-529. doi:10.1001/jamainternmed.2014.7889
Among older persons with critical illness, this prospective cohort study finds that more than half died within 1 month or experienced significant functional decline over the following year. See the Editor’s Note by Covinsky.
Nancy E. Avis, PhD; Sybil L. Crawford, PhD; Gail Greendale, MD; et al.
JAMA Intern Med. 2015;175(4):531-539. doi:10.1001/jamainternmed.2014.8063
This multiracial/multiethnic observational study finds that frequent vasomotor symptoms lasted more than 7 years during the menopausal transition for more than half of the women and persisted for 4.5 years after the final menstrual period. See the Invited Commentary by Richard-Davis and Manson.
Vasomotor Symptom Duration in Midlife Women—Research Overturns Dogma
Gloria Richard-Davis, MD; JoAnn E. Manson, MD, DrPH
Tanjaniina Laukkanen, MSc; Hassan Khan, MD, PhD; Francesco Zaccardi, MD; et al.
JAMA Intern Med. 2015;175(4):542-548. doi:10.1001/jamainternmed.2014.8187
This prospective cohort study found that the frequency of sauna bathing is associated with a reduced risk of fatal cardiovascular and all-cause mortality events.
Health Benefits of Sauna Bathing
Rita F. Redberg, MD, MSc
John J. You, MD, MSc; James Downar, MDCM, MHSc; Robert A. Fowler, MDCM, MS, Epi; et al.
JAMA Intern Med. 2015;175(4):549-556. doi:10.1001/jamainternmed.2014.7732
This multicenter survey study found that hospital-based clinicians perceive the most important barriers to goals of care discussions to be factors related to patients and family members.
Goals of Care Discussion: How Hard It Can Be
James N. Kirkpatrick, MD
S. Ryan Greysen, MD, MHS, MA; Irena Stijacic Cenzer, MA; Andrew D. Auerbach, MD, MPH; et al.
JAMA Intern Med. 2015;175(4):559-565. doi:10.1001/jamainternmed.2014.7756
This nationally representative cohort study of Medicare seniors shows that functional impairment is associated with increased risk of 30-day, all-cause hospital readmission. See also the invited commentary by Burke and Jha.
Charles Seife, MS
JAMA Intern Med. 2015;175(4):567-577. doi:10.1001/jamainternmed.2014.7774
This cross-sectional analysis finds that significant departures from good clinical practice in clinical trials identified by the FDA are seldom reflected in the peer-reviewed literature, even when there is evidence of data fabrication or other forms of research misconduct.
Audio Author Interview:
Research Misconduct Identified by the FDA (JAMA Internal Medicine)
Reporting Research Misconduct in the Medical Literature
Robert Steinbrook, MD; Rita F. Redberg, MD, MSc
Enrico Mossello, MD, PhD; Mariachiara Pieraccioli, MD; Nicola Nesti, MD; et al.
JAMA Intern Med. 2015;175(4):578-585. doi:10.1001/jamainternmed.2014.8164
This cohort study finds that low daytime systolic blood pressure was independently associated with a greater progression of cognitive decline in older patients with dementia and mild cognitive impairment among those treated with antihypertensive drugs. See the Invited Commentary by Sabayan and Westendorp.
Jacek Skarbinski, MD; Eli Rosenberg, PhD; Gabriela Paz-Bailey, MD, MSc, PhD; et al.
JAMA Intern Med. 2015;175(4):588-596. doi:10.1001/jamainternmed.2014.8180
This multistep, static, deterministic model that combined national population data finds that sequential steps along the HIV care continuum were associated with reduced HIV transmission rates. See the Invited Commentary by Giordano.
Amanda R. Markovitz, MPH; Jeffrey A. Alexander, PhD; Paula M. Lantz, PhD; et al.
JAMA Intern Med. 2015;175(4):598-606. doi:10.1001/jamainternmed.2014.8263
This dynamic cohort study suggests that increased implementation of the patient-centered medical home model has significantly greater potential to increase cancer screening in lower socioeconomic status settings.
Matthew Miller, MD, ScD; Catherine W. Barber, MPA; Sarah Leatherman, PhD; et al.
JAMA Intern Med. 2015;175(4):608-615. doi:10.1001/jamainternmed.2014.8071
This propensity score–adjusted cohort study finds that the risk of unintentional opioid overdose injury is related to the prescribed opioid’s duration of action. Accompanying editorial by Katz.
Mitigating the Dangers of Opioids
Mitchell H. Katz, MD
Anupam B. Jena, MD, PhD; Dana P. Goldman, PhD; Seth A. Seabury, PhD
JAMA Intern Med. 2015;175(4):617-623. doi:10.1001/jamainternmed.2014.7886
This longitudinal study found that human papillomavirus vaccination was not associated with increases in sexually transmitted infections.
Less Is More
Kevin Brown, PhD; Kim Valenta, PhD; David Fisman, MD, MSc; et al.
JAMA Intern Med. 2015;175(4):626-633. doi:10.1001/jamainternmed.2014.8273
This retrospective cohort study supports the use of antibiotic stewardship as a means of preventing Clostridium difficile infection.