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Year

Day

October 20, 2020
Original Investigation

Effect of Tocilizumab vs Standard Care on Clinical Worsening in Patients Hospitalized With COVID-19 Pneumonia: A Randomized Clinical Trial

Abstract Full Text
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JAMA Intern Med. Published online October 20, 2020. doi:10.1001/jamainternmed.2020.6615

This randomized clinical trial evaluates the effect of early tocilizumab administration vs standard therapy in preventing clinical worsening in patients hospitalized with COVID-19.

Effect of Tocilizumab vs Usual Care in Adults Hospitalized With COVID-19 and Moderate or Severe Pneumonia: A Randomized Clinical Trial

Abstract Full Text
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JAMA Intern Med. Published online October 20, 2020. doi:10.1001/jamainternmed.2020.6820

This randomized clinical trial examines the effects of tocilizumab vs usual care in patients hospitalized with COVID-19 and moderate-to-severe pneumonia.

Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19

Abstract Full Text
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JAMA Intern Med. Published online October 20, 2020. doi:10.1001/jamainternmed.2020.6252

This cohort study assesses mortality rates among patients with COVID-19 admitted to intensive care who were treated with tocilizumab.

Editorial

Time to Reassess Tocilizumab’s Role in COVID-19 Pneumonia

Abstract Full Text
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JAMA Intern Med. Published online October 20, 2020. doi:10.1001/jamainternmed.2020.6557
October 19, 2020
Viewpoint

Health Care Policy and Law

A Further Weakening of Contraceptive Coverage Under the Affordable Care Act

Abstract Full Text
JAMA Intern Med. Published online October 19, 2020. doi:10.1001/jamainternmed.2020.5533

This Viewpoint discusses how a recent US Supreme Court decision raises questions about whether an employer-based health care system can continue to best serve employees and the public at large.

Original Investigation

Health Care Policy and Law

Association of Medicaid-Focused or Commercial Medicaid Managed Care Plan Type With Outpatient and Acute Care

Abstract Full Text
JAMA Intern Med. Published online October 19, 2020. doi:10.1001/jamainternmed.2020.5408

This cohort study compares the use of outpatient and acute care between Medicaid enrollees randomly assigned to a national commercial managed care plan or a local Medicaid-focused managed care plan.

Trends in Noninvasive and Invasive Mechanical Ventilation Among Medicare Beneficiaries at the End of Life

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JAMA Intern Med. Published online October 19, 2020. doi:10.1001/jamainternmed.2020.5640

This cohort study describes the ventilatory support provided within 30 days of death in older adults with chronic obstructive pulmonary disease, congestive heart failure, cancer, or dementia.

Invited Commentary

Noninvasive Ventilation in Seriously Ill Older Adults at the End of Life—The Evidence Remains Elusive

Abstract Full Text
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JAMA Intern Med. Published online October 19, 2020. doi:10.1001/jamainternmed.2020.5648

Caution in Prescribing Modafinil and Armodafinil to Individuals Who Could Become Pregnant

Abstract Full Text
JAMA Intern Med. Published online October 19, 2020. doi:10.1001/jamainternmed.2020.4206
Research Letter

Pregnancy and Fetal Outcomes Following Exposure to Modafinil and Armodafinil During Pregnancy

Abstract Full Text
JAMA Intern Med. Published online October 19, 2020. doi:10.1001/jamainternmed.2020.4009

This cohort study uses data from the US Provigil/Nuvigil Pregnancy Registry to assess prevalence of fetal major congenital malformations after exposure to modafinil and armodafinil during pregnancy.

Asymptomatic and Presymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Infection Rates in a Multistate Sample of Skilled Nursing Facilities

Abstract Full Text
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JAMA Intern Med. Published online October 19, 2020. doi:10.1001/jamainternmed.2020.5664

This cross-sectional study examines the prevalence of asymptomatic and presymptomatic severe acute respiratory syndrome coronavirus 2 infection in skilled nursing facilities.

Challenges in Clinical Electrocardiography

Unusual Electrocardiographic Findings in a Patient With a Postmyocardial Infarction

Abstract Full Text
JAMA Intern Med. Published online October 19, 2020. doi:10.1001/jamainternmed.2020.1890

This case report presents unusual electrocardiographic findings in a patient with a postmyocardial infarction.

Comment & Response

Anticoagulation Therapy and Fall Reduction

Abstract Full Text
JAMA Intern Med. Published online October 19, 2020. doi:10.1001/jamainternmed.2020.5418

Complexities and Outcomes of Advance Care Planning

Abstract Full Text
JAMA Intern Med. Published online October 19, 2020. doi:10.1001/jamainternmed.2020.5539
Correction

Error in Funding/Support Section of End Matter

Abstract Full Text
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JAMA Intern Med. Published online October 19, 2020. doi:10.1001/jamainternmed.2020.6386
October 12, 2020
Viewpoint

Navigating Through Health Care Data Disrupted by the COVID-19 Pandemic

Abstract Full Text
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JAMA Intern Med. Published online October 12, 2020. doi:10.1001/jamainternmed.2020.5542

This Viewpoint examines the association between the COVID-19 pandemic and health care–related data collection.

Original Investigation

Overall and Cause-Specific Mortality in Randomized Clinical Trials Comparing Percutaneous Interventions With Coronary Bypass Surgery: A Meta-analysis

Abstract Full Text
JAMA Intern Med. Published online October 12, 2020. doi:10.1001/jamainternmed.2020.4748

This meta-analysis evaluates the difference in all-cause and cause-specific mortality in randomized clinical trials comparing percutaneous coronary intervention with coronary artery bypass grafting for the treatment of patients with coronary artery disease.

Implication of Trends in Timing of Dialysis Initiation for Incidence of End-stage Kidney Disease

Abstract Full Text
JAMA Intern Med. Published online October 12, 2020. doi:10.1001/jamainternmed.2020.5009

This large cohort study assesses temporal trends in initiating long-term kidney dialysis by level of estimated glomerular filtration rate to evaluate whether an association exists between these trends and the number of patients with end-stage kidney disease.

Concordance Between Blood Pressure in the Systolic Blood Pressure Intervention Trial and in Routine Clinical Practice

Abstract Full Text
JAMA Intern Med. Published online October 12, 2020. doi:10.1001/jamainternmed.2020.5028

This prognostic study evaluates the concordance between blood pressures obtained in routine clinical practice and those obtained using the Systolic Blood Pressure Intervention Trial protocol and whether concordance varied by target trial blood pressure.

Invited Commentary

A Tale of 2 Blood Pressures

Abstract Full Text
JAMA Intern Med. Published online October 12, 2020. doi:10.1001/jamainternmed.2020.5007
Research Letter

Health Care Policy and Law

Cognition and Take-up of the Medicare Savings Programs

Abstract Full Text
JAMA Intern Med. Published online October 12, 2020. doi:10.1001/jamainternmed.2020.2783

This cross-sectional study examines the association between cognition and Medicare Savings Program enrollment among qualified elderly Medicare beneficiaries.

Health Care Policy and Law

Clinical Evidence Supporting US Food and Drug Administration Clearance of Novel Therapeutic Devices via the De Novo Pathway Between 2011 and 2019

Abstract Full Text
JAMA Intern Med. Published online October 12, 2020. doi:10.1001/jamainternmed.2020.3214

This cross-sectional study characterizes the premarket clinical evidence supporting clearance of moderate-risk novel therapeutic medical devices by the US Food and Drug Administration.

Challenges in Clinical Electrocardiography

The Negative U Wave: The Company U Keep

Abstract Full Text
JAMA Intern Med. Published online October 12, 2020. doi:10.1001/jamainternmed.2020.5024

This case report presents the electrocardiographic findings of a woman in her 60s who arrived in the emergency department with altered mental status, elevated blood pressure, and asymmetric pupils.

October 5, 2020
Original Investigation

Less Is More

Early Noninvasive Cardiac Testing After Emergency Department Evaluation for Suspected Acute Coronary Syndrome

Abstract Full Text
JAMA Intern Med. Published online October 5, 2020. doi:10.1001/jamainternmed.2020.4325

This retrospective cohort study evaluates the effectiveness of early noninvasive cardiac testing in patients presenting to an emergency department with chest pain.

Assessment of Availability, Clinical Testing, and US Food and Drug Administration Review of Biosimilar Biologic Products

Abstract Full Text
JAMA Intern Med. Published online October 5, 2020. doi:10.1001/jamainternmed.2020.3997

This study examines the US Food and Drug Administration’s approval process for biosimilar biologic products by evaluating the site and facility inspections, animal and human studies, and comparative efficacy trials conducted to support the applications.

Association of the National Health Guidance Intervention for Obesity and Cardiovascular Risks With Health Outcomes Among Japanese Men

Abstract Full Text
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JAMA Intern Med. Published online October 5, 2020. doi:10.1001/jamainternmed.2020.4334

This cohort study investigates the association of the national health guidance intervention for obesity and cardiovascular risks with population health outcomes among working-age men in Japan.

Research Letter

COVID-19 and Psychological Distress—Changes in Internet Searches for Mental Health Issues in New York During the Pandemic

Abstract Full Text
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JAMA Intern Med. Published online October 5, 2020. doi:10.1001/jamainternmed.2020.3271

This cross-sectional study analyzes trends in internet searches for mental health issues in New York during the coronavirus disease 2019 lockdown.

Challenges in Clinical Electrocardiography

A Man With a Sixth Wave in Electrocardiogram Results

Abstract Full Text
JAMA Intern Med. Published online October 5, 2020. doi:10.1001/jamainternmed.2020.4783

This case report describes a 39-year-old man with a short history of subjective fever, lethargy, cough, nausea, and vomiting.

Comment & Response

Inaccurate Estimates of Negotiated Reimbursement Prices for Insulin

Abstract Full Text
JAMA Intern Med. Published online October 5, 2020. doi:10.1001/jamainternmed.2020.5050

Health Care Policy and Law

Inaccurate Estimates of Negotiated Reimbursement Prices for Insulin—Reply

Abstract Full Text
JAMA Intern Med. Published online October 5, 2020. doi:10.1001/jamainternmed.2020.5047
Correction

Error in Text

Abstract Full Text
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JAMA Intern Med. Published online October 5, 2020. doi:10.1001/jamainternmed.2020.5834
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