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    Research Letter
    February 5, 2020

    Trends in Liver Disease Etiology Among Adults Awaiting Liver Transplantation in the United States, 2014-2019

    Author Affiliations
    • 1Division of Gastroenterology and Hepatology, Alameda Health System, Highland Hospital, Oakland, California
    • 2Sanford School of Medicine, University of South Dakota, Sioux Falls
    • 3Avera Transplant Institute, Sioux Falls, South Dakota
    JAMA Netw Open. 2020;3(2):e1920294. doi:10.1001/jamanetworkopen.2019.20294

    Effective therapies for the hepatitis C virus (HCV) have transformed the landscape of chronic liver disease in the United States. Alcohol-associated liver disease (ALD) and nonalcoholic steatohepatitis (NASH) have emerged as significant clinical and economic health care burdens.1,2 Lack of effective therapies for ALD and NASH contribute to increasing disease severity among patients with these diseases, leading to cirrhosis and end-stage liver disease requiring liver transplantation (LT). In this cohort study, we updated assessments of liver disease etiology trends among adults awaiting LT in the United States.

    Using the United Network for Organ Sharing database from January 1, 2014, to March 31, 2019, this cohort study evaluated trends in liver disease etiology among adults registered for LT waiting lists in the United States. This study followed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guideline. The Alameda Health System institutional review board granted exempt status and a waiver of informed consent given that the study used deidentified data from a large database and did not pose more than minimal risk.