Trends in Internet Searches for Cannabidiol (CBD) in the United States

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Introduction
Cannabidiol (CBD) is widely promoted as a panacea.For example, the cannabis brand MedMen claims CBD treats acne, anxiety, opioid addiction, pain, and menstrual problems. 1However, the US Food and Drug Administration has only approved highly purified CBD (Epidiolex) for treating epilepsy.To our knowledge, there is currently no population-focused surveillance of public interest in CBD.Consequently, many question whether CBD should be prioritized by public health leaders and regulators.This article describes public interest in CBD within the United States.

Methods
In this longitudinal cross-sectional study, we measured Google searches that mentioned "CBD" or "cannabidiol" emerging from the United States (including by state) from January 1, 2004, through April 23, 2019.We report these measurements as query fractions (QFs), which are the number of searches per every 10 million searches originating nationally or from a respective state.We forecasted searches through 2019 using an autoregressive integrated moving average model, with components estimated using the algorithm developed by Hyndman and Khandakar 2 and data from all months since 2014.This model is robust to time series biases such as recurring periodicities.We also contrasted search volumes during April 2019 for CBD against those for several health topics, products, or alternative medicines, including acupuncture, apple cider vinegar, diet (excluding "Coke" or "Pepsi"), electronic cigarettes ("e cig/s," "e cigarette/s," "electronic cigarette/s," "vape," "vaping," or "vapor," excluding "marijuana" or "cannabis"), exercise, marijuana ("marijuana" or "cannabis"), meditation, vaccines ("vaccine/s," "vaccinate/d," or "vaccination"), veganism, and yoga.Raw search counts were inferred using estimates from the media measurement and analytics company Comscore.Analyses were performed using R statistical software version 3.5.2(R Project for Statistical Computing) and followed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guideline for cross-sectional studies.Ethical review by the institutional review board was not required per 45 CFR part 46 and the standard operating policies and procedures at the University of California, San Diego, which do not require review of studies that do not involve intervention or interaction with individuals and use information that is not individually identifiable.

Results
Nationally, CBD searches were stable from 2004 through 2014 but then substantially increased (Figure 1).Search volumes increased 125.9% during 2017 compared with 2016, 160.4% during 2018 compared with 2017, and are expected to be 117.7%(95% prediction interval, 99.5%-135.6%)higher during 2019 than 2018 based on observed and forecasted volumes.There were 6.Searches for CBD during April 2019 eclipsed those for acupuncture by a factor of 7.49, apple cider vinegar by 5.17, meditation by 3.38, vaccination by 1.63, exercise by 1.59, marijuana by 1.13, and veganism by 1.12 (Figure 2).Searches for CBD are now rivaling searches for yoga and electronic cigarettes, with 0.96 and 0.85 of their respective search volumes, and are searched for more than half as much as dieting (0.51).

Figure 1 .
Figure 1.National and State Google Searches for Cannabidiol or CBD Since 2014

Figure 2 .
Figure 2. Google Searches for Cannabidiol or CBD and for Other Health Topics in April 2019