Effect of Treatment Expectation on Placebo Response and Analgesic Efficacy

This randomized clinical trial assessed the effect of patients’ treatment expectations on the efficacy of propranolol vs placebo among patients with temporomandibular disorder–associated myalgia.


Introduction
Amid the United States' chronic pain crisis, novel analgesics are failing to show efficacy in clinical trials. 1 High failure rates are attributed to an upward trend in placebo response, 2 driven by patients' heightened expectation of treatment benefit. 3We hypothesized that heightened expectations differentially amplify placebo analgesia, leading to underestimation of the treatment effect in randomized clinical trials.

SOPPRANO (Study of Orofacial Pain and Propranolol
) is a double-blind, placebo-controlled, parallelgroup, phase 2b randomized clinical trial that enrolled 200 adults aged 18 to 65 years with examiner-verified temporomandibular disorder-associated myalgia from August 1, 2015, to January 31, 2018, at 3 US study sites.Participants were randomized 1:1 to propranolol hydrochloride (60 mg twice a day) or placebo administered for 9 weeks.Using daily pain diaries, treatment response was defined as the proportion with at least 30% reduction in mean pain index (facial pain intensity multiplied by duration) at 9 weeks.Efficacy was further quantified as the number needed to treat (NNT) with 95% CIs.Treatment expectation was determined from participants' baseline expectation that the study treatment would reduce their facial pain.Ratings of moderate or strong were classified as high treatment expectation, and ratings of none or slight were classified as low expectation.In this planned, intention-to-treat analysis, we tested whether treatment expectation modified the

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Propranolol Placebo
Analgesic efficacy of propranolol (60 mg twice a day) on facial pain in participants with temporomandibular disorder myalgia was modified by baseline expectations of pain relief (P = .07for interaction at week 9 of treatment expectation and treatment group).A, For 80 participants with low treatment expectation, the placebo response was low (decreasing between the third and fourth visits), propranolol was efficacious, and the number needed to treat (NNT) was 3.2.B, For 118 participants with high treatment expectation, placebo response increased at each subsequent visit, and no therapeutic effect of propranolol was evident.Adjusted percentages and their 95% confidence intervals (error bars) were estimated with a log binomial generalized estimating equation regression model allowing for repeated visits by study participants, with adjustment for study site, sex, and self-reported race.The trial protocol and statistical plan are available in Supplement 1.This study followed the Consolidated Standards of Reporting Trials (CONSORT) reporting guidelines, and the study flow diagram is available in the eFigure in Supplement 2. The institutional review boards at each site approved the trial protocol.All participants provided written informed consent.

Results
Among 198 participants in the intention-to-treat sample who rated their treatment expectation, the mean (SD) age was 34 (0.90) years, 155 (78.3%) were women, and 118 (59.6%) had a high expectation of pain relief.Pressure pain sensitivity in the masseter muscle (odds ratio, 1.5; 95% CI, 1.1-2.0)and trapezius muscle (odds ratio, 1.5; 95% CI, 1.1-2.0)was associated with a heightened expectation of pain relief (Table ).Among participants with low expectation of pain relief (Figure , A), treatment responders composed 73.5% in the propranolol group and 42.7% in the placebo group.

Discussion
In this study, propranolol was superior to placebo, but only among participants whose expectations of treatment were modest.In the presence of heightened expectations, placebo analgesia overwhelmed the efficacy signal, inflated the NNT, and nullified differences between treatment groups.The relatively small sample size limited the power to test if magnitude of effect of propranolol on temporomandibular disorder-associated pain differed by treatment expectation, yet our findings offer credible evidence of interaction.Few clinical or psychological factors were associated with heightened expectation, with sensitivity to experimental pressure pain being the exception.Greater pain sensitivity may manifest as greater need for and expectation of pain relief.It is well established that treatment expectations are susceptible to verbal suggestion, physician manner, and social observation. 5A more recent influence may be information relayed through directto-consumer advertising of prescription drugs.Direct-to-consumer advertising budgets for prescription drugs more than quadrupled in the United States from 1997 to 2016, 6 coinciding with the steady increase in placebo response.We recommend assessing treatment expectation to better understand its potential bias on success rates in clinical trials.

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Open. 2020;3(4):e202907.doi:10.1001/jamanetworkopen.2020.2907(Reprinted) April 16, 2020 1/From: https://jamanetwork.com/ on 09/23/2023 analgesic efficacy of propranolol using a log binomial generalized estimating equation regression model incorporating data from 4 study visits with adjustment for covariates.The generalized score statistic for generalized estimating equation models was used to test for modification of analgesic efficacy.A 2-tailed P < .05 was deemed statistically significant, and values of .05 to .10 were deemed credible.Other results were deemed statistically significant when 2-tailed 95% CIs excluded the null value.A separate logistic regression model assessed the odds of high treatment expectation using continuous measures of clinical and experimental pain, psychological factors, and health-related quality of life at baseline, all standardized to z scores.

Figure .
Figure.Propranolol and Temporomandibular Disorder in Low and High Strata of Treatment Expectation

Table . Unadjusted
Associations Between Baseline Participant Characteristics and High Expectation of Treatment Benefit

Table .
Unadjusted Associations Between Baseline Participant Characteristics and High Expectation of Treatment Benefit (continued) Effect of Treatment Expectation on Placebo Response and Analgesic Efficacy c Sex, race/ethnicity (self-reported), and treatment group are binary variables and therefore were not standardized.d Mean pressure pain threshold values are reverse scored so that higher values denote greater sensitivity to experimental pain.JAMA Network Open | Public Health JAMA Network Open.2020;3(4):e202907.doi:10.1001/jamanetworkopen.2020.2907(Reprinted) April 16, 2020 2/4 Downloaded From: https://jamanetwork.com/ on 09/23/2023 SOPPRANO's study flow diagram and checklist are not yet published.