Functional Limitations and Exercise Intolerance in Patients With Post-COVID Condition

This randomized crossover clinical trial investigates postexercise fatigue and physiologic characteristics among nonhospitalized patients with post-COVID condition compared with age- and sex-matched healthy controls.

Other, N (%) 7 ( 30) Have your views on exercising changed during your participation in this study?

PCC n=23 Controls n=18
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Fatigue
-intensity interval training; MICT: moderate-intensity continuous training; ST: strength training © 2024 Tryfonos A et al.JAMA Network Open.eTable 5. Delta changes (Δ) in symptoms from baseline (Pre) to immediate post-and 48h post-exercise in patients with post-covid condition (PCC) and age-and sex-matched healthy controls as assessed by a) Multifactional Fatigue Inventory (MFI), b) Profile of Mood States (POMS), and c) the Somatic (SOMA) and Psychological (PHYCH) Health REport (SPHERE).Data are presented as median (IQR).

eFigure 1 :
Individual delta changes in fatigue from baseline to immediate post-and 48h after each exercise (HIIT: high-intensity interval training; MICT: moderate-intensity continuous training; ST: strength training) in patients with post-covid condition (PCC) and age-and sexmatched healthy controls, as assessed via visual analog scale (VAS).Ascending numbers were used to sort the subjects based on their responses to HIIT (smaller unit changes to larger unit changes).
Responses during 3 exercise sessions.Data are presented as means (SD).
Mean difference in delta changes (Δ) in symptoms from baseline (Pre) to immediate postand 48h post-exercise in patients with post-covid condition (PCC) and age-and sex-matched healthy controls as assessed by a) Multifactional Fatigue Inventory (MFI), b) Profile of Mood States (POMS), and c) the Somatic (SOMA) and Psychological (PHYCH) Health REport (SPHERE).Medians (IQR) for each symptom are presented in eTable 5. Data are presented as mean difference (95% CI).
Data from 48h follow-up cardiopulmonary exercise testing (CPET) in patients with post-covid condition (PCC; N=31) and age-, sexmatched healthy controls (N=31).Data are presented as means and (SD).P values are presented for main effect of Group (G), Exercise (E), and Group x Exercise interaction (G*E).Mean differences in variables from 48h follow-up cardiopulmonary exercise testing (CPET) between the patients with post-covid condition (PCC; N=31) and age-, sex-matched healthy controls (N=31).Means (SD) for each group are presented in eTable 7. Data are presented as mean difference (95% CI).