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    Research Letter
    Oncology
    August 14, 2019

    Evolving Practice Patterns in the Use of Prophylactic Cranial Irradiation for Extensive-Stage Small Cell Lung Cancer

    Author Affiliations
    • 1Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston
    • 2Department of Radiation Medicine, Oregon Health & Science University, Portland
    JAMA Netw Open. 2019;2(8):e199135. doi:10.1001/jamanetworkopen.2019.9135

    The recent phase 3 trial by Takahashi et al1 showed no overall survival benefit with prophylactic cranial irradiation (PCI) over active magnetic resonance imaging (MRI) surveillance among patients with extensive-stage small cell lung cancer (ES-SCLC), questioning the previously established benefit of PCI for this patient group.2 Consequently, in 2018, the National Comprehensive Cancer Network3 established equipoise between MRI surveillance and PCI in ES-SCLC. These developments have fueled debate over the role of PCI in this setting, and current practice patterns remain unclear.4 We conducted a nationwide survey study of radiation oncologists (ROs) to assess changes in the use of PCI for patients with ES-SCLC following publication of the trial by Takahashi et al.1

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