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Invited Commentary
Infectious Diseases
August 21, 2019

Science Should Drive Vaccine Policy

Author Affiliations
  • 1College of Public Health, Kent State University, Kent, Ohio
  • 2Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts
JAMA Netw Open. 2019;2(8):e1910170. doi:10.1001/jamanetworkopen.2019.10170

Using agent-based modeling, Sinclair et al1 have demonstrated the risk that many Texas children face because of their classmates’ religious or philosophical exemptions from measles vaccination. In Texas, vaccine exemption rates have increased 28-fold since 2003, and Texas allows for exemptions “for reasons of conscience,” which include religious and philosophical objections to vaccinations.2 Because of these exemptions, others have warned that many Texas cities are at risk of measles outbreaks.3 Several cities in Texas were previously identified as possible hotspots for outbreaks of vaccine-preventable diseases,4 including Houston, Fort Worth, Plano, and Austin. The article by Sinclair et al1 examines just how large these outbreaks could be given current vaccination rates, finding that epidemics of up to several hundred children could occur. Further, they note that while the group that is unvaccinated would have the most cases, bystanders—including those for whom vaccination failed and students who are medically exempt—would also be susceptible, demonstrating the importance of herd immunity to protect those who do not respond to vaccines or who cannot be vaccinated.

Nevertheless, these results must be considered with some caution. Although agent-based models describe heterogeneity well in populations for which highly granular data (eg, individual-level data) are available, these models are prone to assumptions that may not reflect real-world conditions when such data are not available (as noted by Sinclair et al1 in their Discussion). Further, the authors’ choice to use the basic reproduction number (R0) to run their model likely yielded higher simulated outbreak sizes than would have been estimated if the more appropriate effective reproduction number (REff) had been used instead. Unlike R0, which describes the number of infections that a case will cause in a fully susceptible population, REff describes the number of infections that a case will cause in a population that is not fully susceptible (ie, a population in which some fraction has been effectively vaccinated, such as the state of Texas).

However, as partial empirical validation for the modeling method employed by Sinclair et al,1 Texas has already seen 18 cases of measles in 12 counties from January to mid-July 2019. Indeed, 2019 has been a record year for measles infections in the United States, with 1123 cases reported as of July 11,5 the largest nationwide annual count since 1992.

What can be done to prevent this outcome? Although the authors did not include interventions in their model, we can consider 2 aspects of prevention: that which takes place in the midst of an epidemic and that which occurs otherwise. During an epidemic, strict public health interventions may be put in place. During outbreaks of measles, cases are typically isolated, and those who have been exposed are subject to quarantine. In New York, New York, these measures were not enough to stop the outbreak that began in October 2018; unvaccinated children were banned from schools, and mandatory vaccination orders for measles were put in place.6

An outbreak situation may also encourage individuals to catch up on vaccinations. During Ohio’s 2014 measles outbreak in the Amish population, more than 10 000 individuals were vaccinated with the measles, mumps, and rubella vaccine7; similarly, more than 50 measles cases in early 2019 led to a 10-fold spike in measles vaccinations in Washington.8

The more challenging aspect of prevention is maintaining vaccination rates in the absence of ongoing epidemics, which is complicated by the continued spread of misinformation about vaccines. Texas is an unfortunate leader in this aspect and the current home of Andrew Wakefield, the researcher whose fraudulent 1998 study first erroneously linked the measles, mumps, and rubella vaccine to autism.9 Texas is also home to an effective antivaccine lobbying group, Texans for Vaccine Choice, which has worked to curtail any changes in legislation regarding vaccine exemptions in the state.

Countering such antivaccine rhetoric is not a simple task. Research into the factors driving vaccine hesitancy has not led to any easy answers or readily scalable interventions.10 As such, many in public health are looking to change state laws regarding vaccine exemptions to increase vaccination rates. Mississippi and West Virginia have long allowed only for medical exemptions; religious and/or philosophical exemptions to vaccines are present in other states. California became the third state to eliminate nonmedical exemptions in 2015 with the passage of California Senate Bill 277 following the Disneyland measles outbreak in 2014 to 2015. Because of the 2019 measles epidemic, Maine and New York have similarly modified their vaccine laws, removing nonmedical exemptions. We suggest that studies like Sinclair et al1 may aid legislators in making these changes proactively, before such outbreaks are experienced.

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Article Information

Published: August 21, 2019. doi:10.1001/jamanetworkopen.2019.10170

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2019 Smith TC et al. JAMA Network Open.

Corresponding Author: Tara C. Smith, PhD, College of Public Health, Kent State University, 750 Hilltop Dr, Lowry Hall, Kent, OH 44242 (tsmit176@kent.edu).

Conflict of Interest Disclosures: None reported.

References
1.
Sinclair  DR, Grefenstette  JJ, Krauland  MG,  et al.  Forecasted size of measles outbreaks associated with vaccination exemptions for schoolchildren.  JAMA Netw Open. 2019;2(8):e199768. doi:10.1001/jamanetworkopen.2019.9768Google Scholar
2.
Texas Department of State Health Services. Exemption information: school immunizations. https://www.dshs.texas.gov/immunize/school/exemptions.aspx. Accessed July 17, 2019.
3.
Hotez  PJ.  Texas and its measles epidemics.  PLoS Med. 2016;13(10):e1002153. doi:10.1371/journal.pmed.1002153PubMedGoogle ScholarCrossref
4.
Olive  JK, Hotez  PJ, Damania  A, Nolan  MS.  The state of the antivaccine movement in the United States: a focused examination of nonmedical exemptions in states and counties.  PLoS Med. 2018;15(6):e1002578. doi:10.1371/journal.pmed.1002578PubMedGoogle ScholarCrossref
5.
US Centers for Disease Control and Prevention. Measles cases and outbreaks. https://www.cdc.gov/measles/cases-outbreaks.html. Accessed July 17, 2019.
6.
Pager  T, Mays  JC. New York declares measles emergency, requiring vaccinations in parts of Brooklyn. New York Times. April 9, 2019. https://www.nytimes.com/2019/04/09/nyregion/measles-vaccination-williamsburg.html. Accessed July 22, 2019.
7.
Gastañaduy  PA, Budd  J, Fisher  N,  et al.  A measles outbreak in an underimmunized Amish community in Ohio.  N Engl J Med. 2016;375(14):1343-1354. doi:10.1056/NEJMoa1602295PubMedGoogle ScholarCrossref
8.
Foden-Vencil  K. In a measles outbreak, demand for vaccine spikes. Morning Edition. February 11, 2019. https://www.npr.org/2019/02/11/692825201/in-a-measles-outbreak-demand-for-vaccine-spikes. Accessed July 22, 2019.
9.
Deer  B.  How the case against the MMR vaccine was fixed.  BMJ. 2011;342:c5347. doi:10.1136/bmj.c5347PubMedGoogle ScholarCrossref
10.
Smith  TC.  Vaccine rejection and hesitancy: a review and call to action.  Open Forum Infect Dis. 2017;4(3):ofx146. doi:10.1093/ofid/ofx146PubMedGoogle ScholarCrossref
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