The Role of Positron Emission Tomography–Computed Tomography in the Workup of Non–Small Cell Lung Cancer | Lung Cancer | JAMA Network Open | JAMA Network
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Invited Commentary
November 20, 2019

The Role of Positron Emission Tomography–Computed Tomography in the Workup of Non–Small Cell Lung Cancer

Author Affiliations
  • 1Service of Nuclear Medicine, Diagnostic Department, University Hospital, University of Geneva, Geneva, Switzerland
JAMA Netw Open. 2019;2(11):e1915873. doi:10.1001/jamanetworkopen.2019.15873

Non–small cell lung cancer (NSCLC) remains a significant global health burden and is a leading cause of cancer-related death. The correct staging of patients with NSCLC is a key step in selecting an adequate treatment regimen, and combined positron emission tomography–computed tomography (PET-CT) with fluorine 18–labeled fluorodeoxyglucose (FDG) is increasingly used for staging and treatment monitoring of patients with NSCLC. The principal strengths of PET-CT with FDG in staging NSCLC include the assessment of intrathoracic lymph nodes and the detection of unanticipated stage IV disease. However, data on the effects of PET-CT with FDG on cancer-related mortality in NSCLC remain sparse.

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