Trends in List Prices, Net Prices, and Discounts for Originator Biologics Facing Biosimilar Competition | Oncology | JAMA Network Open | JAMA Network
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    Research Letter
    Health Policy
    December 13, 2019

    Trends in List Prices, Net Prices, and Discounts for Originator Biologics Facing Biosimilar Competition

    Author Affiliations
    • 1Department of Pharmacy and Therapeutics, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania
    • 2Division of General Internal Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    • 3Center for High-Value Health Care, Insurance Services Division, UPMC Health Plan, Pittsburgh, Pennsylvania
    JAMA Netw Open. 2019;2(12):e1917379. doi:10.1001/jamanetworkopen.2019.17379

    Biosimilars hold promise for reducing spending on biologics.1 Biosimilar prices are estimated to be 15% to 16% lower than originator products,2 but it is unclear how list prices, net prices, and discounts for the originator products change with biosimilar competition.

    We selected filgrastim, pegfilgrastim, infliximab, and insulin glargine as case studies because these were the only originator biologics that, by December 2018, faced competition from biosimilars (filgrastim-sndz, filgrastim-aafi, pegfilgrastim-jmdb, infliximab-dyyb, and infliximab-abda) or from other within-molecule substitutes (tbo-filgrastim and insulin glargine [Basaglar; Lilly]).3

    We obtained pricing data from January 2007 to June 2018 from SSR Health,4 which provides quarterly estimates of list prices, net prices, Medicaid discounts, and discounts in other payers for branded products with US sales reported by publicly traded companies. Quarterly net prices are calculated as the ratio between sales and number of units sold. Discounts are calculated as the ratio between the difference in list and net prices (numerator) and the list prices (denominator). Net prices and discounts capture all manufacturer concessions and not solely rebates.4 For each drug and year, we calculated the mean list and net prices and the mean discounts in Medicaid and other payers.5

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