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Figure.  Patient Ratings of Pain Tolerability and Pain Score
Patient Ratings of Pain Tolerability and Pain Score
Table.  Demographic Characteristics
Demographic Characteristics
1.
Ballantyne  JC, Sullivan  MD.  Intensity of chronic pain—the wrong metric?   N Engl J Med. 2015;373(22):2098-2099. doi:10.1056/NEJMp1507136PubMedGoogle ScholarCrossref
2.
Lucas  CE, Vlahos  AL, Ledgerwood  AM.  Kindness kills: the negative impact of pain as the fifth vital sign.   J Am Coll Surg. 2007;205(1):101-107. doi:10.1016/j.jamcollsurg.2007.01.062PubMedGoogle ScholarCrossref
3.
Jensen  MP, Karoly  P, Braver  S.  The measurement of clinical pain intensity: a comparison of six methods.   Pain. 1986;27(1):117-126. doi:10.1016/0304-3959(86)90228-9PubMedGoogle ScholarCrossref
4.
Clark  LL, Taubman  SB.  Brief report: incidence of diagnoses using ICD-9 codes specifying chronic pain (not neoplasm related) in the primary diagnostic position, active component, US Armed Forces, 2007-2014.   MSMR. 2015;22(12):12-15.PubMedGoogle Scholar
5.
Dartmouth Atlas Project. Preference-sensitive care. Accessed March 16, 2020. https://www.dartmouthatlas.org/downloads/reports/preference_sensitive.pdf
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    Research Letter
    Anesthesiology
    April 20, 2020

    Comparison of a Pain Tolerability Question With the Numeric Rating Scale for Assessment of Self-reported Chronic Pain

    Author Affiliations
    • 1Translational Pain Research, Department of Neurosurgery, University of Rochester, Rochester, New York
    • 2Department of Anesthesiology and Perioperative Medicine, University of Rochester, Rochester, New York
    JAMA Netw Open. 2020;3(4):e203155. doi:10.1001/jamanetworkopen.2020.3155
    Introduction

    The exclusive focus of the numeric rating scale (NRS) on pain intensity reduces the experience of chronic pain to a single dimension.1 This drawback minimizes the complex effects of chronic pain on patients’ lives and the trade-offs that are often involved in analgesic decision-making.2 Furthermore, continually asking patients to rate their pain on a scale that is anchored by a pain-free state (ie, 0) implies that being pain free is a readily attainable treatment goal, which may contribute to unrealistic expectations for complete relief.3 We hypothesized that the incorporation of a standardized pain tolerability question (PTQ) (ie, “is your pain tolerable?”) would efficiently augment the information gleaned from the NRS and help to align patients’ expectations with realistic treatment goals.

    Methods

    This cohort study was reviewed and approved by the University of Rochester Research Subjects Review Board with informed consent waived, given that the research presented no more than minimal risk and involved no procedures for which written consent is normally required outside the research context. This study followed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guideline. Participants were recruited electronically after a primary care encounter at 1 of 157 participating primary practices from December 2016 to March 2017. Eligible patients had an active prescription for an analgesic medication or an International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) visit diagnosis associated with chronic pain in their electronic health record, which was adapted using a previously validated ICD-9 chronic pain filter.4 Patients were asked the PTQ “is your pain tolerable?” (yes, no, or not in pain) and asked to rate average pain intensity during the past 24 hours, with 0 indicating no pain and 10 indicating the worst pain imaginable. To assess construct validity of the PTQ, responses to the question “is your pain tolerable?” were compared with responses on the NRS scale using logistic regression. Data analysis was conducted in February 2020 using JMP Pro version 14 (SAS Institute). Statistical significance was set at P < .05, and all tests were 2-tailed.

    Results

    In total, 1384 patients were invited to participate in the survey including the NRS and PTQ; 663 patients (47.9%) responded. Of those, 124 reported a 0 on the NRS or responded not in pain to the PTQ and were excluded. Two additional participants failed to complete the NRS, leaving a final analytic sample of 537 patients, with a median (interquartile range) age of 62.2 (54.0-71.0) years and 206 (38.4%) men (Table). Of these, 202 patients (37.8%) had more than 1 chronic pain diagnosis; the leading diagnosis was musculoskeletal pain (eg, osteoarthritis or soft-tissue disorder), with 295 patients (54.9%). A pain rating of intolerable was associated with higher NRS scores (odds ratio per 1-point increase on NRS, 1.1; 95% CI, 1.02-1.2; P = .01) (Figure). In the moderate range of the NRS (ie, 4-6), 40 of 211 patients (19.0%) characterized their pain as intolerable, whereas in the severe range of the NRS (ie, 7-10), 72 of 137 patients (52.6%) considered it intolerable.

    Discussion

    The overarching goal of chronic pain treatment is to make pain tolerable for the patient rather than to attain a targeted numeric rating. Our findings confirmed the intuitive assumption that most patients with low pain intensity (ie, NRS score, 1-3) find their pain tolerable. In contrast, the tolerability of pain rated between 4 and 6 varies substantially among patients. In this middle range, if a patient describes pain as tolerable, this might decrease the clinician’s inclination to initiate higher-risk treatments.5 A substantial subgroup of patients with severe pain reported their symptoms as tolerable.

    Discordance between tolerability and pain intensity may be an opening for a clinician to explore mood, sleep disruption, or the curtailing of activities to control pain. Asking patients with chronic pain about pain tolerability directly addresses the main limitation of the NRS, which asks patients to rate a complex, highly subjective experience on a unidimensional intensity scale. A limitation of this study is that patients could have had flares of chronic pain or superimposed acute pain episodes at the time of assessment. Research related to the associations of using the PTQ with patient satisfaction regarding communication, treatment goal setting, and treatment effects could further characterize the value of the PTQ.

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    Article Information

    Accepted for Publication: February 20, 2020.

    Published: April 20, 2020. doi:10.1001/jamanetworkopen.2020.3155

    Open Access: This is an open access article distributed under the terms of the CC-BY-NC-ND License. © 2020 Markman JD et al. JAMA Network Open.

    Corresponding Author: John D. Markman, MD, Translational Pain Research Program, Department of Neurosurgery, University of Rochester, 2180 S Clinton Ave, Rochester, NY 14618 (john_markman@urmc.rochester.edu).

    Author Contributions: Drs Markman and Gewandter had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

    Concept and design: All authors.

    Acquisition, analysis, or interpretation of data: All authors.

    Drafting of the manuscript: All authors.

    Critical revision of the manuscript for important intellectual content: All authors.

    Statistical analysis: Markman, Gewandter.

    Obtained funding: Markman.

    Administrative, technical, or material support: Markman, Frazer.

    Supervision: All authors.

    Conflict of Interest Disclosures: Dr Markman reported serving on the advisory boards of Swanbio, Braeburn, Pfizer, Eli Lilly and Co, Quark Therapeutics, Biogen, Chromocell, Diaachi Sankyo, Clexio Bioscience, Sophren, Trevena, Merck, Merck AG, Esteve Pharmaceuticals, Tremeau Pharmaceuticals, and Aptrinyx; serving as a consultant for Editas Medicine, Plasma Surgical, and Averitas; serving on the advisory board and data safety monitoring committee for Novartis; and owning equity in YellowBlack Corp outside the submitted work. No other disclosures were reported.

    Funding/Support: This work was supported by an investigator-initiated grant from Pfizer.

    Role of the Funder/Sponsor: The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

    Additional Contributions: We acknowledge the contribution of the 157 participating primary practices in the Greater Rochester Practice–Based Research Network for their collaboration in this study.

    References
    1.
    Ballantyne  JC, Sullivan  MD.  Intensity of chronic pain—the wrong metric?   N Engl J Med. 2015;373(22):2098-2099. doi:10.1056/NEJMp1507136PubMedGoogle ScholarCrossref
    2.
    Lucas  CE, Vlahos  AL, Ledgerwood  AM.  Kindness kills: the negative impact of pain as the fifth vital sign.   J Am Coll Surg. 2007;205(1):101-107. doi:10.1016/j.jamcollsurg.2007.01.062PubMedGoogle ScholarCrossref
    3.
    Jensen  MP, Karoly  P, Braver  S.  The measurement of clinical pain intensity: a comparison of six methods.   Pain. 1986;27(1):117-126. doi:10.1016/0304-3959(86)90228-9PubMedGoogle ScholarCrossref
    4.
    Clark  LL, Taubman  SB.  Brief report: incidence of diagnoses using ICD-9 codes specifying chronic pain (not neoplasm related) in the primary diagnostic position, active component, US Armed Forces, 2007-2014.   MSMR. 2015;22(12):12-15.PubMedGoogle Scholar
    5.
    Dartmouth Atlas Project. Preference-sensitive care. Accessed March 16, 2020. https://www.dartmouthatlas.org/downloads/reports/preference_sensitive.pdf
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