Association of Ramadan Fasting and Clinical Outcomes in Patients With Myasthenia Gravis | Myasthenia Gravis | JAMA Network Open | JAMA Network
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    Research Letter
    April 23, 2020

    Association of Ramadan Fasting and Clinical Outcomes in Patients With Myasthenia Gravis

    Author Affiliations
    • 1Department of Neurology, Ibn Sina Hospital, Sabah Medical Area, Kuwait City, Kuwait
    • 2Department of Neurology, Beni-Suef University, Beni-Suef, Egypt
    • 3Health Sciences Centre, Department of Medicine, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait
    JAMA Netw Open. 2020;3(4):e204373. doi:10.1001/jamanetworkopen.2020.4373

    Ramadan fasting (RF) is when millions of Muslims abstain from food and drink from dawn until sunset.1 Patients with chronic conditions who are eligible for exemption sometimes insist on fasting without seeking medical advice.2 To our knowledge, the effects of RF on myasthenia gravis (MG) have never been studied, and neurologists usually refrain from advising patients with MG to fast because of the lack of evidence-based knowledge regarding its safety. We aimed to study the association of RF with clinical outcomes in patients with MG and to use clinical characteristics to estimate outcome risk.

    This prospective cohort study was conducted in the main tertiary neurology center at Ibn Sina Hospital in Kuwait from April through June 2019 (Ramadan began May 5 and ended June 3). The study was approved by the institutional review board of the Ministry of Health of the state of Kuwait. All patients provided written informed consent to participate in the study and for their anonymized data to be used for analysis. This study follows the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guideline.