[Skip to Navigation]
Sign In
Table.  Clinical Features and Prognosis of Patients With Coronavirus Disease 2019 From 26 Transmission Cluster Series
Clinical Features and Prognosis of Patients With Coronavirus Disease 2019 From 26 Transmission Cluster Series
1.
Zhu  N, Zhang  D, Wang  W,  et al; China Novel Coronavirus Investigating and Research Team.  A novel coronavirus from patients with pneumonia in China, 2019.   N Engl J Med. 2020;382(8):727-733. doi:10.1056/NEJMoa2001017PubMedGoogle ScholarCrossref
2.
Huang  C, Wang  Y, Li  X,  et al.  Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.   Lancet. 2020;395(10223):497-506. doi:10.1016/S0140-6736(20)30183-5PubMedGoogle ScholarCrossref
3.
Zhang  JJ, Dong  X, Cao  YY,  et al.  Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China.   Allergy. Published online February 19, 2020. doi:10.1111/all.14238PubMedGoogle Scholar
4.
Guan  WJ, Ni  ZY, Hu  Y,  et al; China Medical Treatment Expert Group for Covid-19.  Clinical characteristics of coronavirus disease 2019 in China.   N Engl J Med. 2020;382(18):1708-1720. doi:10.1056/NEJMoa2002032PubMedGoogle ScholarCrossref
10 Comments for this article
EXPAND ALL
Question about the statistical results
Qunfeng Dong, Ph.D. | Loyola University Chicago
Interesting study. I hope that the authors can clarify their statistical results regarding their main finding of "less consumption of CD4+ T lymphocyte in asymptomatic infections".

In the Methods section, the author wrote that "χ2 analysis was conducted to examine the categorical variables. Means for continuous variables were compared using independent group t tests when the data were normally distributed; otherwise, the Mann-Whitney U test was used.". However, in the Results section, the Table only had a column named "χ2 or F test". Therefore, it's unclear if the reported p-value of 0.009 for the continuous
variable "CD4 lymphocyte count" was obtained using F-test (testing for equal variance) or t/U tests (testing for equal mean).

In addition, it may be also important to find out whether "CD4 lymphocyte count" is still significantly different between asymptomatic and symptomatic groups after controlling the effects of age and gender as confounding factors.
CONFLICT OF INTEREST: None Reported
READ MORE
Measuring Viral Shedding
Richard Kazibwe, Hospital Medicine | Sovah Health Danville, VA
When studying asymptomatic patients with Covid-19, the main concern is the public health risk these individuals pose by spreading the virus. I am wondering how in this study viral shedding was measured in both symptomatic and asymptomatic patients. We are entering into a critical time from a public health standpoint as communities are loosening on lockdown restrictions to allow economic activity. I think we will need to pay close attention of tools which can help us detect the community clusters of spread by even detecting asymptomatic carriers of the virus. I understand having a positive PCR on a nasopharyngeal swab does not necessarily indicate ability to spread the virus.
CONFLICT OF INTEREST: None Reported
READ MORE
Markers in (a)symptomatic CoVID19
Camilo Colaco, PhD | ImmunoBiology Ltd
Do you have data on
a. blood d-dimer levels in symptomatic vs asymptomatic patients
b. loss of smell or taste

Thank you,
CC
CONFLICT OF INTEREST: None Reported
Reply to-Measuring Viral Shedding
Yong Xiong, PhD | Department of Infectious Diseases, Zhongnan Hospital, Wuhan University, Wuhan, China
As for the question “How in this study viral shedding was measured in both symptomatic and asymptomatic patients?”:

The participants in this study, whether symptomatic or asymptomatic, were close contacts of confirmed COVID-19 patients with a clear exposure time. In this study, the duration of virus shedding was from the day of exposure to the time when SARS-CoV-2 was detected as negative for the first time.
CONFLICT OF INTEREST: None Reported
Reply to question about the statistical results
Yong Xiong, PhD | Department of Infectious Diseases, Zhongnan Hospital, Wuhan University, Wuhan, China
Re: "it's unclear if the reported p-value of 0.009 for the continuous variable 'CD4 lymphocyte count' was obtained using F-test (testing for equal variance) or t/U tests (testing for equal mean)."

The p-value of 0.009 for the continuous variable "CD4 lymphocyte count" was obtained using t tests.

"In addition, it may be also important to find out whether 'CD4 lymphocyte count' is still significantly different between asymptomatic and symptomatic groups after controlling the effects of age and gender as confounding factors."

Yes,during the recovery, CD4 lymphocyte count is still significantly different between asymptomatic and symptomatic groups after
controlling the effects of age and gender.
CONFLICT OF INTEREST: None Reported
READ MORE
Which statistical tests were used?
Joshua Gray, BS | Johns Hopkins University School of Medicine
I’d like to echo Qunfeng Dong’s questions on the statistical results in this manuscript and follow up with results of my own analysis:

I’ve checked the p values that would result if we assume the test statistics reported in Table 1 are 1) t statistics (as reported by the authors) OR 2) F statistics (F ratios) from a one-way ANOVA.

The results are here at PubPeer: https://pubpeer.com/publications/B8DA47CC63F11E98FE1D5F2C7FB2D8#

Briefly, almost every p value reported in Table 1 can be reproduced to the same significant figure reported by the authors assuming they are F statistics from a
one-way ANOVA. Under the assumption that the statistics are t statistics from a t test, the resulting p values are extremely small (some on the order of 10^(-15)) which would be an astonishing degree of significant difference given an n of 78.
CONFLICT OF INTEREST: None Reported
READ MORE
Corrected comparisons
Yong Xiong, PhD | Department of Infectious Diseases, Zhongnan Hospital, Wuhan University, Wuhan, China
We thank the commenters for these concerns. We have rerun the comparisons using χ2 and t tests.

χ2 analysis was conducted to compare the distributions of categorical variables (sex, baseline liver injury, fluctuated results of SARS-CoV-2 test, and death) between asymptomatic and symptomatic patients. Continuous variables (age, duration of viral shedding, duration of lung recovery, maximum difference of CD4 lymphocytes during treatment, and CD4 lymphocyte count during recovery) were compared using a t-test. The corrected findings are similar to the originally reported comparisons, and the statistical results all indicate P <0.01. We have requested that the article text and
Table be corrected.

We were touched by the reader’s thoughtful responses, and we are also very glad to communicate these corrected data with readers.
CONFLICT OF INTEREST: None Reported
READ MORE
CT results?
Milad Ali |
Interesting study, do you have the result of the CT scan if they were normal or abnormal percentage for symptomatic and asymptomatic patients?
CONFLICT OF INTEREST: None Reported
Re: CT results?
Seth Trueger, PhD | Department of Infectious Diseases, Zhongnan Hospital, Wuhan University, Wuhan, China
Thank you for your attention. All the patients confirmed with SARS-CoV-2 infection received chest CT scan. Among the 33 asymptomatic patients, there were 12 cases had normal chest CT imaging, while all the symptomatic patients had abnormal chest CT imaging.
CONFLICT OF INTEREST: None Reported
Viral load in asymptomatic patients
Brian Haynes |
What were the viral shedding loads found on the nasopharyngeal swabs between the asymptomatic and symptomatic patients? This study is referenced by CDC as evidence of asymptomatic transmission, with statements made by officials that a substantial fraction of transmissions are from asymptomatic people.
CONFLICT OF INTEREST: None Reported
Research Letter
Infectious Diseases
May 27, 2020

Comparison of Clinical Characteristics of Patients with Asymptomatic vs Symptomatic Coronavirus Disease 2019 in Wuhan, China

Author Affiliations
  • 1Department of Infectious Diseases, Zhongnan Hospital, Wuhan University, Wuhan, China
JAMA Netw Open. 2020;3(5):e2010182. doi:10.1001/jamanetworkopen.2020.10182
Introduction

Coronavirus disease 2019 (COVID-19) emerged in Wuhan, China, in December 2019 and has spread globally with sustained human-to-human transmission outside China.1,2 To control the spread of COVID-19 and isolate patients as early as possible, the Chinese government requested that close contacts of individuals with COVID-19 must be screened for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. During the screening process, we found some patients whose test results were positive for SARS-CoV-2 but who had no symptoms or signs throughout the course of the disease. Considering that little is known about the differences of clinical features and prognosis between patients who were asymptomatic vs those who were symptomatic,3,4 this case series aimed to describe the clinical characteristics of patients with SARS-CoV-2 infection confirmed by reverse transcription–polymerase chain reaction (RT-PCR) from 26 transmission cluster series in Wuhan, China, from December 24, 2019, to February 24, 2020.

Methods

This case series was approved by the institutional ethics board of Zhongnan Hospital of Wuhan University. All consecutive patients with COVID-19 confirmed via RT-PCR admitted to Zhongnan Hospital of Wuhan University from December 24, 2019, to February 24, 2020, were enrolled. Oral informed consent was obtained from all patients. Epidemiological, symptoms, signs, laboratory values, chest computed tomography (CT) scans, treatment measures, and outcomes data during the hospital stay were collected. Nasopharyngeal swab samples were collected for extracting SARS-CoV-2 RNA from patients suspected of having SARS-CoV-2 infection.

The indicative patients were recruited from 26 cluster cases and had confirmed history of exposure to the Huanan seafood market or had close contact with another patient who had been hospitalized for COVID-19, and they were confirmed to have SARS-CoV-2 infection by RT-PCR from nasopharyngeal swabs. Routine chest CT scans and SARS-CoV-2 testing from nasopharyngeal swab were performed on their close contacts. The close contacts with other exposure histories were excluded. The included patients who were exposed to the same indicative patients with COVID-19 were defined as clustered cases, and the date of initial exposure was identified to determine incubation period.

Data were analyzed using SPSS statistical software version 19.0 (IBM). Categorical variables were described as frequency rates and percentages, and continuous variables were described using mean, median, and interquartile range (IQR) values. χ2 analysis was conducted to compare the distributions of categorical variables (ie, sex, baseline liver injury, fluctuated results of SARS-CoV-2 test, and death) between asymptomatic and symptomatic patients. Continuous variables (ie, age, duration of viral shedding, duration of lung recovery, maximum difference of CD4 lymphocytes during treatment, and CD4 lymphocyte count during recovery) were compared using t tests. All P values were 2-tailed, and P < .05 was considered to be significant.

Results

This case series includes data for 78 patients from 26 cluster cases of exposure to the Huanan seafood market or close contact with other patients with COVID-19. All patients were confirmed to have SARS-CoV-2 infection by RT-PCR from nasopharyngeal swabs. The median (IQR) number of patients per cluster was 3 (2-3) patients, and the range was 2 to 10 patients per cluster.

The 78 close contacts confirmed with SARS-CoV-2 infection were hospitalized in same medical area and provided the same treatments administered by the same health care workers. A total of 33 patients (42.3%) were asymptomatic, while 45 patients (57.7%) were symptomatic. The symptoms and signs, such as fever, fatigue, and dry cough, were monitored every day. Detecting SARS-CoV-2 from nasopharyngeal swab was monitored every 24 to 48 hours. For patients with stable conditions, a second chest CT was conducted 4 to 6 days after the first time, then 6 to 7 days after the second time. Chest CT was also conducted at any time a patient’s condition became worse. CD4+T lymphocyte count was tested every 5 to 6 days.

Data about clinical characteristics of patients with asymptomatic and symptomatic SARS-CoV-2 infection are presented in the Table. Patients who were asymptomatic, compared with patients with symptomatic SARS-CoV-2 infection, were younger (median [IQR] age, 37 [26-45] years vs 56 [34-63] years; t = −4.627; P < .001), and had a higher proportion of women (22 [66.7%] women vs 14 [31.1%] women; P = .002), lower proportion of liver injuries (1 patients [3.0%] vs 9 patients [20.0%]; P = .03), less consumption of CD4+T lymphocytes (median [IQR] maximum difference of CD4 lymphocytes during treatment, 203 [170-304] per μL vs 328 [145-506] per μL [to convert to to ×109 per liter, multiply by 0.001]; t = −5.383; P < .001), faster lung recovery in CT scans (median [IQR] duration, 9 [6-18] days vs 15 [11-18] days; t = −3.055; P = .003), shorter duration of viral shedding from nasopharynx swabs (median [IQR] duration, 8 [3-12] days vs 19 [16-24] days; t = −3.830; P = .001), and more stable results of SARS-CoV-2 testing (4 fluctuated results [12.1%] vs 15 fluctuated results [33.3%]).

Discussion

Our finding of less consumption of CD4+T lymphocyte in asymptomatic infections suggests that damage to the immune system in asymptomatic infections was milder compared with symptomatic infections. Although patients who were asymptomatic experienced less harm to themselves, they may have been unaware of their disease and therefore not isolated themselves or sought treatment, or they may have been overlooked by health care workers and thus unknowingly transmitted the virus to others. Fortunately, patients with asymptomatic SARS-CoV-2 infection have a shorter duration of viral shedding from nasopharyngeal swabs and lower risk of a recurring positive test result of SARS-CoV-2 from nasopharyngeal swabs, which can provide a reference for improving the prevention and control strategies for patients who are asymptomatic.

This study has some limitations. Although all patients whose RT-PCR tests were positive for SARS-CoV-2 had been exposed to same patients, were hospitalized in same medical area, and provided the same treatments administered by the same health care workers, the clinical differences between patients who were asymptomatic vs those who were symptomatic could have been more objectively observed.

Since patients with asymptomatic COVID-19 were relatively concealed, the fact of viral shedding detected via nasopharyngeal swabs must not be ignored. Therefore, identifying and isolating patients with asymptomatic COVID-19 as early as possible is critical to control the transmission of COVID-19. Close contacts of patients with COVID-19 should be closely monitored to avoid secondary transmission.

Back to top
Article Information

Accepted for Publication: May 1, 2020.

Published: May 27, 2020. doi:10.1001/jamanetworkopen.2020.10182

Correction: This article was corrected on June 26, 2020, to fix incorrect reporting of the statistics.

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2020 Yang R et al. JAMA Network Open.

Corresponding Author: Yong Xiong, Department of Infectious Diseases, Zhongnan Hospital, Wuhan University, Donghu Road 169, Wuchang District, Wuhan city 430071, Hubei Province, China (yongxiong64@163.com).

Author Contributions: Drs Yang and Xiong had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Yang, Xiong.

Acquisition, analysis, or interpretation of data: Yang, Gui.

Drafting of the manuscript: Yang.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Yang.

Obtained funding: Xiong.

Administrative, technical, or material support: Yang, Xiong.

Supervision: All authors.

Conflict of Interest Disclosures: None reported.

Funding/Support: This study was supported by Grant No. TFJC2018002 from the Medical Science Advancement Program (Basical Medical Sciences) of Wuhan University.

Role of the Funder/Sponsor: The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

References
1.
Zhu  N, Zhang  D, Wang  W,  et al; China Novel Coronavirus Investigating and Research Team.  A novel coronavirus from patients with pneumonia in China, 2019.   N Engl J Med. 2020;382(8):727-733. doi:10.1056/NEJMoa2001017PubMedGoogle ScholarCrossref
2.
Huang  C, Wang  Y, Li  X,  et al.  Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.   Lancet. 2020;395(10223):497-506. doi:10.1016/S0140-6736(20)30183-5PubMedGoogle ScholarCrossref
3.
Zhang  JJ, Dong  X, Cao  YY,  et al.  Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China.   Allergy. Published online February 19, 2020. doi:10.1111/all.14238PubMedGoogle Scholar
4.
Guan  WJ, Ni  ZY, Hu  Y,  et al; China Medical Treatment Expert Group for Covid-19.  Clinical characteristics of coronavirus disease 2019 in China.   N Engl J Med. 2020;382(18):1708-1720. doi:10.1056/NEJMoa2002032PubMedGoogle ScholarCrossref
×