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    Original Investigation
    July 8, 2020

    Association of Smoking Cessation and Survival Among Young Adults With Myocardial Infarction in the Partners YOUNG-MI Registry

    Author Affiliations
    • 1Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts
    • 2Division of Cardiology, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut
    • 3New York Presbyterian/Columbia University Irving Medical Center, New York, New York
    • 4Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts
    • 5Department of Medicine, Tufts Medical Center, Boston, Massachusetts
    • 6The Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Baltimore, Maryland
    • 7Center for Outcomes Research, Houston Methodist, Houston, Texas
    JAMA Netw Open. 2020;3(7):e209649. doi:10.1001/jamanetworkopen.2020.9649
    Key Points español 中文 (chinese)

    Question  Is smoking cessation associated with lower mortality among young adults after an initial myocardial infarction (MI)?

    Findings  In this cohort study of 2072 individuals who experienced an initial MI at 50 years or younger, approximately half were smokers at the time of their MI, and 62% continued to smoke at 1 year after MI. Smoking cessation within 1 year after MI was associated with a statistically significant reduction in long-term all-cause and cardiovascular mortality.

    Meaning  Smoking cessation after MI was associated with a clinically significant reduction in all-cause and cardiovascular mortality in a cohort of patients who experienced an MI at a young age.


    Importance  Despite significant progress in primary prevention, the rate of myocardial infarction (MI) continues to increase in young adults.

    Objectives  To identify the prevalence of tobacco use and to examine the association of both smoking and smoking cessation with survival in a cohort of adults who experienced an initial MI at a young age.

    Design, Setting, and Participants  The Partners YOUNG-MI registry is a retrospective cohort study from 2 large academic centers in Boston, Massachusetts, that includes patients who experienced an initial MI at 50 years or younger. Smoking status at the time of presentation and at 1 year after MI was determined from electronic medical records. Participants were 2072 individuals who experienced an MI at 50 years or younger between January 2000 and April 2016. The dates of analysis were October to December 2019.

    Main Outcomes and Measures  Deaths were ascertained from the Social Security Administration Death Master File, the Massachusetts Department of Vital Statistics, and the National Death Index. Cause of death was adjudicated independently by 2 cardiologists. Propensity score–adjusted Cox proportional hazards modeling was used to evaluate the association between smoking cessation and both all-cause and cardiovascular mortality.

    Results  Among the 2072 individuals (median age, 45 years [interquartile range, 42-48 years]; 1669 [80.6%] men), 1088 (52.5%) were smokers at the time of their index hospitalization. Of these, 910 patients were further classified into either the cessation group (343 [37.7%]) or the persistent smoking group (567 [62.3%]) at 1 year after MI. Over a median follow-up of 11.2 years (interquartile range, 7.3-14.2 years), individuals who quit smoking had a statistically significantly lower rate of all-cause mortality (hazard ratio [HR], 0.35; 95% CI, 0.19-0.63; P < .001) and cardiovascular mortality (HR, 0.29; 95% CI, 0.11-0.79; P = .02). These values remained statistically significant after propensity score adjustment (HR, 0.30 [95% CI, 0.16-0.56; P < .001] for all-cause mortality and 0.19 [95% CI, 0.06-0.56; P = .003] for cardiovascular mortality).

    Conclusions and Relevance  In this cohort study, approximately half of individuals who experienced an MI at 50 years or younger were active smokers. Among them, smoking cessation within 1 year after MI was associated with more than 50% lower all-cause and cardiovascular mortality.