Bars denote proportion of shorter radiation regimens by each year chronologically and stratified by cancer type, with overlying lines to demonstrate the longitudinal trend. Error bars denote 95% confidence intervals.
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Gillespie EF, Tringale KR, Bach PB, Bekelman JE. Evaluation of Use of Shorter Radiation Regimens for Breast and Prostate Cancer in the US, 2015-2017. JAMA Netw Open. 2020;3(7):e2010519. doi:10.1001/jamanetworkopen.2020.10519
For breast and prostate cancer, shorter radiation treatment regimens lasting 3 to 5 weeks are evidence-based practices that are similarly effective and safe, and substantially less costly for payers and patients, compared with extended regimens lasting 6 to 9 weeks.1 National guidelines endorsed shorter radiation regimens for breast cancer in 2011 and for prostate cancer in 2018.2,3 In July 2019, the Centers for Medicare & Medicaid Services proposed a mandatory episode-based payment model for radiation services, partly motivated by an interest in accelerating uptake of shorter radiation regimens, and publicly released Medicare data on US radiation episodes during the period from 2015 to 2017.4 During this period prior to guideline endorsement of shorter regimens for prostate cancer, we hypothesized that growth in uptake of shorter regimens would be greater in breast cancer than in prostate cancer.
The data set contains radiation episodes covering 84% of Medicare beneficiaries.4 In this cross-sectional study, we included beneficiaries with breast and prostate cancer treated with external radiation (conventional, intensity-modulated, or proton radiotherapy). We classified episodes into 2 groups: shorter regimens (11 to 20 daily treatments for breast cancer or 11 to 30 for prostate cancer) and extended regimens (>20 or >30 daily treatments, respectively). The study was approved as exempt for the need for informed consent by the Memorial Sloan Kettering Cancer Center institutional review board because publicly available anonymized data were used. The study followed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guidelines.
We calculated compound annual growth rates and used multivariable linear regression to compare rates of change in the use of shorter regimens between breast and prostate cancer. We compared radiation-related spending for shorter vs extended regimens from the amount reimbursed by Medicare for facility and professional services over the 90-day episode, adjusted for inflation to 2017. Statistical significance was set at 2-sided P < .025, applying a Bonferroni correction for 2 main analyses. Data analysis was performed from September to December 2019 using SAS Enterprise Guide statistical software version 9.1 (SAS Institute).
From 2015 to 2017, among 85 570 radiation episodes for women with breast cancer aged 65 to 74 years (67%), 75 to 84 years (28%), and 85 years or older (19%), shorter radiation regimens increased from 33.1% (95% CI, 32.5%-33.6%) to 42.4% (95% CI, 41.9%-43.0%) (P < .001) at a compound annual growth rate of 13.2%. Among 71 720 episodes for men with prostate cancer aged 65 to 74 years (63%), 75 to 84 years (33%), and 85 years or older (4%), shorter regimens increased from 13.4% (95% CI, 13.0%-13.9%) to 16.7% (95% CI, 16.2%-17.2%) (P < .001) at a compound annual growth rate of 11.6% (Figure). Rates of change in use of shorter regimens did not differ significantly between the 2 cancers (compound annual growth rate, 13.2% vs 11.6%; difference, 1.6%).
Mean 90-day radiation-related spending was 33% lower for beneficiaries with breast cancer treated with shorter compared with extended regimens ($9204 [95% CI, $9179-$9229] vs $13 733 [95% CI, $13 707-$13 759]; difference = $4529; P < .001) and 34% lower for prostate cancer ($18 709 [95% CI, $18 580-$18 839] vs $28 262 [95% CI, $28 217-$28 307]; difference = $9553; P < .001) (Table).
Among Medicare beneficiaries receiving radiation treatment between 2015 and 2017, the rate of uptake of shorter radiation regimens was modest and did not differ meaningfully between breast and prostate cancer. We also found that shorter radiation regimens for prostate cancer, like breast cancer, reduce radiation-related spending by approximately one-third. During the study period, guidelines had endorsed shorter regimens for breast cancer but not prostate cancer; comparable uptake underscores the challenge of implementing less costly evidence-based practices in cancer care.5
Today, accelerating uptake of shorter radiation regimens is an urgent priority to enhance evidence-based, patient-centered cancer care. Development, testing, and scaling of strategies to achieve this goal, such as default options, audit and feedback and patient engagement, is warranted.6
This study has limitations. Because the Centers for Medicare & Medicaid Services data set is missing cancer stage and radiation field, these results underestimate the absolute proportion of beneficiaries receiving shorter regimens. However, absent evidence of secular changes in cancer stage or treatment patterns, rate of uptake of shorter regimens is unlikely to be underestimated.
Accepted for Publication: May 4, 2020.
Published: July 16, 2020. doi:10.1001/jamanetworkopen.2020.10519
Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2020 Gillespie EF et al. JAMA Network Open.
Corresponding Author: Erin F. Gillespie, MD, Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 22, New York, NY 10065 (firstname.lastname@example.org).
Author Contributions: Drs Gillespie and Tringale had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Gillespie, Bach, Bekelman.
Acquisition, analysis, or interpretation of data: Gillespie, Tringale, Bekelman.
Drafting of the manuscript: All authors.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: All authors.
Administrative, technical, or material support: Bach.
Supervision: Gillespie, Bach, Bekelman.
Conflict of Interest Disclosures: Dr Gillespie reported being a cofounder of eContour.org, an educational website for radiation oncology professionals. Dr Bach reported receiving grants during the conduct of the study from Kaiser Permanente, the Laura and John Arnold Foundation, and National Institutes of Health Core Grant P30 CA 008748; personal fees unrelated to the submitted work from American Society for Health-System Pharmacists, Gilead Pharmaceuticals, WebMD, Goldman Sachs, Defined Health, Vizient, Anthem, Excellus Health Plan, Hematology Oncology Pharmacy Association, Novartis Pharmaceuticals, Janssen Pharmaceuticals, Third Rock Ventures, JMP Securities, Genentech, Mercer, United Rheumatology, Morgan Stanley, NYS Rheumatology Society, Oppenheimer & Co, and Cello Health; and consulting fees from Foundation Medicine and Grail unrelated to the submitted work. Dr Bekelman reported receiving grants from UnitedHealth Group, Pfizer, North Carolina Blue Cross Blue Shield, and Embedded Health Care during the conduct of the study; personal fees from Optum, CVS Health, and the National Comprehensive Cancer Network; and personal fees in 2017 and 2018 from the Actuarial Research Corporation for serving as a consultant on radiation oncology to the Centers for Medicare & Medicaid Services Center for Medicare and Medicaid Innovation, unrelated to the submitted work. No other disclosures were reported.
Funding/Support: This study was supported by a Memorial Sloan Kettering Cancer Center Grant.
Role of the Funder/Sponsor: The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: Jillian Tsai, MD, PhD (Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center), and Zhigang Zhang, PhD (Department of Biostatistics, Memorial Sloan Kettering Cancer Center), assisted with statistical analysis. They were not compensated beyond their regular salaries.