[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 34.234.223.162. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Limit 200 characters
Limit 25 characters
Conflicts of Interest Disclosure

Identify all potential conflicts of interest that might be relevant to your comment.

Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.

Err on the side of full disclosure.

If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.

Not all submitted comments are published. Please see our commenting policy for details.

Limit 140 characters
Limit 3600 characters or approximately 600 words
    Views 7,813
    Citations 0
    Research Letter
    Infectious Diseases
    July 22, 2020

    Association of Interleukin 7 Immunotherapy With Lymphocyte Counts Among Patients With Severe Coronavirus Disease 2019 (COVID-19)

    Author Affiliations
    • 1Department of Critical Care Medicine, Saint Luc University Hospital, Université Catholique de Louvain, Brussels, Belgium
    • 2Intensive Care Unit Department and Inserm Centre Investigation Clinique 1435 and Unité Mixte de Recherche 1092, University Hospital of Limoges, Limoges, France
    • 3Department of Intensive Care Medicine and Anaesthesiology, University Hospital of Limoges, Limoges, France
    • 4Department of Pediatrics, Washington University School of Medicine in St Louis, St Louis, Missouri
    • 5Department of Anesthesiology and Critical Care Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri
    • 6Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri
    • 7Department of Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri
    JAMA Netw Open. 2020;3(7):e2016485. doi:10.1001/jamanetworkopen.2020.16485

    Cytokine storm–mediated organ injury continues to dominate current thinking as the primary mechanism for coronavirus disease 2019 (COVID-19). Although there is an initial hyper-inflammatory phase, mounting evidence suggests that virus-induced defective host immunity may be the real cause of death in many patients.1,2

    COVID-19 has been called a serial lymphocyte killer because profound and protracted lymphopenia is a near uniform finding among patients with severe COVID-19 and correlates with morbidity and mortality.1,3 Autopsies demonstrate a devastating depletion of lymphocytes in the spleen and other organs.2 CD4, CD8, and natural killer cells, which play important antiviral roles, are depleted and have reduced function, leading to immune collapse.1

    ×