Customize your JAMA Network experience by selecting one or more topics from the list below.
Identify all potential conflicts of interest that might be relevant to your comment.
Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.
Err on the side of full disclosure.
If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.
Not all submitted comments are published. Please see our commenting policy for details.
Callaway CW, Coppler PJ, Faro J, et al. Association of Initial Illness Severity and Outcomes After Cardiac Arrest With Targeted Temperature Management at 36 °C or 33 °C. JAMA Netw Open. 2020;3(7):e208215. doi:10.1001/jamanetworkopen.2020.8215
What is the optimal target temperature for targeted temperature management (TTM) in comatose patients after cardiac arrest?
In a cohort study of 1319 patients, of whom 911 did not have severe cerebral edema or highly malignant electroencephalogram, TTM at 33 °C was associated with better survival than TTM at 36 °C for patients with the most severe post–cardiac arrest illness, but TTM at 36 °C was associated with better survival in patients with mild- to moderate-severity illness. Patients with severe cerebral edema or highly malignant electroencephalogram had poor outcomes regardless of TTM strategy.
The findings of this study suggest that measuring initial illness severity in patients resuscitated from cardiac arrest may guide selection of the optimal TTM strategy.
It is uncertain what the optimal target temperature is for targeted temperature management (TTM) in patients who are comatose following cardiac arrest.
To examine whether illness severity is associated with changes in the association between target temperature and patient outcome.
Design, Setting, and Participants
This cohort study compared outcomes for 1319 patients who were comatose after cardiac arrest at a single center in Pittsburgh, Pennsylvania, from January 2010 to December 2018. Initial illness severity was based on coma and organ failure scores, presence of severe cerebral edema, and presence of highly malignant electroencephalogram (EEG) after resuscitation.
TTM at 36 °C or 33 °C.
Main Outcomes and Measures
Primary outcome was survival to hospital discharge, and secondary outcomes were modified Rankin Scale and cerebral performance category.
Among 1319 patients, 728 (55.2%) had TTM at 33 °C (451 [62.0%] men; median [interquartile range] age, 61 [50-72] years) and 591 (44.8%) had TTM at 36 °C (353 [59.7%] men; median [interquartile range] age, 59 [48-69] years). Overall, 184 of 187 patients (98.4%) with severe cerebral edema died and 234 of 243 patients (96.3%) with highly malignant EEG died regardless of TTM strategy. Comparing TTM at 33 °C with TTM at 36 °C in 911 patients (69.1%) with neither severe cerebral edema nor highly malignant EEG, survival was lower in patients with mild to moderate coma and no shock (risk difference, –13.8%; 95% CI, –24.4% to –3.2%) but higher in patients with mild to moderate coma and cardiopulmonary failure (risk difference, 21.8%; 95% CI, 5.4% to 38.2%) or with severe coma (risk difference, 9.7%; 95% CI, 4.0% to 15.3%). Interactions were similar for functional outcomes. Most deaths (633 of 968 [65.4%]) resulted after withdrawal of life-sustaining therapies.
Conclusions and Relevance
In this study, TTM at 33 °C was associated with better survival than TTM at 36 °C among patients with the most severe post–cardiac arrest illness but without severe cerebral edema or malignant EEG. However, TTM at 36 °C was associated with better survival among patients with mild- to moderate-severity illness.
Create a personal account or sign in to: