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Invited Commentary
July 28, 2020

Benefits of Digital Breast Tomosynthesis Beyond Baseline Screening

Author Affiliations
  • 1Division of Breast Radiology, Department of Diagnostic Imaging, Fox Chase Cancer Center, Philadelphia, Pennsylvania
  • 2Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles
  • 3Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania
JAMA Netw Open. 2020;3(7):e2012361. doi:10.1001/jamanetworkopen.2020.12361

Nearly half a century since its introduction into clinical practice, mammography remains the criterion standard for breast cancer detection. Women who participate in a modern breast cancer screening program have 60% lower risk of dying from breast cancer within 10 years of diagnosis and 47% lower risk within 20 years compared with women who do not.1 Still, the mammogram is an imperfect screening tool, and the sensitivity for cancer detection is inversely proportional to breast density.2 False-positive rates in breast cancer screening are also a considerable limitation of mammography, and high callback rates may lead to unnecessary biopsies, increasing costs, and patient anxiety.3 Although cancer detection is most important, recall reduction is also a valuable metric for women undergoing screening mammography.

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