Age- and Sex-Associated Variations in the Sensitivity of Serological Tests Among Individuals Infected With SARS-CoV-2 | Infectious Diseases | JAMA Network Open | JAMA Network
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    Research Letter
    Infectious Diseases
    February 12, 2021

    Age- and Sex-Associated Variations in the Sensitivity of Serological Tests Among Individuals Infected With SARS-CoV-2

    Rohit Vashisht, PhD1; Ayan Patel, MS1,2; Bridgit O. Crews, PhD3; et al Omai B. Garner, PhD4; Lisa Dahm, PhD2; Charles Wilson, BS2; Atul J. Butte, MD, PhD1,2
    Author Affiliations Article Information
    • 1Bakar Computational Health Sciences Institute, University of California, San Francisco
    • 2Center for Data-driven Insights and Innovation, University of California Health, Oakland
    • 3Department of Pathology and Laboratory Medicine, University of California, Irvine
    • 4Department of Pathology and Laboratory Medicine, UCLA Medical Center, Los Angeles, California
    JAMA Netw Open. 2021;4(2):e210337. doi:10.1001/jamanetworkopen.2021.0337
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    Antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are known to appear 2 to 3 weeks after infection,1-3 but patient characteristics and measurement timing could influence this immune response. This cohort study investigated the sensitivity of antibody tests to detect previous SARS-CoV-2 infection using existing clinical data across the University of California Health (UC Health) system.

    The institutional review boards across the UC Health system determined this cohort study was not human participants research and therefore was exempt from approval and informed consent. This study is reported following the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guideline.

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