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    3 Comments for this article
    What About Mortality?
    Eduardo Quinteros, MD | Clinica Mayo Bell Ville
    The authors mention death, but how many deaths were there?
    Same Question about Deaths
    Stanley Schwartz, MD | WellOK, The Northeastern Oklahoma Business Coalition on Health
    As in the previous comment, the authors included death in the category of severe COVID-19 infection. Not reporting actual mortality seems intentional. Why?
    Patient Sample
    Bradette Varilek, MD |
    Given that the sample was taken from inpatients and ER visits I wonder if it is biased towards a sicker group. What about drive-in clinics and outpatient visits? The national data shows 1-2% hospitalized, not 12%. This seems a little high to me.
    Views 22,393
    Citations 0
    Research Letter
    Infectious Diseases
    April 9, 2021

    Characteristics and Disease Severity of US Children and Adolescents Diagnosed With COVID-19

    Author Affiliations
    • 1COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia
    • 2Epidemic Intelligence Service, Center for Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention, Atlanta, Georgia
    • 3Commissioned Corps, US Public Health Service, Rockville, Maryland
    JAMA Netw Open. 2021;4(4):e215298. doi:10.1001/jamanetworkopen.2021.5298

    In 2020, more than 2 000 000 pediatric COVID-19 cases were reported in the United States.1 Although approximately half of pediatric patients with COVID-19 experience mild disease, some children require admission to intensive care units or use of invasive mechanical ventilation.2 We conducted a cohort study to estimate adjusted associations between demographic and clinical characteristics and severe COVID-19 among hospitalized pediatric patients.

    Discharge data from 869 medical facilities that contributed inpatient and emergency department encounters to the Premier Healthcare Database Special COVID-19 Release (PHD-SR) (release date, December 9, 2020), an administrative all-payer database capturing approximately 20% of US hospitalizations,3 were used to describe patients 18 years or younger who had an inpatient or emergency department encounter with a primary or secondary COVID-19 discharge diagnosis from March 1 through October 31, 2020. The International Statistical Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) diagnosis code U07.1 was used from April 1 through October 31, 2020, and code B97.29 was used from March 1 through April 30, 2020. The discharge data were also used to estimate associations between demographic and clinical characteristics and severe COVID-19 among pediatric patients hospitalized with COVID-19. This study was reviewed by the Centers for Disease Control and Prevention and was deemed exempt from institutional review board oversight per 45 CFR §46.101(b)(4) and exempt from patient informed consent based on 45 CFR §164.506(d)(2)(ii)(B) because the disclosed PHD-SR data are considered deidentified. This study followed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guideline.