This trial protocol describes a randomized clinical trial that aims to determine the efficacy and safety of tropisetron for prevention of emergence delirium in patients undergoing noncardiac surgery.
This phase 1 trial assesses the safety, antitumor activity, and pharmacokinetics of toripalimab in patients with advanced non–small cell lung cancer (NSCLC) and evaluates the utility of JS311, a novel programmed death cell ligand 1 immunohistochemistry assay.
This cohort study compares the risk of secondary sarcoma among patients treated with combinations of surgery, radiation, and chemotherapy with patients treated with surgery alone and with the general population.
This prognostic study evaluates a potential DNA repair–related prognostic signature to improve the accuracy of prediction of the overall survival of patients with breast cancer.
This cohort study uses real-world data to assess patient characteristics and use as well as the safety and effectiveness of edaravone among patients with amyotrophic lateral sclerosis in the US Department of Veterans Affairs Health Care System.
This study evaluates an automated reporting checklist generation tool that uses natural language processing to improve adherence to the Consolidated Standards of Reporting Trials (CONSORT) reporting checklist for randomized clinical trials (RCTs).
This cohort study evaluates whether patients with higher-risk prostate cancer residing in Medicaid expansion states were more likely to receive treatment after expansion compared with patients in states that did not pursue Medicaid expansion.
This cohort study provides epidemiological data on the 20-year secular trend in the incidence rates of central precocious puberty and normal variant puberty among children in Denmark.
This systematic review and network meta-analysis clarifies which first-line treatment is associated with the best tumor response among patients with extensive-stage small cell lung cancer (SCLC).
This quality improvement pilot study evaluates whether an email intervention that communicates an oncologist’s performance in documenting cancer stage relative to that of peer physicians is associated with increased likelihood that stage is documented in the electronic health record (EHR).
This cohort study examines the differences in cost among hospital outpatient departments, ambulatory surgery centers, and office settings for minor hand surgical procedures.
This economic evaluation compares the cost-effectiveness of pembrolizumab-axitinib vs nivolumab-ipilimumab for treatment of advanced renal cell carcinoma (ARCC) in the US.
This cohort study assess the association of receipt of medication for opioid use disorder and mortality after hospitalization for injection drug use–associated infective endocarditis in Massachusetts.
This cross-sectional study explores the utility of community-level data for accurately identifying patients with social risks by comparing the social deprivation index score for the census tract where a patient lives with patient-level social risk screening data.
This secondary analysis of a cluster randomized clinical trial assesses the association between prehospital plasma administration and survival in patients with traumatic brain injury.
This diagnostic study assesses the value of including neighborhood socioeconomic status in models that use electronic health record (EHR) data to predict health care use rates and mortality among adults in a large integrated care system.
This randomized trial of health care professionals evaluates the efficacy of training with a virtual standardized patient on the acquisition and maintenance of motivational interviewing skills compared with traditional academic study.
This cohort study examines stress levels in children based on environment factors, including artificial light at night, near-roadway air pollution, noise, green space, and secondhand smoke.
This systematic review and network meta-analsysis compares antifungal prophylaxis drugs for patients with hematological disease or who are undergoing hematopoietic stem cell transplantation (HSCT).
This cohort study evaluates whether infectious disease physician approval prior to placement of a peripherally inserted central catheter (PICC) for intravenous antimicrobials is associated with more appropriate device use and fewer complications.
This genetic association study assesses whether variants near the apolipoprotein E gene (APOE) are associated with Alzheimer disease independently of ε2/ε3/ε4 genotype.
This cross-sectional study calculates the fragility of survival data in randomized clinical trials evaluating immune checkpoint inhibitors.
This cohort study evaluates the incidence of hyponatremia after the placement of indwelling peritoneal catheters for drainage of malignant ascites and the risk factors associated with its development.
This cohort study assesses whether higher levels of viral persistence are associated with atherosclerosis as assessed by changes in carotid artery intima-media thickness over time in patients living with HIV.
This qualitative study examines perceptions of the workload burden associated with electronic consultations among a national sample of Veterans Health Administration (VHA) primary care clinicians.
This follow-up of the ABC randomized clinical trial compares the risk of asthma or recurrent wheeze among young children who were randomized as infants to either breastfeeding with cow’s milk formula supplementation or breastfeeding with or without elemental formula supplementation in the first few days of life.
This cohort study compares observational associations with genetic associations of body mass index with hepatobiliary diseases and liver biomarkers.
This cohort study uses data from the Health and Retirement Study to examine the association between Patient Protection and Affordable Care Act funded–Medicaid expansion in 2014 and long-term care use among low-income, middle-aged adults newly eligible for Medicaid.
This cohort study examines the association of pretreatment with P2Y12 receptor antagonist with 30-day and 1-year mortality and in-hospital bleeding among patients with non–ST-segment elevation acute coronary syndromes (NSTE-ACS).
This cross-sectional study examines statewide variations in the prevalence of hypertensive disorders in pregnant women across the US.
This cohort study analyzes the preoperative use of benzodiazepines compared with long-term postoperative use of opioids and association with health care costs.
This survey study investigates the association of hospitalized patients’ desire to delegate decisions to their physician with care dissatisfaction.
This case-control study investigates the association of cigarette smoking with cerebrospinal fluid biomarkers of neurodegeneration, neuroinflammation, oxidation, and neuroprotection.
This cohort study examines whether and why regional node irradiation in patients with de novo metastatic breast cancer has different levels of effectiveness for preventing recurrences of cancer in regional nodes and distant mestastases.
This cross-sectional study assesses trends in early adult (ages 18-23 years) vs adolescent (age <18 years) cigarette smoking initiation and transition to daily cigarette smoking from 2002 to 2018.
This cohort study uses national longitudinal data from the Social Insurance Institution of Finland to investigate the incidence of long-term use of benzodiazepines and related drugs among new users and factors associated with development of long-term use.
This cohort study assesses the associations between maternal preeclampsia and offspring systolic blood pressure across early childhood, middle childhood, and adolescence and investigates whether the association varies by cord blood plasma vitamin D level.
This cross-sectional study assesses rates of hypothalamus-pituitary-thyroid dysfunction in patients with Erdheim-Chester disease.
This cohort study assesses the developmental trajectories of nicotine and cannabis vaping from late adolescence to young adulthood in Southern California.
This prognostic study examines the use of endothelial cell phosphorylated-focal adhesion kinase as a biomarker for chemotherapy sensitivity in women with breast cancer.
These 3 randomized clinical trials examine the efficacy of very low-nicotine-content cigarettes in reducing smoking rates among smokers with affective disorders, opioid use disorders, or socioeconomic disadvantage.
This randomized clinical trial examines whether 6-month interventions involving different financial incentives to encourage statin adherence reduce low-density lipoprotein cholesterol levels from baseline to 12 months.
This randomized clinical trial assesses the efficacy and toxicity of radiotherapy plus icotinib compared with radiotherapy alone in older patients with unresectable esophageal squamous cell carcinoma (ESCC) in China.
This cohort study examines the prevalence of pathogenic germline variants in patients with cancer who had received DNA sequencing.
This cohort study assess the association between exposure to Hurricane Irma and 30- and 90-day mortality and morbidity among short- and long-term residents of nursing homes in Florida.
This cohort study assesses whether changes in per capita county-level restaurant advertising spending from 2013 to 2016 are associated with changes in objectively measured body mass index in nearly 6 million US adults across 370 counties.
This survey study assesses the prevalence of mental illness and mental health care use among police officers at a large, urban police department in the US.
This qualitative study uses data from interviews via email and national surgical societies to investigate interprofessional workplace conflicts experienced by women surgeons.
This cohort study assesses the association of reductions in coinsurance for behavioral health services with behavioral health care use and spending among Medicare beneficiaries with severe mental illness.
This economic evaluation identifies the most cost-effective treatment regimen for patients with recurrent Dupuytren contracture.
This cohort study investigates the implications of state Medicaid expansion for liver transplant wait-listing trends for racial/ethnic minorities.
This cohort study examines the frequency and variation in ambulatory follow-up among Medicare beneficiaries discharged from US emergency departments (EDs) and the association between ambulatory follow-up and postdischarge outcomes.
This cohort study compares definitive therapy with oral β-lactam antibiotics vs fluoroquinolones or trimethoprim-sulfamethoxazole after 1 to 5 days of parenteral antibiotics for Enterobacterales bacteremia from a suspected urine source.
This cohort study examines 30-year incidence and mortality trends in upper and lower gastrointestinal bleeding using nationwide health examination survey data from adults in different regions in Finland.
This cohort study assesses the time between an incident mood or other common mental disorder diagnosis and the receipt of disability services during a follow-up period of as long as 20 years among adults in Ontario, Canada.
This cohort study uses group-based trajectory modeling to assess the spending patterns of Medicare beneficiaries over a 2-year period and explores whether such a model can predict spending patterns using potentially modifiable patient characteristics.
This qualitative study explores how Catholic obstetrician-gynecologists integrate their religious values and professional obligations related to family planning services.
This cohort study describes the incidence rates of 4 breast cancer molecular subtypes stratified by race/ethnicity among women in the US.
This systematic review and meta-analysis evaluates 9 randomized clinical trials to assess whether adding cyclin-dependent kinases 4 and 6 inhibitors to endocrine therapy is associated with increased overall survival or with adverse events vs endocrine therapy alone among patients with hormone receptor (HR)–positive, ERBB2-negative metastatic breast cancer.
This case-control study evaluated whether exposure to angiotensin receptor blockers is associated with differential suicide risk compared with exposure to angiotensin converting enzyme inhibitors among veterans in Veterans Health Administration care.
This cross-sectional study examines friend and family perceptions of quality of end-of-life care for individuals enrolled in Medicare Advantage at time of death vs those enrolled in traditional Medicare.
This secondary analysis of the AVANT trial explores the efficacy of adjuvant bevacizumab combined with oxaliplatin-based chemotherapy and disease-free survival (DFS) rates in patients with high-risk, stage II colon cancer.
This cross-sectional study uses data from the National Electronic Injury Surveillance System Firearm Injury Surveillance Study to test the ability of natural language processing combined with 4 machine learning models to predict the locations of nonfatal gunshot injuries.
This cohort study uses data from the Population Assessment of Tobacco and Health from 2015 to 2018 to examine the association between wheezing and past-year use of e-cigarettes among youths.
This cross-sectional study describes the current prion disease surveillance system in Washington state and reports the epidemiological and clinical results of surveillance activities from 2006 through 2017.
This cross-sectional study examines the association between intimate partner violence, nonpartner violence, and nonfatal drug overdose among female sex workers who use drugs in Kazakhstan.
This pilot randomized clinical trial evaluates the feasibility and preliminary effect of the novel dyadic resiliency intervention Recovering Together in reducing symptoms of depression, anxiety, and posttraumatic stress among patients hospitalized in the neuroscience intensive care unit and their informal caregivers.
This randomized clinical trial examines diet and exercise plus bimagrumab vs placebo for physical function in a global population of older adults with sarcopenia.
This cohort study of Veterans Health Administration (VA) health care records examines gender differences in care usage since the national integration of mental health services into primary care for veterans.
This cross-sectional study uses a deep learning system to analyze the temporal trends in cervical spine curvature across sex and age groups in a population of South Korean adults.
This case series assesses whether individuals are using cannabidiol (CBD) to treat diagnosable conditions with proven therapies.
This cross-sectional study evaluates geographic variation and its change with time in treatment process and outcomes for patients with acute myocardial infarction in China.
This cohort study examines the association between operating room laminar airflow ventilation systems and the risk of periprosthetic joint infection in patients undergoing total joint arthroplasty.
This cross-sectional study assesses social risk factors and examines characteristics associated with interest in receiving health care–based social risk assistance among adult patients and adult caregivers of pediatric patients.
This survey study describes social and behavioral determinants of health self-reported by Veterans Affairs patients who are at high risk for hospitalization and assesses whether adding these measures to a model based on electronic health record data improves the accuracy of estimates of 90-day and 180-day all-cause hospital admission risk.
This cross-sectional study uses data from the National Disease and Therapeutic Index to quantify changes in volume and type of primary care visits and changes in visit content associated with the COVID-19 pandemic in the US.
This cross-sectional study examines the variations in care and outcomes of patients with acute ST-segment elevation myocardial infarction (STEMI) at 3 different levels of hospitals—province, prefecture, and county—in China.
This cross-sectional study estimates the prevalence of hypertension and diabetes with biological measures and evaluates access to care among Syrian refugees in northern Jordan.
This cross-sectional study examines medical crowdfunding campaigns in Canada, the UK, and the US and evaluates whether campaign types and demographic characteristics of the beneficiaries are associated with the amounts of money raised.
This case series characterizes the antitumor activity of platinum-based therapies in men with castration-resistant prostate cancer with or without DNA repair gene alterations.
This cross-sectional study uses data from the American Community Survey to examine the association of state-level immigrant integration and criminalization policies and maternal citizenship status with health insurance coverage among US-born Latino youths.
This cohort study investigates the association of human papillomavirus infection status with development of end-stage kidney disease in Taiwan.
This cohort study uses Medicare claims data from nursing home and home health assessments from all US counties to investigate how health care use and survival compares between individuals with Alzheimer disease and related dementia in rural vs urban settings.
This cross-sectional study assesses the within-couple concordance of cardiovascular risk factors and behaviors within couples who participated in a nationwide US employer-sponsored health assessment program.
This cohort study examines the incidence of and mortality associated with second primary cancers that develop after diagnosis of retinoblastoma in Danish patients.
This national cohort study evaluates trends in heart failure incidence across risk factor strata, including hypertension, diabetes, obesity, acute myocardial infarction, and atrial fibrillation among Medicare beneficiaries.
This survey study of participants in an online panel examined willingness to participate in telehealth services to access health services with remote clinicians among participants categorized by sex, age, race/ethnicity, income, and education level.
This cohort study evaluates the association of discharge home vs discharge to institutional postacute care with outcomes following elective lower extremity total joint replacement.
This systematic review and meta-analysis compares acetaminophen with ibuprofen for the short-term treatment of fever or pain in children younger than 2 years.
This cross-sectional study examines the prevalence of positive suicide screening results among veterans in ambulatory care and emergency departments or urgent care clinics and compare acuity of suicide risk among patients screened in these settings.
This cluster randomized clinical trial examines whether the Wingman-Connect program for US Air Force personnel reduces suicidal ideation, depression, and occupational problems compared with a stress management program.
This diagnostic study examines the area under the curve, sensitivity, specificity, and positive predictive value of chest radiograph readings performed by an artificial intelligence algorithm vs by radiology residents.
This randomized clinical trial examines real vs sham electropuncture in treating chronic low back pain in adults.
This cross-sectional study uses data from questionnaires completed by adolescents in secondary schools in Suzhou city, China, to investigate the mental health challenges of youth identifying as transgender and gender nonconforming compared with cisgender adolescents.
This observation study characterizes regions and rates of atrophy in the 3 primary familial frontotemporal lobar degeneration genes (MAPT, GRN, and C9orf72) across all disease stages from asymptomatic to dementia.
This decision analysis estimates the lifetime incremental incidence of hereditary breast and ovarian cancer and the quality-adjusted life-years, costs, and cost-effectiveness of hereditary breast and ovarian cancer genomic screening in an unselected population vs family history–based testing.
This cohort study uses data from participants in the Global Anticoagulant Registry in the Field–Venous Thromboembolism study to examine outcomes among adult patients with venous thromboembolism with and without moderate to severe chronic kidney disease.
This cross-sectional study evaluates the association of adding 1000-mg acetaminophen tablets to the Swiss market with utilization and poisonings.
This cross-sectional study examines and compares the primary care workforce and its growth between urban and rural counties or county-equivalents from 2009 to 2017 in the US.
This population-based cohort study assesses the association between birth defects and cancer risk among children conceived via in vitro fertilization vs children conceived naturally in 4 US states.
This cohort study evaluates the performance of the pooled cohort equations in estimating the risk of atherosclerotic cardiovascular disease risk by body mass index range.
This genetic association study uses fine mapping of the major histocompatibility complex (MHC) region by human leukocyte antigen imputation to determine whether the HLA-B*52:01 allele is associated with cervical cancer (CC) in Japanese women.
This case series evaluates the frequency of sudden unexplained death in childhood (SUDC), explains its epidemiology, and assesses the consistency of death certification among medical examiner and coroner offices in the US death investigation system.
This cohort study of patients with metastatic colorectal cancer examines associations between diet at initiation of first-line treatment and overall survival.
This cohort study assesses admission laboratory and comorbidity features associated with critical illness and mortality risk among patients hospitalized with coronavirus disease 2019 (COVID-19) across 6 Eastern Massachusetts hospitals.
This case series examines the genomic characteristics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and transmission routes during the early stages of the coronavirus disease 2019 (COVID-19) outbreak in Los Angeles, California.
This cohort study examines tumor mutational burden in patients with uncommon cancers not receiving immunotherapy as a biomarker associated with overall survival.
This cohort study examines sociodemographic characteristics associated with coronavirus disease 2019 outcomes among Black and White patients in Michigan.
This survey study measures the prevalence of self-reported mental health symptoms, identifies associated factors, and assesses care seeking among university students in France who experienced quarantine during the coronavirus disease 2019 (COVID-19) pandemic.
This survey study evaluates the factors associated with US adults’ choice of and willingness to accept a hypothetical COVID-19 vaccine.
This cross-sectional study examines the associations of state-level stay-at-home orders and proportion of African American population with coronavirus disease 2019 (COVID-19) case rates from March to May 2020.
This cohort study examines the levels of severity of depressive symptoms among at-risk individuals during the COVID-19 pandemic in the UK.
This decision analytical model assesses the association between construction work during the coronavirus disease 2019 (COVID-19) pandemic and hospitalization rates for construction workers and the surrounding community.
This cross-sectional study evaluates the comparative performance of private equity–owned nursing homes on coronavirus disease 2019 (COVID-19) outcomes.
This consensus statement develops recommendations on acute kidney injury biomarkers based on existing data and expert consensus for practicing clinicians and researchers.
This cross-sectional study evaluates the persistence of chronic condition flags for 51 conditions over single-year and multiyear periods.
This study uses the Mini Z 2.0 survey to assess burnout among male and female members of the American College of Physicians who are internists and internal medicine trainees.
This cohort study examines the association of integrated specialty pharmacy use among members of a university hospital accountable care organization (ACO) with total medical expenditure.
This case-control study assesses the association between past Chlamydia trachomatis infection with first-trimester miscarriage by using an enzyme-linked immunosorbent assay to detect antibodies to the protein Pgp3.
This population-based retrospective cohort study used US Vital Statistics data from 2014-2017 to assess the risk of adverse maternal outcomes at term for Asian women in the US.
This cross-sectional study examines the demographic characteristics of adult cigarette smokers and e-cigarette users in the US.
This cross-sectional study assesses drug coverage, formulary restrictions, median retail prices, and annual out-of-pocket costs associated with commonly used insulin products across Medicare Part D plans.
This cohort study assesses concentrations of γ-aminobutyric acid (GABA) and glutamate in children with attention-deficit/hyperactivity disorder (ADHD) compared with typically developing children.
This case series describes the symptoms and outcomes of sailors during and after an outbreak of coronavirus disease 2019 (COVID-19) on the USS Theodore Roosevelt.
This cohort study attempts to validate the Mental Health Research Network suicide risk–prediction model and estimate associated workloads.
This cohort study explores whether clinician specialty and patient familiarity with the attending clinician are associated with rates of low-dose computerized tomographic lung cancer screening after shared decision-making visits.
This cross-sectional study examines the trends in initiation of buprenorphine treatment for opioid use disorder during emergency department visits in the United States.
This cross-sectional study uses 2017 to 2019 data from the US National Mental Health Services Survey and examines whether there are disparities in the availability of youth-serving mental health facilities associated with suicide risk in rural vs urban youth.
This cross-sectional analysis of a national sample of nonprofit, acute care hospital organizations assesses how these organizations distribute spending for community-building activities among the 9 domains allowed by the Internal Revenue Service.
This cross-sectional study examines US states’ compliance with both Patient Protection and Affordable Care Act demonstration program annual reporting and Medicaid guidelines for Section 1115 experimental program evaluations.
This case-control study investigates the characteristics of patients who use application programming interfaces connected to personal electronic devices to access electronic health information at a single US health care system.
This cross-sectional study evaluates the association between sleep disorders and burnout symptoms among faculty and staff at a large teaching hospital.
This sequential, cross-sectional study examines the prevalence of perforated appendicitis in children in the United States in relation to access to health care from 2001 to 2015.
This cross-sectional study examines the seropositive prevalence of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Wuhan, China, by sex and age group.
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