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November 2021 - May 2018

Decade

Year

Issue

December 2020, Vol 3, No. 12

open access Original Investigation

MEDICAL EDUCATION

Effect of an Educational Intervention on Therapeutic Inertia in Neurologists With Expertise in Multiple Sclerosis: A Randomized Clinical Trial

This randomized clinical trial assesses whether an educational intervention using the traffic light system (based on red, yellow, and green lights associated with actions to stop or proceed) reduces therapeutic inertia (failure to escalate therapy when treatment goals are unmet) in practitioners experienced in the treatment of patients with multiple sclerosis.

JAMA Netw Open. 2020;3(12):e2022227. doi:10.1001/jamanetworkopen.2020.22227
Abstract Full Text pdf link PDF

PEDIATRICS

Association of Prenatal Maternal Anxiety With Fetal Regional Brain Connectivity

This cohort study assesses the association of prenatal maternal psychological distress with in vivo fetal brain resting state functional connectivity.

JAMA Netw Open. 2020;3(12):e2022349. doi:10.1001/jamanetworkopen.2020.22349
Abstract Full Text pdf link PDF

INFECTIOUS DISEASES

Estimated Cost-effectiveness of Newborn Screening for Congenital Cytomegalovirus Infection in China Using a Markov Model

This modeling study examines the cost-effectiveness of newborn screening strategies for congential cytomegalovirus infection from the perspective of the Chinese health care system.

JAMA Netw Open. 2020;3(12):e2023949. doi:10.1001/jamanetworkopen.2020.23949
Abstract Full Text pdf link PDF

HEALTH POLICY

Evaluation of Changes in Veterans Affairs Medical Centers’ Mortality Rates After Risk Adjustment for Socioeconomic Status

This cross-sectional study evaluates changes in Veterans Affairs (VA) medical centers’ risk-standardized mortality rates among veterans hospitalized for heart failure and pneumonia after adjusting for socioeconomic factors.

JAMA Netw Open. 2020;3(12):e2024345. doi:10.1001/jamanetworkopen.2020.24345
Abstract Full Text pdf link PDF

OBSTETRICS AND GYNECOLOGY

Association of Unexpected Newborn Deaths With Changes in Obstetric and Neonatal Process of Care

This cross sectional study investigates whether occurrence of an unexpected newborn death is associated with changes in obstetric and neonatal process of care.

JAMA Netw Open. 2020;3(12):e2024589. doi:10.1001/jamanetworkopen.2020.24589
Abstract Full Text pdf link PDF

ONCOLOGY

Analysis of Radiation Facility Volume and Survival in Men With Lymph Node–Positive Prostate Cancer Treated With Radiation and Androgen Deprivation Therapy

This cohort study evaluates the association between radiation facility case volume and overall survival among men with node-positive prostate cancer.

JAMA Netw Open. 2020;3(12):e2025143. doi:10.1001/jamanetworkopen.2020.25143
Abstract Full Text pdf link PDF

PHARMACY AND CLINICAL PHARMACOLOGY

Bisphosphonate Treatment Beyond 5 Years and Hip Fracture Risk in Older Women

This cohort study examines the association of discontinuing bisphosphonate at study entry, discontinuing at 2 years, and continuing for 5 additional years with hip fracture among women who completed 5 years of treatment at study entry.

JAMA Netw Open. 2020;3(12):e2025190. doi:10.1001/jamanetworkopen.2020.25190
Abstract Full Text pdf link PDF

CARDIOLOGY

Association Between Quality of Life and Procedural Outcome After Catheter Ablation for Atrial Fibrillation: A Secondary Analysis of a Randomized Clinical Trial

This secondary analysis of a randomized clinical trial assesses whether a reduction in atrial fibrillation episodes after ablation for treatment of atrial fibrillation is associated with improved quality of life measures.

JAMA Netw Open. 2020;3(12):e2025473. doi:10.1001/jamanetworkopen.2020.25473
Abstract Full Text pdf link PDF

EMERGENCY MEDICINE

Frequency and Risk Factors of Acute Kidney Injury During Diabetic Ketoacidosis in Children and Association With Neurocognitive Outcomes

This cohort study examines the mechanisms, risk factors, and outcomes associated with acute kidney injury during pediatric diabetic ketoacidosis.

JAMA Netw Open. 2020;3(12):e2025481. doi:10.1001/jamanetworkopen.2020.25481
Abstract Full Text pdf link PDF

ONCOLOGY

Assessment of Financial Toxicity Among Older Adults With Advanced Cancer

This cross-sectional study examines the prevalence of financial toxicity in older adults with advanced cancer, its association with health-related quality of life, and cost conversations between oncologists and patients.

JAMA Netw Open. 2020;3(12):e2025810. doi:10.1001/jamanetworkopen.2020.25810
Abstract Full Text pdf link PDF

HEALTH POLICY

Prevalence of Informal Caregiving in States Participating in the US Patient Protection and Affordable Care Act Balancing Incentive Program, 2011-2018

This cohort study assessed the association of the US Patient Protection and Affordable Care Act (ACA) Balancing Incentives Program with the prevalence and frequency of informal caregiving in the US from 2011 to 2018.

JAMA Netw Open. 2020;3(12):e2025833. doi:10.1001/jamanetworkopen.2020.25833
Abstract Full Text pdf link PDF

HEALTH POLICY

Association Between US Physician Malpractice Claims Rates and Hospital Admission Rates Among Patients With Lower-Risk Syncope

This cross-sectional study assesses the association between physician malpractice claims rates and hospital admission rates after emergency department visits among patients with lower-risk syncope in the US.

JAMA Netw Open. 2020;3(12):e2025860. doi:10.1001/jamanetworkopen.2020.25860
Abstract Full Text pdf link PDF

PEDIATRICS

High-Dose Vitamin D Supplementation in Pregnancy and Neurodevelopment in Childhood: A Prespecified Secondary Analysis of a Randomized Clinical Trial

This prespecified secondary analysis of a randomized clinical trial examines neurodevelopmentdal outcomes among offspring of women using high-dose vs standard dose vitamin D3 supplementation during pregnancy.

JAMA Netw Open. 2020;3(12):e2026018. doi:10.1001/jamanetworkopen.2020.26018
Abstract Full Text pdf link PDF

PSYCHIATRY

Association of Genetic and Phenotypic Assessments With Onset of Disordered Eating Behaviors and Comorbid Mental Health Problems Among Adolescents

This cohort study across numerous European sites assesses whether associations and shared etiologies exist between disordered eating behaviors (dieting, purging, and binge eating) and other mental health disorders in early adolescence.

JAMA Netw Open. 2020;3(12):e2026874. doi:10.1001/jamanetworkopen.2020.26874
Abstract Full Text pdf link PDF

INFECTIOUS DISEASES

Assessment of Racial/Ethnic Disparities in Hospitalization and Mortality in Patients With COVID-19 in New York City

This cohort study of patients testing positive for COVID-19 in a large New York City health system compares rates of hospitalization, critical illness, mortality across racial/ethnic categories.

has active quiz
JAMA Netw Open. 2020;3(12):e2026881. doi:10.1001/jamanetworkopen.2020.26881
Abstract Full Text pdf link PDF CME & MOC

ONCOLOGY

Association of Neighborhood Deprivation Index With Success in Cancer Care Crowdfunding

This cross-sectional study examines whether higher county-level socioeconomic status and the presence (vs absence) of text indicators of beneficiary worth in campaign descriptions are associated with the amount raised from cancer crowdfunding.

JAMA Netw Open. 2020;3(12):e2026946. doi:10.1001/jamanetworkopen.2020.26946
Abstract Full Text pdf link PDF

HEALTH POLICY

Effect of a Social Norm Email Feedback Program on the Unnecessary Prescription of Nimodipine in Ambulatory Care of Older Adults: A Randomized Clinical Trial

This randomized clinical trial examines the effect of a behavioral intervention email based on social norms feedback for physicians to reduce non–evidence-based prescriptions of nimodipine for cognitive impairment among older adults in Argentina.

JAMA Netw Open. 2020;3(12):e2027082. doi:10.1001/jamanetworkopen.2020.27082
Abstract Full Text pdf link PDF

PHARMACY AND CLINICAL PHARMACOLOGY

Effect of Pharmacogenetic Testing for Statin Myopathy Risk vs Usual Care on Blood Cholesterol: A Randomized Clinical Trial

This randomized clinical trial examines the impact of delivering SLCO1B1 pharmacogenetic results to physicians on low-density lipoprotein cholesterol levels and concordance with prescribing guidelines for statin safety and effectiveness.

JAMA Netw Open. 2020;3(12):e2027092. doi:10.1001/jamanetworkopen.2020.27092
Abstract Full Text pdf link PDF

MEDICAL JOURNALS AND PUBLISHING

Assessment of Duplicate Publication of Chinese-Sponsored Randomized Clinical Trials

This cohort study of Chinese-sponsored randomized clinical trials assesses incidence of duplicate publication and the extent to which duplicate publication is associated with the language of publication.

JAMA Netw Open. 2020;3(12):e2027104. doi:10.1001/jamanetworkopen.2020.27104
Abstract Full Text pdf link PDF

ONCOLOGY

Assessment of Cancer Therapy Evaluation Program Advocacy and Inclusion Rates of People Living With HIV in Anti–PD1/PDL1 Clinical Trials

This quality improvement study evaluates trends in the inclusion of people living with HIV in anti–programmed death 1 and anti–programmed death ligand 1 (anti–PD1/PDL1) clinical trials concurrent with ongoing Cancer Therapy Evaluation Program efforts by the National Cancer Institute to promote inclusion of this patient population.

JAMA Netw Open. 2020;3(12):e2027110. doi:10.1001/jamanetworkopen.2020.27110
Abstract Full Text pdf link PDF

CRITICAL CARE MEDICINE

Experiences of Bereaved Family Members Receiving Commemorative Paintings: A Qualitative Study

This qualitative study uses semistructured interviews to explore the influence of personalized paintings of patients who died in the intensive care unit on family members’ bereavement experience and grief process.

JAMA Netw Open. 2020;3(12):e2027259. doi:10.1001/jamanetworkopen.2020.27259
Abstract Full Text pdf link PDF

HEALTH POLICY

Evaluation of a Transitional Care Program After Hospitalization for Heart Failure in an Integrated Health Care System

This cohort study examines the association of individual transitional care program components with all-cause 30-day inpatient or observation stay readmission among patients discharged from the hospital after treatment for heart failure.

JAMA Netw Open. 2020;3(12):e2027410. doi:10.1001/jamanetworkopen.2020.27410
Abstract Full Text pdf link PDF

HEALTH POLICY

Changes in Racial Disparities in Mortality After Cancer Surgery in the US, 2007-2016

This cross-sectional study examines changes in mortality rates over time in White and Black patients undergoing surgery for cancer.

JAMA Netw Open. 2020;3(12):e2027415. doi:10.1001/jamanetworkopen.2020.27415
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Trends in Tobacco Use Among Adolescents by Grade, Sex, and Race, 1991-2019

This cross-sectional study examines how trends in cigarette and smokeless tobacco use among adolescents by grade, sex, and race have changed in recent years as e-cigarette use has increased.

JAMA Netw Open. 2020;3(12):e2027465. doi:10.1001/jamanetworkopen.2020.27465
Abstract Full Text pdf link PDF

NEUROLOGY

Trajectory of Unawareness of Memory Decline in Individuals With Autosomal Dominant Alzheimer Disease

This cohort study investigates the evolution of anosognosia of memory decline in individuals with the PSEN1 E280A variant for autosomal dominant Alzheimer disease compared with family members without the variant.

JAMA Netw Open. 2020;3(12):e2027472. doi:10.1001/jamanetworkopen.2020.27472
Abstract Full Text pdf link PDF

SUBSTANCE USE AND ADDICTION

Comparison of Opioids Prescribed for Patients at Risk for Opioid Misuse Before and After Publication of the Centers for Disease Control and Prevention’s Opioid Prescribing Guidelines

This cross-sectional study uses deidentified patient information from Optum’s deidentified Integrated Claims-Clinical data set to compare frequency of opioid prescriptions for patients at risk for opioid misuse in the 18-month periods before and after publication of the Centers for Disease Control and Prevention (CDC) opioid prescribing guideline.

JAMA Netw Open. 2020;3(12):e2027481. doi:10.1001/jamanetworkopen.2020.27481
Abstract Full Text pdf link PDF

PSYCHIATRY

Association of Social Support During Adolescence With Depression, Anxiety, and Suicidal Ideation in Young Adults

This cohort study assesses whether perceived social support during adolescence is associated with less depression, anxiety, and suicidal ideation and fewer suicide attempts in young adults.

JAMA Netw Open. 2020;3(12):e2027491. doi:10.1001/jamanetworkopen.2020.27491
Abstract Full Text pdf link PDF

GASTROENTEROLOGY AND HEPATOLOGY

Donor Characteristics and Regional Differences in the Utilization of HCV-Positive Donors in Liver Transplantation

This cross-sectional study examines clinical characteristics of liver donors who are positive for hepatitis C virus (HCV) and differences in use of HCV-positive allografts in regions of the United States.

JAMA Netw Open. 2020;3(12):e2027551. doi:10.1001/jamanetworkopen.2020.27551
Abstract Full Text pdf link PDF

PEDIATRICS

Evaluation of Circulating Cardiovascular Biomarker Levels for Early Detection of Congenital Heart Disease in Newborns in Sweden

This diagnostic study assesses the use of dried blood samples to detect prohormone brain-type natriuretic peptide for diagnosis of congenital heart disease in neonates in Sweden.

JAMA Netw Open. 2020;3(12):e2027561. doi:10.1001/jamanetworkopen.2020.27561
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Underage Youth and Young Adult e-Cigarette Use and Access Before and During the Coronavirus Disease 2019 Pandemic

This survey study examines changes in use of e-cigarettes by individuals aged 24 years and younger during the coronavirus 2019 pandemic.

has active quiz
JAMA Netw Open. 2020;3(12):e2027572. doi:10.1001/jamanetworkopen.2020.27572
Abstract Full Text pdf link PDF CME & MOC

GERIATRICS

Cost-effectiveness of Screening for Osteoporosis in Older Men With a History of Falls

This economic evaluation assesses the cost-effectiveness of screening for osteoporosis using dual-energy x-ray absorptiometry followed by osteoporosis treatment in a hypothetical sample of older men with a history of falls.

JAMA Netw Open. 2020;3(12):e2027584. doi:10.1001/jamanetworkopen.2020.27584
Abstract Full Text pdf link PDF

ONCOLOGY

Trends in Cancer Incidence in US Adolescents and Young Adults, 1973-2015

This cross-sectional population-based study characterizes the epidemiology of cancer in US adolescents and young adults aged 15 to 39 years with respect to (1) patient demographic characteristics, (2) cancer type frequencies, and (3) cancer incidence trends over time.

JAMA Netw Open. 2020;3(12):e2027738. doi:10.1001/jamanetworkopen.2020.27738
Abstract Full Text pdf link PDF

NUTRITION, OBESITY, AND EXERCISE

Effect of a Culturally Adapted Behavioral Intervention for Latino Adults on Weight Loss Over 2 Years: A Randomized Clinical Trial

This randomized clinical trial examines the effect of a culturally adapted technology-mediated behavioral intervention for Latino adults on weight loss over 2 years.

JAMA Netw Open. 2020;3(12):e2027744. doi:10.1001/jamanetworkopen.2020.27744
Abstract Full Text pdf link PDF

INFECTIOUS DISEASES

Association of Plasma Matrix Metalloproteinase and Tissue Inhibitors of Matrix Metalloproteinase Levels With Adverse Treatment Outcomes Among Patients With Pulmonary Tuberculosis

This case-control study examines the value of matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) as biomarkers of treatment outcomes among patients with pulmonary tuberculosis.

JAMA Netw Open. 2020;3(12):e2027754. doi:10.1001/jamanetworkopen.2020.27754
Abstract Full Text pdf link PDF

PHARMACY AND CLINICAL PHARMACOLOGY

Effect of Routine Cytochrome P450 2D6 and 2C19 Genotyping on Antipsychotic Drug Persistence in Patients With Schizophrenia: A Randomized Clinical Trial

This randomized clinical trial investigates whether routine CYP2D6 and CYP2C19 genotyping affects the persistence of antipsychotic drug treatment among adults with schizophrenia.

JAMA Netw Open. 2020;3(12):e2027909. doi:10.1001/jamanetworkopen.2020.27909
Abstract Full Text pdf link PDF

NEUROLOGY

Epidemiology of Functional Seizures Among Adults Treated at a University Hospital

This case-control study of patients at a large university medical center provides an epidemiological assessment of functional seizures and their association with comorbidities (eg, cerebrovascular disease) and risk factors (eg, sexual assault trauma).

JAMA Netw Open. 2020;3(12):e2027920. doi:10.1001/jamanetworkopen.2020.27920
Abstract Full Text pdf link PDF

DIABETES AND ENDOCRINOLOGY

Associations of Menstrual Cycle Characteristics Across the Reproductive Life Span and Lifestyle Factors With Risk of Type 2 Diabetes

This cohort study evaluates the associations between menstrual cycle characteristics at different points throughout a woman’s reproductive life span and the risk of type 2 diabetes and the extent to which this association is modified by lifestyle factors.

JAMA Netw Open. 2020;3(12):e2027928. doi:10.1001/jamanetworkopen.2020.27928
Abstract Full Text pdf link PDF

PSYCHIATRY

Association of Posttraumatic Stress and Depressive Symptoms With Mortality in Women

This cohort study examines the association between posttraumatic stress disorder, with and without comorbid depression, and mortality in women.

JAMA Netw Open. 2020;3(12):e2027935. doi:10.1001/jamanetworkopen.2020.27935
Abstract Full Text pdf link PDF

HEALTH POLICY

Association of Electronic Prescribing of Controlled Substances With Opioid Prescribing Rates

This retrospective, longitudinal cohort study assesses the association between use of electronic prescribing of controlled substances and trends in opioid prescribing.

JAMA Netw Open. 2020;3(12):e2027951. doi:10.1001/jamanetworkopen.2020.27951
Abstract Full Text pdf link PDF

PSYCHIATRY

Association of Job Expectations Among High School Students With Early Death During Adulthood

This cohort study estimates the risks of suicide and drug poisoning deaths among adult men whose adolescent occupational expectations were not met in adulthood.

JAMA Netw Open. 2020;3(12):e2027958. doi:10.1001/jamanetworkopen.2020.27958
Abstract Full Text pdf link PDF

ONCOLOGY

Development and Validation of a Preoperative Magnetic Resonance Imaging Radiomics–Based Signature to Predict Axillary Lymph Node Metastasis and Disease-Free Survival in Patients With Early-Stage Breast Cancer

This prognostic study develops and validates dynamic contrast–enhanced magnetic resonance imaging (DCE-MRI) radiomic signatures for preoperative identification of axillary lymph node metastasis and to assess individual disease-free survival in patients with early-stage breast cancer.

JAMA Netw Open. 2020;3(12):e2028086. doi:10.1001/jamanetworkopen.2020.28086
Abstract Full Text pdf link PDF

HEALTH POLICY

Assessment of Physician Sleep and Wellness, Burnout, and Clinically Significant Medical Errors

This survey study examines sleep-related impairment and occupational wellness indicators in physicians to assess the association with self-reported clinically significant medical error, before and after adjusting for burnout.

JAMA Netw Open. 2020;3(12):e2028111. doi:10.1001/jamanetworkopen.2020.28111
Abstract Full Text pdf link PDF

SURGERY

Association of Bariatric Surgical Procedures With Changes in Unhealthy Alcohol Use Among US Veterans

This cohort study examines the long-term risk of developing alcohol abuse or dependence among a predominantly male bariatric population who underwent either a laparoscopic sleeve gastrectomy or a Roux-en-Y gastric bypass.

JAMA Netw Open. 2020;3(12):e2028117. doi:10.1001/jamanetworkopen.2020.28117
Abstract Full Text pdf link PDF

INFECTIOUS DISEASES

Clinical Outcomes, Costs, and Cost-effectiveness of Strategies for Adults Experiencing Sheltered Homelessness During the COVID-19 Pandemic

This decision analytic model assesses the clinical outcomes, costs, and cost-effectiveness associated with strategies for coronavirus disease 2019 (COVID-19) among US adults experiencing sheltered homelessness.

has active quiz
JAMA Netw Open. 2020;3(12):e2028195. doi:10.1001/jamanetworkopen.2020.28195
Abstract Full Text pdf link PDF CME & MOC

HEALTH POLICY

Cost-effectiveness Analysis of Anatomic vs Functional Index Testing in Patients With Low-Risk Stable Chest Pain

This economic evaluation determines whether anatomic approaches are cost-effective compared with functional tests for the assessment of low-risk stable chest pain.

JAMA Netw Open. 2020;3(12):e2028312. doi:10.1001/jamanetworkopen.2020.28312
Abstract Full Text pdf link PDF

UROLOGY

Surgical Delay and Pathological Outcomes for Clinically Localized High-Risk Prostate Cancer

This cohort study examines the association of surgical delay time with pathological and survival outcomes among patients with localized, high-risk prostate cancer.

JAMA Netw Open. 2020;3(12):e2028320. doi:10.1001/jamanetworkopen.2020.28320
Abstract Full Text pdf link PDF

ORTHOPEDICS

Effect of Remote Monitoring on Discharge to Home, Return to Activity, and Rehospitalization After Hip and Knee Arthroplasty: A Randomized Clinical Trial

This randomized clinical trial evaluates the effectiveness of activity monitoring and bidirectional text messaging on discharge to home and clinical outcomes after total hip arthroplasty or total knee arthroplasty among Medicare beneficiaries with intermediate risk of discharge to a facility.

JAMA Netw Open. 2020;3(12):e2028328. doi:10.1001/jamanetworkopen.2020.28328
Abstract Full Text pdf link PDF

CARDIOLOGY

State-Level Variation in Waitlist Mortality and Transplant Outcomes Among Patients Listed for Heart Transplantation in the US From 2011 to 2016

This cohort study uses data from the United Network for Organ Sharing database to evaluate the geographic patterns, extent, and factors associated with state-level variation in outcomes of adult patients listed for heart transplantation in the US.

JAMA Netw Open. 2020;3(12):e2028459. doi:10.1001/jamanetworkopen.2020.28459
Abstract Full Text pdf link PDF

HEALTH POLICY

Trends in Diagnosis Related Groups for Inpatient Admissions and Associated Changes in Payment From 2012 to 2016

This cohort study evaluates trends in Diagnosis Related Groups with a major complication or comorbidity and estimates associated changes in payment.

JAMA Netw Open. 2020;3(12):e2028470. doi:10.1001/jamanetworkopen.2020.28470
Abstract Full Text pdf link PDF

PSYCHIATRY

Assessment of Posttraumatic Stress Disorder and Educational Achievement in Sweden

This population-based cohort study investigates the association between posttraumatic stress disorder and objective indicators of educational attainment across the life span, controlling for familial factors shared by full siblings, psychiatric comorbidity, and general cognitive ability.

JAMA Netw Open. 2020;3(12):e2028477. doi:10.1001/jamanetworkopen.2020.28477
Abstract Full Text pdf link PDF

PULMONARY MEDICINE

Effect of Once-Weekly Azithromycin vs Placebo in Children With HIV-Associated Chronic Lung Disease: The BREATHE Randomized Clinical Trial

This randomized clinical trial examines whether prophylactic azithromycin is effective in preventing worsening of lung function and in reducing acute respiratory exacerbations in children with HIV-associated chronic lung disease taking antiretroviral therapy.

JAMA Netw Open. 2020;3(12):e2028484. doi:10.1001/jamanetworkopen.2020.28484
Abstract Full Text pdf link PDF

PEDIATRICS

Effect of a Community-Based Gender Norms Program on Sexual Violence Perpetration by Adolescent Boys and Young Men: A Cluster Randomized Clinical Trial

This cluster randomized clinical trial compares the effects of a gender norms program with those of a job-readiness program on sexual violence perpetration by adolescent boys and young men in disadvantaged neighborhoods.

JAMA Netw Open. 2020;3(12):e2028499. doi:10.1001/jamanetworkopen.2020.28499
Abstract Full Text pdf link PDF

HEALTH POLICY

Changes in Drug List Prices and Amounts Paid by Patients and Insurers

This cross-sectional study uses data from the IBM MarketScan Commercial Database to examine the association between increases in wholesale list prices of branded medications and amounts paid by patients and insurers for the same drugs.

JAMA Netw Open. 2020;3(12):e2028510. doi:10.1001/jamanetworkopen.2020.28510
Abstract Full Text pdf link PDF

PSYCHIATRY

Association Between Benzodiazepine Use With or Without Opioid Use and All-Cause Mortality in the United States, 1999-2015

This cohort study uses data from the National Health and Nutrition Examination Surveys to evaluate whether benzodiazepine use, with or without opioid use, is associated with increased all-cause mortality relative to the use of low-risk antidepressants.

JAMA Netw Open. 2020;3(12):e2028557. doi:10.1001/jamanetworkopen.2020.28557
Abstract Full Text pdf link PDF

OBSTETRICS AND GYNECOLOGY

Association of Neoadjuvant Chemotherapy With Overall Survival in Women With Metastatic Endometrial Cancer

This cohort study uses data from the National Cancer Database to investigate the association of neoadjuvant therapy with overall survival in women with metastatic endometrial cancer.

JAMA Netw Open. 2020;3(12):e2028612. doi:10.1001/jamanetworkopen.2020.28612
Abstract Full Text pdf link PDF

HEALTH POLICY

Cost-effectiveness of Maintenance Therapy Based on Molecular Classification Following Treatment of Primary Epithelial Ovarian Cancer in the United States

This economic evaluation evaluated the cost-effectiveness of maintenance strategies for patients with (1) a BRCA variant, (2) homologous recombination deficiency without a BRCA variant, or (3) homologous recombination proficiency in the US health care sector using simulated patients with primary epithelial ovarian cancer.

JAMA Netw Open. 2020;3(12):e2028620. doi:10.1001/jamanetworkopen.2020.28620
Abstract Full Text pdf link PDF

ONCOLOGY

Assessment of Trends in Second Primary Cancers in Patients With Metastatic Melanoma From 2005 to 2016

This cohort study assesses the risk of second primary cancers in patients with primary melanoma before (2005-2010) and after (2011-2016) the introduction and approval of immune checkpoint inhibitors.

JAMA Netw Open. 2020;3(12):e2028627. doi:10.1001/jamanetworkopen.2020.28627
Abstract Full Text pdf link PDF

GERIATRICS

Assessment of Plasma Amyloid-β42/40 and Cognitive Decline Among Community-Dwelling Older Adults

This cohort study investigates the associations between plasma amyloid-β42/40 and cognitive decline over time among community-dwelling older adults with subjective memory concerns.

JAMA Netw Open. 2020;3(12):e2028634. doi:10.1001/jamanetworkopen.2020.28634
Abstract Full Text pdf link PDF

ONCOLOGY

Spectrum of Somatic Cancer Gene Variations Among Adults With Appendiceal Cancer by Age

This cohort study characterizes the frequency of somatic variations and genomic patterns among patients with appendiceal cancer age younger than 50 years and those with appendiceal cancer age 50 years or older at clinical sequencing.

JAMA Netw Open. 2020;3(12):e2028644. doi:10.1001/jamanetworkopen.2020.28644
Abstract Full Text pdf link PDF

OCCUPATIONAL HEALTH

Association of Physician Burnout With Suicidal Ideation and Medical Errors

This cross-sectional study uses data from surveys completed by US physicians to examine associations between physician burnout, suicidal ideation, and self-reported medical errors after adjusting for depression.

JAMA Netw Open. 2020;3(12):e2028780. doi:10.1001/jamanetworkopen.2020.28780
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Long-term Health Outcomes Among Survivors Exposed to Sulfur Mustard in Iran

This cohort study investigates the prevalence by sex, age, and symptom severity of long-term lung, eye, and skin complications among survivors exposed to sulfur mustard between 1980 and 1988 during the Iran-Iraq War.

JAMA Netw Open. 2020;3(12):e2028894. doi:10.1001/jamanetworkopen.2020.28894
Abstract Full Text pdf link PDF

SURGERY

Modifiable Factors Associated With Chronic Pain 1 Year After Operative Management of Distal Radius Fractures: A Secondary Analysis of a Randomized Clinical Trial

This secondary analysis identifies modifiable preoperative factors that are significantly associated with developing chronic pain among patients with distal radius fractures who are treated surgically.

JAMA Netw Open. 2020;3(12):e2028929. doi:10.1001/jamanetworkopen.2020.28929
Abstract Full Text pdf link PDF

SUBSTANCE USE AND ADDICTION

Prevalence and Geographic Distribution of Obstetrician-Gynecologists Who Treat Medicaid Enrollees and Are Trained to Prescribe Buprenorphine

This cross-sectional study examines the prevalence and geographic distribution within the US of obstetrician-gynecologists who are able to prescribe buprenorphine for women who are pregnant.

JAMA Netw Open. 2020;3(12):e2029043. doi:10.1001/jamanetworkopen.2020.29043
Abstract Full Text pdf link PDF

CRITICAL CARE MEDICINE

Assessment of Machine Learning to Estimate the Individual Treatment Effect of Corticosteroids in Septic Shock

This cohort study examines treatment effects of using a machine learning–derived treatment strategy vs treat all or treat none strategies using data from 4 randomized clinical trials among patients with septic shock.

JAMA Netw Open. 2020;3(12):e2029050. doi:10.1001/jamanetworkopen.2020.29050
Abstract Full Text pdf link PDF

INFECTIOUS DISEASES

Risk Factors Associated With In-Hospital Mortality in a US National Sample of Patients With COVID-19

This cohort study characterizes patients with coronavirus disease 2019 (COVID-19) who were treated in US hospitals and examines risks factors associated with in-hospital mortality.

has active quiz
JAMA Netw Open. 2020;3(12):e2029058. doi:10.1001/jamanetworkopen.2020.29058
Abstract Full Text pdf link PDF CME & MOC

GERIATRICS

Evaluation of Neighborhood Socioeconomic Characteristics and Advance Care Planning Among Older Adults

This cross-sectional study examines data from University of California San Francisco Health patients aged 65 years and older and whether there is an association between neighborhood socioeconomic status and rates of advance care planning.

JAMA Netw Open. 2020;3(12):e2029063. doi:10.1001/jamanetworkopen.2020.29063
Abstract Full Text pdf link PDF

HEALTH INFORMATICS

Use of Latent Class Analysis and k-Means Clustering to Identify Complex Patient Profiles

This cohort study uses data clustering methods and clinical stakeholder assessment to identify clinical profiles in a population of medically complex patients.

JAMA Netw Open. 2020;3(12):e2029068. doi:10.1001/jamanetworkopen.2020.29068
Abstract Full Text pdf link PDF

PEDIATRICS

Parent-Reported Symptoms and Medications Used Among Children With Severe Neurological Impairment

This cross-sectional study examines whether higher global symptom scores are associated with use of more medications and assesses associations between specific symptoms and medications among children with severe neurological impairment.

JAMA Netw Open. 2020;3(12):e2029082. doi:10.1001/jamanetworkopen.2020.29082
Abstract Full Text pdf link PDF

HEALTH POLICY

Comparison of Use of Health Care Services and Spending for Unauthorized Immigrants vs Authorized Immigrants or US Citizens Using a Machine Learning Model

This cross-sectional study examines health care utilization and expenditures that are attributable to unauthorized immigrants vs authorized immigrants or US-born individuals.

JAMA Netw Open. 2020;3(12):e2029230. doi:10.1001/jamanetworkopen.2020.29230
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Prevalence of Self-Managed Abortion Among Women of Reproductive Age in the United States

This cross-sectional study examines the prevalence of and sociodemographic characteristics associated with reporting attempted self-managed abortion among US women.

JAMA Netw Open. 2020;3(12):e2029245. doi:10.1001/jamanetworkopen.2020.29245
Abstract Full Text pdf link PDF

CRITICAL CARE MEDICINE

Comparison of 2 Triage Scoring Guidelines for Allocation of Mechanical Ventilators

This cohort study compared criteria in the New York State Ventilator Allocation Guideline with an allocation approach designed to save lives and life-years to determine which and how many admissions to US intensive care units were identified as having the lowest priority for ventilator allocation.

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JAMA Netw Open. 2020;3(12):e2029250. doi:10.1001/jamanetworkopen.2020.29250
Abstract Full Text pdf link PDF CME & MOC

PHARMACY AND CLINICAL PHARMACOLOGY

Prescribing Prevalence of Medications With Potential Genotype-Guided Dosing in Pediatric Patients

This cross-sectional study assesses potential opportunities for genotype-guided prescribing in pediatric populations among multiple health systems by examining the prevalence of prescriptions for each drug with the highest level of evidence and estimating the prevalence of potentially actionable prescribing decisions.

JAMA Netw Open. 2020;3(12):e2029411. doi:10.1001/jamanetworkopen.2020.29411
Abstract Full Text pdf link PDF

HEALTH POLICY

Breadth and Exclusivity of Hospital and Physician Networks in US Insurance Markets

This cross-sectional study quantifies network breadth and exclusivity (ie, overlap) among primary care physician, cardiology, and general acute care hospital networks for employer-based, individually purchased, Medicare Advantage, and Medicaid managed care plans.

JAMA Netw Open. 2020;3(12):e2029419. doi:10.1001/jamanetworkopen.2020.29419
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Public Opinion Perceptions, Private Support, and Public Actions of US Adults Regarding Gun Safety Policy

This 3-part survey study assesses whether correcting the public’s misperceptions of gun safety is associated with greater private support for and public actions on gun safety.

JAMA Netw Open. 2020;3(12):e2029571. doi:10.1001/jamanetworkopen.2020.29571
Abstract Full Text pdf link PDF

ORTHOPEDICS

Comparison of Treatments for Frozen Shoulder: A Systematic Review and Meta-analysis

This systematic review and meta-analysis assesses and compares the effectiveness of available treatment options for frozen shoulder to guide musculoskeletal practitioners and inform guidelines.

JAMA Netw Open. 2020;3(12):e2029581. doi:10.1001/jamanetworkopen.2020.29581
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Patient-Reported Experiences of Discrimination in the US Health Care System

This cross-sectional study examines the responses to a recent National Opinion Research Center survey to assess the prevalence, frequency, and main types of discrimination experienced by adult patients in the US health care system.

JAMA Netw Open. 2020;3(12):e2029650. doi:10.1001/jamanetworkopen.2020.29650
Abstract Full Text pdf link PDF

GLOBAL HEALTH

Multiomics Characterization of Preterm Birth in Low- and Middle-Income Countries

This diagnostic/prognostic study describes the use of cell-free transcriptomics, urine metabolomics, and plasma proteomics for identifying the biological measurements associated with preterm birth.

JAMA Netw Open. 2020;3(12):e2029655. doi:10.1001/jamanetworkopen.2020.29655
Abstract Full Text pdf link PDF

OPHTHALMOLOGY

Trends in the Surgical Treatment of Pseudotumor Cerebri Syndrome in the United States

This cross-sectional analysis of nationally representative hospitalizations uses data from the National Inpatient Sample and 3 national surveys of ambulatory surgery to compare the frequency of use of optic nerve sheath fenestration vs cerebrospinal fluid shunt placement for the treatment of pseudotumor cerebri syndrome.

JAMA Netw Open. 2020;3(12):e2029669. doi:10.1001/jamanetworkopen.2020.29669
Abstract Full Text pdf link PDF

SUBSTANCE USE AND ADDICTION

Comparison of Rates of Overdose and Hospitalization After Initiation of Medication for Opioid Use Disorder in the Inpatient vs Outpatient Setting

This comparative effectiveness research study uses 2010-2017 data from the MarketScan Commercial Claims and Encounters Database to compare the rates of opioid-related overdose and all-cause hospitalization after treatment of opioid use disorder in outpatient vs inpatient care settings.

JAMA Netw Open. 2020;3(12):e2029676. doi:10.1001/jamanetworkopen.2020.29676
Abstract Full Text pdf link PDF

ONCOLOGY

Development of a Nomogram Model for Treatment of Nonmetastatic Nasopharyngeal Carcinoma

This cohort study evaluates a comprehensive nomogram to estimate individualized overall survival among patients with nometastatic nasopharyngeal carcinoma and explores stratified treatment regimens for risk subgroups.

JAMA Netw Open. 2020;3(12):e2029882. doi:10.1001/jamanetworkopen.2020.29882
Abstract Full Text pdf link PDF

HEALTH POLICY

Assessment of Prevalence and Cost of Care Cascades After Routine Testing During the Medicare Annual Wellness Visit

This cohort study uses US Medicare claims data to estimate the prevalence of routine electrocardiogram, urinalyses, and thyrotropin tests performed during annual wellness visits and assesses the prevalence and cost of laboratory tests, imaging tests, procedures, visits, hospitalizations, and new diagnoses that may follow.

JAMA Netw Open. 2020;3(12):e2029891. doi:10.1001/jamanetworkopen.2020.29891
Abstract Full Text pdf link PDF

ONCOLOGY

Lung Cancer Survival in Patients With Autoimmune Disease

This cohort study seeks to determine the association between autoimmune disease and lung cancer survival.

JAMA Netw Open. 2020;3(12):e2029917. doi:10.1001/jamanetworkopen.2020.29917
Abstract Full Text pdf link PDF

ONCOLOGY

Assessment of Time-to-Treatment Initiation and Survival in a Cohort of Patients With Common Cancers

This cohort study of patients with breast, prostate, non-small cell lung, and colon cancer assesses the association of time from diagnosis to treatment with all-cause mortality.

JAMA Netw Open. 2020;3(12):e2030072. doi:10.1001/jamanetworkopen.2020.30072
Abstract Full Text pdf link PDF

GERIATRICS

Evaluation of Peer-to-Peer Support and Health Care Utilization Among Community-Dwelling Older Adults

This comparative effectiveness study investigates whether a community-designed peer-to-peer support program is associated with lower acute health care utilization compared with standard community services among older adults.

JAMA Netw Open. 2020;3(12):e2030090. doi:10.1001/jamanetworkopen.2020.30090
Abstract Full Text pdf link PDF

ONCOLOGY

Total Neoadjuvant Therapy vs Standard Therapy in Locally Advanced Rectal Cancer: A Systematic Review and Meta-analysis

This systematic review and meta-analysis assesses the differences in rates of pathologic complete response, disease-free and overall survival, sphincter-preserving surgery, and ileostomy between patients with locally advanced rectal cancer receiving total neoadjuvant therapy vs standard chemoradiotherapy followed by surgery and adjuvant chemotherapy.

JAMA Netw Open. 2020;3(12):e2030097. doi:10.1001/jamanetworkopen.2020.30097
Abstract Full Text pdf link PDF

DERMATOLOGY

Identification of Incidental Skin Cancers Among Adults Referred to Dermatologists for Suspicious Skin Lesions

This cohort study examines the use of total body skin examinations for detection of incidental skin cancers in patients referred to dermatology clinics for evaluation of a clinically suspicious index lesion.

JAMA Netw Open. 2020;3(12):e2030107. doi:10.1001/jamanetworkopen.2020.30107
Abstract Full Text pdf link PDF

SUBSTANCE USE AND ADDICTION

Assessment of Nicotine and Cannabis Vaping and Respiratory Symptoms in Young Adults

This cross-sectional study examines whether nicotine vaping and cannabis vaping are associated with bronchitic symptoms, wheeze, and shortness of breath in young adults.

JAMA Netw Open. 2020;3(12):e2030189. doi:10.1001/jamanetworkopen.2020.30189
Abstract Full Text pdf link PDF

SUBSTANCE USE AND ADDICTION

Incidence and Characteristics of Nonfatal Opioid Overdose Among Youths Aged 11 to 24 Years by Sex

This cohort study compares the sociodemographic and clinical characteristics of US youths who have experienced a nonfatal opioid overdose and examines the incidence of nonfatal opioid overdose by sex.

JAMA Netw Open. 2020;3(12):e2030201. doi:10.1001/jamanetworkopen.2020.30201
Abstract Full Text pdf link PDF

OBSTETRICS AND GYNECOLOGY

Association of Improved Periconception Hemoglobin A1c With Pregnancy Outcomes in Women With Diabetes

This cohort study examines whether there is an association between a reduction in hemoglobin A1c during the first half of pregnancy and both perinatal and maternal outcomes among women with prepregnacy diabetes in Ontario, Canada.

JAMA Netw Open. 2020;3(12):e2030207. doi:10.1001/jamanetworkopen.2020.30207
Abstract Full Text pdf link PDF

HEALTH POLICY

Association of the National Dependent Coverage Expansion With Insurance Use for Sexual and Reproductive Health Services by Female Young Adults

This cross-sectional study evaluates whether implementation of the Patient Protection and Affordable Care Act Dependent Coverage Expansion was associated with changes in the use of insurance for sexual and reproductive services among female young adults.

JAMA Netw Open. 2020;3(12):e2030214. doi:10.1001/jamanetworkopen.2020.30214
Abstract Full Text pdf link PDF

DIABETES AND ENDOCRINOLOGY

Effects of Fecal Microbiome Transfer in Adolescents With Obesity: The Gut Bugs Randomized Controlled Trial

This randomized, double-masked, placebo-controlled clinical trial of 87 adolescents assesses the effect of fecal microbiome transfer on weight loss. Follow-up examination was conducted for the primary outcome at 6 weeks with intention-to-treat analyses, and was measured by body mass index standard deviation score.

JAMA Netw Open. 2020;3(12):e2030415. doi:10.1001/jamanetworkopen.2020.30415
Abstract Full Text pdf link PDF

GASTROENTEROLOGY AND HEPATOLOGY

Evaluation of the Cherokee Nation Hepatitis C Virus Elimination Program in the First 22 Months of Implementation

This cohort study evaluates the first 22 months of implementation of the Cherokee Nation Heath Services community-based program designed to eliminate hepatitis C virus (HCV) infection.

JAMA Netw Open. 2020;3(12):e2030427. doi:10.1001/jamanetworkopen.2020.30427
Abstract Full Text pdf link PDF

IMAGING

Development and Validation of a Machine Learning Model to Explore Tyrosine Kinase Inhibitor Response in Patients With Stage IV EGFR Variant–Positive Non–Small Cell Lung Cancer

This diagnostic/prognostic study proposes a clinically applicable large-scale bidirectional generative adversarial network for predicting the efficacy of epidermal growth factor receptor–tyrosine kinase inhibitor therapy in patients with non–small cell lung cancer.

JAMA Netw Open. 2020;3(12):e2030442. doi:10.1001/jamanetworkopen.2020.30442
Abstract Full Text pdf link PDF

OBSTETRICS AND GYNECOLOGY

Assessment of Maternal and Neonatal SARS-CoV-2 Viral Load, Transplacental Antibody Transfer, and Placental Pathology in Pregnancies During the COVID-19 Pandemic

This cohort study examines maternal and neonatal severe acute respiratory syndrome coronavirus 2 viral load, transplacental antibody transfer, and placental pathology among pregnant women.

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JAMA Netw Open. 2020;3(12):e2030455. doi:10.1001/jamanetworkopen.2020.30455
Abstract Full Text pdf link PDF CME & MOC

INFECTIOUS DISEASES

Comparison of Trends in Rates of Sexually Transmitted Infections Before vs After Initiation of HIV Preexposure Prophylaxis Among Men Who Have Sex With Men

This cohort study examines trends in sexually transmitted infection (STI) test positivity among high-risk men who have sex with men before and after the start of preexposure prophylaxis (PrEP) for HIV.

JAMA Netw Open. 2020;3(12):e2030806. doi:10.1001/jamanetworkopen.2020.30806
Abstract Full Text pdf link PDF

OBSTETRICS AND GYNECOLOGY

Racial Differences in Postpartum Blood Pressure Trajectories Among Women After a Hypertensive Disorder of Pregnancy

This cohort study describes the blood pressure trajectory in the first 6 weeks post partum after a hypertensive disorder of pregnancy and evaluates whether blood pressure trajectories differ by self-reported race.

JAMA Netw Open. 2020;3(12):e2030815. doi:10.1001/jamanetworkopen.2020.30815
Abstract Full Text pdf link PDF

NEUROLOGY

Association of Optical Coherence Tomography With Longitudinal Neurodegeneration in Veterans With Chronic Mild Traumatic Brain Injury

This cohort study examines neurodegeneration through longitudinal evaluation of changes in retinal layer thickness using optical coherence tomography in veterans with a history of mild traumatic brain injury (TBI).

JAMA Netw Open. 2020;3(12):e2030824. doi:10.1001/jamanetworkopen.2020.30824
Abstract Full Text pdf link PDF

PSYCHIATRY

Association of Burnout With Depression and Anxiety in Critical Care Clinicians in Brazil

This cross-sectional study examines the associations of symptoms of burnout, depression, and anxiety in intensive care unit clinicians in Brazil.

JAMA Netw Open. 2020;3(12):e2030898. doi:10.1001/jamanetworkopen.2020.30898
Abstract Full Text pdf link PDF

PEDIATRICS

Frequency, Timing, Risk Factors, and Outcomes of Desaturation in Infants With Acute Bronchiolitis and Initially Normal Oxygen Saturation

This cohort study examines the frequency, timing, risk factors, and outcomes associated with oxygen desaturation in infants with acute bronchiolitis and initially normal oxygen saturation.

JAMA Netw Open. 2020;3(12):e2030905. doi:10.1001/jamanetworkopen.2020.30905
Abstract Full Text pdf link PDF

HEALTH INFORMATICS

Development of a Machine Learning Model Using Multiple, Heterogeneous Data Sources to Estimate Weekly US Suicide Fatalities

This cross-sectional study uses machine learning to estimate weekly suicide fatalities in the US in near real time.

JAMA Netw Open. 2020;3(12):e2030932. doi:10.1001/jamanetworkopen.2020.30932
Abstract Full Text pdf link PDF

HEALTH POLICY

Evaluation of Changes in Beverage Prices and Volume Sold Following the Implementation and Repeal of a Sweetened Beverage Tax in Cook County, Illinois

This study using interrupted time series analysis to assess whether the implementation and repeal of a sweetened beverage tax in Cook County, Illinois, were associated with lasting changes in sweetened beverage prices or volume sold.

JAMA Netw Open. 2020;3(12):e2031083. doi:10.1001/jamanetworkopen.2020.31083
Abstract Full Text pdf link PDF

MEDICAL EDUCATION

Effectiveness of Immersive Virtual Reality on Orthopedic Surgical Skills and Knowledge Acquisition Among Senior Surgical Residents: A Randomized Clinical Trial

This randomized clinical trial evaluates whether immersive virtual reality improves learning effectiveness among orthopedic surgery residents performing reverse shoulder arthroplasty.

JAMA Netw Open. 2020;3(12):e2031217. doi:10.1001/jamanetworkopen.2020.31217
Abstract Full Text pdf link PDF

UROLOGY

Regional Variation in Active Surveillance for Low-Risk Prostate Cancer in the US

This cohort study examines variations in the use of active surveillance and watchful waiting in men with low-risk prostate cancer throughout the US.

JAMA Netw Open. 2020;3(12):e2031349. doi:10.1001/jamanetworkopen.2020.31349
Abstract Full Text pdf link PDF

PSYCHIATRY

Evaluation of Suicide Mortality Among Sexual Minority US Veterans From 2000 to 2017

This cohort study compares suicide mortality among sexual minority veterans with suicide mortality in the general US and veteran populations.

JAMA Netw Open. 2020;3(12):e2031357. doi:10.1001/jamanetworkopen.2020.31357
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Accuracy of US College Football Players’ Estimates of Their Risk of Concussion or Injury

This survey study uses questionnaires collected from college football players in the most competitive conferences of the US National Collegiate Athletic Association to analyze whether the players accurately estimate their risk of concussion and nonconcussion injury.

JAMA Netw Open. 2020;3(12):e2031509. doi:10.1001/jamanetworkopen.2020.31509
Abstract Full Text pdf link PDF

HEALTH INFORMATICS

Patient Characteristics Associated With Telemedicine Access for Primary and Specialty Ambulatory Care During the COVID-19 Pandemic

This cohort study evaluates whether inequities are present in telemedicine use and video visit use for telemedicine visits during the coronavirus disease 2019 pandemic.

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JAMA Netw Open. 2020;3(12):e2031640. doi:10.1001/jamanetworkopen.2020.31640
Abstract Full Text pdf link PDF CME & MOC

SURGERY

Association of Gabapentinoids With the Risk of Opioid-Related Adverse Events in Surgical Patients in the United States

This cohort study evaluates the association between perioperative coadministration of gabapentinoids and opioids with inpatient opioid-related adverse events in US surgical patients.

JAMA Netw Open. 2020;3(12):e2031647. doi:10.1001/jamanetworkopen.2020.31647
Abstract Full Text pdf link PDF

GLOBAL HEALTH

Household Transmission of SARS-CoV-2: A Systematic Review and Meta-analysis

This systematic review and meta-analysis examines evidence for household transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), disaggregated by several covariates, and compares it with other coronaviruses

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JAMA Netw Open. 2020;3(12):e2031756. doi:10.1001/jamanetworkopen.2020.31756
Abstract Full Text pdf link PDF CME & MOC

INFECTIOUS DISEASES

Assessment of Air Contamination by SARS-CoV-2 in Hospital Settings

This systematic review distills the current evidence on air contamination with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in hospital settings and assesses the factors associated with contamination, including viral load and particle size.

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JAMA Netw Open. 2020;3(12):e2033232. doi:10.1001/jamanetworkopen.2020.33232
Abstract Full Text pdf link PDF CME & MOC

CARDIOLOGY

Assessment of Prevalence, Awareness, and Characteristics of Isolated Systolic Hypertension Among Younger and Middle-Aged Adults in China

This cross-sectional study includes younger and middle-aged adult participants from the China Patient-Centered Evaluative Assessment of Cardiac Events Million Persons Project to assess the prevalence, awareness, and individual characteristics of isolated systolic hypertension (ISH) among this population.

JAMA Netw Open. 2020;3(12):e209743. doi:10.1001/jamanetworkopen.2020.9743
Abstract Full Text pdf link PDF
open access Editorial

Coronary Computed Tomography Angiography in Stable Chest Pain to Prevent Myocardial Infarction and Reduce Costs—Seeing Is Believing

JAMA Netw Open. 2020;3(12):e2030996. doi:10.1001/jamanetworkopen.2020.30996
Abstract Full Text pdf link PDF
open access Invited Commentary

CARDIOLOGY

Assessing the Benefits of Atrial Fibrillation Ablation—Nothing Succeeds Like Success

JAMA Netw Open. 2020;3(12):e2025674. doi:10.1001/jamanetworkopen.2020.25674
Abstract Full Text pdf link PDF

MEDICAL JOURNALS AND PUBLISHING

Avoidance of Duplicate Publications From Randomized Clinical Trials

JAMA Netw Open. 2020;3(12):e2027184. doi:10.1001/jamanetworkopen.2020.27184
Abstract Full Text pdf link PDF

PSYCHIATRY

Longitudinal Analyses Suggest Genomic and Psychological Origins of Disordered Eating and Comorbidities

JAMA Netw Open. 2020;3(12):e2027188. doi:10.1001/jamanetworkopen.2020.27188
Abstract Full Text pdf link PDF

ONCOLOGY

Crowdfunded Cancer Care—A Reflection on Health Care Delivery in the US

JAMA Netw Open. 2020;3(12):e2027191. doi:10.1001/jamanetworkopen.2020.27191
Abstract Full Text pdf link PDF

HEALTH POLICY

Improving Surgical Cancer Care: A Rising Tide May Lift All Boats, Yet Inequity Persists

JAMA Netw Open. 2020;3(12):e2027809. doi:10.1001/jamanetworkopen.2020.27809
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Declines in Electronic Cigarette Use Among US Youth in the Era of COVID-19—A Critical Opportunity to Stop Youth Vaping in Its Tracks

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JAMA Netw Open. 2020;3(12):e2028221. doi:10.1001/jamanetworkopen.2020.28221
Abstract Full Text pdf link PDF CME & MOC

SURGERY

Unhealthy Alcohol Use—A Common Iatrogenic Complication of Bariatric Surgery

JAMA Netw Open. 2020;3(12):e2028222. doi:10.1001/jamanetworkopen.2020.28222
Abstract Full Text pdf link PDF

ONCOLOGY

Radiomics For Surgical Planning and Prognostication

JAMA Netw Open. 2020;3(12):e2028608. doi:10.1001/jamanetworkopen.2020.28608
Abstract Full Text pdf link PDF

CARDIOLOGY

Geographic Variation in US Heart Transplant Outcomes and Consequences for Health Care Equity

JAMA Netw Open. 2020;3(12):e2028856. doi:10.1001/jamanetworkopen.2020.28856
Abstract Full Text pdf link PDF

CRITICAL CARE MEDICINE

Smarter Use of Corticosteroids in Treating Patients with Septic Shock

JAMA Netw Open. 2020;3(12):e2029323. doi:10.1001/jamanetworkopen.2020.29323
Abstract Full Text pdf link PDF

CRITICAL CARE MEDICINE

Crisis Triage—Attention to Values in Addition to Efficiency

JAMA Netw Open. 2020;3(12):e2029326. doi:10.1001/jamanetworkopen.2020.29326
Abstract Full Text pdf link PDF

PEDIATRICS

A Case to Optimize Medications in Children With Severe Neurological Impairment

JAMA Netw Open. 2020;3(12):e2029728. doi:10.1001/jamanetworkopen.2020.29728
Abstract Full Text pdf link PDF

ONCOLOGY

The Association of Autoimmune Disease With Lung Cancer Survival

JAMA Netw Open. 2020;3(12):e2030506. doi:10.1001/jamanetworkopen.2020.30506
Abstract Full Text pdf link PDF

ONCOLOGY

The “New Normal” of Cancer Treatment Delays Is Nothing New

JAMA Netw Open. 2020;3(12):e2030507. doi:10.1001/jamanetworkopen.2020.30507
Abstract Full Text pdf link PDF

ONCOLOGY

Personalizing Treatment for Rectal Cancer: Total Neoadjuvant Therapy Is Leading the Way

JAMA Netw Open. 2020;3(12):e2030508. doi:10.1001/jamanetworkopen.2020.30508
Abstract Full Text pdf link PDF

OBSTETRICS AND GYNECOLOGY

Protecting Pregnant Women and Their Infants From COVID-19: Clues From Maternal Viral Loads, Antibody Responses, and Placentas

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JAMA Netw Open. 2020;3(12):e2030564. doi:10.1001/jamanetworkopen.2020.30564
Abstract Full Text pdf link PDF CME & MOC

ONCOLOGY

Multimodality Therapy for Locoregional Nasopharyngeal Carcinoma—A Decision Tool for Treatment Optimization

JAMA Netw Open. 2020;3(12):e2030672. doi:10.1001/jamanetworkopen.2020.30672
Abstract Full Text pdf link PDF

GERIATRICS

Understanding and Measuring the Value of Peer-to-Peer Community Support Programs for Older Adults

JAMA Netw Open. 2020;3(12):e2030674. doi:10.1001/jamanetworkopen.2020.30674
Abstract Full Text pdf link PDF

SUBSTANCE USE AND ADDICTION

The Importance of Studying Sex and Gender Differences in Opioid Misuse

JAMA Netw Open. 2020;3(12):e2030676. doi:10.1001/jamanetworkopen.2020.30676
Abstract Full Text pdf link PDF

INFECTIOUS DISEASES

Preventing Disease, Not Sex—Harm Reduction, HIV Preexposure Prophylaxis, and Sexually Transmitted Infections

JAMA Netw Open. 2020;3(12):e2031102. doi:10.1001/jamanetworkopen.2020.31102
Abstract Full Text pdf link PDF

OBSTETRICS AND GYNECOLOGY

Race Differences in Blood Pressure Trajectory After Delivery—A Window Into Opportunities to Decrease Racial Disparities in Maternal Morbidity and Mortality

JAMA Netw Open. 2020;3(12):e2031122. doi:10.1001/jamanetworkopen.2020.31122
Abstract Full Text pdf link PDF

INFECTIOUS DISEASES

A Data-Driven Rationale for High-Throughput SARS-CoV-2 Mass Screening Programs

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JAMA Netw Open. 2020;3(12):e2031577. doi:10.1001/jamanetworkopen.2020.31577
Abstract Full Text pdf link PDF CME & MOC

SURGERY

Exploring the Combination of Gabapentinoids and Opioids for Postoperative Analgesia

JAMA Netw Open. 2020;3(12):e2032139. doi:10.1001/jamanetworkopen.2020.32139
Abstract Full Text pdf link PDF

HEALTH INFORMATICS

From the Exposome to the Socioexposome in COVID-19 Research—A Call for More Multidisciplinary Research

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JAMA Netw Open. 2020;3(12):e2032287. doi:10.1001/jamanetworkopen.2020.32287
Abstract Full Text pdf link PDF CME & MOC

HEALTH POLICY

Is the Association Between Beverage Taxes and Reductions in Sales Driven by Communication of Health Consequences in Addition to Price Increases?

JAMA Netw Open. 2020;3(12):e2032537. doi:10.1001/jamanetworkopen.2020.32537
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Bloviating and Bungling the COVID-19 Pandemic

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JAMA Netw Open. 2020;3(12):e2032540. doi:10.1001/jamanetworkopen.2020.32540
Abstract Full Text pdf link PDF CME & MOC
open access Research Letter

EMERGENCY MEDICINE

Rate of Pediatric Appendiceal Perforation at a Children’s Hospital During the COVID-19 Pandemic Compared With the Previous Year

This cross-sectional study assesses the rate of appendiceal perforations during the COVID-19 pandemic at a children’s hospital during10-week periods in 2020 vs 2019.

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JAMA Netw Open. 2020;3(12):e2027948. doi:10.1001/jamanetworkopen.2020.27948
Abstract Full Text pdf link PDF CME & MOC

NEUROLOGY

Assessment of Tau Tangles and Amyloid-β Plaques Among Super Agers Using PET Imaging

This cross-sectional study examines positron emission tomography (PET) imaging to investigate the burden of tau tangles and amyloid β plaques in super agers, normal agers, and patients with mild cognitive impairment vs younger amyloid-negative controls.

JAMA Netw Open. 2020;3(12):e2028337. doi:10.1001/jamanetworkopen.2020.28337
Abstract Full Text pdf link PDF

SURGERY

Evaluation of a Risk Stratification Model Using Preoperative and Intraoperative Data for Major Morbidity or Mortality After Cardiac Surgical Treatment

This cohort study evaluates performance of risk stratification models using preoperative, intraoperative, or combined data to assess composite risk after cardiac surgical treatment.

JAMA Netw Open. 2020;3(12):e2028361. doi:10.1001/jamanetworkopen.2020.28361
Abstract Full Text pdf link PDF

HEALTH POLICY

Comparison of Direct-to-Consumer Telemedicine Visits With Primary Care Visits

This cross-sectional study compares patients who used a direct-to-consumer telemedicine service with patients who used primary care visits in the 20 US states where the service was available.

JAMA Netw Open. 2020;3(12):e2028392. doi:10.1001/jamanetworkopen.2020.28392
Abstract Full Text pdf link PDF

HEALTH POLICY

Perceptions of Parenting Challenges and Career Progression Among Physician Faculty at an Academic Hospital

This survey study compares the perceptions of male and female physician faculty members who have children regarding parenting challenges and career progression at an academic hospital.

JAMA Netw Open. 2020;3(12):e2029076. doi:10.1001/jamanetworkopen.2020.29076
Abstract Full Text pdf link PDF

GERIATRICS

Characteristics and Work Life Quality of Nursing Home Care Aides in Canada

This cross-sectional study describes care aides’ characteristics and quality of work life in Western Canadian nursing homes.

JAMA Netw Open. 2020;3(12):e2029121. doi:10.1001/jamanetworkopen.2020.29121
Abstract Full Text pdf link PDF

ONCOLOGY

Updated Analysis of Complication Rates Associated With Invasive Diagnostic Procedures After Lung Cancer Screening

This case-control study compares complication rates associated with invasive diagnostic procedures before and after Medicare and Medicaid coverage of lung cancer screening tests.

JAMA Netw Open. 2020;3(12):e2029874. doi:10.1001/jamanetworkopen.2020.29874
Abstract Full Text pdf link PDF

PEDIATRICS

Clinical Characteristics and Disease Severity Among Infants With SARS-CoV-2 Infection in Montreal, Quebec, Canada

This case series describes clinical characteristics and disease severity in infants who had SARS-CoV-2 infection in Montreal, Quebec, Canada.

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JAMA Netw Open. 2020;3(12):e2030470. doi:10.1001/jamanetworkopen.2020.30470
Abstract Full Text pdf link PDF CME & MOC

SUBSTANCE USE AND ADDICTION

Analysis of US Teen Driving After Using Marijuana, 2017

This cross-sectional study examines the prevalence of and factors associated with driving after using marijuana among US adolescents.

JAMA Netw Open. 2020;3(12):e2030473. doi:10.1001/jamanetworkopen.2020.30473
Abstract Full Text pdf link PDF

SURGERY

Associations Between the Severity of Influenza Seasons and Mortality and Readmission Risks After Elective Surgical Aortic Valve Replacement and Coronary Artery Bypass Graft Surgery in Older Adults

This cross-sectional study uses Centers for Medicare and Medicaid Services claims data to investigate associations between influenza season severity and mortality and readmission risks after elective surgical aortic valve replacement (SAVR) and coronary artery bypass grafting (CABG) among older adults.

JAMA Netw Open. 2020;3(12):e2031078. doi:10.1001/jamanetworkopen.2020.31078
Abstract Full Text pdf link PDF

HEALTH INFORMATICS

Investigator Use of Social Media for Recruitment of Patients for Cancer Clinical Trials

This survey study discusses the use of social media for recruitment of patients for cancer clinical trials and investigators’ concerns about this recruitment approach.

JAMA Netw Open. 2020;3(12):e2031202. doi:10.1001/jamanetworkopen.2020.31202
Abstract Full Text pdf link PDF

INFECTIOUS DISEASES

Assessment of an Online Tool to Simulate the Effect of Pooled Testing for SARS-CoV-2 Detection in Asymptomatic and Symptomatic Populations

This diagnostic study describes an online tool created with actual severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus copy number data to help policy makers understand how pooled testing compares with single-sample testing in different populations.

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JAMA Netw Open. 2020;3(12):e2031517. doi:10.1001/jamanetworkopen.2020.31517
Abstract Full Text pdf link PDF CME & MOC

PUBLIC HEALTH

Assessment of German Public Attitudes Toward Health Communications With Varying Degrees of Scientific Uncertainty Regarding COVID-19

This survey study assesses attitudes of the German public regarding COVID-19 health communications with varying degrees of scientific uncertainty.

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JAMA Netw Open. 2020;3(12):e2032335. doi:10.1001/jamanetworkopen.2020.32335
Abstract Full Text pdf link PDF CME & MOC

PUBLIC HEALTH

US Public Attitudes Toward COVID-19 Vaccine Mandates

This survey study assesses the acceptability of coronavirus disease 2019 (COVID-19) vaccine mandates among members of the US public.

has active quiz
JAMA Netw Open. 2020;3(12):e2033324. doi:10.1001/jamanetworkopen.2020.33324
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open access Letter

Notice of Retraction. Hodkinson et al. Accelerometer- and Pedometer-Based Physical Activity Interventions Among Adults With Cardiometabolic Conditions: A Systematic Review and Meta-analysis. JAMA Netw Open. 2019;2(10):e1912895.

JAMA Netw Open. 2020;3(12):e2032700. doi:10.1001/jamanetworkopen.2020.32700
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open access Correction

Error in Methods

JAMA Netw Open. 2020;3(12):e2028432. doi:10.1001/jamanetworkopen.2020.28432
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Errors in Panels B and C in Figure 1

JAMA Netw Open. 2020;3(12):e2030697. doi:10.1001/jamanetworkopen.2020.30697
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Error in Author Byline

JAMA Netw Open. 2020;3(12):e2030880. doi:10.1001/jamanetworkopen.2020.30880
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Error in Results Section

JAMA Netw Open. 2020;3(12):e2031402. doi:10.1001/jamanetworkopen.2020.31402
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Error in Subject Area

JAMA Netw Open. 2020;3(12):e2031600. doi:10.1001/jamanetworkopen.2020.31600
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Omitted Acknowledgment

JAMA Netw Open. 2020;3(12):e2031636. doi:10.1001/jamanetworkopen.2020.31636
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Error in Conflict of Interest Disclosures

JAMA Netw Open. 2020;3(12):e2032460. doi:10.1001/jamanetworkopen.2020.32460
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Error in Abstract

JAMA Netw Open. 2020;3(12):e2032624. doi:10.1001/jamanetworkopen.2020.32624
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Error in Article Information Section

JAMA Netw Open. 2020;3(12):e2033114. doi:10.1001/jamanetworkopen.2020.33114
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JAMA Network Open

JAMA Netw Open. 2020;3(12):e2032019. doi:10.1001/jamanetworkopen.2020.32019
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