This cross-sectional survey study describes the cardiopulmonary resuscitation preferences of patients receiving dialysis and how these preferences are associated with their responses to questions about other aspects of end-of-life care.
This cohort study examines the performance of risk assessment scores among US patients with acute pulmonary embolism.
This cross-sectional study evaluates the pattern of aspirin use and statin use and adherence in US veterans with premature atherosclerotic cardiovascular disease.
This cross-sectional study evaluates whether socioeconomic status, insurance status, or race/ethnicity are associated with the presence of metastases at the time of diagnosis of sarcoma.
This cohort study examines associations of reported mental health issues at ages 7 and 14 years with health behaviors in adolescence.
This nationally representative cohort study assesses whether exposure to the ubiquitous chemical bisphenol A is associated with long-term risk of mortality from cardiovascular disease, cancer, or all causes among US adults.
This cohort study developed and validated a machine learning–based algorithm that can provide survival risk stratification for patients with advanced oral cancer who have comprehensive clinicopathologic and genetic data.
This meta-analysis compares shorter duration with 1 year of adjuvant trastuzumab for patients with early breast cancer.
This randomized clinical trial evaluates whether clinician training in the Modular Approach to Therapy for Children (MATCH) is associated with more use of empirically supported treatment and better clinical outcomes than usual care among adolescents receiving mental health care in New Zealand.
This systematic review and meta-analysis assesses whether metformin is associated with improved outcomes of in vitro fertilization or intracytoplasmic sperm injection and embryo transfer among women with polycystic ovarian syndrome.
This serial cross-sectional study of the National Health Interview Survey evaluates temporal trends in and sociodemographic and behavioral factors associated with cigarette smoking cessation among adult cancer survivors in the US.
This cross-sectional study uses data from the CDC WONDER database and the Area Health Resources Files to examine historical trends and disparities in mortality rates between Black and White adults 65 years and older living in urban and rural communities in the US from 1968 to 2016.
This randomized clinical trial compares treatment with candesartan vs lisinopril among adults with hypertension and mild cognitive impairment.
This randomized clinical trial assesses whether emotional memory retrieval in adult patients before receiving electroconvulsive therapy (ECT) weakens underlying cognitive schemas, improves ECT effectiveness, increases ECT response, and reduces relapse rates.
This cross-sectional study describes application of the reverse fragility index in establishing the clinical relevance of published clinical trials with null results.
This economic evaluation study compares the cost-effectiveness of 2 strategies (mechanical thrombectomy with standard medical care vs standard medical care alone) for various subgroups of patients with acute ischemic stroke who were receiving care more than 6 hours after symptom onset.
This economic evaluation study compares the cost-effectiveness of 9 Clostridioides difficile single intervention strategies and 8 multi-intervention bundles.
This meta-analysis examines the association of sex, age, and Eastern Cooperative Oncology Group performance status with overall survival in patients treated with immune checkpoint inhibitors for advanced cancer.
This statewide cohort study of more than 1.5 million person-years uses a comparative interrupted time series analysis to assess whether implementing an incentive metric is associated with effective contraceptive use among women enrolled in the Oregon Medicaid program.
This survey study examines the prevalence, individual characteristics and experiences, and costs associated with bypassing the nearest health care facility among women in Ghana.
This cross-sectional study examines the mediating role of childhood peer bullying in the association between childhood intrafamilial aggression and depression in Chinese adults.
This systematic review and meta-analysis assesses the association between experiences of childhood maltreatment and suicide behaviors in children and young adults.
his cohort study examines antenatal care quality indicators for women who experience imprisonment compared with women in the general population in Ontario, Canada.
This randomized clinical trial evaluates the effectiveness of spinal manipulation and spinal mobilization compared with a placebo at reducing pain and disability among young adults with mild to moderate chronic low back pain.
This systematic review and meta-analysis of 28 randomized controlled trials examines the effectiveness in mindfulness-based interventions in reducing anxiety and depression in adult patients with cancer.
This cross-sectional study examines the differences in treatment decisions between a heart team and an original treating interventional cardiologist for patients with multivessel coronary artery disease.
This survey study examines the associations of internal medicine program directors’ perceptions of health disparities programs with those of the residents in internal medicine programs.
This cross-sectional national study investigates possible differences in occupational burnout, depressive symptoms, career satisfaction, and work-life integration by race/ethnicity in a sample of US physicians.
This cross-sectional study examines the prevalence of food insecurity in the context of obesity and other sociodemographic factors among adults aged 20 years or older.
This cohort study assesses whether receipt of outpatient care within 7 days of psychiatric hospital discharge is associated with a reduced risk of subsequent suicide among child and adolescent inpatients and examines factors associated with timely follow-up care.
This diagnostic study internally and externally validates a machine learning risk score for detecting acute kidney injury in hospitalized patients.
This cohort study assesses new bloodstream infections in people who inject drugs (PWID) and are receiving treatment for infective endocarditis and investigates whether new infections and treatment settings are associated with mortality.
This survey study characterizes pediatric practitioner recommendations regarding complementary food introduction and waiting periods between the introduction of new foods.
This diagnostic study examines whether plasma biomarkers can differentiate collegiate athletes who return to sport in less than 14 days vs 14 days or more following a sports-related concussion.
This cohort study examines whether MUC16 mutation is associated with response to treatment with immune checkpoint inhibitors and outcomes among patients with solid tumors, non–small cell lung cancer, and melanoma.
This randomized clinical trial evaluates whether ketamine dose and brain glutamate and glutamine (Glx) and γ-aminobutyric acid (GABA) level responses to ketamine are related to antidepressant benefit and adverse effects.
This cross-sectional study examines the incidence of different molecular subtypes of breast cancers among different racial/ethnic and age groups.
This systematic review and meta-analysis assesses levels of anhedonia in healthy individuals and patients with mental illness according to the Snaith-Hamilton Pleasure Scale.
This cohort study estimates the risk of older adult fall injury within and across discrete periods during a 12-month care episode anchored by an acute hospitalization.
This randomized clinical trial evaluates whether D-cycloserine potentiates the effect of concentrated exposure and response prevention among patients with difficult-to-treat obsessive-compulsive disorder.
This randomized clinical trial examines the effect of a brief mindfulness-based program on stress reduction among health care professionals in a US research hospital.
This cohort study examines the long-term trajectories of posttraumatic stress and depressive symptoms among older, community-living adults who were affected by the 2011 Great East Japan earthquake and tsunami.
This cohort study examines all-cause mortality in individuals with stable weight or weight changes over time.
This cross-sectional study examines whether pregnancy and insurance status are associated with a woman’s ability to obtain an appointment with an opioid use disorder treatment clinician.
This cohort study of healthy offspring from the Avon Longitudinal Study of Parents and Children examines the association of time spent in moderate to vigorous–intensity and light-intensity physical activity throughout adolescence with peak hip strength in adulthood.
This cross-sectional study describes key attributes of sole-source, off-patent, off-exclusivity drugs; characterizes the prevalence of price increases; and identifies attributes associated with price increases.
This cross-sectional study of results from the National Survey on Drug Use and Health compares patterns of opioid use and misuse among cancer survivors with respondents without a history of cancer.
This systematic review and meta-analysis examines the factors associated with burnout and stress among physicians receiving standard postgraduate training.
This cohort study examines trajectories of cognitive and social activities from midlife to late life and evaluates whether these trajectories are associated with brain structure, functional connectivity, and cognition.
This cross-sectional study examines the association of depression with past-month cannabis use among US adults and the time trends for this association from 2005 to 2016.
This population-based cohort study describes the epidemiology and health care costs associated with potentially avoidable delays in intensive care unit discharge among adult patients in a large integrated health care system.
This quality improvement study examines quality testing of prescription pharmaceutical products that are manufactured in various regions of the world and marketed in the US.
This cohort study compares survival outcomes between primary cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) vs primary cytoreductive surgery alone for patients with stage III epithelial ovarian cancer.
This diagnostic study assesses interobserver reliability of nephrologist examination of urine sediment using high-resolution digital images and videos of the urine sediment of patients across the US undergoing kidney biopsy.
This quasi-experimental cohort study uses data from the Danish population register of adult immigrants arriving from 1986 to 1998 and health outcomes from the inpatient clinic register, outpatient clinic register, and prescription drug register to assess the association between disadvantaged neighborhoods and cardiovascular disease risk among refugees.
This randomized clinical trial examines whether a multicomponent intervention results in a higher proportion of pediatric patients with acute lymphoblastic leukemia maintaining mercaptopurine adherence rates of 95% or higher compared with education alone.
This network meta-analysis compares the efficacy and safety of 8 antibiotics used for treatment of scrub typhus.
This secondary analysis of 8 randomized clinical trials assesses whether stratification by sex and race is associated with meaningful differences in physical function response to weight loss among older adults.
This cohort study uses data from the Reasons for Geographic and Racial Differences in Stroke study to examine differences between Black and White patients in end-of-life care in a population sample with well-characterized causes of death.
This randomized clinical trial assesses the comparative effectiveness of the Healthy Choices intervention when delivered in a clinic- vs home-based setting on medication adherence and alcohol use among youths and young adults living with HIV.
This cross-sectional study assesses characteristics and trends in clinical trials registered in ClinicalTrials.gov from 2000 to 2019 and how they differed by sponsor type.
This cross-sectional study examines incidence, distribution, and lethality of firearm injuries in California from 2005 to 2015.
This cohort study estimates atrial fibrillation (AF) incidence rates from 2006 to 2018 in a US community-based setting and investigates possible explanations for increasing AF by evaluating the changing features of incident AF cases and the pool of patients at risk for AF.
This national registry study examines national trends in racial/ethnic disparities in the receipt of predialysis nephrology care at least 1 year before dialysis initiation among adults with end-stage kidney disease in the United States from 2005 to 2015.
This cross-sectional study examines the concordance of self-reported measures of hearing difficulty with objective hearing data and the factors associated with the potential discordances among these measures in people 50 years and older in England.
This cross-sectional study uses data from the National Family Health Survey to assess the association of public vs private sector health facilities with the increase in cesarean delivery rates and to estimate the avoidable burden of cesarean deliveries in India between 2005 and 2016.
This cross-sectional study draws from identified and linked and health administrative data in Ontario, Canada, to compare the sociodemographic characteristics and health care use of transgender individuals with the general population of the province.
This cross-sectional analysis evaluates the association between exposure to select endocrine-disrupting chemicals during adolescence and attention-deficit/hyperactivity (ADHD)–related behaviors.
This randomized clinical trial evaluates the effect of short-term integrated palliative care vs standard care among patients severely affected by long-term neurological conditions.
This systematic review and meta-analysis assesses the risk of developing chronic cardiomyopathy among patients with acute and indeterminate chronic forms of Chagas disease.
This cross-sectional study identifies the drugs that have adhered to the new US Food and Drug Administration Pregnancy and Lactation Labeling Rule, sheds light on the continued need for implementation of pregnancy, lactation, and reproduction into clinical studies, and evaluates how many new therapeutic products have human and animal data specific to pregnancy and lactation.
This cohort study examines the association between all-cause dementia, including Alzheimer disease, and different types of androgen deprivation therapy among patients with prostate cancer in Taiwan.
This economic evaluation uses data from historically Black medical schools that were closed during the period surrounding the publication of the 1910 Flexner report to examine the implications of these school closures for the number of African American medical school graduates and physicians.
This cluster randomized clinical trial examines whether a coached, digital, cognitive behavior therapy intervention improves outcomes for college women with eating disorders compared with referral to usual care.
This randomized clinical trial examines the effectiveness of depression treatment tele-delivered by lay counselors compared with by clinicians or an attention control among older adults who are homebound.
This cohort study examines coronavirus disease 2019 outcomes in nursing homes where staff self-confined with residents compared with overall national outcomes in France.
This cohort study compares the performance of International Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) codes specific for fever, cough, and dyspnea with electronic medical record review for patients tested for coronavirus disease 2019 (COVID-19).
This cohort study evaluates the association of race with all-cause, in-hospital mortality among patients with coronavirus disease 2019, adjusting for sociodemographic and clinical factors.
This cohort study uses data from a level 1 trauma center database to evaluate the association of computer-assisted virtual preoperative planning with the risk of 90-day all-cause mortality and postoperative complications among older patients with intertrochanteric hip fractures in China.
This cross-sectional study of Medicaid-enrolled children from 5 US states evaluates whether access to community water fluoridation is associated with decreased prevalence of dental surgery under general anesthesia.
This nonrandomized controlled trial examines the association of magnetic seizure therapy with suicidality in patients with treatment-resistant depression.
This cross-sectional study examines trends in total standardized 30-day costs of care associated with an emergency department visit among Medicare beneficiaries.
This cohort study examines the association of molecular alterations in cerebrospinal fluid (CSF) with the survival of patients with a diagnosis of lung adenocarcinoma and central nervous system (CNS) metastases.
This cohort study examines outcomes associated with geriatric comanaged perioperative care vs care managed by the surgery team alone among patients aged 75 years and older with cancer.
This cohort study determines whether data-driven phenotypes of MODS based on the trajectory of 6 organ dysfunctions have prognostic and therapeutic relevance in critically ill children.
This cross-sectional study examines the patient and visit characteristics associated with online portal-based scheduling of medical visits.
This cross-sectional study uses a novel “stickiness” measure to evaluate which mobile applications for smoking cessation, meditation, and other behavioral health areas are associated with long-term engagement.
This cohort study examines the association between second-generation drug-eluting stent length and cardiovascular and bleeding events in Japanese patients with ischemic heart disease.
This economic evaluation explores how Medicare’s new technology add-on payment program (NTAP), which provides reimbursement for newly available drugs and devices, has changed during its lifetime since its initiation in 2013.
This cohort study uses data from a single-center cardiac catheter database to investigate the association of cardiac stent restenosis in patients with diabetes mellitus and comorbid triglyceride deposit cardiomyovasculopathy.
This cross-sectional study examines trends in menthol cigarette use compared with nonmenthol cigarette use in the US.
This diagnostic study investigates whether there are clinically significant differences between Snellen visual acuity examinations performed by a human vs a smart speaker.
This cross-sectional study examines acyl-ghrelin levels in Pakistani adolescents who experienced severe trauma and have posttraumatic stress disorder (PTSD) compared with adolescents who have not experienced severe trauma.
This cohort study examines the association of overall survival with endocrine therapy to treat hormone receptor–positive, ERBB2-negative breast cancer.
This cross-sectional study examines the number of patients prescribed buprenorphine by US clinicians who were waivered to treat 30, 100, or 275 patients concurrently.
This cross-sectional study examines the prevalence of mental health disorders and substance use among professional staff members at community social service agencies 1 year after a mass shooting in Pittsburgh, Pennsylvania.
This cross-sectional study compares appointment wait times at Veterans Health Administration facilities and those at community medical centers accessed via the Veterans Choice Program.
This cross-sectional study examines clinician-assigned New York Heart Association (NYHA) classification vs patient-reported health status using the Kansas City Cardiomyopathy Questionnaire.
This cross-sectional study provides a 5-year update on the status and availability of postmarket evidence for high-risk medical devices that received FDA premarket approval in 2010 and 2011.
This cross-sectional study uses data from the US Consumer Product Safety Commission’s National Electronic Injury Surveillance System to assess trends in the prevalence of electric scooter injuries in the US from 2014 to 2019.
This retrospective study uses data from the National Cancer Database of new cancer diagnoses across the US to examine trends in proportional diagnosis rates and management of patients with high-risk prostate cancer.
This cross-sectional study compares health care spending by age in the US with spending in 8 other high-income countries.
This cross-sectional study examines changes in the number of patients with newly identified cancer before and during the coronavirus disease 2019 (COVID-19) pandemic in the United States.
This cross-sectional study evaluates the prevalence of and factors associated with burnout among frontline health care workers during the coronavirus disease 2019 (COVID-19) pandemic in Japan.
This cross-sectional study investigates oscillatory patterns in daily reported infections and deaths for coronavirus disease 2019.
This cohort study compares the excess deaths in New York City during the peak of the 1918 H1N1 influenza pandemic with those during the early period of the COVID-19 pandemic.
This cohort study assesses the prevalence of lupus anticoagulant (LA) positivity in patients with coronavirus disease 2019 (COVID-19) and examines the association of LA positivity with patient outcomes.
This case-control study examines the association between receipt of the bradykinin 2 (B2) receptor antagonist icatibant and improved oxygenation in patients with coronavirus disease 2019 (COVID-19).
This cross-sectional study evaluates the readability of information on COVID-19 on websites of international agencies, governments of 15 countries, and US health departments.
This case series describes severe acute respiratory syndrome coronavirus (SARS-CoV-2) transmission on a international commercial airline flight.
This cohort study describes the COVID-19 burden among incarcerated individuals and staff in Massachusetts jails and prisons and assesses the association of COVID-19 case rates with decarceration and testing rates.
This mathematical modeling study examines the potential for contract tracing to reduce the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the context of reduced physical distancing under different assumptions for case detection, tracing, and quarantine efficacy.
This cross-sectional study assesses changes in numbers of pediatric outpatient visits for notifiable infectious diseases acquired through droplet transmission, contact transmission, or both after implementation of coronavirus disease 2019 (COVID-19)–related public health measures during the COVID-19 outbreak in Beijing, China.
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