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September 2021 - May 2018

Decade

Year

Issue

January 2021, Vol 4, No. 1

open access Original Investigation

ONCOLOGY

Evaluation of Clear Cell, Papillary, and Chromophobe Renal Cell Carcinoma Metastasis Sites and Association With Survival

This cohort study evaluates the prevalence of metastasis sites for clear cell, papillary, and chromophobe renal cell carcinoma (RCC) and examines the association between site of metastasis and overall survival.

JAMA Netw Open. 2021;4(1):e2021869. doi:10.1001/jamanetworkopen.2020.21869
Abstract Full Text pdf link PDF

HEALTH POLICY

Proportion, Type, and Characteristics of Physician Entrepreneurship in Massachusetts

This cross-sectional study uses Massachusetts medical licensure and business registration records to examine the proportion of physician-founded companies and the types of businesses started.

JAMA Netw Open. 2021;4(1):e2026938. doi:10.1001/jamanetworkopen.2020.26938
Abstract Full Text pdf link PDF

HEALTH POLICY

Assessment of Racial Disparities in Primary Care Physician Specialty Referrals

This cross-sectional study examines whether differences exist between Black and White Medicare beneficiaries in the observed patterns of patient sharing between primary care physicians and physicians in the 6 specialties to which patients were most frequently referred.

JAMA Netw Open. 2021;4(1):e2029238. doi:10.1001/jamanetworkopen.2020.29238
Abstract Full Text pdf link PDF

NEUROLOGY

Progression of Behavioral Disturbances and Neuropsychiatric Symptoms in Patients With Genetic Frontotemporal Dementia

This cohort study uses data from tertiary frontotemporal dementia research clinics across Europe and Canada to assess the frequency and severity of behavioral symptoms and their progression in different forms of genetic frontotemporal dementia.

JAMA Netw Open. 2021;4(1):e2030194. doi:10.1001/jamanetworkopen.2020.30194
Abstract Full Text pdf link PDF

OBSTETRICS AND GYNECOLOGY

Association of Female Reproductive Factors With Incidence of Fracture Among Postmenopausal Women in Korea

This cohort study uses data from the Korean National Health Insurance System database to investigate whether female reproductive factors are associated with fractures among postmenopausal women in Korea.

JAMA Netw Open. 2021;4(1):e2030405. doi:10.1001/jamanetworkopen.2020.30405
Abstract Full Text pdf link PDF

CARDIOLOGY

Association of Sickle Cell Trait With Incidence of Coronary Heart Disease Among African American Individuals

This cohort study evaluates whether African American individuals with sickle cell trait have a higher incidence of myocardial infarction or composite coronary heart disease outcomes compared with those without sickle cell trait.

JAMA Netw Open. 2021;4(1):e2030435. doi:10.1001/jamanetworkopen.2020.30435
Abstract Full Text pdf link PDF

MEDICAL EDUCATION

Evaluation of Women and Underrepresented Racial and Ethnic Group Representation in a General Cardiology Fellowship After a Systematic Recruitment Initiative

This quality improvement study assess a systematic recruitment initiative aimed at ensuring adequate matriculation of women and underrepresented racial and ethnic groups in a general cardiology fellowship.

JAMA Netw Open. 2021;4(1):e2030832. doi:10.1001/jamanetworkopen.2020.30832
Abstract Full Text pdf link PDF

DIABETES AND ENDOCRINOLOGY

Development and Validation of a Machine Learning Model to Predict Near-Term Risk of Iatrogenic Hypoglycemia in Hospitalized Patients

This cohort study of hospitalized patients uses a machine learning model to predict the risk of iatrogenic hypoglycemia within 24 hours after blood glucose measurement during hospitalization.

JAMA Netw Open. 2021;4(1):e2030913. doi:10.1001/jamanetworkopen.2020.30913
Abstract Full Text pdf link PDF

NEPHROLOGY

Development and Validation of a Deep Learning Model to Quantify Glomerulosclerosis in Kidney Biopsy Specimens

This prognostic study compares performances between pathologists and a deep learning model to quantify percent global glomerulosclerosis on images of kidney biopsy specimens and assesses the potential benefit of the model on donor kidney discard rates.

JAMA Netw Open. 2021;4(1):e2030939. doi:10.1001/jamanetworkopen.2020.30939
Abstract Full Text pdf link PDF

SUBSTANCE USE AND ADDICTION

Assessment of Prescription Opioid Medical Use and Misuse Among Parents and Their Adolescent Offspring in the US

This cross-sectional study examines the associations between parental and adolescent prescription opioid medical use and misuse among parent and adolescent dyads in the National Survey on Drug Use and Health.

JAMA Netw Open. 2021;4(1):e2031073. doi:10.1001/jamanetworkopen.2020.31073
Abstract Full Text pdf link PDF

INFECTIOUS DISEASES

Association of Immunosuppression and Viral Load With Subcortical Brain Volume in an International Sample of People Living With HIV

This cross-sectional study examines structural brain associations with CD4+ T-cell count and viral load in HIV-positive individuals taking and not taking combination antiretroviral therapy.

JAMA Netw Open. 2021;4(1):e2031190. doi:10.1001/jamanetworkopen.2020.31190
Abstract Full Text pdf link PDF

INFECTIOUS DISEASES

Safety, Reactogenicity, and Health-Related Quality of Life After Trivalent Adjuvanted vs Trivalent High-Dose Inactivated Influenza Vaccines in Older Adults: A Randomized Clinical Trial

This randomized clinical trial assesses whether injection-site pain and reactogenicity are noninferior in trivalent adjuvanted inactivated influenza vaccine (aIIV3) compared with trivalent high-dose inactivated influenza vaccine (HD-IIV3) among adults aged 65 years and older.

JAMA Netw Open. 2021;4(1):e2031266. doi:10.1001/jamanetworkopen.2020.31266
Abstract Full Text pdf link PDF

NEUROLOGY

Association of Cognitive Function Trajectories in Centenarians With Postmortem Neuropathology, Physical Health, and Other Risk Factors for Cognitive Decline

This cohort study examines trajectories of cognitive function and their associations with cognitive reserve, physical health, and postmortem levels of neuropathology associated with Alzheimer disease in Dutch centenarians.

JAMA Netw Open. 2021;4(1):e2031654. doi:10.1001/jamanetworkopen.2020.31654
Abstract Full Text pdf link PDF

ONCOLOGY

Association of Radiotherapy for Rectal Cancer and Second Gynecological Malignant Neoplasms

This cohort study assesses the association between radiotherapy and the risk of individual types of second gynecological malignant neoplasms in patients with rectal cancer and estimates survival outcomes for patients with secondary cancers.

JAMA Netw Open. 2021;4(1):e2031661. doi:10.1001/jamanetworkopen.2020.31661
Abstract Full Text pdf link PDF

CARDIOLOGY

Evaluation of Dietary Niacin and New-Onset Hypertension Among Chinese Adults

This cohort study of a large nationwide database of Chinese adults assesses the association between dietary niacin intake and the risk of new-onset hypertension.

JAMA Netw Open. 2021;4(1):e2031669. doi:10.1001/jamanetworkopen.2020.31669
Abstract Full Text pdf link PDF

HEALTH INFORMATICS

Assessment of a Clinical Trial–Derived Survival Model in Patients With Metastatic Castration-Resistant Prostate Cancer

This cohort study assesses the performance of a prognostic survival model derived from randomized clinical trial data when the model is applied to real-world data from the electronic health records of patients with metastatic castration-resistant prostate cancer.

JAMA Netw Open. 2021;4(1):e2031730. doi:10.1001/jamanetworkopen.2020.31730
Abstract Full Text pdf link PDF

PULMONARY MEDICINE

Association of Obstructive Sleep Apnea With the Risk of Male Infertility in Taiwan

This case-control study examines the demographic variables, comorbidities, exposure to obstructive sleep apnea, and obstructive sleep apnea therapies in adult men with or without an infertility diagnosis.

JAMA Netw Open. 2021;4(1):e2031846. doi:10.1001/jamanetworkopen.2020.31846
Abstract Full Text pdf link PDF

HEALTH INFORMATICS

Evaluation of Attention Switching and Duration of Electronic Inbox Work Among Primary Care Physicians

This cross-sectional study examines primary care physicians’ frequency of attention switching associated with electronic inbox work and identifies potentially modifiable factors associated with attention switching and inbox work duration.

JAMA Netw Open. 2021;4(1):e2031856. doi:10.1001/jamanetworkopen.2020.31856
Abstract Full Text pdf link PDF

SUBSTANCE USE AND ADDICTION

Assessment of Racial Differences in Pharmacotherapy Efficacy for Smoking Cessation: Secondary Analysis of the EAGLES Randomized Clinical Trial

This secondary analysis of the Evaluating Adverse Events in a Global Smoking Cessation Study (EAGLES) randomized clinical trial compares the pharmacotherapy efficacy of varenicline, bupropion, and nicotine replacement therapy in quitting smoking for Black vs White US smokers.

JAMA Netw Open. 2021;4(1):e2032053. doi:10.1001/jamanetworkopen.2020.32053
Abstract Full Text pdf link PDF

ENVIRONMENTAL HEALTH

Associations Between Simulated Future Changes in Climate, Air Quality, and Human Health

This modeling study uses 2 climate models and under 2 air pollutant emission scenarios to model the associations between future changes in climate, air quality, and human health.

JAMA Netw Open. 2021;4(1):e2032064. doi:10.1001/jamanetworkopen.2020.32064
Abstract Full Text pdf link PDF

ONCOLOGY

Evaluation of Aspirin Use With Cancer Incidence and Survival Among Older Adults in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

This cohort study investigates the association of aspirin use with risk of developing new cancers and site-specific cancer-associated survival in bladder, breast, esophageal, gastric, pancreatic, and uterine cancers.

JAMA Netw Open. 2021;4(1):e2032072. doi:10.1001/jamanetworkopen.2020.32072
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Comparison of All-Cause Mortality Rates and Inequities Between Black and White Populations Across the 30 Most Populous US Cities

This cross-sectional study examines city-level data from the 30 most populous US cities regarding all-cause mortality rates and racial inequities within cities and seeks to determine whether these measures changed during the past decade.

JAMA Netw Open. 2021;4(1):e2032086. doi:10.1001/jamanetworkopen.2020.32086
Abstract Full Text pdf link PDF

SURGERY

Derivation of Patient-Defined Adverse Cardiovascular and Noncardiovascular Events Through a Modified Delphi Process

This qualitative study attempts to derive patient-defined adverse cardiovascular and noncardiovascular events through a modified Delphi consensus-based process involving panel discussions with patients and their caregivers and clinicians.

JAMA Netw Open. 2021;4(1):e2032095. doi:10.1001/jamanetworkopen.2020.32095
Abstract Full Text pdf link PDF

HEALTH POLICY

Associations of Government-Mandated Closures and Restrictions With Aggregate Mobility Trends and SARS-CoV-2 Infections in Nigeria

This cross-sectional study uses data from smartphone users to examine the association of government-mandated closures and restrictions with aggregate mobility and the association of changes in mobility with confirmed SARS-CoV-2 infections in Nigeria.

has active quiz
JAMA Netw Open. 2021;4(1):e2032101. doi:10.1001/jamanetworkopen.2020.32101
Abstract Full Text pdf link PDF CME & MOC

PEDIATRICS

Parental Factors Associated With the Decision to Participate in a Neonatal Clinical Trial

This survey study compared parents who chose to participate in a neonatal clinical trial with those who declined, assessing differences in demographic characteristics, opinions on the severity of their child’s medical condition, and levels of trust in medical researchers.

JAMA Netw Open. 2021;4(1):e2032106. doi:10.1001/jamanetworkopen.2020.32106
Abstract Full Text pdf link PDF

HEALTH POLICY

Comparison of Access to Primary Care Medical and Dental Appointments Between Simulated Patients Who Were Deaf and Patients Who Could Hear

This cross-sectional study compares the rate at which patients who are deaf are offered primary care medical or dental appointments with the rate at which appointments are offered to patients who can hear.

JAMA Netw Open. 2021;4(1):e2032207. doi:10.1001/jamanetworkopen.2020.32207
Abstract Full Text pdf link PDF

OPHTHALMOLOGY

Characterization of Ebola Virus–Associated Eye Disease

This cross-sectional analysis of compares rates of ocular sequelae in antibody-positive survivors of Ebola virus disease and antibody-negative close contacts.

JAMA Netw Open. 2021;4(1):e2032216. doi:10.1001/jamanetworkopen.2020.32216
Abstract Full Text pdf link PDF

IMAGING

Brain Responses to Noxious Stimuli in Patients With Chronic Pain: A Systematic Review and Meta-analysis

This meta-analysis assesses differential brain responses to noxious stimuli in patients with chronic pain using functional magnetic resonance imaging while adhering to current best practices for neuroimaging meta-analyses.

JAMA Netw Open. 2021;4(1):e2032236. doi:10.1001/jamanetworkopen.2020.32236
Abstract Full Text pdf link PDF

IMAGING

Noninvasive Prediction of Occult Peritoneal Metastasis in Gastric Cancer Using Deep Learning

This cohort study assesses the use of a deep learning model for predicting occult peritoneal metastasis based on preoperative computed tomographic images in patients with gastric cancer.

JAMA Netw Open. 2021;4(1):e2032269. doi:10.1001/jamanetworkopen.2020.32269
Abstract Full Text pdf link PDF

ONCOLOGY

Association of Race, Socioeconomic Factors, and Treatment Characteristics With Overall Survival in Patients With Limited-Stage Small Cell Lung Cancer

This cohort study investigates the associations of race, socioeconomic factors, and treatment characteristics with overall survival (OS) among patients with limited-stage small cell lung cancer (SCLC).

JAMA Netw Open. 2021;4(1):e2032276. doi:10.1001/jamanetworkopen.2020.32276
Abstract Full Text pdf link PDF

EMERGENCY MEDICINE

Effect of Machine Learning on Dispatcher Recognition of Out-of-Hospital Cardiac Arrest During Calls to Emergency Medical Services: A Randomized Clinical Trial

This randomized clinical trial examines how a machine learning model trained to identify out-of-hospital cardiac arrest and alert dispatchers during emergency calls affected the recognition of and response to out-of-hospital cardiac arrests.

JAMA Netw Open. 2021;4(1):e2032320. doi:10.1001/jamanetworkopen.2020.32320
Abstract Full Text pdf link PDF

GASTROENTEROLOGY AND HEPATOLOGY

Association of Intensive Endoscopic Screening Burden With Gastric Cancer Detection

This cohort study compares the numbers of endoscopic examinations for gastric cancer screening over quarters of a calendar year with rates of gastric cancer diagnosed during those periods.

JAMA Netw Open. 2021;4(1):e2032542. doi:10.1001/jamanetworkopen.2020.32542
Abstract Full Text pdf link PDF

MEDICAL EDUCATION

Measurement of American Indian and Alaska Native Racial Identity Among Medical School Applicants, Matriculants, and Graduates, 1996-2017

This cohort study uses interrupted time series regression to assess the association between changes in race/ethnicity data collection in the American Medical College Application System survey and trends in applicants, matriculants, and graduates self-reporting as American Indian and Alaska Native.

JAMA Netw Open. 2021;4(1):e2032550. doi:10.1001/jamanetworkopen.2020.32550
Abstract Full Text pdf link PDF

HEALTH POLICY

Comparison of Utilization, Costs, and Quality of Medicaid vs Subsidized Private Health Insurance for Low-Income Adults

This cross-sectional study uses data from 3 state agencies merging comprehensive insurance claims with income eligibility data for Colorado Medicaid expansion and Marketplace enrollees to investigate health care utilization, cost, and quality between public and private health insurance for low-income adults.

JAMA Netw Open. 2021;4(1):e2032669. doi:10.1001/jamanetworkopen.2020.32669
Abstract Full Text pdf link PDF

SURGERY

Exploration of Individual and System-Level Well-being Initiatives at an Academic Surgical Residency Program: A Mixed-Methods Study

This mixed-methods study explores individual and workplace factors that are associated with surgical trainees’ well-being, differences by gender identity, and end-user perceptions of experience.

JAMA Netw Open. 2021;4(1):e2032676. doi:10.1001/jamanetworkopen.2020.32676
Abstract Full Text pdf link PDF

SURGERY

Outcomes After Elective Inguinal Hernia Repair Performed by Associate Clinicians vs Medical Doctors in Sierra Leone: A Randomized Clinical Trial

This randomized clinical trial examined outcomes of inguinal hernia surgery performed by associate clinicians vs nonspecialist medical doctors among men in Sierra Leone.

JAMA Netw Open. 2021;4(1):e2032681. doi:10.1001/jamanetworkopen.2020.32681
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Effect of Exposure to e-Cigarettes With Salt vs Free-Base Nicotine on the Appeal and Sensory Experience of Vaping: A Randomized Clinical Trial

This randomized clinical trial assessed whether controlled exposure to e-cigarette puffs with salt vs free-base nicotine formulations improved the appeal and sensory experience of vaping among adult current nicotine or tobacco product users.

JAMA Netw Open. 2021;4(1):e2032757. doi:10.1001/jamanetworkopen.2020.32757
Abstract Full Text pdf link PDF

PEDIATRICS

Association of Youth Age at Exposure to Household Dysfunction With Outcomes in Early Adulthood

This cohort study examines the association between age at exposure to household dysfunction during childhood and adolescence and outcomes in early adulthood.

JAMA Netw Open. 2021;4(1):e2032769. doi:10.1001/jamanetworkopen.2020.32769
Abstract Full Text pdf link PDF

PEDIATRICS

Mortality Among Young Adults Born Preterm and Early Term in 4 Nordic Nations

This cohort study examines the risk of all-cause and noncommunicable disease deaths among young adults born preterm and early term in 4 Nordic countries.

JAMA Netw Open. 2021;4(1):e2032779. doi:10.1001/jamanetworkopen.2020.32779
Abstract Full Text pdf link PDF

HEALTH POLICY

Assessment of Mortality Among Durable Left Ventricular Assist Device Recipients Ineligible for Clinical Trials

This cohort study estimates the proportion of recipients of durable left ventricular assist devices (LVADs) who are ineligible for clinical trial participation and assesses whether an association exists between ineligibility and mortality.

JAMA Netw Open. 2021;4(1):e2032865. doi:10.1001/jamanetworkopen.2020.32865
Abstract Full Text pdf link PDF

CARDIOLOGY

Association of Timing of Electrocardiogram Acquisition After Return of Spontaneous Circulation With Coronary Angiography Findings in Patients With Out-of-Hospital Cardiac Arrest

This cohort study evaluates the association between the time from the return of spontaneous circulation to electrocardiogram (ECG) acquisition and the diagnostic accuracy of ECG for ST-segment elevation myocardial infarction in patients who experience out-of-hospital cardiac arrest.

JAMA Netw Open. 2021;4(1):e2032875. doi:10.1001/jamanetworkopen.2020.32875
Abstract Full Text pdf link PDF

NEUROLOGY

Assessment of Advanced Glycation End Products and Receptors and the Risk of Dementia

This cohort study examines the association of advanced glycation end products and their receptor with dementia in the general Dutch population.

JAMA Netw Open. 2021;4(1):e2033012. doi:10.1001/jamanetworkopen.2020.33012
Abstract Full Text pdf link PDF

DIABETES AND ENDOCRINOLOGY

Evaluation of Patient Willingness to Adopt Remote Digital Monitoring for Diabetes Management

This survey study identifies the minimum effectiveness patients with type 1 and type 2 diabetes report they require to adopt 36 different remote digital diabetes monitoring scenarios.

JAMA Netw Open. 2021;4(1):e2033115. doi:10.1001/jamanetworkopen.2020.33115
Abstract Full Text pdf link PDF

EMERGENCY MEDICINE

Association of Helicopter vs Ground Emergency Medical Transportation With 1-Year Mortality in Denmark

This cohort study assesses whether emergency medical transportation by helicopter vs by ground is associated with differences in mortality among patients in Denmark.

JAMA Netw Open. 2021;4(1):e2033318. doi:10.1001/jamanetworkopen.2020.33318
Abstract Full Text pdf link PDF

HEALTH POLICY

Assessment of the Patient Protection and Affordable Care Act’s Increase in Fees for Primary Care and Access to Care for Dual-Eligible Beneficiaries

This cohort study evaluates whether the Affordable Care Act’s increase in Medicaid fees to Medicare levels for primary care practitioners was associated with increases in primary care visits for dual-eligible Medicare and Medicaid beneficiaries.

JAMA Netw Open. 2021;4(1):e2033424. doi:10.1001/jamanetworkopen.2020.33424
Abstract Full Text pdf link PDF

NUTRITION, OBESITY, AND EXERCISE

Evaluation of Nutritional Support and In-Hospital Mortality in Patients With Malnutrition

This cohort study examines the association of nutritional support with mortality rates among hospitalized patients with malnutrition in Switzerland.

JAMA Netw Open. 2021;4(1):e2033433. doi:10.1001/jamanetworkopen.2020.33433
Abstract Full Text pdf link PDF

ONCOLOGY

Evaluation of the Cost-effectiveness of Doublet Therapy in Metastatic BRAF Variant Colorectal Cancer

This economic evaluation uses Markov modeling to identify and compare the cost and utility of doublet and standard treatments for patients with BRAF V600E variant colorectal cancer.

JAMA Netw Open. 2021;4(1):e2033441. doi:10.1001/jamanetworkopen.2020.33441
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Longitudinal Associations of Mental Disorders With Physical Diseases and Mortality Among 2.3 Million New Zealand Citizens

This cohort study uses data from the New Zealand Integrated Data Infrastructure database to examine the association of mental disorders with subsequent physical diseases and mortality among the New Zealand population over a 30-year observation period.

JAMA Netw Open. 2021;4(1):e2033448. doi:10.1001/jamanetworkopen.2020.33448
Abstract Full Text pdf link PDF

NUTRITION, OBESITY, AND EXERCISE

Effect of Bimagrumab vs Placebo on Body Fat Mass Among Adults With Type 2 Diabetes and Obesity: A Phase 2 Randomized Clinical Trial

This randomized clinical trial evaluates the efficacy and safety of bimagrumab on body composition and glycemic control in adults with type 2 diabetes and overweight or obesity.

JAMA Netw Open. 2021;4(1):e2033457. doi:10.1001/jamanetworkopen.2020.33457
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Public Concern About Violence, Firearms, and the COVID-19 Pandemic in California

This survey study describes individuals’ concerns regarding violence in the context of the coronavirus disease 2019 (COVID-19) pandemic, experiences of pandemic-related unfair treatment, prevalence of and reasons for firearm acquisition, and changes in firearm storage practices due to the pandemic.

has active quiz
JAMA Netw Open. 2021;4(1):e2033484. doi:10.1001/jamanetworkopen.2020.33484
Abstract Full Text pdf link PDF CME & MOC

PSYCHIATRY

Assessment of Suicidal Behaviors Among Individuals With Autism Spectrum Disorder in Denmark

This cohort study uses national register data to analyze whether people with ASD have higher rates of suicide attempt and suicide compared with people without ASD, identify potential risk factors for suicide attempts and suicide among those with ASD, and examine associations with comorbid disorders.

JAMA Netw Open. 2021;4(1):e2033565. doi:10.1001/jamanetworkopen.2020.33565
Abstract Full Text pdf link PDF

INFECTIOUS DISEASES

Estimation of US SARS-CoV-2 Infections, Symptomatic Infections, Hospitalizations, and Deaths Using Seroprevalence Surveys

This cross-sectional study assesses the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease burden in the US, using surveillance data and seroprevalence surveys to estimate the number of SARS-CoV-2 infections, symptomatic infections, hospitalizations, and deaths through November 15, 2020.

has active quiz
JAMA Netw Open. 2021;4(1):e2033706. doi:10.1001/jamanetworkopen.2020.33706
Abstract Full Text pdf link PDF CME & MOC

PEDIATRICS

Racial and Ethnic Differences in Emergency Department Diagnostic Imaging at US Children’s Hospitals, 2016-2019

This cross-sectional study assesses the racial and ethnic differences in the performance of common emergency department imaging studies and examines patterns across diagnoses among US children’s hospitals.

JAMA Netw Open. 2021;4(1):e2033710. doi:10.1001/jamanetworkopen.2020.33710
Abstract Full Text pdf link PDF

STATISTICS AND RESEARCH METHODS

Cost-effectiveness of Pembrolizumab as a Second-Line Therapy for Hepatocellular Carcinoma

This economic evaluation analyzes the cost-effectiveness of pembrolizumab as a second-line treatment in patients with advanced hepatocellular carcinoma.

JAMA Netw Open. 2021;4(1):e2033761. doi:10.1001/jamanetworkopen.2020.33761
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Evaluation of Revised US Preventive Services Task Force Lung Cancer Screening Guideline Among Women and Racial/Ethnic Minority Populations

This cross-sectional study assesses the changes associated with the revised US Preventive Services Task Force guideline with lung cancer screening eligibility among female, Black, and Hispanic populations using a large nationwide survey.

JAMA Netw Open. 2021;4(1):e2033769. doi:10.1001/jamanetworkopen.2020.33769
Abstract Full Text pdf link PDF

ONCOLOGY

Cost-effectiveness of Prostate Radiation Therapy for Men With Newly Diagnosed Low-Burden Metastatic Prostate Cancer

This economic evaluation assesses the cost-effectiveness of the addition of prostate radiation therapy to androgen deprivation therapy for men with low-volume metastatic hormone-sensitive prostate cancer.

JAMA Netw Open. 2021;4(1):e2033787. doi:10.1001/jamanetworkopen.2020.33787
Abstract Full Text pdf link PDF

SURGERY

Temporal Trends in Incidence Rates of Lower Extremity Amputation and Associated Risk Factors Among Patients Using Veterans Health Administration Services From 2008 to 2018

This cohort study examines temporal trends and risk factors associated with lower extremity amputation among veterans using Veterans Health Administration services.

JAMA Netw Open. 2021;4(1):e2033953. doi:10.1001/jamanetworkopen.2020.33953
Abstract Full Text pdf link PDF

ONCOLOGY

Medical Oncology Professionals’ Perceptions of Telehealth Video Visits

This qualitative study surveyed physicians and other health professionals working in oncology to determine the perceived advantages and disadvantages of telehealth video visits in cancer care.

JAMA Netw Open. 2021;4(1):e2033967. doi:10.1001/jamanetworkopen.2020.33967
Abstract Full Text pdf link PDF

HEALTH POLICY

Evaluation of Data Sharing After Implementation of the International Committee of Medical Journal Editors Data Sharing Statement Requirement

This cross-sectional study evaluates the implementation of the International Committee of Medical Journal Editors (ICMJE) data sharing statement requirement in 3 leading medical journals.

JAMA Netw Open. 2021;4(1):e2033972. doi:10.1001/jamanetworkopen.2020.33972
Abstract Full Text pdf link PDF

GERIATRICS

Information Sharing Practices Between US Hospitals and Skilled Nursing Facilities to Support Care Transitions

This survey study evaluates the current state of the completeness, timeliness, and usability of information sharing, and identifies characteristics associated with better sharing, to support patient care transitions between hospitals and skilled nursing facilities.

JAMA Netw Open. 2021;4(1):e2033980. doi:10.1001/jamanetworkopen.2020.33980
Abstract Full Text pdf link PDF

NEPHROLOGY

Association of the Estimated Glomerular Filtration Rate With vs Without a Coefficient for Race With Time to Eligibility for Kidney Transplant

This cohort study assesses the association between estimated glomerular filtration rate (eGFR) calculated with vs without a coefficient for race and time to achievement of an eGFR less than 20 mL/min/1.73 m2.

JAMA Netw Open. 2021;4(1):e2034004. doi:10.1001/jamanetworkopen.2020.34004
Abstract Full Text pdf link PDF

ONCOLOGY

Accuracy of Magnetic Resonance Imaging–Guided Biopsy to Verify Breast Cancer Pathologic Complete Response After Neoadjuvant Chemotherapy: A Nonrandomized Controlled Trial

This nonrandomized controlled trial uses data from a single tertiary care center in the US to investigate the accuracy of magnetic resonance imaging (MRI)–guided biopsy compared with surgical resection for assessing pathologic complete response after neoadjuvant chemotherapy in patients with breast cancer.

JAMA Netw Open. 2021;4(1):e2034045. doi:10.1001/jamanetworkopen.2020.34045
Abstract Full Text pdf link PDF

GERIATRICS

A Method to Quantify Mean Hypertension Treatment Daily Dose Intensity Using Health Care System Data

This cross-sectional study develops and validates a method to more precisely quantify dose intensity of hypertension treatment using only health system administrative pharmacy fill data.

JAMA Netw Open. 2021;4(1):e2034059. doi:10.1001/jamanetworkopen.2020.34059
Abstract Full Text pdf link PDF

ONCOLOGY

Development of a Model to Estimate the Association Between Delay in Cancer Treatment and Local Tumor Control and Risk of Metastases

This decision analytical model presents a simplified mathematical model of tumor growth, control, and new metastases for cancers with varying doubling times and metastatic potential and estimates tumor control probability and metastases risk as a function of treatment delay interval.

has active quiz
JAMA Netw Open. 2021;4(1):e2034065. doi:10.1001/jamanetworkopen.2020.34065
Abstract Full Text pdf link PDF CME & MOC

NEPHROLOGY

Facility-Level Variation in Dialysis Use and Mortality Among Older Veterans With Incident Kidney Failure

This cohort study examines which patient and facility factors in the US Department of Veterans Affairs health care system are associated with dialysis approaches and outcomes.

JAMA Netw Open. 2021;4(1):e2034084. doi:10.1001/jamanetworkopen.2020.34084
Abstract Full Text pdf link PDF

MEDICAL EDUCATION

Association of Graduate Medical Education With Hospital Performance and Patient Outcomes

This economic evaluation examines graduate medical education funding, an annual subsidy awarded to academic hospitals, and whether it is associated with a hospital’s financial standing, clinical outcomes, or resident academic performance.

JAMA Netw Open. 2021;4(1):e2034196. doi:10.1001/jamanetworkopen.2020.34196
Abstract Full Text pdf link PDF

ONCOLOGY

Factors Modifying the Associations of Single or Combination Programmed Cell Death 1 and Programmed Cell Death Ligand 1 Inhibitor Therapies With Survival Outcomes in Patients With Metastatic Clear Cell Renal Cell Carcinoma: A Systematic Review and Meta-analysis

This systematic review and meta-analysis assesses trials that reported on factors associated with differential response to programmed cell death 1 and programmed cell death ligand 1 inhibitors among patients diagnosed with metastatic clear cell renal cell carcinoma and synthesizes the magnitude to which each factor was associated with the response to programmed cell death 1/programmed cell death ligand 1 inhibitors.

JAMA Netw Open. 2021;4(1):e2034201. doi:10.1001/jamanetworkopen.2020.34201
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Association of Intensive Care Unit Patient Load and Demand With Mortality Rates in US Department of Veterans Affairs Hospitals During the COVID-19 Pandemic

This cohort study examines the association of patient caseload and demand with mortality among patients with coronavirus disease 2019 (COVID-19) in US Veterans Affairs (VA) intensive care units.

has active quiz has audio
JAMA Netw Open. 2021;4(1):e2034266. doi:10.1001/jamanetworkopen.2020.34266
Abstract Full Text pdf link PDF CME & MOC

CARDIOLOGY

Genetics of Smoking and Risk of Atherosclerotic Cardiovascular Diseases: A Mendelian Randomization Study

This mendelian randomization study evaluates summary statistics from genome-wide associations involving more than 1 million individuals to assess whether there are differential associations between genetic liability to smoking and risk of coronary artery disease, peripheral artery disease, and large-artery stroke.

JAMA Netw Open. 2021;4(1):e2034461. doi:10.1001/jamanetworkopen.2020.34461
Abstract Full Text pdf link PDF

GASTROENTEROLOGY AND HEPATOLOGY

Effect of Text Messaging on Bowel Preparation and Appointment Attendance for Outpatient Colonoscopy: A Randomized Clinical Trial

This randomized clinical trial examines the effectiveness of information and reminders via automated text message vs usual care for coloscopy attendance and preparation.

JAMA Netw Open. 2021;4(1):e2034553. doi:10.1001/jamanetworkopen.2020.34553
Abstract Full Text pdf link PDF

OBSTETRICS AND GYNECOLOGY

Perceptions and Motivations for Uterus Transplant in Transgender Women

This survey study assesses perceptions of and motivations for uterus transplant among transgender women and explores their willingness to undergo the procedure.

JAMA Netw Open. 2021;4(1):e2034561. doi:10.1001/jamanetworkopen.2020.34561
Abstract Full Text pdf link PDF

CRITICAL CARE MEDICINE

Association of Serum Mannose With Acute Respiratory Distress Syndrome Risk and Survival

This cohort study systematically evaluates the association of blood metabolites with acute respiratory distress syndrome risk and survival.

JAMA Netw Open. 2021;4(1):e2034569. doi:10.1001/jamanetworkopen.2020.34569
Abstract Full Text pdf link PDF

HEALTH POLICY

Association of Social and Economic Inequality With Coronavirus Disease 2019 Incidence and Mortality Across US Counties

This cross-sectional ecological analysis quantifies the association of economic inequality, racial/ethnic composition, political factors, and state health care policy with the incidence and mortality burden associated with coronavirus disease 2019 (COVID-19) at the US county level.

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JAMA Netw Open. 2021;4(1):e2034578. doi:10.1001/jamanetworkopen.2020.34578
Abstract Full Text pdf link PDF CME & MOC

ONCOLOGY

Clinical Efficacy of Enzalutamide vs Bicalutamide Combined With Androgen Deprivation Therapy in Men With Metastatic Hormone-Sensitive Prostate Cancer: A Randomized Clinical Trial

This randomized clinical trial examines the efficacy of enzalutamide vs bicalutamide in combination with androgen deprivation therapy (ADT) in men with metastatic hormone-sensitive prostate cancer.

JAMA Netw Open. 2021;4(1):e2034633. doi:10.1001/jamanetworkopen.2020.34633
Abstract Full Text pdf link PDF

HEMATOLOGY

Evaluation of Ruxolitinib for Steroid-Refractory Chronic Graft-vs-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation

This case series investigates the clinical response to ruxolitinib in patients with steroid-refractory chronic graft-vs-host disease after allogeneic hematopoietic stem cell transplantation and evaluates its safety profile during the treatment course.

JAMA Netw Open. 2021;4(1):e2034750. doi:10.1001/jamanetworkopen.2020.34750
Abstract Full Text pdf link PDF

HEALTH POLICY

Physician, Practice, and Patient Characteristics Associated With Biosimilar Use in Medicare Recipients

This cross-sectional study examines patient, physician, and practice characteristics associated with biosimilar usage in the Medicare population.

JAMA Netw Open. 2021;4(1):e2034776. doi:10.1001/jamanetworkopen.2020.34776
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Association of Police Transport With Survival Among Patients With Penetrating Trauma in Philadelphia, Pennsylvania

This cohort study assesses mortality among patients with penetrating trauma who are transported to trauma centers by police vs emergency medical services in Philadelphia, Pennsylvania.

JAMA Netw Open. 2021;4(1):e2034868. doi:10.1001/jamanetworkopen.2020.34868
Abstract Full Text pdf link PDF

HEALTH POLICY

Reports of Forgone Medical Care Among US Adults During the Initial Phase of the COVID-19 Pandemic

This survey study examines the frequency of and reasons for reported forgone care among US adults during the COVID-19 pandemic.

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JAMA Netw Open. 2021;4(1):e2034882. doi:10.1001/jamanetworkopen.2020.34882
Abstract Full Text pdf link PDF CME & MOC

HEALTH POLICY

Allocation of National Institutes of Health Funding by Disease Category in 2008 and 2019

This cohort study examines the factors associated with National Institutes of Health funding in 2019 for 46 diseases.

JAMA Netw Open. 2021;4(1):e2034890. doi:10.1001/jamanetworkopen.2020.34890
Abstract Full Text pdf link PDF

GLOBAL HEALTH

Assessment of Knowledge of HIV/AIDS and Association With Socioeconomic Disparities Among Young Women in Low- and Middle-Income Countries, 2003 to 2018

This cross-sectional study provides an up-to-date assessment of the levels of and changes in knowledge of HIV/AIDs and its association with socioeconomic disparity among young women in low- and middle-income countries.

JAMA Netw Open. 2021;4(1):e2035000. doi:10.1001/jamanetworkopen.2020.35000
Abstract Full Text pdf link PDF

HEALTH INFORMATICS

Molecular Diversity of Clinically Stable Human Kidney Allografts

This prognostic study uses microarray gene expression data from the National Center for Biotechnology Information Gene Expression Omnibus to assess whether immunologic heterogeneity can be identified in histologically stable kidney allografts.

JAMA Netw Open. 2021;4(1):e2035048. doi:10.1001/jamanetworkopen.2020.35048
Abstract Full Text pdf link PDF

INFECTIOUS DISEASES

SARS-CoV-2 Transmission From People Without COVID-19 Symptoms

This decision analytical model assesses the proportion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmissions in the community that likely occur from persons without symptoms.

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JAMA Netw Open. 2021;4(1):e2035057. doi:10.1001/jamanetworkopen.2020.35057
Abstract Full Text pdf link PDF CME & MOC

PUBLIC HEALTH

Evaluation of Seasonal Respiratory Virus Activity Before and After the Statewide COVID-19 Shelter-in-Place Order in Northern California

This cohort study analyzes the implications of pandemic-related stay-at-home restrictions for the positivity rates of influenza and other seasonal respiratory viruses in Northern California.

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JAMA Netw Open. 2021;4(1):e2035281. doi:10.1001/jamanetworkopen.2020.35281
Abstract Full Text pdf link PDF CME & MOC

CARDIOLOGY

Use and Outcomes of Dual Chamber or Cardiac Resynchronization Therapy Defibrillators Among Older Patients Requiring Ventricular Pacing in the National Cardiovascular Data Registry Implantable Cardioverter Defibrillator Registry

This cohort study assesses outcomes, variability in use of device type, and trends in use of device type over time among patients undergoing implantable cardioverter defibrillator implantation.

JAMA Netw Open. 2021;4(1):e2035470. doi:10.1001/jamanetworkopen.2020.35470
Abstract Full Text pdf link PDF

ONCOLOGY

Assessment of RAS Dependency for BRAF Alterations Using Cancer Genomic Databases

This cross-sectional study assesses existing BRAF alteration classifications and the spectrum of coexisting alterations of RAS pathway genes and cancer types in which they occur using nonredundant cancer samples from cancer genomics databases.

JAMA Netw Open. 2021;4(1):e2035479. doi:10.1001/jamanetworkopen.2020.35479
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Prevalence and Risk Factors Associated With Self-reported Psychological Distress Among Children and Adolescents During the COVID-19 Pandemic in China

This cross-sectional study examines risk factors and prevalence of self-reported psychological distress among school-aged children and adolescents in China during the COVID-19 pandemic.

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JAMA Netw Open. 2021;4(1):e2035487. doi:10.1001/jamanetworkopen.2020.35487
Abstract Full Text pdf link PDF CME & MOC

PUBLIC HEALTH

Outcomes of COVID-19 Among Hospitalized Health Care Workers in North America

This propensity score–matched multicenter cohort study assesses the association between health care worker status and outcomes among hospitalized patients with coronavirus disease 2019 (COVID-19) in North America.

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JAMA Netw Open. 2021;4(1):e2035699. doi:10.1001/jamanetworkopen.2020.35699
Abstract Full Text pdf link PDF CME & MOC

CARDIOLOGY

Development of Electronic Health Record–Based Prediction Models for 30-Day Readmission Risk Among Patients Hospitalized for Acute Myocardial Infarction

This cohort study compares multiple externally validated machine learning models using electronic health record data to predict 30-day readmission among patients hospitalized for acute myocardial infarction.

JAMA Netw Open. 2021;4(1):e2035782. doi:10.1001/jamanetworkopen.2020.35782
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Association Between Receipt of Unemployment Insurance and Food Insecurity Among People Who Lost Employment During the COVID-19 Pandemic in the United States

This cohort study evaluates the association between receipt of unemployment insurance, including a $600/wk federal supplement between April and July, and food insecurity among US residents who lost their jobs during the coronavirus disease 2019 (COVID-19) pandemic.

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JAMA Netw Open. 2021;4(1):e2035884. doi:10.1001/jamanetworkopen.2020.35884
Abstract Full Text pdf link PDF CME & MOC

INFECTIOUS DISEASES

Respiratory and Psychophysical Sequelae Among Patients With COVID-19 Four Months After Hospital Discharge

This cohort study examines prevalence and risk factors associated with lung function or physical impairment or posttraumatic stress symptoms among survivors of severe coronavirus disease 2019 (COVID-19).

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JAMA Netw Open. 2021;4(1):e2036142. doi:10.1001/jamanetworkopen.2020.36142
Abstract Full Text pdf link PDF CME & MOC

PUBLIC HEALTH

Association of Social and Demographic Factors With COVID-19 Incidence and Death Rates in the US

This cross-sectional study examines the county-level associations of sociodemographic risk factors with coronavirus disease 2019 incidence and mortality in the US.

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JAMA Netw Open. 2021;4(1):e2036462. doi:10.1001/jamanetworkopen.2020.36462
Abstract Full Text pdf link PDF CME & MOC
open access Editorial

Reporting Clinical Studies Affected by the COVID-19 Pandemic: Guidelines for Authors

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JAMA Netw Open. 2021;4(1):e2036155. doi:10.1001/jamanetworkopen.2020.36155
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open access Invited Commentary

MEDICAL EDUCATION

Dismantling Structural Discrimination in Cardiology Fellowship Recruitment

JAMA Netw Open. 2021;4(1):e2031473. doi:10.1001/jamanetworkopen.2020.31473
Abstract Full Text pdf link PDF

Rethinking How to Persuade More Parents From Diverse or Disadvantaged Backgrounds to Enroll Infants in Neonatal Clinical Trials

JAMA Netw Open. 2021;4(1):e2032137. doi:10.1001/jamanetworkopen.2020.32137
Abstract Full Text pdf link PDF

NEUROLOGY

Cognitive Trajectories and Resilience in Centenarians—Findings From the 100-Plus Study

JAMA Netw Open. 2021;4(1):e2032538. doi:10.1001/jamanetworkopen.2020.32538
Abstract Full Text pdf link PDF

HEALTH INFORMATICS

Building Predictive Models for Clinical Care—Where to Build and What to Predict?

JAMA Netw Open. 2021;4(1):e2032539. doi:10.1001/jamanetworkopen.2020.32539
Abstract Full Text pdf link PDF

PEDIATRICS

Critical Periods in Child Development and the Transition to Adulthood

JAMA Netw Open. 2021;4(1):e2033359. doi:10.1001/jamanetworkopen.2020.33359
Abstract Full Text pdf link PDF

CARDIOLOGY

Delaying Electrocardiography in Cardiac Arrest: A Pause for the Cause

JAMA Netw Open. 2021;4(1):e2033360. doi:10.1001/jamanetworkopen.2020.33360
Abstract Full Text pdf link PDF

PEDIATRICS

Adult Mortality After Preterm Birth—Time to Translate Findings Into Clinical Practice

JAMA Netw Open. 2021;4(1):e2033361. doi:10.1001/jamanetworkopen.2020.33361
Abstract Full Text pdf link PDF

EMERGENCY MEDICINE

Patient Outcomes From Ground vs Helicopter Emergency Medical Services: The Challenges of an Accurate Comparison

JAMA Netw Open. 2021;4(1):e2033362. doi:10.1001/jamanetworkopen.2020.33362
Abstract Full Text pdf link PDF

NUTRITION, OBESITY, AND EXERCISE

Nutritional Support Should Target the Cause of Malnutrition in Hospitalized Patients

JAMA Netw Open. 2021;4(1):e2033925. doi:10.1001/jamanetworkopen.2020.33925
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PUBLIC HEALTH

Intersection of Surging Firearm Sales and COVID-19, Psychological Distress, and Health Disparities in the US—A Call for Action

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JAMA Netw Open. 2021;4(1):e2034017. doi:10.1001/jamanetworkopen.2020.34017
Abstract Full Text pdf link PDF CME & MOC

PSYCHIATRY

Death by Suicide Among People With Autism: Beyond Zebrafish

JAMA Netw Open. 2021;4(1):e2034018. doi:10.1001/jamanetworkopen.2020.34018
Abstract Full Text pdf link PDF

PEDIATRICS

Racial Inequities in Pediatric Emergency Care

JAMA Netw Open. 2021;4(1):e2034019. doi:10.1001/jamanetworkopen.2020.34019
Abstract Full Text pdf link PDF

STATISTICS AND RESEARCH METHODS

Challenges in Assessing the Cost-effectiveness of Cancer Immunotherapy

JAMA Netw Open. 2021;4(1):e2034020. doi:10.1001/jamanetworkopen.2020.34020
Abstract Full Text pdf link PDF

NEPHROLOGY

Systemic Kidney Transplant Inequities for Black Individuals: Examining the Contribution of Racialized Kidney Function Estimating Equations

JAMA Netw Open. 2021;4(1):e2034630. doi:10.1001/jamanetworkopen.2020.34630
Abstract Full Text pdf link PDF

ONCOLOGY

Successful Recruitment of Black Men to Prostate Cancer Clinical Trials—A Lesson in Achievement

JAMA Netw Open. 2021;4(1):e2034652. doi:10.1001/jamanetworkopen.2020.34652
Abstract Full Text pdf link PDF

ENVIRONMENTAL HEALTH

How Can We Solve Our Air Quality Problem in the Face of Climate Change?

JAMA Netw Open. 2021;4(1):e2035010. doi:10.1001/jamanetworkopen.2020.35010
Abstract Full Text pdf link PDF

GERIATRICS

Bridging the Hospital-Skilled Nursing Facility Information Continuity Divide

JAMA Netw Open. 2021;4(1):e2035040. doi:10.1001/jamanetworkopen.2020.35040
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Intensive Care Unit Strain and Mortality Risk Among Critically Ill Patients With COVID-19—There Is No “Me” in COVID

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JAMA Netw Open. 2021;4(1):e2035041. doi:10.1001/jamanetworkopen.2020.35041
Abstract Full Text pdf link PDF CME & MOC

HEALTH POLICY

Trials and Tribulations—11 Reasons Why We Need to Promote Clinical Trials Data Sharing

JAMA Netw Open. 2021;4(1):e2035043. doi:10.1001/jamanetworkopen.2020.35043
Abstract Full Text pdf link PDF

ONCOLOGY

In Search of Clinical Biomarkers of Response to Checkpoint Inhibitor Therapy in Renal Cell Carcinoma

JAMA Netw Open. 2021;4(1):e2035120. doi:10.1001/jamanetworkopen.2020.35120
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Police Transport for Penetrating Trauma—Lessons From Patients in Philadelphia

JAMA Netw Open. 2021;4(1):e2035122. doi:10.1001/jamanetworkopen.2020.35122
Abstract Full Text pdf link PDF

PHARMACY AND CLINICAL PHARMACOLOGY

Ranitidine’s N-nitrosodimethylamine Problem May be Tip of the Iceberg

JAMA Netw Open. 2021;4(1):e2035158. doi:10.1001/jamanetworkopen.2020.35158
Abstract Full Text pdf link PDF

HEMATOLOGY

Ruxolitinib for the Treatment of Steroid-Refractory Chronic Graft-vs-Host Disease—Another Hopeful Step Forward

JAMA Netw Open. 2021;4(1):e2035719. doi:10.1001/jamanetworkopen.2020.35719
Abstract Full Text pdf link PDF

GASTROENTEROLOGY AND HEPATOLOGY

Texting to Improve Colonoscopy Preparation and Adherence Needs More Study

JAMA Netw Open. 2021;4(1):e2035720. doi:10.1001/jamanetworkopen.2020.35720
Abstract Full Text pdf link PDF

PUBLIC HEALTH

The COVID-19 Economy, Unemployment Insurance, and Population Health

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JAMA Netw Open. 2021;4(1):e2035955. doi:10.1001/jamanetworkopen.2020.35955
Abstract Full Text pdf link PDF CME & MOC
open access Research Letter

ONCOLOGY

Association of Pertuzumab, Trastuzumab, and Docetaxel Combination Therapy With Overall Survival in Patients With Metastatic Breast Cancer

This cohort study compares the findings of combined pertuzumab, trastuzumab, and docetaxel therapy in women with metastatic breast cancer with those in the CLEOPATRA trial.

JAMA Netw Open. 2021;4(1):e2027764. doi:10.1001/jamanetworkopen.2020.27764
Abstract Full Text pdf link PDF

GENETICS AND GENOMICS

Assessment of rAAVrh.74.MHCK7.micro-dystrophin Gene Therapy Using Magnetic Resonance Imaging in Children With Duchenne Muscular Dystrophy

This case-control study uses magnetic resonance imaging and spectroscopy to evaluate the association between treatment with recombinant adeno-associated virus serotype rh74 (rAAVrh74) and muscle quality in children with Duchenne muscular dystrophy.

JAMA Netw Open. 2021;4(1):e2031851. doi:10.1001/jamanetworkopen.2020.31851
Abstract Full Text pdf link PDF

EMERGENCY MEDICINE

Comparison of Out-of-Hospital Cardiac Arrests and Fatalities in the Metro Detroit Area During the COVID-19 Pandemic With Previous-Year Events

This cross-sectional study compares trends in out-of-hospital cardiac arrests and fatalities in the Detroit area during the COVID-19 pandemic with year-earlier events for the same period.

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JAMA Netw Open. 2021;4(1):e2032331. doi:10.1001/jamanetworkopen.2020.32331
Abstract Full Text pdf link PDF CME & MOC

PEDIATRICS

Assessment of Duplicate Evidence in Systematic Reviews of Imaging Findings of Children With COVID-19

This cross-sectional study maps a coronavirus research question to illustrate the overlap and shortcomings of the evidence syntheses in this area.

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JAMA Netw Open. 2021;4(1):e2032690. doi:10.1001/jamanetworkopen.2020.32690
Abstract Full Text pdf link PDF CME & MOC

HEALTH POLICY

Using Lorenz Curves to Measure Racial Inequities in COVID-19 Testing

This cross-sectional study uses Lorenz curves as a metric for quantifying racial inequities in coronavirus disease 2019 (COVID-19) testing.

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JAMA Netw Open. 2021;4(1):e2032696. doi:10.1001/jamanetworkopen.2020.32696
Abstract Full Text pdf link PDF CME & MOC

PUBLIC HEALTH

Evaluation of Internet-Based Crowdsourced Fundraising to Cover Health Care Costs in the United States

This serial cross-sectional study examines online crowdsourced fundraising for US health care costs from 2010 to 2018 and evaluates whether there are trends by medical condition and geographic distribution.

JAMA Netw Open. 2021;4(1):e2033157. doi:10.1001/jamanetworkopen.2020.33157
Abstract Full Text pdf link PDF

MEDICAL EDUCATION

Assessment of Skin Phenotype Representation in a Popular Medical Licensing Educational Resource

This cross-sectional study examines the representation of darker skin phenotypes in tools used by students in preparation for medical licensure testing.

JAMA Netw Open. 2021;4(1):e2033164. doi:10.1001/jamanetworkopen.2020.33164
Abstract Full Text pdf link PDF

ANESTHESIOLOGY

Association of Automated Text Messaging With Patient Response Rate After Same-Day Surgery

This quality improvement study assesses the association of automated text messaging follow-up with the patient response rate after same-day surgery.

JAMA Netw Open. 2021;4(1):e2033312. doi:10.1001/jamanetworkopen.2020.33312
Abstract Full Text pdf link PDF

MEDICAL EDUCATION

Assessment of Interruptive Behavior at Residency Teaching Conferences by Gender

This cohort study examines interruptions by residents and faculty discussants during residency teaching conferences by gender.

JAMA Netw Open. 2021;4(1):e2033469. doi:10.1001/jamanetworkopen.2020.33469
Abstract Full Text pdf link PDF

CARDIOLOGY

Referral Rates for Cardiac Rehabilitation Among Eligible Inpatients After Implementation of a Default Opt-Out Decision Pathway in the Electronic Medical Record

This quality improvement study assesses referral rates for cardiac rehabilitation after a default opt-out option is added to the decision pathway in the electronic medical record.

JAMA Netw Open. 2021;4(1):e2033472. doi:10.1001/jamanetworkopen.2020.33472
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Public Mobility and Social Media Attention in Response to COVID-19 in Sweden and Denmark

This ecological study evaluates the public mobility and social media attention associated with COVID-19 spread and societal interventions from February 15 to June 14, 2020, in Denmark and Sweden.

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JAMA Netw Open. 2021;4(1):e2033478. doi:10.1001/jamanetworkopen.2020.33478
Abstract Full Text pdf link PDF CME & MOC

PUBLIC HEALTH

Exposure to Common Geographic COVID-19 Prevalence Maps and Public Knowledge, Risk Perceptions, and Behavioral Intentions

This survey study examines knowledge, risk perceptions, and behavioral intentions among survey respondents exposed to different types of COVID-19 prevalence maps.

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JAMA Netw Open. 2021;4(1):e2033538. doi:10.1001/jamanetworkopen.2020.33538
Abstract Full Text pdf link PDF CME & MOC

MEDICAL EDUCATION

Demographic Factors and Academic Outcomes Associated With Taking a Leave of Absence From Medical School

This cross-sectional study uses 2007-2012 data from the Association of American Medical Colleges’ Matriculating Student Questionnaire to evaluate student factors and academic outcomes associated with taking a leave of absence from medical school.

JAMA Netw Open. 2021;4(1):e2033570. doi:10.1001/jamanetworkopen.2020.33570
Abstract Full Text pdf link PDF

HEALTH POLICY

Association of Out-of-Pocket Spending With Insulin Adherence in Medicare Part D

This cross-sectional study examines whether efforts to limit out-of-pocket spending for enrollees in nonsubsidized Medicare Part D plans are associated with insulin adherence rates among these patients.

JAMA Netw Open. 2021;4(1):e2033988. doi:10.1001/jamanetworkopen.2020.33988
Abstract Full Text pdf link PDF

STATISTICS AND RESEARCH METHODS

Physician Density by Specialty Type in Urban and Rural Counties in the US, 2010 to 2017

This cross-sectional study uses data from the American Medical Association Physician Masterfile to examine physician density by specialty type across metropolitan and rural US counties from 2010 to 2017.

JAMA Netw Open. 2021;4(1):e2033994. doi:10.1001/jamanetworkopen.2020.33994
Abstract Full Text pdf link PDF

INFECTIOUS DISEASES

Factors Associated With US Public Motivation to Use and Distribute COVID-19 Self-tests

This survey study examines factors associated with motivation to use and distribute self-tests for COVID-19 infection among US adults.

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JAMA Netw Open. 2021;4(1):e2034001. doi:10.1001/jamanetworkopen.2020.34001
Abstract Full Text pdf link PDF CME & MOC

PUBLIC HEALTH

Suicide-Related Internet Searches During the Early Stages of the COVID-19 Pandemic in the US

This cross-sectional study assesses trends in suicide-related internet search rates in the early stages of the COVID-19 pandemic in the US.

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JAMA Netw Open. 2021;4(1):e2034261. doi:10.1001/jamanetworkopen.2020.34261
Abstract Full Text pdf link PDF CME & MOC

PUBLIC HEALTH

Suicide Deaths During the COVID-19 Stay-at-Home Advisory in Massachusetts, March to May 2020

This cohort study evaluates the association between the coronavirus disease 2019 (COVID-19) stay-at-home orders and suicide deaths in Massachusetts.

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JAMA Netw Open. 2021;4(1):e2034273. doi:10.1001/jamanetworkopen.2020.34273
Abstract Full Text pdf link PDF CME & MOC

GASTROENTEROLOGY AND HEPATOLOGY

Prevalence of Appropriate Testing for Incident Anemia in the US Department of Veterans Affairs

This cohort study assesses the prevalence of appropriate testing for incident anemia in a large cohort from a national integrated health care system.

JAMA Netw Open. 2021;4(1):e2034406. doi:10.1001/jamanetworkopen.2020.34406
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Epidemiology of Coronavirus Disease 2019 in US Immigration and Customs Enforcement Detention Facilities

This cohort study describes the burden of coronavirus disease 2019 among people detained by US Immigration and Customs Enforcement compared with the US population.

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JAMA Netw Open. 2021;4(1):e2034409. doi:10.1001/jamanetworkopen.2020.34409
Abstract Full Text pdf link PDF CME & MOC

OBSTETRICS AND GYNECOLOGY

Insurance Coverage and Perinatal Health Care Use Among Low-Income Women in the US, 2015-2017

This cross-sectional study uses 2015-2017 data from the Pregnancy Risk Surveillance and Monitoring System to examine the association between health insurance coverage and use of perinatal health care among low-income women in the US.

JAMA Netw Open. 2021;4(1):e2034549. doi:10.1001/jamanetworkopen.2020.34549
Abstract Full Text pdf link PDF

GERIATRICS

Utility of Restricted Mean Survival Time for Analyzing Time to Nursing Home Placement Among Patients With Dementia

This cohort study assesses the utility of restricted mean survival time as a method for quantifying time to nursing home placement among patients with dementia.

JAMA Netw Open. 2021;4(1):e2034745. doi:10.1001/jamanetworkopen.2020.34745
Abstract Full Text pdf link PDF

PHARMACY AND CLINICAL PHARMACOLOGY

Analysis of Ranitidine-Associated N-Nitrosodimethylamine Production Under Simulated Physiologic Conditions

This study characterizes conditions of N-nitrosodimethylamine production under simulated physiologic gastric states.

JAMA Netw Open. 2021;4(1):e2034766. doi:10.1001/jamanetworkopen.2020.34766
Abstract Full Text pdf link PDF

SUBSTANCE USE AND ADDICTION

Racial/Ethnic Disparities in Unintentional Fatal and Nonfatal Emergency Medical Services–Attended Opioid Overdoses During the COVID-19 Pandemic in Philadelphia

This cross-sectional study describes the differential associations of the coronavirus disease 2019 (COVID-19) pandemic with opioid-related overdoses among racial/ethnic groups in Philadelphia, Pennsylvania.

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JAMA Netw Open. 2021;4(1):e2034878. doi:10.1001/jamanetworkopen.2020.34878
Abstract Full Text pdf link PDF CME & MOC

HEALTH POLICY

Trends in Within-Class Changes in US Average Wholesale Prices for Brand-Name Medications for Common Conditions From 2015 to 2020

This cross-sectional study examines within-class changes in US wholesale drug prices for brand-name medications from 2015 to 2020.

JAMA Netw Open. 2021;4(1):e2035064. doi:10.1001/jamanetworkopen.2020.35064
Abstract Full Text pdf link PDF

EMERGENCY MEDICINE

Association of Race/Ethnicity and Other Demographic Characteristics With Use of Physical Restraints in the Emergency Department

This cross-sectional study assesses the association of race/ethnicity and other demographic factors with risk of receiving physical restraint during an emergency department (ED) visit.

JAMA Netw Open. 2021;4(1):e2035241. doi:10.1001/jamanetworkopen.2020.35241
Abstract Full Text pdf link PDF

DIABETES AND ENDOCRINOLOGY

Trends in Pain Medication Initiation Among Patients With Newly Diagnosed Diabetic Peripheral Neuropathy, 2014-2018

This cohort study assesses trends in the rates of initiation of pain medication among patients with newly diagnosed diabetic peripheral neuropathy and the types of pain medication prescribed from 2014 to 2018.

JAMA Netw Open. 2021;4(1):e2035632. doi:10.1001/jamanetworkopen.2020.35632
Abstract Full Text pdf link PDF

NEPHROLOGY

Prevalence of Chronic Kidney Disease Among Black Individuals in the US After Removal of the Black Race Coefficient From a Glomerular Filtration Rate Estimating Equation

This cross-sectional study examines whether removal of the Black race coefficient from a glomerular filtration rate (GFR) estimating equation is associated with a change in the estimated prevalence of chronic kidney disease (CKD) in the general Black population and among Black veterans in the US.

JAMA Netw Open. 2021;4(1):e2035636. doi:10.1001/jamanetworkopen.2020.35636
Abstract Full Text pdf link PDF

ENVIRONMENTAL HEALTH

Estimation of the Carbon Footprint Associated With Attendees of the American Psychiatric Association Annual Meeting

This cross-sectional study uses data from the 2018 and 2019 American Psychiatric Association (APA) annual meetings to assess the carbon dioxide equivalent emissions associated with the conferences and how they may be reduced.

JAMA Netw Open. 2021;4(1):e2035641. doi:10.1001/jamanetworkopen.2020.35641
Abstract Full Text pdf link PDF

Trends in Oncology Clinical Trials Launched Before and During the COVID-19 Pandemic

This cohort study evaluates the association of the coronavirus disease 2019 (COVID-19) pandemic with clinical research and development for cancer by studying the initiation of oncology clinical trials over time.

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JAMA Netw Open. 2021;4(1):e2036353. doi:10.1001/jamanetworkopen.2020.36353
Abstract Full Text pdf link PDF CME & MOC
open access Correction

Errors in Figure 2

JAMA Netw Open. 2021;4(1):e2034976. doi:10.1001/jamanetworkopen.2020.34976
Abstract Full Text pdf link PDF

Clarification of Role of Funder Statement

JAMA Netw Open. 2021;4(1):e2035088. doi:10.1001/jamanetworkopen.2020.35088
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Error in References Section

JAMA Netw Open. 2021;4(1):e2036103. doi:10.1001/jamanetworkopen.2020.36103
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Error in Results Section

JAMA Netw Open. 2021;4(1):e2036665. doi:10.1001/jamanetworkopen.2020.36665
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Errors in Citations, Data Reporting, and the Supplement

JAMA Netw Open. 2021;4(1):e2037105. doi:10.1001/jamanetworkopen.2020.37105
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Errors in Introduction, Results Section, and Table and Omitted Caption for Figure

JAMA Netw Open. 2021;4(1):e2037142. doi:10.1001/jamanetworkopen.2020.37142
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JAMA Netw Open. 2021;4(1):e2037247. doi:10.1001/jamanetworkopen.2020.37247
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JAMA Netw Open. 2021;4(1):e2037904. doi:10.1001/jamanetworkopen.2020.37904
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open access JAMA Network Open Masthead

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JAMA Netw Open. 2021;4(1):e2035535. doi:10.1001/jamanetworkopen.2020.35535
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