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May 2022 - May 2018

Decade

Year

Issue

May 2021, Vol 4, No. 5

open access Original Investigation

INFECTIOUS DISEASES

Estimation of Transmission of COVID-19 in Simulated Nursing Homes With Frequent Testing and Immunity-Based Staffing

This decision analytical modeling study examines the associations of cohorting, staffing, and testing interventions with COVID-19 transmission in nursing homes.

has active quiz
JAMA Netw Open. 2021;4(5):e2110071. doi:10.1001/jamanetworkopen.2021.10071
Abstract Full Text pdf link PDF CME & MOC

PEDIATRICS

Evaluation of the 2020 Pediatric Emergency Physician Workforce in the US

This cross-sectional study reviews the self-reported demographic characteristics, geographic distribution, as well as board certification and training of US-based clinically active physicians who provide emergency care to children and adolescents.

JAMA Netw Open. 2021;4(5):e2110084. doi:10.1001/jamanetworkopen.2021.10084
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Assessment of a Crowdsourcing Open Call for Approaches to University Community Engagement and Strategic Planning During COVID-19

This qualitative study evaluates a crowdsourcing open call as an approach to university community engagement and strategic planning to ensure safety during the COVID-19 pandemic.

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JAMA Netw Open. 2021;4(5):e2110090. doi:10.1001/jamanetworkopen.2021.10090
Abstract Full Text pdf link PDF CME & MOC

PSYCHIATRY

Association Between Bipolar Disorder or Schizophrenia and Oral Anticoagulation Use in Danish Adults With Incident or Prevalent Atrial Fibrillation

This cohort study examines the use of oral anticoagulation therapy in patients with bipolar disorder or schizophrenia who develop atrial fibrillation.

JAMA Netw Open. 2021;4(5):e2110096. doi:10.1001/jamanetworkopen.2021.10096
Abstract Full Text pdf link PDF

DIABETES AND ENDOCRINOLOGY

Effect of Behaviorally Designed Gamification With Social Incentives on Lifestyle Modification Among Adults With Uncontrolled Diabetes: A Randomized Clinical Trial

This randomized clinical trial examines the effectiveness of behaviorally designed gamification to promote lifestyle change among adults with uncontrolled type 2 diabetes.

JAMA Netw Open. 2021;4(5):e2110255. doi:10.1001/jamanetworkopen.2021.10255
Abstract Full Text pdf link PDF

NEUROLOGY

Characteristics and Outcomes Among US Patients Hospitalized for Ischemic Stroke Before vs During the COVID-19 Pandemic

This cohort study uses data from the Vizient Clinical Data Base to examine hospital discharge rates and outcomes of hospitalizations as well as demographic factors among US patients with ischemic stroke before and during the COVID-19 pandemic.

has active quiz
JAMA Netw Open. 2021;4(5):e2110314. doi:10.1001/jamanetworkopen.2021.10314
Abstract Full Text pdf link PDF CME & MOC

NEUROLOGY

Association of Socioeconomic Status With Dementia Diagnosis Among Older Adults in Denmark

This cross-sectional study describes the development of dementia and the level of cognitive decline among individuals with varying socioeconomic backgrounds who underwent a diagnostic evaluation for dementia.

JAMA Netw Open. 2021;4(5):e2110432. doi:10.1001/jamanetworkopen.2021.10432
Abstract Full Text pdf link PDF

ONCOLOGY

Evaluation of Oncology Trial Results Reporting Over a 10-Year Period

This cohort study examines the rate of results reporting among interventional cancer trials registered on ClinicalTrials.gov from 2007 to 2017.

JAMA Netw Open. 2021;4(5):e2110438. doi:10.1001/jamanetworkopen.2021.10438
Abstract Full Text pdf link PDF

PHARMACY AND CLINICAL PHARMACOLOGY

Assessment of the Implementation of Pharmacogenomic Testing in a Pediatric Tertiary Care Setting

This cohort study assesses the implementation outcomes of a pharmacogenomic testing program comprising a point-of-care model evaluating targeted drugs and a preemptive model using whole-genome sequencing to evaluate potential drug therapies among children in a pediatric tertiary care setting.

JAMA Netw Open. 2021;4(5):e2110446. doi:10.1001/jamanetworkopen.2021.10446
Abstract Full Text pdf link PDF

HEALTH POLICY

Patient Participation in Clinical Trials of Oncology Drugs and Biologics Preceding Approval by the US Food and Drug Administration

This cohort study estimates the volume of patients required to achieve a first US Food and Drug Administration (FDA) approval for a new anticancer drug or biologic therapy.

JAMA Netw Open. 2021;4(5):e2110456. doi:10.1001/jamanetworkopen.2021.10456
Abstract Full Text pdf link PDF

GASTROENTEROLOGY AND HEPATOLOGY

Comparative Effectiveness of Machine Learning Approaches for Predicting Gastrointestinal Bleeds in Patients Receiving Antithrombotic Treatment

This cross-sectional study compares 3 machine learning algorithms with the most widely used existing model to assess which best predicts the risk of gastrointestinal (GI) bleeding in adult patients receiving antithrombotic treatment.

JAMA Netw Open. 2021;4(5):e2110703. doi:10.1001/jamanetworkopen.2021.10703
Abstract Full Text pdf link PDF

IMAGING

Association of Lumbar Spine Radiographic Changes With Severity of Back Pain–Related Disability Among Middle-aged, Community-Dwelling Women

This cohort study uses data from the Chingford 1000 Women Study to examine both cross-sectional and longitudinal associations between lumbar spine radiographic changes and the severity of back pain–related disability among middle-aged, community-dwelling women.

JAMA Netw Open. 2021;4(5):e2110715. doi:10.1001/jamanetworkopen.2021.10715
Abstract Full Text pdf link PDF

SUBSTANCE USE AND ADDICTION

Comparison of Methods for Alcohol and Drug Screening in Primary Care Clinics

This quality improvement study compares commonly used screening methods for alcohol and drug use among adult patients at primary care clinics to examine their association with implementation outcomes and to evaluate the best approach for implementing electronic health record–integrated screening.

JAMA Netw Open. 2021;4(5):e2110721. doi:10.1001/jamanetworkopen.2021.10721
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Consumer Views on Using Digital Data for COVID-19 Control in the United States

This cross-sectional survey study assesses use of consumer digital information for COVID-19 control that US adults consider to be acceptable and the factors associated with higher or lower approval of use of this information.

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JAMA Netw Open. 2021;4(5):e2110918. doi:10.1001/jamanetworkopen.2021.10918
Abstract Full Text pdf link PDF CME & MOC

PSYCHIATRY

Association of Prenatal, Early Postnatal, or Current Exposure to Secondhand Smoke With Attention-Deficit/Hyperactivity Disorder Symptoms in Children

This cross-sectional study analyzes data collected via questionnaires to assess whether associations exist between prenatal, early postnatal, or current exposure to secondhand smoke and symptoms or subtypes of attention-deficit/hyperactivity disorder among school-aged children in China.

JAMA Netw Open. 2021;4(5):e2110931. doi:10.1001/jamanetworkopen.2021.10931
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Effect of Community Health Workers on 30-Day Hospital Readmissions in an Accountable Care Organization Population: A Randomized Clinical Trial

This randomized clinical trial examines the effect of community health worker care on hospital readmissions within 30 days for adults enrolled in an accountable care organization.

JAMA Netw Open. 2021;4(5):e2110936. doi:10.1001/jamanetworkopen.2021.10936
Abstract Full Text pdf link PDF

ONCOLOGY

Association of Increased Prostate-Specific Antigen Levels After Treatment and Mortality in Men With Locally Advanced vs Localized Prostate Cancer: A Secondary Analysis of 2 Randomized Clinical Trials

This cohort study evaluates whether the association between prostate-specific antigen (PSA) failure and death may be different in men with locally advanced vs localized prostate cancer enrolled in 2 randomized clinical trials.

JAMA Netw Open. 2021;4(5):e2111092. doi:10.1001/jamanetworkopen.2021.11092
Abstract Full Text pdf link PDF

ONCOLOGY

Association Between First-Line Immune Checkpoint Inhibition and Survival for Medicare-Insured Patients With Advanced Non–Small Cell Lung Cancer

This cohort study assesses the treatment patterns of and survival outcomes associated with checkpoint inhibitor immunotherapy, cytotoxic chemotherapy, and combined chemoimmunotherapy for older patients with advanced non–small cell lung cancer and Medicare coverage.

JAMA Netw Open. 2021;4(5):e2111113. doi:10.1001/jamanetworkopen.2021.11113
Abstract Full Text pdf link PDF

PSYCHIATRY

Longitudinal Changes in Posttraumatic Stress Disorder After Resettlement Among Yazidi Female Refugees Exposed to Violence

This cohort study assesses longitudinal changes in posttraumatic stress disorder severity and posttraumatic coping among severely traumatized Yazidi female refugees, as well as risk and protective factors for posttraumatic stress disorder course.

JAMA Netw Open. 2021;4(5):e2111120. doi:10.1001/jamanetworkopen.2021.11120
Abstract Full Text pdf link PDF

HEALTH INFORMATICS

Development and Validation of a Deep Learning Model to Quantify Interstitial Fibrosis and Tubular Atrophy From Kidney Ultrasonography Images

This diagnostic study attempts to develop and validate a deep learning algorithm to quantify interstitial fibrosis and tubular atrophy (IFTA) using kidney ultrasonography images.

JAMA Netw Open. 2021;4(5):e2111176. doi:10.1001/jamanetworkopen.2021.11176
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Development and Validation of a Machine Learning Model Using Administrative Health Data to Predict Onset of Type 2 Diabetes

This decision analytical model study assesses whether a machine learning model trained on routinely collected administrative health data from a single-payer health system in Canada can be used to predict the onset of type 2 diabetes in the population.

JAMA Netw Open. 2021;4(5):e2111315. doi:10.1001/jamanetworkopen.2021.11315
Abstract Full Text pdf link PDF

ONCOLOGY

Real-World Survival Outcomes Associated With First-Line Immunotherapy, Targeted Therapy, and Combination Therapy for Metastatic Clear Cell Renal Cell Carcinoma

This cohort study assesses the association of first-line targeted therapy, immunotherapy, and combination targeted therapy and immunotherapy regimens with overall survival in a real-world cohort of patients with metastatic clear cell renal cell carcinoma (ccRCC).

JAMA Netw Open. 2021;4(5):e2111329. doi:10.1001/jamanetworkopen.2021.11329
Abstract Full Text pdf link PDF

DIABETES AND ENDOCRINOLOGY

Association of Circulating Sex Hormones With Inflammation and Disease Severity in Patients With COVID-19

This cohort study investigates the association of sex hormones with disease severity and inflammatory cytokines in patients with COVID-19.

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JAMA Netw Open. 2021;4(5):e2111398. doi:10.1001/jamanetworkopen.2021.11398
Abstract Full Text pdf link PDF CME & MOC

INFECTIOUS DISEASES

Association Between Bitter Taste Receptor Phenotype and Clinical Outcomes Among Patients With COVID-19

This cohort study evaluates the association between bitter taste receptor phenotype and patient clinical course after infection with SARS-CoV-2.

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JAMA Netw Open. 2021;4(5):e2111410. doi:10.1001/jamanetworkopen.2021.11410
Abstract Full Text pdf link PDF CME & MOC

INFECTIOUS DISEASES

Assessment of the Frequency and Variety of Persistent Symptoms Among Patients With COVID-19: A Systematic Review

This systematic review uses data from cohort studies to examine the frequency, variety, and severity of persistent symptoms among individuals with previous COVID-19 infection.

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JAMA Netw Open. 2021;4(5):e2111417. doi:10.1001/jamanetworkopen.2021.11417
Abstract Full Text pdf link PDF CME & MOC

HEALTH POLICY

Personal and Professional Factors Associated With Work-Life Integration Among US Physicians

This cross-sectional study examines which personal and professional factors may be associated with lower work-life integration scores among US physicians.

JAMA Netw Open. 2021;4(5):e2111575. doi:10.1001/jamanetworkopen.2021.11575
Abstract Full Text pdf link PDF

PHYSICAL MEDICINE AND REHABILITATION

Home-Based vs Supervised Inpatient and/or Outpatient Rehabilitation Following Knee Meniscectomy: A Systematic Review and Meta-analysis

This meta-analysis examines 8 randomized clinical trials and assesses whether home-based rehabilitation or inpatient and/or outpatient rehabilitation is associated with better outcomes among patients recovering from arthroscopic isolated meniscectomy.

JAMA Netw Open. 2021;4(5):e2111582. doi:10.1001/jamanetworkopen.2021.11582
Abstract Full Text pdf link PDF

OBSTETRICS AND GYNECOLOGY

Use of Patient-Reported Outcome Measures to Assess Outpatient Postpartum Recovery: A Systematic Review

This systematic review uses Consensus-Based Standards for the Selection of Health Measurement Instruments guidelines to identify the best available multidomain patient-reported outcome measure tools that assess maternal postpartum recovery beyond delivery hospitalization.

JAMA Netw Open. 2021;4(5):e2111600. doi:10.1001/jamanetworkopen.2021.11600
Abstract Full Text pdf link PDF

ENVIRONMENTAL HEALTH

Exposure to Particulate Matter Air Pollution and Anosmia

This case-control study investigated the association between long-term exposure to particulate matter with an aerodynamic diameter of no more than 2.5 μm with anosmia.

JAMA Netw Open. 2021;4(5):e2111606. doi:10.1001/jamanetworkopen.2021.11606
Abstract Full Text pdf link PDF

SURGERY

Analysis of Delayed Surgical Treatment and Oncologic Outcomes in Clinical Stage I Non–Small Cell Lung Cancer

This cohort study examines the association between delayed surgical treatment and recurrence and survival among patients with non–small cell lung cancer in a cohort of patients treated in the Veterans Health Administration system.

JAMA Netw Open. 2021;4(5):e2111613. doi:10.1001/jamanetworkopen.2021.11613
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Factors Associated With Racial/Ethnic Group–Based Medical Mistrust and Perspectives on COVID-19 Vaccine Trial Participation and Vaccine Uptake in the US

This survey study of adults residing in Michigan during June to December 2020 examines associations between race/ethnicity, medical mistrust within racial/ethnic groups, and willingness to participate in COVID-19 vaccine trials or to receive a COVID-19 vaccine.

has active quiz
JAMA Netw Open. 2021;4(5):e2111629. doi:10.1001/jamanetworkopen.2021.11629
Abstract Full Text pdf link PDF CME & MOC

INFECTIOUS DISEASES

Assessment of the Association of Vitamin D Level With SARS-CoV-2 Seropositivity Among Working-Age Adults

This cohort study examines whether low levels of vitamin D are associated with SARS-CoV-2 seropositivity, an indicator of previous infection.

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JAMA Netw Open. 2021;4(5):e2111634. doi:10.1001/jamanetworkopen.2021.11634
Abstract Full Text pdf link PDF CME & MOC

HEALTH POLICY

Medicare Support for Dental and Podiatry Graduate Medical Education Programs

This cross-sectional study investigates the amount of Medicare funding for dental and podiatry graduate medical education programs at teaching hospitals from 1998 to 2018.

JAMA Netw Open. 2021;4(5):e2111797. doi:10.1001/jamanetworkopen.2021.11797
Abstract Full Text pdf link PDF

ONCOLOGY

Assessment of Modifiable Factors for the Association of Marital Status With Cancer-Specific Survival

This cohort study evaluates the extent to which marriage is associated with cancer-specific survival, stage at diagnosis, and treatment among patients with 9 common solid cancers and recommends methods for reducing the survival gap.

JAMA Netw Open. 2021;4(5):e2111813. doi:10.1001/jamanetworkopen.2021.11813
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Exposure to Family Member Incarceration and Adult Well-being in the United States

This cross-sectional study assesses the associations of incarceration of a family member with perceived well-being and projected life expectancy among adults in the US.

JAMA Netw Open. 2021;4(5):e2111821. doi:10.1001/jamanetworkopen.2021.11821
Abstract Full Text pdf link PDF

OBSTETRICS AND GYNECOLOGY

Factors Associated With Use of an Online Telemedicine Service to Access Self-managed Medical Abortion in the US

This cross-sectional study assesses the reasons that individuals in the US are accessing self-managed medication abortion through online telemedicine services and the factors associated with these requests.

JAMA Netw Open. 2021;4(5):e2111852. doi:10.1001/jamanetworkopen.2021.11852
Abstract Full Text pdf link PDF

HEALTH POLICY

Association of the Comprehensive Care for Joint Replacement Model With Disparities in the Use of Total Hip and Total Knee Replacement

This cohort study evaluates whether the implementation of a large-scale Medicare policy is associated with unequal use of and access to joint replacement care among older adults from various racial/ethnic groups and socioeconomic backgrounds.

JAMA Netw Open. 2021;4(5):e2111858. doi:10.1001/jamanetworkopen.2021.11858
Abstract Full Text pdf link PDF

NEUROLOGY

Global Incidence of Neurological Manifestations Among Patients Hospitalized With COVID-19—A Report for the GCS-NeuroCOVID Consortium and the ENERGY Consortium

This cohort study investigates the neurological phenotypes, incidence, and outcomes among adults hospitalized with COVID-19.

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JAMA Netw Open. 2021;4(5):e2112131. doi:10.1001/jamanetworkopen.2021.12131
Abstract Full Text pdf link PDF CME & MOC

NUTRITION, OBESITY, AND EXERCISE

Long-term Intake of Gluten and Cognitive Function Among US Women

This cohort study examines whether gluten intake is associated with cognitive function in women without celiac disease.

JAMA Netw Open. 2021;4(5):e2113020. doi:10.1001/jamanetworkopen.2021.13020
Abstract Full Text pdf link PDF

PSYCHIATRY

Association of Low-Dose Quetiapine and Diabetes

This cohort study investigates whether there is an association between prescription of low-dose quetiapine and risk for type 2 diabetes among Danish adults.

JAMA Netw Open. 2021;4(5):e213209. doi:10.1001/jamanetworkopen.2021.3209
Abstract Full Text pdf link PDF

HEALTH POLICY

Evaluation of Between-County Disparities in Premature Mortality Due to Stroke in the US

This cross-sectional study compares the numbers and factors associated with death due to stroke in younger and middle-aged adults among US counties.

JAMA Netw Open. 2021;4(5):e214488. doi:10.1001/jamanetworkopen.2021.4488
Abstract Full Text pdf link PDF

PEDIATRICS

Prevalence of Bacterial Meningitis Among Febrile Infants Aged 29-60 Days With Positive Urinalysis Results: A Systematic Review and Meta-analysis

This systematic review and meta-analysis assesses the prevalence of bacterial meningitis among febrile infants 29 to 60 days of age with a positive urinalysis result to evaluate whether lumbar puncture is routinely required.

JAMA Netw Open. 2021;4(5):e214544. doi:10.1001/jamanetworkopen.2021.4544
Abstract Full Text pdf link PDF

HEALTH POLICY

Evaluation of Trials Comparing Single-Enantiomer Drugs to Their Racemic Precursors: A Systematic Review

This systematic review uses data from randomized clinical trials to investigate how often new single-enantiomer drugs are compared with their existing racemic precursors and determine whether safety or efficacy differences are observed.

JAMA Netw Open. 2021;4(5):e215731. doi:10.1001/jamanetworkopen.2021.5731
Abstract Full Text pdf link PDF

CARDIOLOGY

Association of Wearable Device Use With Pulse Rate and Health Care Use in Adults With Atrial Fibrillation

This cohort study investigates the association of wearable device use with pulse rate and health care use among adults with atrial fibrillation (AF).

JAMA Netw Open. 2021;4(5):e215821. doi:10.1001/jamanetworkopen.2021.5821
Abstract Full Text pdf link PDF

HEALTH INFORMATICS

Development and Validation of a Deep Learning Model Using Convolutional Neural Networks to Identify Scaphoid Fractures in Radiographs

This diagnostic study develops and validates a deep convolutional neural network to detect both apparent and occult scaphoid fractures from radiographic images.

JAMA Netw Open. 2021;4(5):e216096. doi:10.1001/jamanetworkopen.2021.6096
Abstract Full Text pdf link PDF

PEDIATRICS

Association of Infant Physical Development and Rapid Growth With Pubertal Onset Among Girls in Rural China

This birth cohort study examines the associations of infant physical development and rapid growth with the timing of puberty onset in girls in China.

JAMA Netw Open. 2021;4(5):e216831. doi:10.1001/jamanetworkopen.2021.6831
Abstract Full Text pdf link PDF

SURGERY

Development and Implementation of Preoperative Optimization for High-Risk Patients With Abdominal Wall Hernia

This quality improvement study describes current trends in preoperative patient optimization, identifies barriers to optimization, develops interventions to address these barriers, and then pilots these interventions among high-risk patients undergoing ventral and incisional hernia repair.

JAMA Netw Open. 2021;4(5):e216836. doi:10.1001/jamanetworkopen.2021.6836
Abstract Full Text pdf link PDF

HEMATOLOGY

Screening for Cognitive Dysfunction Using the Rowland Universal Dementia Assessment Scale in Adults With Sickle Cell Disease

This cross-sectional study describes the administration and outcome of a short screening tool for assessing executive function, memory, language, and perceptual motor function of adults with sickle cell disease.

JAMA Netw Open. 2021;4(5):e217039. doi:10.1001/jamanetworkopen.2021.7039
Abstract Full Text pdf link PDF

HEALTH POLICY

Associations of Medicaid Expansion With Insurance Coverage, Stage at Diagnosis, and Treatment Among Patients With Genitourinary Malignant Neoplasms

This case-control study assesses the association of Medicaid expansion with health insurance status, stage at diagnosis, and receipt of treatment among patients with newly diagnosed genitourinary cancers.

JAMA Netw Open. 2021;4(5):e217051. doi:10.1001/jamanetworkopen.2021.7051
Abstract Full Text pdf link PDF

HEALTH POLICY

Rates of Serious Surgical Errors in California and Plans to Prevent Recurrence

This cross-sectional study examines surgical never events occurring in hospitals in California and summarizes recommendations to prevent future events.

JAMA Netw Open. 2021;4(5):e217058. doi:10.1001/jamanetworkopen.2021.7058
Abstract Full Text pdf link PDF

ETHICS

Evaluation of Drug Trials in High-, Middle-, and Low-Income Countries and Local Commercial Availability of Newly Approved Drugs

This cross-sectional study examines where drugs were tested for US Food and Drug Administration approval and determines how commonly and quickly these drugs received marketing approval in the countries where they were tested, both overall and by country income level and geographical region.

JAMA Netw Open. 2021;4(5):e217075. doi:10.1001/jamanetworkopen.2021.7075
Abstract Full Text pdf link PDF

STATISTICS AND RESEARCH METHODS

Development of a Method for Clinical Evaluation of Artificial Intelligence–Based Digital Wound Assessment Tools

This diagnostic study develops a quantitative and qualitative method to evaluate artificial intelligence–based wound assessment tools compared with expert human assessments.

JAMA Netw Open. 2021;4(5):e217234. doi:10.1001/jamanetworkopen.2021.7234
Abstract Full Text pdf link PDF

PEDIATRICS

Association of Adherence to Surfactant Best Practice Uses With Clinical Outcomes Among Neonates in Sweden

This cohort study evaluates registered use, off-label use, and omissions of surfactant treatment by gestational age and associations with outcomes, mainly among very preterm infants (gestational age <32 weeks).

JAMA Netw Open. 2021;4(5):e217269. doi:10.1001/jamanetworkopen.2021.7269
Abstract Full Text pdf link PDF

HEALTH POLICY

Risk of Recall Among Medical Devices Undergoing US Food and Drug Administration 510(k) Clearance and Premarket Approval, 2008-2017

This cohort study compares risk of recall and high-risk recall between medical devices that received US Food and Drug Administration 510(k) clearance and those that received premarket approval.

JAMA Netw Open. 2021;4(5):e217274. doi:10.1001/jamanetworkopen.2021.7274
Abstract Full Text pdf link PDF

ANESTHESIOLOGY

Variability and Costs of Low-Value Preoperative Testing for Cataract Surgery Within the Veterans Health Administration

This cohort study of Veterans Health Administration records examines the prevalence of low-value preoperative tests for eye cataract operations and associations with patient demographic characteristics, procedure type, and facility size.

JAMA Netw Open. 2021;4(5):e217470. doi:10.1001/jamanetworkopen.2021.7470
Abstract Full Text pdf link PDF

SUBSTANCE USE AND ADDICTION

Comparison of Treatments for Cocaine Use Disorder Among Adults: A Systematic Review and Meta-analysis

This systematic review and meta-analysis uses data from clinical trials to compare treatments for cocaine use disorder and examines whether any treatment approaches are associated with reductions in cocaine use among adults who are actively using cocaine.

JAMA Netw Open. 2021;4(5):e218049. doi:10.1001/jamanetworkopen.2021.8049
Abstract Full Text pdf link PDF

HEALTH POLICY

Nivolumab vs Pembrolizumab for Treatment of US Patients With Platinum-Refractory Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: A Network Meta-analysis and Cost-effectiveness Analysis

This network meta-analysis and cost-effectiveness analysis assesses whether nivolumab or pembrolizumab is more cost-effective for treatment of US patients with platinum-refractory recurrent or metastatic head and neck squamous cell carcinoma (HNSCC).

JAMA Netw Open. 2021;4(5):e218065. doi:10.1001/jamanetworkopen.2021.8065
Abstract Full Text pdf link PDF

ONCOLOGY

Comparison of Duration of Response vs Conventional Response Rates and Progression-Free Survival as Efficacy End Points in Simulated Immuno-oncology Clinical Trials

This simulated modeling study examines whether using restricted mean duration of response in phase 2 trials can better inform decisions about continuing or discontinuing before starting phase 3 immuno-oncology clinical trials compared with progression-free survival and objective response rate.

JAMA Netw Open. 2021;4(5):e218175. doi:10.1001/jamanetworkopen.2021.8175
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Racial and Ethnic Disparities in Primary Open-Angle Glaucoma Clinical Trials: A Systematic Review and Meta-analysis

This meta-analysis investigates the prevalence of participants from racial/ethnic minority groups compared with White individuals in clinical trials for primary open-angle glaucoma.

JAMA Netw Open. 2021;4(5):e218348. doi:10.1001/jamanetworkopen.2021.8348
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Comparison of 20-Year Obesity-Associated Cancer Mortality Trends With Heart Disease Mortality Trends in the US

This cross-sectional study investigates whether trends in obesity-associated cancer mortality mirror the slowed mortality improvements observed for heart disease associated with the obesity epidemic.

JAMA Netw Open. 2021;4(5):e218356. doi:10.1001/jamanetworkopen.2021.8356
Abstract Full Text pdf link PDF

NEUROLOGY

Trends in Incidence of Intracerebral Hemorrhage and Association With Antithrombotic Drug Use in Denmark, 2005-2018

This case-control study estimates the association between use of antithrombotic drugs and risk of intracerebral hemorrhage and assesses changes in the incidence of intracerebral hemorrhage in the general population in Denmark.

JAMA Netw Open. 2021;4(5):e218380. doi:10.1001/jamanetworkopen.2021.8380
Abstract Full Text pdf link PDF

OBSTETRICS AND GYNECOLOGY

Preeclampsia Prevalence, Risk Factors, and Pregnancy Outcomes in Sweden and China

This cross-sectional study compared preeclampsia prevalence, risk factors, and pregnancy outcomes between the Swedish and Chinese populations.

JAMA Netw Open. 2021;4(5):e218401. doi:10.1001/jamanetworkopen.2021.8401
Abstract Full Text pdf link PDF

UROLOGY

Assessment of Diagnostic Yield of Cystoscopy and Computed Tomographic Urography for Urinary Tract Cancers in Patients Evaluated for Microhematuria: A Systematic Review and Meta-analysis

This systematic review and meta-analysis uses data from observational studies to assess the diagnostic yields of cystoscopy and computed tomographic urography for the detection of urinary tract cancers among patients evaluated for microhematuria.

JAMA Netw Open. 2021;4(5):e218409. doi:10.1001/jamanetworkopen.2021.8409
Abstract Full Text pdf link PDF

INFECTIOUS DISEASES

Factors Associated With Access to and Timing of Coronavirus Testing Among US Adults After Onset of Febrile Illness

This cohort study examines rates of testing for SARS-CoV-2 and receipt of test results within 7 days of febrile illness onset using data from smartphone-based weekly surveys administered as part of the COVID-19 Citizen Science Study.

has active quiz
JAMA Netw Open. 2021;4(5):e218500. doi:10.1001/jamanetworkopen.2021.8500
Abstract Full Text pdf link PDF CME & MOC

NUTRITION, OBESITY, AND EXERCISE

An Empirically Derived Definition of Metabolically Healthy Obesity Based on Risk of Cardiovascular and Total Mortality

This cohort study formulates a new definition of metabolically healthy obesity and examines its use in estimation of cardiovascular disease mortality and total mortality.

JAMA Netw Open. 2021;4(5):e218505. doi:10.1001/jamanetworkopen.2021.8505
Abstract Full Text pdf link PDF

STATISTICS AND RESEARCH METHODS

Incorporating Present-on-Admission Indicators in Medicare Claims to Inform Hospital Quality Measure Risk Adjustment Models

This comparative effectiveness study uses national Medicare data on hospitalizations to evaluate whether the inclusion of present-on-admission indicators is associated with improved discrimination in Centers for Medicare & Medicaid Services (CMS) hospital quality risk models for 30-day mortality and readmission.

JAMA Netw Open. 2021;4(5):e218512. doi:10.1001/jamanetworkopen.2021.8512
Abstract Full Text pdf link PDF

OPHTHALMOLOGY

Automated Explainable Multidimensional Deep Learning Platform of Retinal Images for Retinopathy of Prematurity Screening

This diagnostic study uses data from the eye examinations of preterm infants to assess whether a deep learning algorithm can perform at a level comparable with that of ophthalmologists in identifying retinopathy of prematurity on wide-field retinal images.

JAMA Netw Open. 2021;4(5):e218758. doi:10.1001/jamanetworkopen.2021.8758
Abstract Full Text pdf link PDF

HEALTH POLICY

Association of Opioid Consumption Profiles After Hospitalization With Risk of Adverse Health Care Events

This cohort study assesses the association of duration, dose, current use status, and type of ingredients in prescription opioids consumed by patients before and after hospital discharge with risk of opioid-related adverse health care events.

JAMA Netw Open. 2021;4(5):e218782. doi:10.1001/jamanetworkopen.2021.8782
Abstract Full Text pdf link PDF

ONCOLOGY

Cost-effectiveness of Nivolumab-Ipilimumab Combination Therapy for the Treatment of Advanced Non–Small Cell Lung Cancer

This economic evaluation uses data from the CheckMate 227 clinical trial and a Markov model to examine the cost-effectiveness of nivolumab-ipilimumab combination therapy vs platinum-doublet chemotherapy as first-line treatment for patients with advanced non–small cell lung cancer.

JAMA Netw Open. 2021;4(5):e218787. doi:10.1001/jamanetworkopen.2021.8787
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Association Between Income Inequality and County-Level COVID-19 Cases and Deaths in the US

This cohort study evaluates the association between county-level income inequality and COVID-19 cases and deaths from March 2020 through February 2021 in bimonthly time epochs.

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JAMA Netw Open. 2021;4(5):e218799. doi:10.1001/jamanetworkopen.2021.8799
Abstract Full Text pdf link PDF CME & MOC

PSYCHIATRY

Comparison of Long-Acting Injectable Antipsychotics With Oral Antipsychotics and Suicide and All-Cause Mortality in Patients With Newly Diagnosed Schizophrenia

This cohort study investigates the associations of long-acting injectable antipsychotics with all-cause, natural-cause, and suicide mortality risks in patients with newly diagnosed schizophrenia.

JAMA Netw Open. 2021;4(5):e218810. doi:10.1001/jamanetworkopen.2021.8810
Abstract Full Text pdf link PDF

HEALTH POLICY

Correlation Between Changes in Brand-Name Drug Prices and Patient Out-of-Pocket Costs

This cohort study examines the association between price changes for brand-name drugs and out-of-pocket spending by patients with different insurance plans.

JAMA Netw Open. 2021;4(5):e218816. doi:10.1001/jamanetworkopen.2021.8816
Abstract Full Text pdf link PDF

PEDIATRICS

Clinical Characteristics and Transmission of COVID-19 in Children and Youths During 3 Waves of Outbreaks in Hong Kong

This cross-sectional study investigates the clinical characteristics and sources of infection of COVID-19 among children and youths in Hong Kong.

has active quiz
JAMA Netw Open. 2021;4(5):e218824. doi:10.1001/jamanetworkopen.2021.8824
Abstract Full Text pdf link PDF CME & MOC

PUBLIC HEALTH

Trends in Patient Characteristics and COVID-19 In-Hospital Mortality in the United States During the COVID-19 Pandemic

This cohort study of patients included in the US American Heart Association COVID-19 Cardiovascular Disease Registry evaluates whether any changes in the in-hospital COVID-19 mortality rates during the first 9 months of the pandemic are associated with individual characteristics of patients with COVID-19.

has active quiz
JAMA Netw Open. 2021;4(5):e218828. doi:10.1001/jamanetworkopen.2021.8828
Abstract Full Text pdf link PDF CME & MOC

HEALTH POLICY

Association of Drug Rebates and Competition With Out-of-Pocket Coinsurance in Medicare Part D, 2014 to 2018

This study describes the out-of-pocket burden on patients with coinsurance and assesses its association with pharmaceutical competition.

JAMA Netw Open. 2021;4(5):e219030. doi:10.1001/jamanetworkopen.2021.9030
Abstract Full Text pdf link PDF

ETHICS

Assessment of Factors Associated With Parental Perceptions of Voluntary Decisions About Child Participation in Leukemia Clinical Trials

This cross-sectional study assesses whether health literacy, contextual factors, or sociodemographic characteristics are associated with perception of voluntariness among parents who consent for their child’s participation in a leukemia therapeutic clinical trial.

JAMA Netw Open. 2021;4(5):e219038. doi:10.1001/jamanetworkopen.2021.9038
Abstract Full Text pdf link PDF

SUBSTANCE USE AND ADDICTION

Patient-Reported Outcomes of Treatment of Opioid Dependence With Weekly and Monthly Subcutaneous Depot vs Daily Sublingual Buprenorphine: A Randomized Clinical Trial

This randomized clinical trial compares patient satisfaction between depot buprenorphine and sublingual buprenorphine in adult outpatients with opioid dependence.

JAMA Netw Open. 2021;4(5):e219041. doi:10.1001/jamanetworkopen.2021.9041
Abstract Full Text pdf link PDF

PHARMACY AND CLINICAL PHARMACOLOGY

Qualitative Exploration of Barriers to Statin Adherence and Lipid Control: A Secondary Analysis of a Randomized Clinical Trial

This qualitative study identifies barriers to improving statin therapy adherence and control of cholesterol levels with financial incentives and insights for the design of future interventions among patients with high cholesterol levels.

JAMA Netw Open. 2021;4(5):e219211. doi:10.1001/jamanetworkopen.2021.9211
Abstract Full Text pdf link PDF

NEPHROLOGY

Accounting for the Competing Risk of Death to Predict Kidney Failure in Adults With Stage 4 Chronic Kidney Disease

This population-based validation study compares the prediction of kidney failure from models that do and do not account for the competing risk of death in adults with severe chronic kidney disease.

JAMA Netw Open. 2021;4(5):e219225. doi:10.1001/jamanetworkopen.2021.9225
Abstract Full Text pdf link PDF

PEDIATRICS

Medical Treatment Following Violence Exposure in a National Sample of Children and Youth

This survey study examines data from interviews with youth aged 10 to 17 years and caregivers of children aged 2 to 9 years to assess how many youth in these age groups have received medical care in the US as a result of violence.

JAMA Netw Open. 2021;4(5):e219250. doi:10.1001/jamanetworkopen.2021.9250
Abstract Full Text pdf link PDF

SUBSTANCE USE AND ADDICTION

Prevalence of Medical Cannabis Use and Associated Health Conditions Documented in Electronic Health Records Among Primary Care Patients in Washington State

This cross-sectional study describes the prevalence and clinical characteristics of primary care patients with cannabis use documented in their electronic health records.

JAMA Netw Open. 2021;4(5):e219375. doi:10.1001/jamanetworkopen.2021.9375
Abstract Full Text pdf link PDF

PEDIATRICS

Mortality and Morbidity of Infants Born Extremely Preterm at Tertiary Medical Centers in China From 2010 to 2019

This cohort study examines the association of preterm birth with risk of mortality and morbidity among infants born in China from 2010 to 2019.

JAMA Netw Open. 2021;4(5):e219382. doi:10.1001/jamanetworkopen.2021.9382
Abstract Full Text pdf link PDF

PSYCHIATRY

Association of Borderline Personality Disorder Criteria With Suicide Attempts Among US Adults

This cross-sectional study uses data from the National Epidemiologic Survey on Alcohol and Related Conditions to examine associations between specific criteria of borderline personality disorder and suicide attempts in US adults.

JAMA Netw Open. 2021;4(5):e219389. doi:10.1001/jamanetworkopen.2021.9389
Abstract Full Text pdf link PDF

UROLOGY

Variation in Prostate-Specific Antigen Testing Rates and Prostate Cancer Treatments and Outcomes in a National 20-Year Cohort

This cohort study uses a simulation model to assess the association between increases in screening for prostate cancer and prostate cancer diagnosis, treatment, and mortality.

JAMA Netw Open. 2021;4(5):e219444. doi:10.1001/jamanetworkopen.2021.9444
Abstract Full Text pdf link PDF

UROLOGY

Association of Prostate-Specific Antigen Velocity With Clinical Progression Among African American and Non-Hispanic White Men Treated for Low-Risk Prostate Cancer With Active Surveillance

This cohort study evaluates whether prostate-specific antigen velocity is associated with clinical progression in patients with low-risk prostate cancer treated with active surveillance and identifies differences between African American and non-Hispanic White patients.

JAMA Netw Open. 2021;4(5):e219452. doi:10.1001/jamanetworkopen.2021.9452
Abstract Full Text pdf link PDF

HEALTH POLICY

Comparison of the Quality of Chronic Disease Management Between Adults With and Without Dementia

This cross-sectional study compares the quality of diabetes care and medication management provided to adults with dementia with that provided to adults without dementia who had similar limited life expectancy.

JAMA Netw Open. 2021;4(5):e219622. doi:10.1001/jamanetworkopen.2021.9622
Abstract Full Text pdf link PDF

COMPLEMENTARY AND ALTERNATIVE MEDICINE

Flotation Restricted Environmental Stimulation Therapy for Chronic Pain: A Randomized Clinical Trial

This randomized clinical trial assesses whether 5 sessions of flotation–restricted environmental stimulation therapy alleviate chronic pain in adults.

JAMA Netw Open. 2021;4(5):e219627. doi:10.1001/jamanetworkopen.2021.9627
Abstract Full Text pdf link PDF

HEMATOLOGY

Comparison of Allogeneic Stem Cell Transplant and Autologous Stem Cell Transplant in Refractory or Relapsed Peripheral T-Cell Lymphoma: A Systematic Review and Meta-analysis

This meta-analysis compares the effectiveness and safety of allogeneic vs autologous hematopoietic stem cell transplant in patients with refractory or relapsed peripheral T-cell lymphoma.

JAMA Netw Open. 2021;4(5):e219807. doi:10.1001/jamanetworkopen.2021.9807
Abstract Full Text pdf link PDF

ALLERGY

Evaluation of a Pharmacist-Led Penicillin Allergy Assessment Program and Allergy Delabeling in a Tertiary Care Hospital

This cross-sectional study examines the association of initiation of pharmacist-led assessment of allergy status in patients with self-reported penicillin allergy with antimicrobial use and clinical outcomes in a tertiary care hospital in the US.

JAMA Netw Open. 2021;4(5):e219820. doi:10.1001/jamanetworkopen.2021.9820
Abstract Full Text pdf link PDF

PEDIATRICS

Clinical and Biochemical Features of Hypopituitarism Among Brazilian Children With Zika Virus–Induced Microcephaly

This cohort study investigates postnatal growth and hormone levels among Brazilian children with microcephaly caused by Zika virus.

JAMA Netw Open. 2021;4(5):e219878. doi:10.1001/jamanetworkopen.2021.9878
Abstract Full Text pdf link PDF
open access Editorial

Colorectal Cancer Screening Starting at Age 45 Years—Ensuring Benefits Are Realized by All

JAMA Netw Open. 2021;4(5):e2112593. doi:10.1001/jamanetworkopen.2021.12593
Abstract Full Text pdf link PDF

Prostate-Specific Antigen Screening and Active Surveillance for High-Risk Individuals

JAMA Netw Open. 2021;4(5):e219711. doi:10.1001/jamanetworkopen.2021.9711
Abstract Full Text pdf link PDF
open access Invited Commentary

PEDIATRICS

Addressing Shortages in Pediatric Emergency Care—The Evolution of Health Care Access

JAMA Netw Open. 2021;4(5):e2110115. doi:10.1001/jamanetworkopen.2021.10115
Abstract Full Text pdf link PDF

PSYCHIATRY

Bipolar Disorder, Schizophrenia, and Uptake of Oral Anticoagulation Therapy in Patients With Atrial Fibrillation

JAMA Netw Open. 2021;4(5):e2110116. doi:10.1001/jamanetworkopen.2021.10116
Abstract Full Text pdf link PDF

DIABETES AND ENDOCRINOLOGY

Enhancing the Collaborative Experience of a Collaborative Game to Achieve Lifestyle Change

JAMA Netw Open. 2021;4(5):e2110308. doi:10.1001/jamanetworkopen.2021.10308
Abstract Full Text pdf link PDF

INFECTIOUS DISEASES

The Multisystem Inflammatory Syndrome in Adults With SARS-CoV-2 Infection—Another Piece of an Expanding Puzzle

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JAMA Netw Open. 2021;4(5):e2110344. doi:10.1001/jamanetworkopen.2021.10344
Abstract Full Text pdf link PDF CME & MOC

ONCOLOGY

Considering Trial Registries as a Platform for Timely Access to Study Results

JAMA Netw Open. 2021;4(5):e2110466. doi:10.1001/jamanetworkopen.2021.10466
Abstract Full Text pdf link PDF

PHARMACY AND CLINICAL PHARMACOLOGY

Clinical Implications of Pharmacogenomic Testing in the Real World—Insights From a Pediatric Program

JAMA Netw Open. 2021;4(5):e2110467. doi:10.1001/jamanetworkopen.2021.10467
Abstract Full Text pdf link PDF

GASTROENTEROLOGY AND HEPATOLOGY

Machine Learning for Predicting Rare Clinical Outcomes—Finding Needles in a Haystack

JAMA Netw Open. 2021;4(5):e2110738. doi:10.1001/jamanetworkopen.2021.10738
Abstract Full Text pdf link PDF

HEMATOLOGY

Autologous vs Allogeneic Hematopoietic Cell Transplantation for Patients With Peripheral T-cell Lymphomas—Closer, Yet Still So Far to Go

JAMA Netw Open. 2021;4(5):e2111674. doi:10.1001/jamanetworkopen.2021.11674
Abstract Full Text pdf link PDF

OBSTETRICS AND GYNECOLOGY

Deconstructing Current Postpartum Recovery Research—The Need to Contextualize Patient-Reported Outcome Measures

JAMA Netw Open. 2021;4(5):e2111689. doi:10.1001/jamanetworkopen.2021.11689
Abstract Full Text pdf link PDF

INFECTIOUS DISEASES

Reassessing the Association of Vitamin D Level With SARS-CoV-2 Seropositivity

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JAMA Netw Open. 2021;4(5):e2111750. doi:10.1001/jamanetworkopen.2021.11750
Abstract Full Text pdf link PDF CME & MOC

HEALTH INFORMATICS

Deep Convolutional Neural Networks as a Diagnostic Aid—A Step Toward Minimizing Undetected Scaphoid Fractures on Initial Hand Radiographs

JAMA Netw Open. 2021;4(5):e216393. doi:10.1001/jamanetworkopen.2021.6393
Abstract Full Text pdf link PDF

PEDIATRICS

Surfactant Treatment—A National, Population-Based Study of Adherence to Best Practice, Off-Label Use, and Associations With Outcomes

JAMA Netw Open. 2021;4(5):e217848. doi:10.1001/jamanetworkopen.2021.7848
Abstract Full Text pdf link PDF

STATISTICS AND RESEARCH METHODS

Setting Assessment Standards for Artificial Intelligence Computer Vision Wound Annotations

JAMA Netw Open. 2021;4(5):e217851. doi:10.1001/jamanetworkopen.2021.7851
Abstract Full Text pdf link PDF

NUTRITION, OBESITY, AND EXERCISE

Metabolically Healthy Obesity Redefined

JAMA Netw Open. 2021;4(5):e218860. doi:10.1001/jamanetworkopen.2021.8860
Abstract Full Text pdf link PDF

PEDIATRICS

Addressing Children’s Exposure to Violence and the Role of Health Care

JAMA Netw Open. 2021;4(5):e219164. doi:10.1001/jamanetworkopen.2021.9164
Abstract Full Text pdf link PDF

NEUROLOGY

Intracerebral Hemorrhage and Exposure to Antithrombotic Drugs

JAMA Netw Open. 2021;4(5):e219175. doi:10.1001/jamanetworkopen.2021.9175
Abstract Full Text pdf link PDF

OPHTHALMOLOGY

A Step Forward in Using Artificial Intelligence to Identify Serious Retinopathy of Prematurity—A Start With a Long Road Ahead

JAMA Netw Open. 2021;4(5):e219245. doi:10.1001/jamanetworkopen.2021.9245
Abstract Full Text pdf link PDF

HEALTH POLICY

The Association Between Postdischarge Opioid Use and Serious Adverse Events—A Warning Signal From the North

JAMA Netw Open. 2021;4(5):e219707. doi:10.1001/jamanetworkopen.2021.9707
Abstract Full Text pdf link PDF

SUBSTANCE USE AND ADDICTION

Extended-Release Buprenorphine and Its Evaluation With Patient-Reported Outcomes

JAMA Netw Open. 2021;4(5):e219708. doi:10.1001/jamanetworkopen.2021.9708
Abstract Full Text pdf link PDF

PEDIATRICS

The Importance of Harmonized Databases for Infants Born Extremely Preterm—If You Are Not Counted, You Are Not Accounted

JAMA Netw Open. 2021;4(5):e219709. doi:10.1001/jamanetworkopen.2021.9709
Abstract Full Text pdf link PDF

MEDICAL EDUCATION

Declines in the Proportion of US Black Obstetrics and Gynecology Residents

JAMA Netw Open. 2021;4(5):e219710. doi:10.1001/jamanetworkopen.2021.9710
Abstract Full Text pdf link PDF
open access Research Letter

CARDIOLOGY

Availability of Specific Direct Oral Anticoagulant Reversal Agents in US Hospitals

This cross-sectional study assesses the availability of the direct oral anticoagulant reversal agents idarucizumab and andexanet alfa in US hospitals.

JAMA Netw Open. 2021;4(5):e2110079. doi:10.1001/jamanetworkopen.2021.10079
Abstract Full Text pdf link PDF

OBSTETRICS AND GYNECOLOGY

Perinatal Outcomes During the COVID-19 Pandemic in Ontario, Canada

This cohort study evaluates rates of preterm birth and stillbirth in Ontario, Canada, during the first 6 months of the COVID-19 pandemic.

has active quiz
JAMA Netw Open. 2021;4(5):e2110104. doi:10.1001/jamanetworkopen.2021.10104
Abstract Full Text pdf link PDF CME & MOC

HEALTH POLICY

Transparency, Accessibility, and Variability of US Hospital Price Data

This cross-sectional study evaluates the compliance of hospitals with a Centers for Medicare & Medicaid Services ruling mandating that hospital chargemasters be publicly available in a machine-readable file.

JAMA Netw Open. 2021;4(5):e2110109. doi:10.1001/jamanetworkopen.2021.10109
Abstract Full Text pdf link PDF

PEDIATRICS

Assessment of Feasibility of Face Covering in School-Aged Children With Autism Spectrum Disorders and Attention-Deficit/Hyperactivity Disorder

This cohort study reports the outcomes of using positive behavior supports to promote masking in school-aged children with autism spectrum disorders (ASD) and/or attention-deficit/hyperactivity disorder (ADHD) attending a summer day treatment program.

has active quiz
JAMA Netw Open. 2021;4(5):e2110281. doi:10.1001/jamanetworkopen.2021.10281
Abstract Full Text pdf link PDF CME & MOC

OBSTETRICS AND GYNECOLOGY

Trends in Home Birth Information Seeking in the United States and United Kingdom During the COVID-19 Pandemic

This cross-sectional study used online search data to assess changes in home birth information-seeking behaviors across the United States and United Kingdom during the COVID-19 pandemic.

has active quiz
JAMA Netw Open. 2021;4(5):e2110310. doi:10.1001/jamanetworkopen.2021.10310
Abstract Full Text pdf link PDF CME & MOC

INFECTIOUS DISEASES

Characteristics Associated With Multisystem Inflammatory Syndrome Among Adults With SARS-CoV-2 Infection

This cohort study describes the clinical characteristics and outcomes of patients with multisystem inflammatory syndrome among adults with laboratory-confirmed SARS-CoV-2 infection at a single US tertiary care medical center.

has active quiz
JAMA Netw Open. 2021;4(5):e2110323. doi:10.1001/jamanetworkopen.2021.10323
Abstract Full Text pdf link PDF CME & MOC

HEALTH POLICY

Community Factors Associated With Telemedicine Use During the COVID-19 Pandemic

This cross-sectional study investigates which community factors may be associated with the increase in telemedicine use during the COVID-19 pandemic.

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JAMA Netw Open. 2021;4(5):e2110330. doi:10.1001/jamanetworkopen.2021.10330
Abstract Full Text pdf link PDF CME & MOC

SUBSTANCE USE AND ADDICTION

Drug Overdose Deaths Before and After Shelter-in-Place Orders During the COVID-19 Pandemic in San Francisco

This cross-sectional study evaluates the association of the shelter-in-place order with fatal drug overdoses in San Francisco, California.

JAMA Netw Open. 2021;4(5):e2110452. doi:10.1001/jamanetworkopen.2021.10452
Abstract Full Text pdf link PDF

OBSTETRICS AND GYNECOLOGY

Knowledge, Attitudes, and Practice Patterns Relating to Female Sexual Health Among Obstetricians and Gynecologists in China

This survey study examines knowledge, attitudes, and practice patterns relating to female sexual health among obstetricians and gynecologists in China.

JAMA Netw Open. 2021;4(5):e2110695. doi:10.1001/jamanetworkopen.2021.10695
Abstract Full Text pdf link PDF

MEDICAL EDUCATION

Evaluation of Equitable Racial and Ethnic Representation Among Departmental Chairs in Academic Medicine, 1980-2019

This cross-sectional study evaluates racial and ethnic representation among departmental chairs and faculty in academic medicine in the US from 1980 to 2019.

JAMA Netw Open. 2021;4(5):e2110726. doi:10.1001/jamanetworkopen.2021.10726
Abstract Full Text pdf link PDF

INFECTIOUS DISEASES

Medication Use Patterns in Hospitalized Patients With COVID-19 in California During the Pandemic

This cohort study examines trends in medication use among patients hospitalized for COVID-19–related treatment in a large US university health care system from the start of stay-at-home orders in March 2020 throughout the rest of the year.

has active quiz
JAMA Netw Open. 2021;4(5):e2110775. doi:10.1001/jamanetworkopen.2021.10775
Abstract Full Text pdf link PDF CME & MOC

PUBLIC HEALTH

Variation in SARS-CoV-2 Infection Risk and Socioeconomic Disadvantage Among a Mayan-Latinx Population in Oakland, California

This cross-sectional study examines variation in SARS-CoV-2 infection risk and socioeconomic disadvantage among a Mayan-Latinx population in the Fruitvale, California, community.

has active quiz
JAMA Netw Open. 2021;4(5):e2110789. doi:10.1001/jamanetworkopen.2021.10789
Abstract Full Text pdf link PDF CME & MOC

MEDICAL EDUCATION

Examination of Medical College Admission Test Scores and US Medical Licensing Examination Step 1 and Step 2 Clinical Knowledge Scores Among Students With Disabilities

This cohort study examines the association between Medical College Admission Test (MCAT) scores, disability status and category, and performance on US Medical Licensing Examination (USMLE) Step 1 and Step 2 CK scores.

JAMA Netw Open. 2021;4(5):e2110914. doi:10.1001/jamanetworkopen.2021.10914
Abstract Full Text pdf link PDF

SUBSTANCE USE AND ADDICTION

Trends and Characteristics of Manufactured Cannabis Product and Cannabis Plant Product Exposures Reported to US Poison Control Centers, 2017-2019

This cross-sectional study examines reports of cannabis exposure at US poison control centers for trends in patient and product characteristics, stratified by manufactured cannabis products and plant materials.

JAMA Netw Open. 2021;4(5):e2110925. doi:10.1001/jamanetworkopen.2021.10925
Abstract Full Text pdf link PDF

ONCOLOGY

Socioeconomic and Racial Inequities in Breast Cancer Screening During the COVID-19 Pandemic in Washington State

This cohort study investigates the rates of breast cancer screening before and during the COVID-19 pandemic among women in Washington State.

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JAMA Netw Open. 2021;4(5):e2110946. doi:10.1001/jamanetworkopen.2021.10946
Abstract Full Text pdf link PDF CME & MOC

ONCOLOGY

Olaparib vs Cabazitaxel in Metastatic Castration-Resistant Prostate Cancer

This comparative effectiveness research compares survival end points and response rates among patients with metastatic castration-resistant prostate cancer (mCRPC) treated with olaparib and cabazitaxel using results from 2 phase 3 randomized clinical trials.

JAMA Netw Open. 2021;4(5):e2110950. doi:10.1001/jamanetworkopen.2021.10950
Abstract Full Text pdf link PDF

OCCUPATIONAL HEALTH

Characterization of Mental Illness Among US Coal Miners

This cohort study examines the prevalence of and risk factors for mental illness among current and former coal miners in the United States.

JAMA Netw Open. 2021;4(5):e2111110. doi:10.1001/jamanetworkopen.2021.11110
Abstract Full Text pdf link PDF

HEALTH POLICY

Reporting of Participant Race, Sex, and Socioeconomic Status in Randomized Clinical Trials in General Medical Journals, 2015 vs 2019

This cross-sectional study evaluates changes in reporting practices for race, sex, and socioeconomic status in randomized clinical trials in 2015 vs 2019.

JAMA Netw Open. 2021;4(5):e2111516. doi:10.1001/jamanetworkopen.2021.11516
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Trends in Suicide Rates by Race and Ethnicity in the United States

This cross-sectional study examines trends in the suicide rate among racial and ethnic subgroups in the United States from 1999 to 2019.

JAMA Netw Open. 2021;4(5):e2111563. doi:10.1001/jamanetworkopen.2021.11563
Abstract Full Text pdf link PDF

ONCOLOGY

Assessment of New Molecular Entities Approved for Cancer Treatment in 2020

This cross-sectional study of all hematology/oncology drugs approved by the US Food and Drug Administration in 2020 assesses the functioning of the drug approval process following disruptions related to the COVID-19 pandemic.

JAMA Netw Open. 2021;4(5):e2112558. doi:10.1001/jamanetworkopen.2021.12558
Abstract Full Text pdf link PDF

SUBSTANCE USE AND ADDICTION

Measuring the Burden of Opioid-Related Mortality in Ontario, Canada, During the COVID-19 Pandemic

This cross-sectional study quantifies the added burden of fatal opioid overdoses during the first 6 months of the COVID-19 pandemic in Ontario, Canada.

has active quiz
JAMA Netw Open. 2021;4(5):e2112865. doi:10.1001/jamanetworkopen.2021.12865
Abstract Full Text pdf link PDF CME & MOC

HEALTH INFORMATICS

Accessibility and Usability of State Health Department COVID-19 Vaccine Websites: A Qualitative Study

This qualitative study analyzes department of health websites for all 50 US states for accessibility and usability in obtaining COVID-19 vaccine eligibility information and appointments.

has active quiz
JAMA Netw Open. 2021;4(5):e2114861. doi:10.1001/jamanetworkopen.2021.14861
Abstract Full Text pdf link PDF CME & MOC

PUBLIC HEALTH

Prevalence of Immunosuppressive Drug Use Among Commercially Insured US Adults, 2018-2019

This cross-sectional study uses direct pharmaceutical claims data from a commercial claims database to assess the use of 6 types of immunosuppressive drugs among commercially insured US adults in 2018 and 2019.

JAMA Netw Open. 2021;4(5):e214920. doi:10.1001/jamanetworkopen.2021.4920
Abstract Full Text pdf link PDF

ONCOLOGY

Prevalence of High-Risk Nonvaccine Human Papillomavirus Types in Advanced Squamous Cell Carcinoma Among Individuals of African vs Non-African Ancestry

This cross-sectional study assesses the prevalence of high-risk human papillomavirus (hrHPV) types not covered by the 9-valent HPV vaccine among patients of African vs non-African ancestry with advanced squamous cell carcinoma.

JAMA Netw Open. 2021;4(5):e216481. doi:10.1001/jamanetworkopen.2021.6481
Abstract Full Text pdf link PDF

ONCOLOGY

Evaluation of BRCA1 and BRCA2 as Indicators of Response to Immune Checkpoint Inhibitors

This cohort study examines the association of BRCA1 and BRCA2 with tumor mutation burden and response to immune checkpoint inhibitors.

JAMA Netw Open. 2021;4(5):e217728. doi:10.1001/jamanetworkopen.2021.7728
Abstract Full Text pdf link PDF

HEALTH POLICY

Assessment of Patient Attribution to Care From Medical Oncologists, Surgeons, or Radiation Oncologists After Newly Diagnosed Cancer

This cohort study uses data from the Surveillance, Epidemiology, and End Results–Medicare Linked Database to assess the attribution of patients with newly diagnosed lung, breast, colorectal, or prostate cancer to care from multidisciplinary specialists—medical oncologists, surgeons, or radiation oncologists—within 6 months after diagnosis.

JAMA Netw Open. 2021;4(5):e218055. doi:10.1001/jamanetworkopen.2021.8055
Abstract Full Text pdf link PDF

GLOBAL HEALTH

Age at Smoking Initiation and Prevalence of Cigarette Use Among Youths in Sub-Saharan Africa, 2014-2017

This cross-sectional study examines age at smoking initiation, prevalence of cigarette use, and prevalence of exposure to smoking-related risk factors among youths in sub-Saharan Africa.

JAMA Netw Open. 2021;4(5):e218060. doi:10.1001/jamanetworkopen.2021.8060
Abstract Full Text pdf link PDF

HEALTH POLICY

Paid Parental Leave Policies Among U.S. News & World Report 2020-2021 Best Hospitals and Best Hospitals for Cancer

This cross-sectional study examines paid parental leave policies for faculty and staff physicians at leading US hospitals and cancer centers.

JAMA Netw Open. 2021;4(5):e218518. doi:10.1001/jamanetworkopen.2021.8518
Abstract Full Text pdf link PDF

HEALTH POLICY

Assessment of Primary Care Appointment Times and Appropriate Prescribing of Statins for At-Risk Patients

This cohort study examines whether there is an association between primary care appointment times and statin prescribing rates for patients with elevated risk of major adverse cardiovascular events.

JAMA Netw Open. 2021;4(5):e219050. doi:10.1001/jamanetworkopen.2021.9050
Abstract Full Text pdf link PDF

MEDICAL EDUCATION

Racial and Ethnic Diversity Among Obstetrics and Gynecology, Surgical, and Nonsurgical Residents in the US From 2014 to 2019

This cross-sectional study examines racial and ethnic diversity among obstetrics and gynecology (OBGYN), surgical, and nonsurgical residents in the US.

JAMA Netw Open. 2021;4(5):e219219. doi:10.1001/jamanetworkopen.2021.9219
Abstract Full Text pdf link PDF

PSYCHIATRY

Trends in Autism Spectrum Disorder Diagnoses in Japan, 2009 to 2019

This cohort study examines the geographical variations in the incidence of autism spectrum disorder (ASD) and calculates the nationwide cumulative incidence of ASD in Japan.

JAMA Netw Open. 2021;4(5):e219234. doi:10.1001/jamanetworkopen.2021.9234
Abstract Full Text pdf link PDF

HEALTH POLICY

Changes in US Medicaid Enrollment During the COVID-19 Pandemic

This cross-sectional study analyzes changes in Medicaid enrollment for all 50 US states and Washington, DC, during the first 9 months of 2020, at the beginning of the COVID-19 pandemic.

has active quiz
JAMA Netw Open. 2021;4(5):e219463. doi:10.1001/jamanetworkopen.2021.9463
Abstract Full Text pdf link PDF CME & MOC

MEDICAL EDUCATION

Gender Differences in Physician Use of Social Media for Professional Advancement

This survey study examines gender difference in physician use of social media for professional advancement.

JAMA Netw Open. 2021;4(5):e219834. doi:10.1001/jamanetworkopen.2021.9834
Abstract Full Text pdf link PDF

PEDIATRICS

Frequency and Duration of Advertising on Popular Child-Directed Channels on a Video-Sharing Platform

This cross-sectional study quantifies the number and duration of distinct advertisements that appear during child-directed videos on a video-sharing platform as well as the frequency of age-inappropriate ads.

JAMA Netw Open. 2021;4(5):e219890. doi:10.1001/jamanetworkopen.2021.9890
Abstract Full Text pdf link PDF
open access Correction

Error in Results Section

JAMA Netw Open. 2021;4(5):e2113597. doi:10.1001/jamanetworkopen.2021.13597
Abstract Full Text pdf link PDF

Error in Affiliations

JAMA Netw Open. 2021;4(5):e2114100. doi:10.1001/jamanetworkopen.2021.14100
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Error in Discussion

JAMA Netw Open. 2021;4(5):e2114112. doi:10.1001/jamanetworkopen.2021.14112
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Errors in Tables 1 and 2

JAMA Netw Open. 2021;4(5):e2114136. doi:10.1001/jamanetworkopen.2021.14136
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Error in Author Degrees

JAMA Netw Open. 2021;4(5):e2114399. doi:10.1001/jamanetworkopen.2021.14399
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Errors in Methods Section and Figure Key

JAMA Netw Open. 2021;4(5):e2114947. doi:10.1001/jamanetworkopen.2021.14947
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Errors in the Results, Figures 2 to 5, and the Supplement

JAMA Netw Open. 2021;4(5):e2115032. doi:10.1001/jamanetworkopen.2021.15032
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Error in the Methods Section

JAMA Netw Open. 2021;4(5):e2115436. doi:10.1001/jamanetworkopen.2021.15436
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Error in Table 1

JAMA Netw Open. 2021;4(5):e2115446. doi:10.1001/jamanetworkopen.2021.15446
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Error in the Results and eTable 2 in Supplement 2

JAMA Netw Open. 2021;4(5):e2115510. doi:10.1001/jamanetworkopen.2021.15510
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Errors in Abstract and Discussion

JAMA Netw Open. 2021;4(5):e2115843. doi:10.1001/jamanetworkopen.2021.15843
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JAMA Netw Open. 2021;4(5):e2112744. doi:10.1001/jamanetworkopen.2021.12744
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