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September 2021 - May 2018

Decade

Year

Issue

July 2021, Vol 4, No. 7

open access Original Investigation

COMPLEMENTARY AND ALTERNATIVE MEDICINE

Chuna Manual Therapy vs Usual Care for Patients With Nonspecific Chronic Neck Pain: A Randomized Clinical Trial

This randomized clinical trial assesses whether Chuna manual therapy is more effective than usual care (electrotherapy and oral medication) for patients in Korea with chronic neck pain.

JAMA Netw Open. 2021;4(7):e2113757. doi:10.1001/jamanetworkopen.2021.13757
Abstract Full Text pdf link PDF

PEDIATRICS

Comparison of Untargeted Metabolomic Profiling vs Traditional Metabolic Screening to Identify Inborn Errors of Metabolism

This cross-sectional study examines the utility of untargeted metabolomics as a primary screening tool for inborn errors of metabolism by comparing the diagnostic rate of clinical metabolomics with the recommended traditional metabolic screening approach.

JAMA Netw Open. 2021;4(7):e2114155. doi:10.1001/jamanetworkopen.2021.14155
Abstract Full Text pdf link PDF

GASTROENTEROLOGY AND HEPATOLOGY

Comparison of Survival and Patterns of Recurrence in Gastric Neuroendocrine Carcinoma, Mixed Adenoneuroendocrine Carcinoma, and Adenocarcinoma

This cohort study examines differences in long-term survival and patterns of recurrence among patients with gastric neuroendocrine carcinoma, gastric mixed adenoneuroendocrine carcinoma, and gastric adenocarcinoma.

JAMA Netw Open. 2021;4(7):e2114180. doi:10.1001/jamanetworkopen.2021.14180
Abstract Full Text pdf link PDF

CARDIOLOGY

Disparities in Anticoagulant Therapy Initiation for Incident Atrial Fibrillation by Race/Ethnicity Among Patients in the Veterans Health Administration System

This cohort study uses data from the Veterans Health Administration system to compare rates of initiation of anticoagulant therapy by race/ethnicity.

JAMA Netw Open. 2021;4(7):e2114234. doi:10.1001/jamanetworkopen.2021.14234
Abstract Full Text pdf link PDF

CRITICAL CARE MEDICINE

Assessment of Magnetic Resonance Imaging Changes and Functional Outcomes Among Adults With Severe Herpes Simplex Encephalitis

This cohort study investigates the association between early collected magnetic resonance imaging (MRI) data and functional outcomes 90 days after intensive care unit admission among adults with severe herpes simplex encephalitis.

JAMA Netw Open. 2021;4(7):e2114328. doi:10.1001/jamanetworkopen.2021.14328
Abstract Full Text pdf link PDF

GENETICS AND GENOMICS

Principles of Genomic Newborn Screening Programs: A Systematic Review

This systematic review identifies what has been discovered following the reporting of the first genomic newborn screening pilot projects and summarizes key points for the design of these programs.

JAMA Netw Open. 2021;4(7):e2114336. doi:10.1001/jamanetworkopen.2021.14336
Abstract Full Text pdf link PDF

PEDIATRICS

Dietary Intake and Anthropometric Measurement at Age 36 Months Among Aboriginal and/or Torres Strait Islander Children in Australia: A Secondary Analysis of the Baby Teeth Talk Randomized Clinical Trial

This secondary analysis reports the follow-up results of a dental care service provided to Indigenous Australian children and their caregivers who participated in the Baby Teeth Talk randomized clinical trial.

JAMA Netw Open. 2021;4(7):e2114348. doi:10.1001/jamanetworkopen.2021.14348
Abstract Full Text pdf link PDF

NEUROLOGY

Disparities by Race and Ethnicity Among Adults Recruited for a Preclinical Alzheimer Disease Trial

This cross-sectional study of screening data from a preclinical Alzheimer disease trial assesses differences in recruitment strategies and trial eligibility among racial and ethnic groups.

JAMA Netw Open. 2021;4(7):e2114364. doi:10.1001/jamanetworkopen.2021.14364
Abstract Full Text pdf link PDF

CARDIOLOGY

Cost-effectiveness of Dapagliflozin for the Treatment of Heart Failure With Reduced Ejection Fraction

This economic evaluation examined the cost-effectiveness of adding dapagliflozin to guideline-directed medical therapy for heart failure with reduced ejection fraction in a simulated cohort of patients with or without diabetes.

JAMA Netw Open. 2021;4(7):e2114501. doi:10.1001/jamanetworkopen.2021.14501
Abstract Full Text pdf link PDF

MEDICAL JOURNALS AND PUBLISHING

Gender Disparity in Citations in High-Impact Journal Articles

This cross-sectional study evaluates whether academic articles in high-impact medical journals written by men and women are cited differently.

JAMA Netw Open. 2021;4(7):e2114509. doi:10.1001/jamanetworkopen.2021.14509
Abstract Full Text pdf link PDF

ONCOLOGY

Association of Chemotherapy, Enzalutamide, Abiraterone, and Radium 223 With Cognitive Function in Older Men With Metastatic Castration-Resistant Prostate Cancer

This cohort study examines the association between cognitive function and chemotherapy in older men with metastatic castration-resistant prostate cancer.

JAMA Netw Open. 2021;4(7):e2114694. doi:10.1001/jamanetworkopen.2021.14694
Abstract Full Text pdf link PDF

PEDIATRICS

Prevalence of Headache Days and Disability 3 Years After Participation in the Childhood and Adolescent Migraine Prevention Medication Trial

This survey study assesses migraine prevalence and disability of participants who completed the Childhood and Adolescent Migraine Prevention trial during 3 years of follow-up.

JAMA Netw Open. 2021;4(7):e2114712. doi:10.1001/jamanetworkopen.2021.14712
Abstract Full Text pdf link PDF

HEALTH INFORMATICS

Performance of a Machine Learning Algorithm Using Electronic Health Record Data to Identify and Estimate Survival in a Longitudinal Cohort of Patients With Lung Cancer

This cohort study investigates the performance of a machine learning algorithm used to extract a cohort of patients with lung cancer from electronic health records and estimate overall survival.

JAMA Netw Open. 2021;4(7):e2114723. doi:10.1001/jamanetworkopen.2021.14723
Abstract Full Text pdf link PDF

INFECTIOUS DISEASES

Association of Remdesivir Treatment With Survival and Length of Hospital Stay Among US Veterans Hospitalized With COVID-19

This cohort study assesses the association of remdesivir treatment with 30-day survival and length of hospital stay among US veterans hospitalized with COVID-19 between May and October 2020.

has active quiz
JAMA Netw Open. 2021;4(7):e2114741. doi:10.1001/jamanetworkopen.2021.14741
Abstract Full Text pdf link PDF CME & MOC

ONCOLOGY

Prevalence of Germline Alterations on Targeted Tumor-Normal Sequencing of Esophagogastric Cancer

This genetic association study examines the prevalence of likely pathogenic or pathogenic germline alterations among patients with esophagogastric cancer and assesses associations between germline variant prevalence and demographic and clinicopathologic features.

JAMA Netw Open. 2021;4(7):e2114753. doi:10.1001/jamanetworkopen.2021.14753
Abstract Full Text pdf link PDF

SURGERY

Association of Bariatric Surgery With Vascular Outcomes

This cohort study identifies variables associated with vascular remodeling after bariatric surgery and examines how sex, race, and metabolic status are associated with microvascular and macrovascular outcomes.

JAMA Netw Open. 2021;4(7):e2115267. doi:10.1001/jamanetworkopen.2021.15267
Abstract Full Text pdf link PDF

ONCOLOGY

Comparison of Multimodal Therapies and Outcomes Among Patients With High-Risk Prostate Cancer With Adverse Clinicopathologic Features

This cohort study assesses prostate cancer–specific mortality and distant metastasis outcomes among men with high-risk prostate cancer treated with radical prostatectomy or external beam radiotherapy with or without brachytherapy boost.

JAMA Netw Open. 2021;4(7):e2115312. doi:10.1001/jamanetworkopen.2021.15312
Abstract Full Text pdf link PDF

MEDICAL EDUCATION

Clinical Knowledge and Trends in Physicians' Prescribing of Opioids for New Onset Back Pain, 2009-2017

This cross-sectional study compares the association of clinical knowledge with opioid prescribing from 2009 to 2011 when prescribing peaked nationally with 2015 to 2017 when guidelines shifted away from opioid prescribing.

JAMA Netw Open. 2021;4(7):e2115328. doi:10.1001/jamanetworkopen.2021.15328
Abstract Full Text pdf link PDF

HEALTH INFORMATICS

Length and Redundancy of Outpatient Progress Notes Across a Decade at an Academic Medical Center

This cross-sectional study examines whether author experience and method of note entry are associated with the length and redundancy of progress notes among multiple medical specialties.

JAMA Netw Open. 2021;4(7):e2115334. doi:10.1001/jamanetworkopen.2021.15334
Abstract Full Text pdf link PDF

HEALTH POLICY

Characterization of US Hospital Advertising and Association With Hospital Performance, 2008-2016

This cross-sectional study uses data from the Centers for Medicare & Medicaid Services to assess whether higher-performing hospitals are more likely to advertise their services directly to consumers.

JAMA Netw Open. 2021;4(7):e2115342. doi:10.1001/jamanetworkopen.2021.15342
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Association of the Extension for Community Healthcare Outcomes Project With Use of Direct-Acting Antiviral Treatment Among US Adults With Hepatitis C

This cohort study uses data from Medicare beneficiaries to assess the association between Project ECHO (Extension for Community Healthcare Outcomes) and increased use of hepatitis C virus treatment, particularly in resource-limited areas.

JAMA Netw Open. 2021;4(7):e2115523. doi:10.1001/jamanetworkopen.2021.15523
Abstract Full Text pdf link PDF

OBSTETRICS AND GYNECOLOGY

Association of Travel Distance to Nearest Abortion Facility With Rates of Abortion

This cross-sectional geographic study examines the association between travel distance to the nearest abortion care facility and abortion rate and models the effect of reduced travel distance among US female residents of reproduction age.

JAMA Netw Open. 2021;4(7):e2115530. doi:10.1001/jamanetworkopen.2021.15530
Abstract Full Text pdf link PDF

MEDICAL EDUCATION

Gender Disparity in Evaluation of Internal Medicine Clerkship Performance

This cohort study assesses whether there are gender differences in objective or subjective evaluations of third-year medical students participating in an internal medicine clerkship.

JAMA Netw Open. 2021;4(7):e2115661. doi:10.1001/jamanetworkopen.2021.15661
Abstract Full Text pdf link PDF

ONCOLOGY

Characteristics of Registered Studies of Chimeric Antigen Receptor Therapies: A Systematic Review

This systematic review analyzes the characteristics of registered chimeric antigen receptor–related trials with dual focuses on trial methods and intent.

JAMA Netw Open. 2021;4(7):e2115668. doi:10.1001/jamanetworkopen.2021.15668
Abstract Full Text pdf link PDF

ONCOLOGY

Trends in Patient Volume by Hospital Type and the Association of These Trends With Time to Cancer Treatment Initiation

This cross-sectional study uses data from the National Cancer Database to investigate trends in patient volume by hospital type and the association of patient volume with time to treatment initiation for patients with cancer by hospital type.

JAMA Netw Open. 2021;4(7):e2115675. doi:10.1001/jamanetworkopen.2021.15675
Abstract Full Text pdf link PDF

PSYCHIATRY

Characteristics and Precipitating Circumstances of Suicide Among Children Aged 5 to 11 Years in the United States, 2013-2017

This qualitative study assesses characteristics and precipitating circumstances of suicide among children aged 5 to 11 years in the US.

JAMA Netw Open. 2021;4(7):e2115683. doi:10.1001/jamanetworkopen.2021.15683
Abstract Full Text pdf link PDF

SUBSTANCE USE AND ADDICTION

Feasibility and Acceptability of a Smoking Cessation Program for Individuals Released From an Urban, Pretrial Jail: A Pilot Randomized Clinical Trial

This pilot randomized clinical trial examines the acceptability, feasibility, and preliminary clinical outcomes of a smoking cessation intervention for individuals who are incarcerated in a pretrial, urban jail.

JAMA Netw Open. 2021;4(7):e2115687. doi:10.1001/jamanetworkopen.2021.15687
Abstract Full Text pdf link PDF

INFECTIOUS DISEASES

Seroprevalence of and Risk Factors Associated With SARS-CoV-2 Infection in Health Care Workers During the Early COVID-19 Pandemic in Italy

This cross-sectional study investigates seroprevalence and odds of SARS-CoV-2 infection among health care workers in different professional categories and operational units in Italy.

has active quiz
JAMA Netw Open. 2021;4(7):e2115699. doi:10.1001/jamanetworkopen.2021.15699
Abstract Full Text pdf link PDF CME & MOC

PSYCHIATRY

Development and Validation of Computerized Adaptive Assessment Tools for the Measurement of Posttraumatic Stress Disorder Among US Military Veterans

This diagnostic study develops and validates a tool for use in diagnostic screening of US military veterans for posttraumatic stress disorder.

JAMA Netw Open. 2021;4(7):e2115707. doi:10.1001/jamanetworkopen.2021.15707
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Annual Incidence of Hospitalization for Nonfatal Firearm-Related Injuries in New York From 2005 to 2016

This cross-sectional study uses data from the New York Statewide Planning and Research Cooperative System to assess the annual incidence of hospitalization for nonfatal firearm-related injuries in New York overall and by sex, race/ethnicity, county of residence, and calendar year from 2005 to 2016.

JAMA Netw Open. 2021;4(7):e2115713. doi:10.1001/jamanetworkopen.2021.15713
Abstract Full Text pdf link PDF

HEALTH POLICY

Health Insurance Deductibles and Health Care–Seeking Behaviors in a Consumer-Driven Health Care System With Universal Coverage

This cross-sectional study examines the association between insurance plan deductibles and forgoing of health care, with consideration of socioeconomic factors, in a consumer-driven health care system with universal coverage in Switzerland.

JAMA Netw Open. 2021;4(7):e2115722. doi:10.1001/jamanetworkopen.2021.15722
Abstract Full Text pdf link PDF

NEUROLOGY

Disability-Adjusted Life-Years Associated With Intracerebral Hemorrhage and Secondary Injury

This cohort study examines the association of intracerebral hemorrhage and secondary injury with disability-adjusted life years.

JAMA Netw Open. 2021;4(7):e2115859. doi:10.1001/jamanetworkopen.2021.15859
Abstract Full Text pdf link PDF

HEMATOLOGY

Association Between Measurable Residual Disease in Patients With Intermediate-Risk Acute Myeloid Leukemia and First Remission, Treatment, and Outcomes

This registry-based cohort study investigates postremission treatment choices and outcomes based on dynamic measurable residual disease in adults with intermediate-risk acute myeloid leukemia (AML).

JAMA Netw Open. 2021;4(7):e2115991. doi:10.1001/jamanetworkopen.2021.15991
Abstract Full Text pdf link PDF

PEDIATRICS

Assessment of 2-Year Neurodevelopmental Outcomes in Extremely Preterm Infants Receiving Opioids and Benzodiazepines

This cohort study describes the use of opioids and benzodiazepines in extremely preterm infants during neonatal intensive care unit hospitalization and explores these drugs’ association with neurodevelopmental outcomes at 2 years’ corrected age.

JAMA Netw Open. 2021;4(7):e2115998. doi:10.1001/jamanetworkopen.2021.15998
Abstract Full Text pdf link PDF

CARDIOLOGY

Cost Conversations About Anticoagulation Between Patients With Atrial Fibrillation and Their Clinicians: A Secondary Analysis of a Randomized Clinical Trial

This cohort study, a secondary analysis of a randomized clinical trial, assesses factors contributing to cost conversations about care plans between clinicians and patients with atrial fibrillation.

JAMA Netw Open. 2021;4(7):e2116009. doi:10.1001/jamanetworkopen.2021.16009
Abstract Full Text pdf link PDF

HEALTH POLICY

Characteristics of Deaths Among Individuals in US Immigration and Customs Enforcement Detention Facilities, 2011-2018

This case series described the characteristics of deaths among individuals detained in US Immigration and Customs Enforcement (ICE) facilities from 2011 to 2018.

JAMA Netw Open. 2021;4(7):e2116019. doi:10.1001/jamanetworkopen.2021.16019
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Effect of a Universal Postpartum Nurse Home Visiting Program on Child Maltreatment and Emergency Medical Care at 5 Years of Age: A Randomized Clinical Trial

This randomized clinical trial examines the effect of randomization to the Family Connects program on child maltreatment investigations and emergency medical care through 5 years of age.

JAMA Netw Open. 2021;4(7):e2116024. doi:10.1001/jamanetworkopen.2021.16024
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Public Preferences for Social Distancing Policy Measures to Mitigate the Spread of COVID-19 in Missouri

This survey study evaluates public preferences for social distancing strategies weighed against the hypothetical risk of acquiring COVID-19 and anticipated income loss.

has active quiz
JAMA Netw Open. 2021;4(7):e2116113. doi:10.1001/jamanetworkopen.2021.16113
Abstract Full Text pdf link PDF CME & MOC

ONCOLOGY

Adherence to Follow-up Testing Recommendations in US Veterans Screened for Lung Cancer, 2015-2019

This cohort study examines adherence to follow-up testing recommendations after lung cancer screening among US veterans.

JAMA Netw Open. 2021;4(7):e2116233. doi:10.1001/jamanetworkopen.2021.16233
Abstract Full Text pdf link PDF

ONCOLOGY

Effectiveness and Safety of Apatinib Plus Chemotherapy as Neoadjuvant Treatment for Locally Advanced Gastric Cancer: A Nonrandomized Controlled Trial

This nonrandomized controlled trial evaluates the resection rate, responses, survival, adverse events, and surgical outcomes associated with a drug regimen for locally advanced gastric cancer.

JAMA Netw Open. 2021;4(7):e2116240. doi:10.1001/jamanetworkopen.2021.16240
Abstract Full Text pdf link PDF

ONCOLOGY

Association Between Participation in Clinical Trials and Overall Survival Among Children With Intermediate- or High-risk Neuroblastoma

This cohort study investigates whether participation in a clinical trial is associated with improved survival among children with neuroblastoma and investigates potential recruitment bias of patients in clinical trials.

JAMA Netw Open. 2021;4(7):e2116248. doi:10.1001/jamanetworkopen.2021.16248
Abstract Full Text pdf link PDF

NUTRITION, OBESITY, AND EXERCISE

Effect of Gamification With and Without Financial Incentives to Increase Physical Activity Among Veterans Classified as Having Obesity or Overweight: A Randomized Clinical Trial

This randomized clinical trial examines the effectiveness of gamification with social support, with and without a loss-framed financial incentive, to increase physical activity among veterans with overweight and obesity.

JAMA Netw Open. 2021;4(7):e2116256. doi:10.1001/jamanetworkopen.2021.16256
Abstract Full Text pdf link PDF

HEALTH POLICY

Evaluation of Insurance Coverage and Cancer Stage at Diagnosis Among Low-Income Adults With Renal Cell Carcinoma After Passage of the Patient Protection and Affordable Care Act

This cohort study tests the hypothesis that implementation of the Patient Protection and Affordable Care Act may be associated with increased access to care through expansion of insurance, which may vary based on income, among patients with renal cell carcinoma.

JAMA Netw Open. 2021;4(7):e2116267. doi:10.1001/jamanetworkopen.2021.16267
Abstract Full Text pdf link PDF

ONCOLOGY

Phase-Specific and Lifetime Costs of Multiple Myeloma Among Older Adults in the US

This cohort study examines the costs associated with the prediagnosis, initial care, continuing care, and terminal phases of multiple myeloma in older adults.

JAMA Netw Open. 2021;4(7):e2116357. doi:10.1001/jamanetworkopen.2021.16357
Abstract Full Text pdf link PDF

PEDIATRICS

Exploration of Experiences and Perpetration of Identity-Based Bullying Among Adolescents by Race/Ethnicity and Other Marginalized Identities

This cross-sectional survey study of high school students at 13 public high schools in a large US city examines associations of bullying based on racial/ethnic, gender, and other marginalized identities with outcomes for health, mental health, and violence.

JAMA Netw Open. 2021;4(7):e2116364. doi:10.1001/jamanetworkopen.2021.16364
Abstract Full Text pdf link PDF

NUTRITION, OBESITY, AND EXERCISE

Interventions Using Wearable Physical Activity Trackers Among Adults With Cardiometabolic Conditions: A Systematic Review and Meta-analysis

This systematic review an meta-analysis assesses the association of interventions using wearable physical activity tracking devices with physical activity levels and other health outcomes among adults with cardiometabolic conditions.

JAMA Netw Open. 2021;4(7):e2116382. doi:10.1001/jamanetworkopen.2021.16382
Abstract Full Text pdf link PDF

ONCOLOGY

Association of Concomitant Bone Resorption Inhibitors With Overall Survival Among Patients With Metastatic Castration-Resistant Prostate Cancer and Bone Metastases Receiving Abiraterone Acetate With Prednisone as First-Line Therapy

This cohort study examines whether the addition of bone resorption inhibitors is associated with improvements in overall survival and skeletal-related events among patients with metastatic castration-resistant prostate cancer receiving abiraterone acetate with prednisone as first-line therapy.

JAMA Netw Open. 2021;4(7):e2116536. doi:10.1001/jamanetworkopen.2021.16536
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Association Between COVID-19 Exposure and Self-reported Compliance With Public Health Guidelines Among Essential Employees at an Institution of Higher Education in the US

This cross-sectional study evaluates self-reported behaviors and cases of SARS-CoV-2 infection among essential in-person employees during the first 6 months of the COVID-19 pandemic at a US institution of higher education.

has active quiz
JAMA Netw Open. 2021;4(7):e2116543. doi:10.1001/jamanetworkopen.2021.16543
Abstract Full Text pdf link PDF CME & MOC

SUBSTANCE USE AND ADDICTION

Compliance With Cannabis Act Regulations Regarding Online Promotion Among Canadian Commercial Cannabis-Licensed Firms

This cross-sectional study evaluates compliance among licensed firms in Canada to the Cannabis Act and analyzes trends among violations regarding promotional material.

JAMA Netw Open. 2021;4(7):e2116551. doi:10.1001/jamanetworkopen.2021.16551
Abstract Full Text pdf link PDF

INFECTIOUS DISEASES

Effectiveness of a Multicomponent Intervention to Reduce Multidrug-Resistant Organisms in Nursing Homes: A Cluster Randomized Clinical Trial

This cluster randomized clinical trial examines the effectiveness of a multicomponent infection prevention intervention for multidrug resistant organisms in nursing homes.

JAMA Netw Open. 2021;4(7):e2116555. doi:10.1001/jamanetworkopen.2021.16555
Abstract Full Text pdf link PDF

CARDIOLOGY

Long-term Outcomes Associated With Permanent Pacemaker Implantation After Surgical Aortic Valve Replacement

This cohort study investigates the association of long-term adverse clinical outcomes, including mortality, with permanent pacemaker implantation after surgical aortic valve replacement.

JAMA Netw Open. 2021;4(7):e2116564. doi:10.1001/jamanetworkopen.2021.16564
Abstract Full Text pdf link PDF

NEPHROLOGY

Estimated SARS-CoV-2 Seroprevalence in US Patients Receiving Dialysis 1 Year After the Beginning of the COVID-19 Pandemic

This cross-sectional study uses data from a dialysis organization in the US to assess the seroprevalence of SARS-CoV-2 antibodies among patients receiving dialysis and to estimate the seroprevalence among the adult population 1 year into the COVID-19 pandemic.

has active quiz
JAMA Netw Open. 2021;4(7):e2116572. doi:10.1001/jamanetworkopen.2021.16572
Abstract Full Text pdf link PDF CME & MOC

PEDIATRICS

Association of Early Antibiotic Exposure With Childhood Body Mass Index Trajectory Milestones

This cohort study uses data from the National Patient-Centered Clinical Research Network (PCORnet) Antibiotics Childhood Growth Study to examine the association of antibiotic use during the first 4 years of life and body mass index trajectory milestones during childhood in a large cohort of children.

JAMA Netw Open. 2021;4(7):e2116581. doi:10.1001/jamanetworkopen.2021.16581
Abstract Full Text pdf link PDF

PSYCHIATRY

Electroconvulsive Therapy and the Risk of Suicide in Hospitalized Patients With Major Depressive Disorder

This cohort study uses data from the Swedish National Quality Register to investigate the association of electroconvulsive therapy with suicide risk in hospitalized patients diagnosed with major depressive disorder.

JAMA Netw Open. 2021;4(7):e2116589. doi:10.1001/jamanetworkopen.2021.16589
Abstract Full Text pdf link PDF

DIABETES AND ENDOCRINOLOGY

Effectiveness of Combining Antiobesity Medication With an Employer-Based Weight Management Program for Treatment of Obesity: A Randomized Clinical Trial

This randomized clinical trial examines whether access to antiobesity medication combined with participation in a real-world, employer-based weight management program achieves clinically meaningful and superior weight loss compared with participation in the weight loss program alone among adults with obesity.

JAMA Netw Open. 2021;4(7):e2116595. doi:10.1001/jamanetworkopen.2021.16595
Abstract Full Text pdf link PDF

NEUROLOGY

Genetic Variants Associated With Intraparenchymal Hemorrhage Progression After Traumatic Brain Injury

This genetic association study examines the association of DNA sequence variability in ABCC8 and TRPM4 with intraparenchymal hemorrhage progression in patients with severe traumatic brain injury (TBI).

JAMA Netw Open. 2021;4(7):e2116839. doi:10.1001/jamanetworkopen.2021.16839
Abstract Full Text pdf link PDF

PSYCHIATRY

Assessment of Somatosensory Function and Self-harm in Adolescents

This cross-sectional study assesses somatosensory function in adolescents and compares their somatosensory profiles with community control participants to investigate associations with the incidence and frequency of self-harm.

JAMA Netw Open. 2021;4(7):e2116853. doi:10.1001/jamanetworkopen.2021.16853
Abstract Full Text pdf link PDF

SUBSTANCE USE AND ADDICTION

Changes in Initial Opioid Prescribing Practices After the 2016 Release of the CDC Guideline for Prescribing Opioids for Chronic Pain

This cohort examines trends in opioid prescribing for patients who were opioid naive before and after the release of prescribing guidelines by the Centers for Disease Control and Prevention (CDC).

JAMA Netw Open. 2021;4(7):e2116860. doi:10.1001/jamanetworkopen.2021.16860
Abstract Full Text pdf link PDF

HEALTH INFORMATICS

Clinical Characterization and Prediction of Clinical Severity of SARS-CoV-2 Infection Among US Adults Using Data From the US National COVID Cohort Collaborative

This cohort study evaluates COVID-19 severity and factors associated with severity over time and assesses the use of machine learning to predict clinical severity.

has active quiz
JAMA Netw Open. 2021;4(7):e2116901. doi:10.1001/jamanetworkopen.2021.16901
Abstract Full Text pdf link PDF CME & MOC

PHARMACY AND CLINICAL PHARMACOLOGY

Personal Formularies of Primary Care Physicians Across 4 Health Care Systems

This cohort study examines how primary care physicians’ personal formularies differ at 4 institutions; evaluates associations between personal formularies and patient, physician, and practice site characteristics; and examines the variability of the top 200 core drugs prescribed at the 4 sites.

JAMA Netw Open. 2021;4(7):e2117038. doi:10.1001/jamanetworkopen.2021.17038
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Assessment of COVID-19–Related Immigration Concerns Among Latinx Immigrants in the US

This cross-sectional survey study examines the proportion of adult Latinx immigrants in the US who endorse statements about the immigration ramifications of engaging in COVID-19–related testing, treatment, and contact tracing.

has active quiz
JAMA Netw Open. 2021;4(7):e2117049. doi:10.1001/jamanetworkopen.2021.17049
Abstract Full Text pdf link PDF CME & MOC

ETHICS

Physician Use of Stigmatizing Language in Patient Medical Records

This qualitative study examines both negative and positive attitudes expressed by physicians about patients in electronic medical records.

JAMA Netw Open. 2021;4(7):e2117052. doi:10.1001/jamanetworkopen.2021.17052
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Characterization of Respiratory Symptoms Among Youth Using Heated Tobacco Products in Hong Kong

This cross-sectional study investigates associations of persistent respiratory symptoms with heated tobacco product use, cigarette use, and dual use among youth in Hong Kong.

JAMA Netw Open. 2021;4(7):e2117055. doi:10.1001/jamanetworkopen.2021.17055
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Association of Socioeconomic Characteristics With Disparities in COVID-19 Outcomes in Japan

This cross-sectional study examines the association of socioeconomic characteristics with COVID-19 incidence and mortality in Japanese prefectures.

has active quiz
JAMA Netw Open. 2021;4(7):e2117060. doi:10.1001/jamanetworkopen.2021.17060
Abstract Full Text pdf link PDF CME & MOC

PUBLIC HEALTH

Association Between Structural Housing Repairs for Low-Income Homeowners and Neighborhood Crime

This cross-sectional study examines the association between a housing renewal grant program implemented in socially disadvantaged, racially segregated communities in Philadelphia, Pennsylvania, and neighborhood crime.

JAMA Netw Open. 2021;4(7):e2117067. doi:10.1001/jamanetworkopen.2021.17067
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Black and Latinx Community Perspectives on COVID-19 Mitigation Behaviors, Testing, and Vaccines

This qualitative study explores the experiences of Black and Latinx communities during the pandemic to better understand their perspectives on COVID-19 mitigation behaviors (eg, mask wearing), testing, and vaccines.

has active quiz
JAMA Netw Open. 2021;4(7):e2117074. doi:10.1001/jamanetworkopen.2021.17074
Abstract Full Text pdf link PDF CME & MOC

INFECTIOUS DISEASES

Effect of Physician-Delivered COVID-19 Public Health Messages and Messages Acknowledging Racial Inequity on Black and White Adults’ Knowledge, Beliefs, and Practices Related to COVID-19: A Randomized Clinical Trial

This randomized clinical trial evaluates whether messages delivered by physicians improve COVID-19 knowledge and preventive behaviors and assesses the differential effectiveness of messages tailored to the Black community.

has active quiz
JAMA Netw Open. 2021;4(7):e2117115. doi:10.1001/jamanetworkopen.2021.17115
Abstract Full Text pdf link PDF CME & MOC

SUBSTANCE USE AND ADDICTION

High-Dose Buprenorphine Induction in the Emergency Department for Treatment of Opioid Use Disorder

This case series examines the safety and tolerability of high-dose (>12 mg) buprenorphine induction in the emergency department (ED) for treatment of opioid use disorder.

JAMA Netw Open. 2021;4(7):e2117128. doi:10.1001/jamanetworkopen.2021.17128
Abstract Full Text pdf link PDF

HEALTH INFORMATICS

Development and Validation of an Artificial Intelligence System to Optimize Clinician Review of Patient Records

This prognostic study evaluates the utility of and potential time savings, accuracy, and user experience associated with an artificial intelligence–optimized electronic health record tested by 12 gastroenterologists.

JAMA Netw Open. 2021;4(7):e2117391. doi:10.1001/jamanetworkopen.2021.17391
Abstract Full Text pdf link PDF

NEUROLOGY

Changes in Health-Related Quality of Life After Transient Ischemic Attack

This cohort study investigates changes in patient-reported global health as measured before vs after transient ischemic attack.

JAMA Netw Open. 2021;4(7):e2117403. doi:10.1001/jamanetworkopen.2021.17403
Abstract Full Text pdf link PDF

OBSTETRICS AND GYNECOLOGY

Association of Elevated Maternal Serum Total Bile Acids With Low Birth Weight and Intrauterine Fetal Growth Restriction

This cohort study investigates the association between maternal serum total bile acid concentrations during pregnancy and the risk of intrauterine growth restriction.

JAMA Netw Open. 2021;4(7):e2117409. doi:10.1001/jamanetworkopen.2021.17409
Abstract Full Text pdf link PDF

OPHTHALMOLOGY

Association of Vision Impairment With Cognitive Decline Across Multiple Domains in Older Adults

This cohort study examines the association between visual and cognitive impairments across multiple cognitive domains using multiple measures of vision.

JAMA Netw Open. 2021;4(7):e2117416. doi:10.1001/jamanetworkopen.2021.17416
Abstract Full Text pdf link PDF

SURGERY

High-Intensity vs Low-Intensity Knowledge Translation Interventions for Surgeons and Their Association With Process and Outcome Measures Among Patients Undergoing Rectal Cancer Surgery

This quality improvement study uses administrative patient data from 14 regions in Ontario, Canada, to evaluate the association of sustained, iterative, integrated knowledge translation interventions for rectal cancer surgery directed at all surgeons in a geographic region with process and outcome measures among patients undergoing rectal cancer surgery.

JAMA Netw Open. 2021;4(7):e2117536. doi:10.1001/jamanetworkopen.2021.17536
Abstract Full Text pdf link PDF

PEDIATRICS

Association Between Intravenous Magnesium Therapy in the Emergency Department and Subsequent Hospitalization Among Pediatric Patients With Refractory Acute Asthma: Secondary Analysis of a Randomized Clinical Trial

This cohort study assesses the association between intravenous magnesium therapy administered in the emergency department and subsequent hospitalization among pediatric patients with refractory acute asthma in Canada.

JAMA Netw Open. 2021;4(7):e2117542. doi:10.1001/jamanetworkopen.2021.17542
Abstract Full Text pdf link PDF

ONCOLOGY

Correlation Between Surrogate End Points and Overall Survival in a Multi-institutional Clinicogenomic Cohort of Patients With Non–Small Cell Lung or Colorectal Cancer

This cohort study measures associations between candidate surrogate end points and overall survival in a multi-institutional clinicogenomic data set of patients with non–small cell lung cancer (NSCLC) or colorectal cancer.

JAMA Netw Open. 2021;4(7):e2117547. doi:10.1001/jamanetworkopen.2021.17547
Abstract Full Text pdf link PDF

ONCOLOGY

Time Trends in Colorectal Cancer Incidence Rates by Income and Age at Diagnosis in Canada From 1992 to 2016

This cohort study examines changes in the incidence of colorectal cancer from 1992 to 2016 in individuals in Canada by age group and income quintile.

JAMA Netw Open. 2021;4(7):e2117556. doi:10.1001/jamanetworkopen.2021.17556
Abstract Full Text pdf link PDF

NEUROLOGY

Association of Sleep and β-Amyloid Pathology Among Older Cognitively Unimpaired Adults

This cross-sectional study evaluates the associations between daytime and nighttime sleep duration with regional β-amyloid pathology in older cognitively unimpaired adults.

JAMA Netw Open. 2021;4(7):e2117573. doi:10.1001/jamanetworkopen.2021.17573
Abstract Full Text pdf link PDF

ORTHOPEDICS

Assessment of Racial Disparities in the Risks of Septic and Aseptic Revision Total Knee Replacements

This cohort study assesses the risk of septic and aseptic revision total knee replacement in Black and White patients and examines interactions among race and socioeconomic and hospital-related variables associated with revision risk.

JAMA Netw Open. 2021;4(7):e2117581. doi:10.1001/jamanetworkopen.2021.17581
Abstract Full Text pdf link PDF

EMERGENCY MEDICINE

Comparison of HIV Screening Strategies in the Emergency Department: A Randomized Clinical Trial

This randomized clinical trial examines 76 561 emergency department patient visits to compare effectiveness of targeted and nontargeted HIV screening strategies for finding new diagnoses.

JAMA Netw Open. 2021;4(7):e2117763. doi:10.1001/jamanetworkopen.2021.17763
Abstract Full Text pdf link PDF

MEDICAL EDUCATION

Public Perceptions of Physician Attire and Professionalism in the US

This survey study uses data from a national survey of US adults to investigate perceptions of physician professionalism based on attire and whether gender biases exist.

JAMA Netw Open. 2021;4(7):e2117779. doi:10.1001/jamanetworkopen.2021.17779
Abstract Full Text pdf link PDF

HEALTH POLICY

Assessment of the Financial Health of Rural Hospitals After Implementation of the Georgia Rural Hospital Tax Credit Program

This cross-sectional study examines the association of Georgia’s Rural Hospital Tax Credit Program with the financial health of participating rural hospitals.

JAMA Netw Open. 2021;4(7):e2117791. doi:10.1001/jamanetworkopen.2021.17791
Abstract Full Text pdf link PDF

HEALTH INFORMATICS

Evaluation of a Clinical Decision Support Strategy to Increase Seasonal Influenza Vaccination Among Hospitalized Children Before Inpatient Discharge

This quality improvement study evaluates a clinical decision support strategy to increase the proportion of eligible hospitalized children who receive a seasonal influenza vaccine prior to inpatient discharge.

JAMA Netw Open. 2021;4(7):e2117809. doi:10.1001/jamanetworkopen.2021.17809
Abstract Full Text pdf link PDF

PEDIATRICS

Identifying Conditions With High Prevalence, Cost, and Variation in Cost in US Children’s Hospitals

This cohort study examines prevalence, cost, and variation in cost of hospitalizations in US pediatric hospitals.

JAMA Netw Open. 2021;4(7):e2117816. doi:10.1001/jamanetworkopen.2021.17816
Abstract Full Text pdf link PDF

HEALTH POLICY

Using Consistently Low Performance to Identify Low-Quality Physician Groups

This cross-sectional study assesses the use of consistently low performance scores for physician groups across multiple performance measures and over multiple years to identify low-quality physician groups.

JAMA Netw Open. 2021;4(7):e2117954. doi:10.1001/jamanetworkopen.2021.17954
Abstract Full Text pdf link PDF

CARDIOLOGY

Assessment of North American Clinical Research Site Performance During the Start-up of Large Cardiovascular Clinical Trials

This cohort study uses data from 9 randomized clinical cardiovascular trials to assess the start-up times of various milestones for North American research sites and how these metrics vary by time and regulatory process.

JAMA Netw Open. 2021;4(7):e2117963. doi:10.1001/jamanetworkopen.2021.17963
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Perceptions of Diseases of Despair by Members of Rural and Urban High-Prevalence Communities: A Qualitative Study

This qualitative study explores the perceptions of people residing in rural and urban areas with high prevalence of diseases of despair regarding potential causes and intervention strategies.

JAMA Netw Open. 2021;4(7):e2118134. doi:10.1001/jamanetworkopen.2021.18134
Abstract Full Text pdf link PDF

CARDIOLOGY

Comparison of Long-term Outcomes of Valve-Sparing and Transannular Patch Procedures for Correction of Tetralogy of Fallot

This cohort study compares the long-term outcomes associated with valve-sparing procedures vs transannular patches for correction of tetralogy of Fallot.

JAMA Netw Open. 2021;4(7):e2118141. doi:10.1001/jamanetworkopen.2021.18141
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Health Care Utilization Before and After the “Muslim Ban” Executive Order Among People Born in Muslim-Majority Countries and Living in the US

This cohort study investigates the association between health care utilization and the so-called Muslim ban executive order for people born in Muslim-majority countries and living in Minneapolis-St. Paul, Minnesota.

JAMA Netw Open. 2021;4(7):e2118216. doi:10.1001/jamanetworkopen.2021.18216
Abstract Full Text pdf link PDF

SUBSTANCE USE AND ADDICTION

Methadone Access for Opioid Use Disorder During the COVID-19 Pandemic Within the United States and Canada

This cross-sectional study examines the proportion of clinics accepting new patients with opioid use disorder and time until first appointment in the US and Canada.

has active quiz
JAMA Netw Open. 2021;4(7):e2118223. doi:10.1001/jamanetworkopen.2021.18223
Abstract Full Text pdf link PDF CME & MOC

HEALTH POLICY

Individual- and Institutional-level Concerns of Health Care Workers in Canada During the COVID-19 Pandemic: A Qualitative Analysis

This qualitative analysis uses an online COVID-19 forum available to employees at a large health care institution to examine sources of distress and concern for health care workers in Canada during the COVID-19 pandemic.

has active quiz
JAMA Netw Open. 2021;4(7):e2118425. doi:10.1001/jamanetworkopen.2021.18425
Abstract Full Text pdf link PDF CME & MOC

ONCOLOGY

Cancer Clinical Trial Participation at the 1-Year Anniversary of the Outbreak of the COVID-19 Pandemic

This cohort study examines the experience of cancer clinical trial enrollment 1 year after the COVID-19 outbreak.

has active quiz
JAMA Netw Open. 2021;4(7):e2118433. doi:10.1001/jamanetworkopen.2021.18433
Abstract Full Text pdf link PDF CME & MOC

GASTROENTEROLOGY AND HEPATOLOGY

Global Incidence and Mortality of Gastric Cancer, 1980-2018

This cohort study uses data from national and global cancer registries to evaluate the incidence and mortality of gastric cancer between 1980 and 2018 and compares the global incidence between younger and older populations.

JAMA Netw Open. 2021;4(7):e2118457. doi:10.1001/jamanetworkopen.2021.18457
Abstract Full Text pdf link PDF

ONCOLOGY

Effect of Bevacizumab in Combination With Standard Oxaliplatin-Based Regimens in Patients With Metastatic Colorectal Cancer: A Randomized Clinical Trial

This randomized clinical trial compares outcomes of concomitant and sequential administration of bevacizumab in combination with standard oxaliplatin-based regimens in untreated or single line–treated patients with metastatic colorectal cancer.

JAMA Netw Open. 2021;4(7):e2118475. doi:10.1001/jamanetworkopen.2021.18475
Abstract Full Text pdf link PDF

HEALTH POLICY

Evaluation of a Chronic Pain Screening Program Implemented in Primary Care

This cross-sectional study evaluated a 2-item tool used to assess patients’ pain and its interference with activities of daily living in a primary care setting.

JAMA Netw Open. 2021;4(7):e2118495. doi:10.1001/jamanetworkopen.2021.18495
Abstract Full Text pdf link PDF

ONCOLOGY

Seroprevalence of Measles and Mumps Antibodies Among Individuals With Cancer

This cross-sectional study examines serological test results for protective antibodies for measles and mumps among patients with hematologic malignant neoplasm or solid tumors.

JAMA Netw Open. 2021;4(7):e2118508. doi:10.1001/jamanetworkopen.2021.18508
Abstract Full Text pdf link PDF

PSYCHIATRY

Cost-effectiveness of Internet-Delivered vs In-Person Cognitive Behavioral Therapy for Children and Adolescents With Obsessive-Compulsive Disorder

This economic evaluation assesses the cost-effectiveness of guided internet-delivered cognitive behavioral therapy implemented within a stepped-care model compared with in-person cognitive behavioral therapy for young people with obsessive-compulsive disorder.

JAMA Netw Open. 2021;4(7):e2118516. doi:10.1001/jamanetworkopen.2021.18516
Abstract Full Text pdf link PDF

ONCOLOGY

Prevalence of Hashimoto Thyroiditis in Adults With Papillary Thyroid Cancer and Its Association With Cancer Recurrence and Outcomes

his cohort study assesses the prevalence of and outcomes associated with Hashimoto thyroiditis among adults with papillary thyroid cancer.

JAMA Netw Open. 2021;4(7):e2118526. doi:10.1001/jamanetworkopen.2021.18526
Abstract Full Text pdf link PDF

CARDIOLOGY

Evaluation of Sudden Cardiac Arrest by Race/Ethnicity Among Residents of Ventura County, California, 2015-2020

This cohort study examines the incidence of sudden cardiac arrest and risk factors by race/ethnicity in residents of Ventura County, California.

JAMA Netw Open. 2021;4(7):e2118537. doi:10.1001/jamanetworkopen.2021.18537
Abstract Full Text pdf link PDF

INFECTIOUS DISEASES

Serologic Surveillance and Phylogenetic Analysis of SARS-CoV-2 Infection Among Hospital Health Care Workers

This cohort study investigates prevalence and transmission routes of SARS-CoV-2 infection among hospital health care workers in the Netherlands using serologic surveillance and phylogenetic and epidemiological analyses.

has active quiz
JAMA Netw Open. 2021;4(7):e2118554. doi:10.1001/jamanetworkopen.2021.18554
Abstract Full Text pdf link PDF CME & MOC

GASTROENTEROLOGY AND HEPATOLOGY

Assessment of Video Capsule Endoscopy in the Management of Acute Gastrointestinal Bleeding During the COVID-19 Pandemic

This cohort study examines the use of video capsule endoscopy vs standard invasive diagnostic procedures to evaluate gastrointestinal (GI) bleeding in patients with COVID-19.

has active quiz
JAMA Netw Open. 2021;4(7):e2118796. doi:10.1001/jamanetworkopen.2021.18796
Abstract Full Text pdf link PDF CME & MOC

EMERGENCY MEDICINE

Patient Preference and Risk Assessment in Opioid Prescribing Disparities: A Secondary Analysis of a Randomized Clinical Trial

This secondary analysis of data from a randomized clinical trial characterizes racial disparities in opioid prescribing and examines whether a clinician intervention describing patient treatment preference and risk of opioid misuse was able to mitigate disparities among patients with acute pain.

JAMA Netw Open. 2021;4(7):e2118801. doi:10.1001/jamanetworkopen.2021.18801
Abstract Full Text pdf link PDF

DIABETES AND ENDOCRINOLOGY

Association of Insulin Resistance and Type 2 Diabetes With Gut Microbial Diversity: A Microbiome-Wide Analysis From Population Studies

This cross-sectional study assesses whether gut microbial taxa play a role in the development of type 2 diabetes using data from 2 Dutch population-based prospective cohorts.

JAMA Netw Open. 2021;4(7):e2118811. doi:10.1001/jamanetworkopen.2021.18811
Abstract Full Text pdf link PDF

NEUROLOGY

Assessment of Trends in Guideline-Based Oral Anticoagulant Prescription for Patients With Ischemic Stroke and Atrial Fibrillation in China

This quality improvement study assesses adherence to guideline-recommended oral anticoagulants, the temporal improvement in adherence, and the risk factors associated with oral anticoagulant prescriptions.

JAMA Netw Open. 2021;4(7):e2118816. doi:10.1001/jamanetworkopen.2021.18816
Abstract Full Text pdf link PDF

PEDIATRICS

Association Between Periconceptional Weight of Maternal Grandmothers and Attention-Deficit/Hyperactivity Disorder in Grandchildren

This cohort study analyzes data from mother-daughter dyad participants in the Nurses’ Health Study II to assess whether a woman’s weight before or during pregnancy is associated with attention-deficit/hyperactivity disorder (ADHD) in grandchildren.

JAMA Netw Open. 2021;4(7):e2118824. doi:10.1001/jamanetworkopen.2021.18824
Abstract Full Text pdf link PDF

STATISTICS AND RESEARCH METHODS

Clinician Conceptualization of the Benefits of Treatments for Individual Patients

This survey study explores clinicians’ conceptualizations of the chance that treatments will decrease the risk of disease outcomes for individual hypothetical patients.

JAMA Netw Open. 2021;4(7):e2119747. doi:10.1001/jamanetworkopen.2021.19747
Abstract Full Text pdf link PDF

HEMATOLOGY

Comparison of Hepatotoxicity Associated With New BCR-ABL Tyrosine Kinase Inhibitors vs Imatinib Among Patients With Chronic Myeloid Leukemia: A Systematic Review and Meta-analysis

This systematic review and meta-analysis examines the relative risk of hepatotoxicity of new-generation BCR-ABL fusion oncoprotein tyrosine kinase inhibitors (TKIs) vs imatinib among patients with chronic myeloid leukemia.

JAMA Netw Open. 2021;4(7):e2120165. doi:10.1001/jamanetworkopen.2021.20165
Abstract Full Text pdf link PDF
open access Consensus Statement

GLOBAL HEALTH

Guidance for Health Care Leaders During the Recovery Stage of the COVID-19 Pandemic: A Consensus Statement

This consensus statement coauthored by worldwide leaders in health care–related fields outlines imperatives of leadership important to adapting to the recovery stage of the COVID-19 pandemic.

JAMA Netw Open. 2021;4(7):e2120295. doi:10.1001/jamanetworkopen.2021.20295
Abstract Full Text pdf link PDF
open access Editorial

Cost Conversations About Atrial Fibrillation Care—Who Is Talking the Talk?

JAMA Netw Open. 2021;4(7):e2116670. doi:10.1001/jamanetworkopen.2021.16670
Abstract Full Text pdf link PDF
open access Invited Commentary

NEUROLOGY

Inclusion of Underrepresented Groups in Preclinical Alzheimer Disease Trials—Opportunities Abound

JAMA Netw Open. 2021;4(7):e2114606. doi:10.1001/jamanetworkopen.2021.14606
Abstract Full Text pdf link PDF

COMPLEMENTARY AND ALTERNATIVE MEDICINE

East or West—Manual Therapy As a Viable Nonpharmacologic Option for Chronic Neck Pain

JAMA Netw Open. 2021;4(7):e2114784. doi:10.1001/jamanetworkopen.2021.14784
Abstract Full Text pdf link PDF

PEDIATRICS

Weighing the Unintended Consequences of Early Dental Care in Indigenous Australian Children

JAMA Netw Open. 2021;4(7):e2114786. doi:10.1001/jamanetworkopen.2021.14786
Abstract Full Text pdf link PDF

MEDICAL JOURNALS AND PUBLISHING

Gender Disparities in Journal Citations—Another Metric of Inequity in Academia

JAMA Netw Open. 2021;4(7):e2114787. doi:10.1001/jamanetworkopen.2021.14787
Abstract Full Text pdf link PDF

PEDIATRICS

Implications of 3-Year Follow-up Data From the Childhood and Adolescent Migraine Prevention Medication Trial

JAMA Netw Open. 2021;4(7):e2114788. doi:10.1001/jamanetworkopen.2021.14788
Abstract Full Text pdf link PDF

ONCOLOGY

Expanding Germline Testing to All Patients With Esophagogastric Cancers—Easy to Do, Harder to Justify

JAMA Netw Open. 2021;4(7):e2114789. doi:10.1001/jamanetworkopen.2021.14789
Abstract Full Text pdf link PDF

ONCOLOGY

Can the Health Care System Manage Increased Workloads From Expanded Access to Cancer Treatment?

JAMA Netw Open. 2021;4(7):e2115763. doi:10.1001/jamanetworkopen.2021.15763
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Using State Hospitalization Databases to Improve Firearm Injury Data—A Step in the Right Direction

JAMA Netw Open. 2021;4(7):e2115807. doi:10.1001/jamanetworkopen.2021.15807
Abstract Full Text pdf link PDF

INFECTIOUS DISEASES

Remdesivir Use and Hospital Length of Stay—The Paradox of a Clinical Trial vs Real-Life Use

JAMA Netw Open. 2021;4(7):e2116057. doi:10.1001/jamanetworkopen.2021.16057
Abstract Full Text pdf link PDF

HEALTH INFORMATICS

Progress in the Application of Machine Learning Algorithms to Cancer Research and Care

JAMA Netw Open. 2021;4(7):e2116063. doi:10.1001/jamanetworkopen.2021.16063
Abstract Full Text pdf link PDF

NUTRITION, OBESITY, AND EXERCISE

Integrated Physical Activity Campaign With Wearable Devices and Practitioner Consultation

JAMA Netw Open. 2021;4(7):e2116671. doi:10.1001/jamanetworkopen.2021.16671
Abstract Full Text pdf link PDF

PSYCHIATRY

Benefits of Electroconvulsive Therapy for Patients With Major Depressive Disorder

JAMA Netw Open. 2021;4(7):e2116674. doi:10.1001/jamanetworkopen.2021.16674
Abstract Full Text pdf link PDF

ONCOLOGY

Use of Bone Resorption Inhibitors in Metastatic Castration-Resistant Prostate Cancer—20 Years Later, and the Answer Is Still Yes

JAMA Netw Open. 2021;4(7):e2117159. doi:10.1001/jamanetworkopen.2021.17159
Abstract Full Text pdf link PDF

HEALTH INFORMATICS

Aggregating Electronic Health Record Data for COVID-19 Research—Caveat Emptor

JAMA Netw Open. 2021;4(7):e2117175. doi:10.1001/jamanetworkopen.2021.17175
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Housing Repair and Crime—Investment at a Small Scale for a Potential Big Impact

JAMA Netw Open. 2021;4(7):e2117624. doi:10.1001/jamanetworkopen.2021.17624
Abstract Full Text pdf link PDF

ONCOLOGY

Assessing Clinical Outcomes in a Data-Rich World—A Reality Check on Real-World Data

JAMA Netw Open. 2021;4(7):e2117826. doi:10.1001/jamanetworkopen.2021.17826
Abstract Full Text pdf link PDF

PEDIATRICS

Exploration of Identity-Based Bullying by Race/Ethnicity and Other Marginalized Identities Among Adolescents

JAMA Netw Open. 2021;4(7):e2117827. doi:10.1001/jamanetworkopen.2021.17827
Abstract Full Text pdf link PDF

CARDIOLOGY

Reconfiguring the Cardiovascular Clinical Trial Enterprise in the United States

JAMA Netw Open. 2021;4(7):e2118176. doi:10.1001/jamanetworkopen.2021.18176
Abstract Full Text pdf link PDF

INFECTIOUS DISEASES

Physician-Delivered Messaging as a Tool to Increase COVID-19 Knowledge and Preventive Behaviors—Implications Beyond a Pandemic

JAMA Netw Open. 2021;4(7):e2118297. doi:10.1001/jamanetworkopen.2021.18297
Abstract Full Text pdf link PDF

HEALTH INFORMATICS

Using Artificial Intelligence to Make Use of Electronic Health Records Less Painful—Fighting Fire With Fire

JAMA Netw Open. 2021;4(7):e2118298. doi:10.1001/jamanetworkopen.2021.18298
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Anti-Immigrant Rhetoric and Policy as Manifestations of Structural Racism—Implications for Advancing Health Equity

JAMA Netw Open. 2021;4(7):e2118299. doi:10.1001/jamanetworkopen.2021.18299
Abstract Full Text pdf link PDF

NEUROLOGY

Finding a Place for Candidate Gene Studies in a Genome-Wide Association Study World

JAMA Netw Open. 2021;4(7):e2118594. doi:10.1001/jamanetworkopen.2021.18594
Abstract Full Text pdf link PDF

OPHTHALMOLOGY

Beyond Visual Acuity—A Comprehensive Assessment of Vision and Cognition in Older Adults With Visual Impairment

JAMA Netw Open. 2021;4(7):e2119033. doi:10.1001/jamanetworkopen.2021.19033
Abstract Full Text pdf link PDF

INFECTIOUS DISEASES

Post-acute Sequelae of SARS-CoV-2 Infection and Subjective Memory Problems

JAMA Netw Open. 2021;4(7):e2119335. doi:10.1001/jamanetworkopen.2021.19335
Abstract Full Text pdf link PDF

SURGERY

High-Intensity vs Low-Intensity Knowledge Translation and Performance Metrics in Patients With Rectal Cancer

JAMA Netw Open. 2021;4(7):e2119393. doi:10.1001/jamanetworkopen.2021.19393
Abstract Full Text pdf link PDF

MEDICAL EDUCATION

Has the Physician’s White Coat Seen Its Day?

JAMA Netw Open. 2021;4(7):e2119881. doi:10.1001/jamanetworkopen.2021.19881
Abstract Full Text pdf link PDF
open access Research Letter

ONCOLOGY

Risk Stratification for Imminent Risk of Death at the Time of Palliative Radiotherapy Consultation

This cohort study of patients with advanced cancer who received palliative radiotherapy within 30 days of death assesses models of prognostic criteria for providing radiotherapy at the end of life and compares outcomes with similar prognostic tools.

JAMA Netw Open. 2021;4(7):e2115641. doi:10.1001/jamanetworkopen.2021.15641
Abstract Full Text pdf link PDF

PUBLIC HEALTH

Evaluation of Health Equity in COVID-19 Vaccine Distribution Plans in the United States

This cross-sectional study evaluates measures of health equity in COVID-19 vaccination plans in the 50 US states and Washington, DC.

has active quiz
JAMA Netw Open. 2021;4(7):e2115653. doi:10.1001/jamanetworkopen.2021.15653
Abstract Full Text pdf link PDF CME & MOC

INFECTIOUS DISEASES

Assessment of Prolonged Physiological and Behavioral Changes Associated With COVID-19 Infection

This cohort study examines the duration and variation of recovery among COVID-19–positive verses COVID-19–negative individuals.

has active quiz
JAMA Netw Open. 2021;4(7):e2115959. doi:10.1001/jamanetworkopen.2021.15959
Abstract Full Text pdf link PDF CME & MOC

PHYSICAL MEDICINE AND REHABILITATION

Association of Chronic Pain With Participation in Motor Skill Activities in Children With Cerebral Palsy

This cross-sectional study examines the association between pain and activities requiring motor skill performance among a nationally representative sample of US children with cerebral palsy.

JAMA Netw Open. 2021;4(7):e2115970. doi:10.1001/jamanetworkopen.2021.15970
Abstract Full Text pdf link PDF

INFECTIOUS DISEASES

Asymptomatic and Symptomatic COVID-19 Infections Among Health Care Personnel Before and After Vaccination

This cohort study investigates asymptomatic and symptomatic COVID-19 case rates before and after the initial vaccine rollout among health care personnel in Orange County, California.

has active quiz
JAMA Netw Open. 2021;4(7):e2115980. doi:10.1001/jamanetworkopen.2021.15980
Abstract Full Text pdf link PDF CME & MOC

PEDIATRICS

Evaluation of Thyroid Nodule Malignant Neoplasms and Obesity Among Children and Young Adults

This cross-sectional study examines the association of obesity in childhood and adolescence with the incidence of malignant thyroid nodules.

JAMA Netw Open. 2021;4(7):e2116369. doi:10.1001/jamanetworkopen.2021.16369
Abstract Full Text pdf link PDF

HEALTH INFORMATICS

Differences in Clinician Electronic Health Record Use Across Adult and Pediatric Primary Care Specialties

This cross-sectional study examines differences in electronic health record use across adult and pediatric primary care specialties.

JAMA Netw Open. 2021;4(7):e2116375. doi:10.1001/jamanetworkopen.2021.16375
Abstract Full Text pdf link PDF

SUBSTANCE USE AND ADDICTION

Trends in Drug Overdose Mortality Rates in Kentucky, 2019-2020

This cross-sectional study evaluates the changes in drug overdose mortality rates for Kentucky residents between 2019 and 2020.

has active quiz
JAMA Netw Open. 2021;4(7):e2116391. doi:10.1001/jamanetworkopen.2021.16391
Abstract Full Text pdf link PDF CME & MOC

PEDIATRICS

Evaluation of a Point-of-Care Ultrasonography Decision-Support Algorithm for the Diagnosis of Transient Synovitis in the Pediatric Emergency Department

This case series evaluates the performance of a point-of-care ultrasonography (POCUS) decision-support algorithm for the diagnosis of transient synovitis in the pediatric emergency department (ED).

JAMA Netw Open. 2021;4(7):e2116915. doi:10.1001/jamanetworkopen.2021.16915
Abstract Full Text pdf link PDF

PEDIATRICS

Prevalence of Serious Bacterial Infections Among Febrile Infants 90 Days or Younger in a Canadian Urban Pediatric Emergency Department During the COVID-19 Pandemic

This cross-sectional study compares the prevalence of severe bacterial infections in febrile neonates and infants before vs during the COVID-19 pandemic in Montreal, Quebec, Canada.

has active quiz
JAMA Netw Open. 2021;4(7):e2116919. doi:10.1001/jamanetworkopen.2021.16919
Abstract Full Text pdf link PDF CME & MOC

SUBSTANCE USE AND ADDICTION

Changes in Admissions to Specialty Addiction Treatment Facilities in California During the COVID-19 Pandemic

This cohort study examines changes in initiations of treatment in specialty addiction treatment facilities before vs during the COVID-19 pandemic in California.

has active quiz
JAMA Netw Open. 2021;4(7):e2117029. doi:10.1001/jamanetworkopen.2021.17029
Abstract Full Text pdf link PDF CME & MOC

PSYCHIATRY

Factors Associated With Symptoms of Depression and Anxiety Among Women Experiencing Homelessness and Unstable Housing During the COVID-19 Pandemic

This cross-sectional study examines symptoms of depression and anxiety among women experiencing homelessness and unstable housing during the COVID-19 pandemic.

has active quiz
JAMA Netw Open. 2021;4(7):e2117035. doi:10.1001/jamanetworkopen.2021.17035
Abstract Full Text pdf link PDF CME & MOC

NEPHROLOGY

Analysis of Estimated and Measured Glomerular Filtration Rates and the CKD-EPI Equation Race Coefficient in the Chronic Renal Insufficiency Cohort Study

This diagnostic/prognostic study examines the estimated glomerular filtration rates (eGFR) and iothalamate clearance glomerular filtration rates (iGFR) and the Chronic Kidney Disease-Epidemiology (CKD-EPI) equation race coefficient in the Chronic Renal Insufficiency Cohort study.

JAMA Netw Open. 2021;4(7):e2117080. doi:10.1001/jamanetworkopen.2021.17080
Abstract Full Text pdf link PDF

HEALTH POLICY

Trends in Diversity and Representativeness of Health Care Workers in the United States, 2000 to 2019

This cross-sectional study examines national trends in representativeness in select health care occupations by race/ethnicity and sex.

JAMA Netw Open. 2021;4(7):e2117086. doi:10.1001/jamanetworkopen.2021.17086
Abstract Full Text pdf link PDF

HEALTH POLICY

Sociodemographic Characteristics and Inequities Associated With Access to In-Person and Remote Elementary Schooling During the COVID-19 Pandemic in New York State

This cross-sectional study compares in-person school reopening decisions by student sociodemographic characteristics among elementary schools in New York State.

has active quiz
JAMA Netw Open. 2021;4(7):e2117267. doi:10.1001/jamanetworkopen.2021.17267
Abstract Full Text pdf link PDF CME & MOC

ONCOLOGY

Association of Edmonton Symptom Assessment System Global Distress Score With Overall Survival in Patients With Advanced Cancer

This cohort study examines the association of the Edmonton Symptom Assessment, including the Global Distress Score, with overall survival rates in patients with advanced cancer.

JAMA Netw Open. 2021;4(7):e2117295. doi:10.1001/jamanetworkopen.2021.17295
Abstract Full Text pdf link PDF

GLOBAL HEALTH

Exploring the Gap Between Excess Mortality and COVID-19 Deaths in 67 Countries

This cross-sectional study examines the difference between COVID-19 confirmed mortality and excess mortality in 67 countries.

has active quiz
JAMA Netw Open. 2021;4(7):e2117359. doi:10.1001/jamanetworkopen.2021.17359
Abstract Full Text pdf link PDF CME & MOC

HEALTH POLICY

Primary Care Spending in the Veterans Health Administration in 2014 and 2018

This quality improvement study assesses the proportion of primary care spending in the Veterans Health Administration in 2014 and 2018.

JAMA Netw Open. 2021;4(7):e2117533. doi:10.1001/jamanetworkopen.2021.17533
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HEALTH POLICY

Association of a High-Efficiency Particulate Air Filter COVID-19 Testing Booth With Testing Capacity, Cost Per Test Acquired, and Use of Personal Protective Equipment

This quality improvement study compares COVID-19 testing throughput, personal protective equipment use, and cost per test before vs after the introduction of high-efficiency particulate air–filtered, positive-pressure Hexapod personal protection booths at a hospital in Boston, Massachusetts.

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JAMA Netw Open. 2021;4(7):e2117698. doi:10.1001/jamanetworkopen.2021.17698
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MEDICAL EDUCATION

Comparison of Medical School Financing Plans Among Matriculating US Medical Students From 2017 to 2019

This survey study explores US students’ financing plans for medical school overall and by several demographic factors, focusing on race/ethnicity and household income.

JAMA Netw Open. 2021;4(7):e2117704. doi:10.1001/jamanetworkopen.2021.17704
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PUBLIC HEALTH

Analysis of Physician Use of Social Media

This cross-sectional study assesses social media presence, activity, followers, and research activity among physicians from different surgical and medical specialties at top-rated US hospitals.

JAMA Netw Open. 2021;4(7):e2118213. doi:10.1001/jamanetworkopen.2021.18213
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HEALTH INFORMATICS

Use of Electronic Health Record Patient Portal Accounts Among Patients With Smartphone-Only Internet Access

This cross-sectional study assesses data from the 2017-2020 Health Information National Trends Survey to examine whether smartphone-only internet access is associated with patient portal use.

JAMA Netw Open. 2021;4(7):e2118229. doi:10.1001/jamanetworkopen.2021.18229
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MEDICAL JOURNALS AND PUBLISHING

Temporal Trends, Characteristics, and Citations of Retracted Articles in Cardiovascular Medicine

This systematic review examines temporal trends of retractions in cardiology literature and assesses their effect.

JAMA Netw Open. 2021;4(7):e2118263. doi:10.1001/jamanetworkopen.2021.18263
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HEMATOLOGY

Evaluation of Frequency of Administration of Intravenous Bisphosphonate and Recurrent Skeletal-Related Events in Patients With Multiple Myeloma

This cohort study examines the risk of skeletal-related events associated with the frequency of bisphosphonate treatment in patients with multiple myeloma.

JAMA Netw Open. 2021;4(7):e2118410. doi:10.1001/jamanetworkopen.2021.18410
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HEALTH INFORMATICS

Assessment of the Performance Consistency of an Adverse Outcome Prediction Tool for Patients Hospitalized With COVID-19

This prognostic study reports on the performance of a previously validated COVID-19 severity prediction tool when applied to data during the second wave of the pandemic.

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JAMA Netw Open. 2021;4(7):e2118413. doi:10.1001/jamanetworkopen.2021.18413
Abstract Full Text pdf link PDF CME & MOC

ONCOLOGY

Comparison of Chemotherapy vs Chemotherapy Plus Total Hysterectomy for Women With Uterine Cancer With Distant Organ Metastasis

This cohort study evaluates the overall survival for patients with uterine cancer with distant organ metastasis treated with chemotherapy alone vs chemotherapy plus total abdominal hysterectomy.

JAMA Netw Open. 2021;4(7):e2118603. doi:10.1001/jamanetworkopen.2021.18603
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PUBLIC HEALTH

Trends in Bone Marrow Donor Registration in Japan Following a Celebrity’s Disclosure of Leukemia

This cohort study examines the association of a celebrity’s public disclosure of an acute lymphocytic leukemia diagnosis and trends in bone marrow donor registration in Japan.

JAMA Netw Open. 2021;4(7):e2118698. doi:10.1001/jamanetworkopen.2021.18698
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INFECTIOUS DISEASES

Effect of Targeted Behavioral Science Messages on COVID-19 Vaccination Registration Among Employees of a Large Health System: A Randomized Trial

This randomized trial evaluates whether individually addressed emails designed with behaviorally informed features increase COVID-19 vaccination rates.

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JAMA Netw Open. 2021;4(7):e2118702. doi:10.1001/jamanetworkopen.2021.18702
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GASTROENTEROLOGY AND HEPATOLOGY

Trends in Liver Transplantation for Acute Alcohol-Associated Hepatitis During the COVID-19 Pandemic in the US

This cohort study examines rates of adding patients with acute alcohol-associated hepatitis to the liver transplant waiting list and receipt of transplants by these patients in the US during the COVID-19 pandemic compared with before the pandemic.

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JAMA Netw Open. 2021;4(7):e2118713. doi:10.1001/jamanetworkopen.2021.18713
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INFECTIOUS DISEASES

Self-reported Memory Problems 8 Months After COVID-19 Infection

This cohort study examines self-reported memory problems 8 months after COVID-19 infection.

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JAMA Netw Open. 2021;4(7):e2118717. doi:10.1001/jamanetworkopen.2021.18717
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GLOBAL HEALTH

Self-reported vs Directly Observed Face Mask Use in Kenya

This cross-sectional study examines the extent to which mask mandates are followed and quantify the bias of self-reported mask usage in Kenya.

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JAMA Netw Open. 2021;4(7):e2118830. doi:10.1001/jamanetworkopen.2021.18830
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HEALTH POLICY

Primary Care Health Professional Shortage Area Designations Before and After the Affordable Care Act’s Shortage Designation Modernization Project

This cross-sectional study evaluates whether the Patient Protection and Affordable Care Act (ACA) Shortage Designation Modernization Project is associated with changes in primary care health professional shortage area (PC-HPSA) designations.

JAMA Netw Open. 2021;4(7):e2118836. doi:10.1001/jamanetworkopen.2021.18836
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open access Correction

Error in Data Management and Number of Study Respondents

JAMA Netw Open. 2021;4(7):e2120448. doi:10.1001/jamanetworkopen.2021.20448
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Error in Byline

JAMA Netw Open. 2021;4(7):e2120854. doi:10.1001/jamanetworkopen.2021.20854
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Errors in Byline

JAMA Netw Open. 2021;4(7):e2122388. doi:10.1001/jamanetworkopen.2021.22388
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Numeric Error in Table 1

JAMA Netw Open. 2021;4(7):e2123147. doi:10.1001/jamanetworkopen.2021.23147
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Error in Description of Limitations

JAMA Netw Open. 2021;4(7):e2123159. doi:10.1001/jamanetworkopen.2021.23159
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Errors in Figure Captions

JAMA Netw Open. 2021;4(7):e2123189. doi:10.1001/jamanetworkopen.2021.23189
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Error in Key Points

JAMA Netw Open. 2021;4(7):e2124224. doi:10.1001/jamanetworkopen.2021.24224
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open access JAMA Network Open Masthead

JAMA Network Open

JAMA Netw Open. 2021;4(7):e2120220. doi:10.1001/jamanetworkopen.2021.20220
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