This survey study evaluates the outcomes of menthol cigarette bans on youth menthol cigarette smoking and characterizes youth menthol cigarette smokers in terms of demographics and cigarette consumption and dependence.
This cross-sectional study investigates the contributions of doctor consultations, medicines, diagnostic tests, and nonmedical costs to out-of-pocket expenditure on health care in India.
This comparative effectiveness research study investigates the association of order substitutions and education for the use of lactated Ringer solution with major adverse kidney events in an integrated health care system.
This cohort study examines associations of sequential implementation of antimicrobial stewardship initiatives with trends in antibiotic use and incidence of multidrug resistant organisms.
This systematic review and meta-analysis examines the association of transitional care interventions with hospital and emergency department readmissions for patients 65 years and older who are transitioning in and out of long-term care facilities and explores factors that potentially mitigate the outcomes and implementation of transitional care interventions.
This cohort study examines the preferences of women for treatment of ductal carcinoma in situ on the basis of magnetic resonance imaging findings and surgeon recommendations.
This randomized clinical trial evaluates the efficacy, dose response, safety, and pharmacokinetics of 3 different doses of difelikefalin compared with placebo for the treatment of moderate to severe pruritus among Japanese patients receiving hemodialysis.
This cohort study of female nurses examines the association between rotating night shift work and healthy aging after 24 years of follow-up in the Nurses’ Health Study.
This cross-sectional study assesses whether neighborhood opportunity is associated with type 1 diabetes–related outcomes by race and ethnicity, including readmissions for diabetic ketoacidosis and co-occurring acute kidney injury and cerebral edema.
This cohort study compares use of insulin pumps in children with type 1 diabetes in Québec, Canada, where full funding is available, with use in Manitoba, Canada, where funding is partial.
This cohort study assesses the risk of hospitalization for motor vehicle crash injuries among Taiwanese adults with young-onset dementia compared with age-matched individuals without dementia.
This cohort study uses data from 2 nationally representative cohorts of US kindergarteners followed up through grade 5 to assess whether body mass growth differed after implementation of the Healthy, Hunger-Free Kids Act of 2010 among children in low-income families.
This prognostic study develops and validates a clinical scoring system for predicting poor neurocognitive outcomes after acute carbon monoxide poisoning.
This cohort study assesses the execution and interpretation of SARS-CoV-2 rapid antigen detection tests when performed by untrained persons an intended-use setting.
This quality improvement study evaluates the outcomes associated with a program to improve clinician adherence to management guidelines for acute ischemic stroke in hospitals in China.
This cohort study evaluates whether concurrent hearing and vision deficits, ie, dual sensory impairment, is associated with incident dementia in older adults.
This cohort study evaluates the associations between the use of psychotropic medications and the risk of COVID-19 infection among adults with serious mental illness receiving long-term inpatient psychiatric treatment.
This pilot randomized clinical trial assesses whether a structured professional group coaching program for female resident physicians would lead to decreased burnout.
This cross-sectional study evaluates the Pediatric Intensive Care Unit Quality of Dying and Death instrument and examines differences between disciplines and end-of-life circumstances.
This survey study evaluates the prevalence and sources of mistreatment among physicians and associations between mistreatment, occupational well-being, and physicians’ perceptions of protective workplace systems.
This survey study evaluates patient perspectives on care transition experiences from hospitals or skilled nursing facilities to home.
This cohort study investigates the induction of neutralizing antibodies against the SARS-CoV-2 Omicron variant after 2 and 3 doses of the BNT162b2 mRNA vaccine among recipients of different ages.
This individual participant data meta-analysis uses time-to-event data to compare the long-term oncologic outcomes after laparoscopic and open surgery for adult patients with rectal cancer.
This systematic review and meta-analysis analyzed the association of age, sex, and cancer types and therapies with survival rates among patients with both cancer and COVID-19 diagnosis.
This survey study describes the current state of social mission commitment within dental, medical, and nursing schools in the US and examines how social mission engagement and performance compares across school types.
This cross-sectional study examines differences in intentions and attempts to quit smoking by sexual minority status among smokers exposed to the Tips From Former Smokers campaign.
This cohort study investigates changes in the treatment of colorectal cancer (CRC) and short-term outcomes during the first wave of the COVID-19 pandemic in Sweden, compared with the year before.
This nonrandomized controlled trial examines the association of a multimedia communication with the public and education for health care professionals with guideline-based use of aspirin for prevention of cardiovascular disease (CVD).
This consensus statement and systematic review from the WikiGuidelines Group, an online collaborative research initiative, examines standards of evidence for pyogenic osteomyelitis care and offers clinical recommendations.
This nonrandomized, stepped-wedge quality improvement study assesses a pharmacist-led antimicrobial stewardship program to review and identify inappropriate prescriptions at hospital discharge and evaluate the association of the intervention with optimized therapy and adverse events among patients with common infections.
This cohort study examines differences between men and women in survival after surgery for ruptured abdominal aortic aneurysm.
This comparative effectiveness study evaluates distribution of buprenorphine and naltrexone initiation among individuals with opioid use disorder with or without cooccurring substance use disorder.
This economic evaluation assesses whether providing the World Health Organization’s Self-Help Plus intervention combined with enhanced usual care is cost-effective compared with enhanced usual care alone for conflict-exposed Syrian refugees or asylum seekers hosted in Turkey.
This cohort study conducted at a specialized multiple sclerosis (MS) clinic investigates factors associated with serological response to tozinameran in patients with MS receiving rituximab.
This survey study investigates whether patterns of reported suicidal ideation, planning, and behavior differ among US adults who own a firearm vs those who do not own a firearm.
This cohort study compares the use of a bayesian vs frequentist trial design in the Stroke Hyperglycemia Insulin Network Effort trial.
This systematic review and meta-analysis compares strength training vs power training for improving physical function in adults aged 60 years and older.
This cohort study with a case-crossover analytical design examines the associations between prescription stimulant use and drug-related poisonings and buprenorphine treatment retention among patients with opioid use disorder.
This cross-sectional study evaluates the use of patient-reported outcome instruments as primary and secondary outcomes in randomized clinical trials conducted in China.
This survey study compares the use of cannabis for medical purposes as reported in electronic health records (EHRs) with use reported in a confidential survey.
This cohort study investigates the rate of intensive care admissions with deliberate self-harm among children and adolescents in Australia during the SARS-CoV-2 outbreak.
This cohort study uses data from the Veterans Health Administration Corporate Data Warehouse database to evaluate the association between the intensity of thyroid hormone treatment and cardiovascular mortality.
This cross-sectional study evaluates prostate cancer–specific mortality rates between 1999 and 2019, comparing trends in rates before and after the change in the 2012 US Preventive Services Task Force prostate-specific antigen screening guideline.
This qualitative study investigates the health care experiences and racial discrimination encountered by Black veterans with chronic kidney disease in the US.
This cohort study evaluates the risk of cardiovascular mortality, coronary heart disease, stroke, heart failure, and atrial fibrillation among Black individuals with aortic stenosis as well as trace or mild aortic regurgitation or mitral regurgitation.
This cohort study estimates the true burden of influenza-like illness in the US population using a surrogate measure of daily steps lost as measured by commercial wearable sensors.
This cohort study evaluates the association of congenital and acquired cardiovascular conditions with severity of COVID-19 among pediatric patients in the US.
This prognostic study examines whether an artificial intelligence platform is able to accurately predict postoperative complications using automated real-time electronic health record data and provide automated outputs directly to surgeons’ mobile devices.
This cohort study investigates the association between distance to the nearest abortion facility and abortion and pregnancy outcome among individuals seeking abortion care and information online.
This cohort study compares long-term outcomes after endovascular vs open abdominal aortic aneurysm repair.
This cohort study evaluates the respective and combined abilities of a real-time machine learning model and the Columbia Suicide Severity Rating Scale to predict suicide attempt and suicidal ideation among adults.
This cross-sectional study uses an epidemiological assessment to examine rural-urban trends in the 5-year survival of patients with lung, prostate, breast, and colorectal cancers.
This cross-sectional study of clinical trials of cancer drugs compares rates of treatment discontinuation because of adverse events or withdrawal in an adjuvant setting vs a metastatic setting.
This cross-sectional study examines patterns of diagnostic testing for and incidence of tick-borne diseases in North Carolina.
This cohort study evaluates the sustainability of recommended site-of-care decision-making support 4 years after an initial intervention to increase outpatient management of acute pulmonary embolism among patients presenting to the emergency department (ED).
This cohort study of patients with metastatic clear cell renal cell carcinoma assesses whether cytoreductive nephrectomy is associated with improved overall survival.
This randomized clinical trial compares the effects of regulation of cues weight loss treatment with behavioral weight loss treatment on body mass index (BMI) in adults with overweight or obesity.
This cluster randomized clinical trial evaluates the effectiveness of a lifestyle coaching intervention vs an enhanced pharmacotherapy protocol compared with usual care in controlling blood pressure in Black adults with persistent uncontrolled hypertension.
This survey study examines barriers to and facilitators of obtaining a waiver to prescribe buprenorphine among office-based clinicians in Texas.
This cohort study compares outcomes of abdominal wall reconstruction performed by surgical fellows with those of procedures performed by assistant, associate, and senior-level professors.
This cohort study assesses the regulatory context, pivotal design characteristics, and postmarket requirements and commitments of novel drugs approved by the US Food and Drug Administration (FDA) in 2020 to characterize the state of evidence at the time of approval.
This cross-sectional study examines hospital arrival time and use of ambulances following implementation of a community education program to increase recognition of stroke.
This survey study examines the preferences of staff and students at the University of Hong Kong regarding receipt of the COVID-19 vaccine.
This cross-sectional study investigates all-cause mortality among children younger than 5 years in 77 low- and middle-income countries and compares the mortality rates among children younger than 2 years with those aged 2 to 4 years.
This cross-sectional study of neonates at risk for a late-preterm birth assesses whether new evidence on the benefit of steroid administration is associated with changes in clinical practice and neonatal outcomes.
This cohort study examines associations between urinary levels of 2 cell-cycle arrest biomarkers and 30-day survival among patients with septic shock who developed acute kidney injury staged based on kidney function.
This meta-analysis assesses whether the variability in symptom onset of Alzheimer disease in Down syndrome is similar to autosomal dominant Alzheimer disease and its association with mortality.
This randomized clinical trial examines whether the addition of timing and coordination training to a standard exercise program for strength and endurance improved walking among community-dwelling older adults more than strength and endurance training alone.
This prognostic study of US patients who underwent cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy develops and validates a model for predicting major postoperative complications using machine learning technology.
This systematic review and network meta-analysis compares amitriptyline with Food and Drug Administration–approved treatments for fibromyalgia related to sleep, fatigue, and health-related quality of life outcomes.
This cross-sectional study assesses the association between extreme heat and all-cause mortality rates in the US from 2008 to 2017.
This secondary analysis of a randomized clinical trial investigates bystander willingness to perform cardiopulmonary resuscitation on a stranger, theoretical knowledge retention, and dissemination of cardiopulmonary resuscitation awareness 6 months after undergoing short face-to-face or virtual reality training.
This randomized clinical trial investigates the effect of grocery gift cards and fruit and vegetable boxes provided to caregivers on healthfulness of diets among their children.
This cohort study investigates factors associated with anti–SARS-CoV-2 antibody levels.
This cohort study assesses the association between pharmacotherapy and the development of alcohol-associated liver disease in patients with alcohol use disorder.
This cross-sectional study examines the prevalence of germline findings in patients undergoing tumor/normal matched sequencing among cancer types lacking guidelines.
This cross-sectional study examines the occurrence of mistreatment of and discrimination toward physicians by patients, families, and visitors by physician characteristics and the association between such interactions and experiencing burnout.
This nonrandomized clinical trial assesses the association of an automated telephone call 2 days after emergency department discharge with the likelihood of an unplanned emergency department revisit at both 72 hours and 7 days after the index visit and with perceived care metrics measured at 14 days.
This qualitative study assesses whether bias exists in patient safety reporting systems based on the gender, race and ethnicity, or faculty rank of the physician who is the subject of the event report.
This cross-sectional study uses data from the Korea Youth Risk Behavior Web-Based Survey to examine the associations of duration of smartphone use and types of content most frequently accessed via smartphone with body image distortion and weight loss behaviors in Korean adolescents.
This cohort study examines the associations of serial measures of plasma trimethylamine N-oxide and related metabolites with the risk of total and cause-specific death, including cardiovascular and noncardiovascular–related death, among older adults enrolled in the Cardiovascular Health Study.
This cross-sectional study investigates the associations between exposure to outdoor artificial light at night and sleep disorders among a general population of Chinese children.
This cross-sectional study assesses whether viral antigens are detectable in the cerebrospinal fluid of patients with COVID-19 and compares cerebrospinal fluid biomarker profiles of patients with and without neurologic symptoms and with moderate vs severe COVID-19.
This randomized clinical trial evaluates urinary retention, uterine contraction pain, depressive symptoms, and lactation after acupoint hot compress treatment in women during their early postpartum period.
This cross-sectional study examines the association of having editorial staff members affiliated with low- and middle-income countries with publications reporting research from low- and middle-income countries in leading biomedical journals.
This qualitative study assesses fertility knowledge and concerns and evaluates barriers to family building and impact on academic attrition reported by female physicians.
This cohort study examines the rates of severe maternal and neonatal morbidity in physicians compared with nonphysicians in Ontario, Canada.
This cross-sectional study of adults undergoing major surgery evaluates whether racial disparities in access to surgical care occurred during the first wave of the COVID-19 pandemic.
This cross-sectional study assesses associations among fine particulate matter 2.5 μm or smaller, age-specific mortality risk, and socioeconomic status.
This cohort study uses data from Danish medical registries to examine the short-term and long-term risks of common neurologic and psychiatric outcomes for patients after hospitalization for cardiac arrest.
This systematic review examines the trial characteristics and cumulative progress of phase 3 clinical trials of systemic therapy for metastatic colorectal cancer over the last 3 decades and assesses the associated outcomes reported in the Surveillance, Epidemiology and End Results (SEER) database.
This cohort study compares the secondary attack rate and infectious viral shedding kinetics of SARS-CoV-2 in fully vaccinated vs partially vaccinated and unvaccinated individuals.
This economic evaluation compares the cost-effectiveness of lung cancer screening strategies using low-dose computed tomography (LDCT) and a plasma-based biomarker or LDCT alone in a simulated population of Chinese adults with a history of smoking.
This cohort study investigates the association of montelukast treatment with adverse neuropsychiatric outcomes among patients with asthma or allergic rhinitis.
This case series evaluates the injury characteristics, outcomes, and resource use among individuals who have sustained nonfatal injuries in civilian public mass shootings.
This cross-sectional study uses data from the Nationwide Emergency Department Sample to estimate recent national- and state-level trends in diabetes-related emergency department use overall and by race and ethnicity, rural or urban location, and insurance status.
This randomized clinical trial of older adults in a German clinical research center examines the effectiveness of spermidine as a dietary supplement over 12 months for improving memory and other key measures of cognitive performance compared with placebo.
This cohort study investigates the thromboembolic risks associated with atrial fibrillation (AF) in patients with pneumonia, assesses the risk of recurrent AF, and examines the association of initiation of anticoagulation therapy with new-onset AF.
This cohort study evaluates whether human papillomavirus (HPV) vaccination is associated with decreased positive predictive value for abnormal cervical cytology.
This cohort study compares the overall survival between patients who currently or formerly smoked with patients who never smoked and initiated pembrolizumab monotherapy as first-line treatment for advanced non–small lung cancer.
This cohort study evaluates the comparative safety and health care expenditures of inappropriate vs appropriate oral antibiotic prescriptions for common outpatient pediatric infections.
This health care improvement study examines the effectiveness of integrating hemoglobin A1c testing for diabetes and prediabetes into a low-barrier COVID-19 testing site in a Latinx community in a large US city.
This case series assesses population-level immunity to SARS-CoV-2 during March 2020 through May 2021 in Rhode Island, Massachusetts, and Connecticut.
This cohort study examines the association of marital status with total and cause-specific mortality in Asian populations.
This systematic review and meta-analysis compares 4 lower gastrointestinal bleeding risk scores based on prognostic performance.
This survey study assesses whether certain attitudes and characteristics of primary care clinicians are associated with a predisposition to prescribe antibiotics for asymptomatic bacteriuria.
This cohort study examines the incidence of autism spectrum disorder at age 18 months among the offspring of mothers who received epidural or combined spinal-epidural analgesia during labor.
This cross-sectional study estimates the prevalence of opioid prescriptions from US surgeons and dentists dispensed more than 30 days after writing and evaluates changes as a result of US state laws enacted to shorten the maximum period between opioid prescription writing and dispensing.
This randomized clinical trial investigates whether an educational intervention directed to patients and their clinicians stimulates the use of oral anticoagulants in patients with atrial fibrillation (AF) who are not receiving oral anticoagulants (OACs).
This cohort study assesses whether late preterm birth and size for gestational age are associated with cardiometabolic risk in childhood among participants aged 3 to 12 years.
This cohort study investigates the prevalence of nighttime masked uncontrolled hypertension and its associations with cardiovascular and kidney outcomes in patients with chronic kidney disease (CKD) who were not receiving dialysis.
This prognostic study compares the outcomes of oncologists vs a machine learning model in predicting mortality in patients with advanced metastatic cancer.
This cross-sectional study evaluates whether patients with pneumonia admitted to hospitals with higher risk-standardized readmission rates had a higher risk of adverse events.
This cohort study assesses the procedural success and major adverse event rates associated with left atrial appendage occlusion procedures among patients in China.
This meta-analysis and systematic review assesses whether treatment at a high-volume center is associated with better survival and neurological outcomes in patients with nontraumatic out-of-hospital cardiac arrest (OHCA).
This cohort study using data from a large multinational clinical trial of older adults examines the association of dementia risk with a coinciding decline in gait and memory compared with domain-specific prognostic models.
This cross-sectional study evaluates the association between the category of opioid use among pregnant people and subsequent overdose or death.
This cohort study assesses the association between zip code–level vaccination coverage and COVID-19 mortality in Chicago, Illinois.
This cohort study of patients with multisystem inflammatory syndrome in children assesses whether rare deleterious genetic variants that affect immune-related genes are enriched in patients of Middle Eastern origin.
This cross-sectional study assesses factors correlated with satisfaction and dissatisfaction with mobile health apps for weight loss among Chinese users and examines whether differences in these correlations are asymmetric.
This genetic association study assesses the associations of observed and genetic cardiovascular health profiles with brain health among asymptomatic adults.
This cross-sectional study evaluates nonnicotine e-cigarette use patterns, including common flavors, brands, and ingredients.
This systematic review and meta-analysis evaluates whether multidomain interventions, composed of 2 or more interventions, are associated with greater improvements in cognition among older adults with mild cognitive impairment (MCI) than a single intervention on its own.
This cohort study of 2 longitudinal cohorts of Irish children and adolescents develops a schema of person-centered psychopathological profiles based on evaluative questionnaire data.
This cohort study examines the feasibility of assessing solid tumor response to treatment from electronic health record (EHR) documentation and the concordance between EHR-based assessment and clinical trial standards.
This comparative effectiveness study evaluates the associations of sleeve gastrectomy and Roux-en-Y gastric bypass with ambulatory health care costs and use for 4 years after surgery.
This cross-sectional study evaluates the consistency of state comprehensive cancer control plan objectives compared with the 2016 US Preventive Services Task Force (USPSTF) recommendations for the age and frequency that women should undergo mammography.
This planned secondary analysis of a nonrandomized clinical trial investigates the factors associated with the failure of nonoperative management of pediatric appendicitis and compares patient-reported outcomes between patients whose treatment succeeded and those whose treatment failed.
This cohort study examines changes in naloxone and opioid prescribing rates in the outpatient setting at 1 integrated health care system after the launch of decision-support prompts in the electronic health record (HER) in compliance with the State of California Assembly Bill 2760.
This cohort study assesses the risk and rate of accumulating chronic conditions in people with depression, anxiety, or comorbid depression and anxiety stratified by age and sex.
This case-control study assesses the sex-specific associations of demographic, clinical, and psychosocial risk factors with first acute myocardial infarction among adults younger than 55 years, overall, and by infarction subtype.
This diagnostic study develops and prospectively validates a deep learning algorithm that uses ocular fundus images to recognize numerous retinal diseases in a clinical setting at 65 screening centers in 19 Chinese provinces.
This survey study assesses out-of-pocket costs and factors associated with these costs for a first visit to a musculoskeletal urgent care center for uninsured and underinsured patients in the US.
This randomized clinical trial evaluates the effectiveness of the Empowering Patients in Chronic Care intervention compared with usual care when delivered by clinicians engaged in routine care of patients with type 2 diabetes.
This cross-sectional study uses US vital statistics data to evaluate alcohol use disorder–related mortality rates from 2012 to 2021, with a focus on trends during the COVID-19 pandemic.
This survey study describes the results of a nationally representative survey on artificial intelligence use in health care delivery.
This case series study compares the prevalence of common pregnancy complications and placental pathologies by race and ethnicity among individuals treated at a community hospital in New York City.
This randomized clinical trial tests the effect of a mailed, at-home disposal kit on disposal rates of unused opioids after surgery.
This cohort study compares firearm, suffocation, and poisoning suicide rates among recently separated veterans with those among the general veteran population and examines demographic and military characteristics associated with risk of method-specific suicide mortality among recently separated veterans.
This repeated cross-sectional analysis examines national trends in emergency department (ED) treatment of children with acute gastroenteritis.
This survey study uses data from the National Survey on Drug Use and Health to examine trends and patterns in young adults’ perceived reasons for not seeking treatment for depression.
This cross-sectional study investigates the occurrence of the prescribing cascade of antiemetic after hormone therapy.
This randomized clinical trial assesses the effect of a smartphone-based intervention with financial incentive on peripartum smoking among pregnant individuals.
This cohort study compares the antispike antibody titers of the mRNA-1273 and BNT162b2 vaccines for SARS-CoV-2 in incrementally immunosuppressed patients.
This cohort study examines neutralizing antibodies against the SARS-CoV-2 Omicron variant (BA.1) after the second and third doses of the BNT162b2 mRNA vaccine among Danish adults.
This randomized clinical trial compares patient comprehension of electronic health records in the US when common medical abbreviations are expanded.
This cross-sectional study examines age-specific COVID-19 mortality rates in the US from March 2020 to October 2021 by sex and race and ethnicity.
This comparative-effectiveness study uses data from 2 clinical trials to evaluate whether the use of gabapentin for pain management is associated with less opioid use and feeding tube placement among adult patients with head and neck cancer receiving chemoradiotherapy.
This case series study of COVID-19 data from a US university examines the effectiveness of various vaccination, testing, and surveillance measures to mitigate spread of the Omicron variant.
This cohort study assesses COVID-19 prevention measures against the Delta variant by measuring the secondary attack rate for cases in students, teachers, and staff of New York City public schools from October to December 2021 and analyzing the likely direction of transmission for secondary cases.
This cross-sectional study examines the rate of active SARS-CoV-2 infection among Afghan refugees arriving in Qatar after the withdrawal of coalition forces from Afghanistan.
This cohort study examines admissions to intensive care units for COVID-19–associated acute respiratory distress syndrome by COVID-19 vaccination status among adults in the Veneto region of Italy from May to December 2021.
This cohort study assesses recall rates among patients and their proxies who consented to participate in a randomized clinical trial.
This cross-sectional study reviews emergency medical services (EMS) treatment protocols for adults presenting with cardiac arrest or overdose to evaluate whether current protocols include the consideration of opioid overdose for patients with possible out-of-hospital cardiac arrest.
This cross-sectional study evaluates trends in catastrophic health care expenditures associated with chronic diseases in US households from 2008 to 2018.
This cross-sectional study documents 2021 insurance network participation rates among hospital-based physicians nationally and by state.
This case series examines numbers of US clinicians receiving waivers from the Drug Enforcement Administration allowing them to prescribe buprenorphine for opioid use disorder before and during the COVID-19 pandemic.
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