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February 2003

Qualifications to the Report of a New Case of Creutzfeldt-Jakob Disease in the Recipient of a Corneal Transplant

Arch Neurol. 2003;60(2):294. doi:10.1001/archneur.60.2.293-a

In reply

We agree that the issue of iatrogenic transmission of CJD by corneal transplantation is not trivial. We also agree that the risk of such transmission is currently extremely low given the strict control of potential donors. However, CJD has a remarkably long latency period before any manifestations of the disease become evident, and molecular genetic techniques that allow diagnosis during the presymptomatic phase have become available only recently. Although dura mater donors are regularly screened, occasional cases of CJD transmission have occurred after grafting.1-3

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