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February 2008

Stroke Secondary to Meningococcal Meningitidis: A Potential Link Between Endothelial Dysfunction and Cytokines—Reply

Author Affiliations

Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2008

Arch Neurol. 2008;65(2):282-284. doi:10.1001/archneurol.2007.35

In reply

Drs de Souza and Seguro stress the importance of interactions between the cytokine network, coagulations inhibitors, and development of brain infarctions in patients with meningococcal meningitis. In their comment, they postulate a hypothesis on a causal relation between brain infarction and interleukin 6 (IL-6) in meningococcal meningitis. Although interesting, their assumptions on IL-6 and brain infarction are based on 1 single case report, and systematic evidence to support their hypothesis is lacking.1