The Need for Appropriate Genotyping Strategies for Glucocerebrosidase Mutations in Cohorts With Parkinson Disease

The article by Tan et al¹ reporting mutations in the glucocerebrosidase gene (GBA) in Chinese patients with Parkinson disease (PD) is the third recent article in series of patients of Chinese ancestry.^1-3 These studies are important because they support the previously described association of GBA mutations and parkinsonism in white and Ashkenazi Jewish PD cohorts^4,5 in a population that is clearly of non–Ashkenazi Jewish ancestry.