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June 2008

The Need for Appropriate Genotyping Strategies for Glucocerebrosidase Mutations in Cohorts With Parkinson Disease

Arch Neurol. 2008;65(6):849-852. doi:10.1001/archneur.65.6.850

The article by Tan et al1 reporting mutations in the glucocerebrosidase gene (GBA) in Chinese patients with Parkinson disease (PD) is the third recent article in series of patients of Chinese ancestry.1-3 These studies are important because they support the previously described association of GBA mutations and parkinsonism in white and Ashkenazi Jewish PD cohorts4,5 in a population that is clearly of non–Ashkenazi Jewish ancestry.

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