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November 2010

Worse Outcomes and Guideline-Driven Care—Reply

Author Affiliations

Author Affiliations: Department of Neurology, Rush University Medical Center, Chicago, Illinois (Dr Prabhakaran); and the Department of Neurology, St Luke's Roosevelt Hospital Center, New York, New York (Dr Chong).

Arch Neurol. 2010;67(11):1413-1414. doi:10.1001/archneurol.2010.288

In reply

We appreciate the insightful comments made by the investigators and largely agree with several important issues and concerns that our article has raised. Ideally, modern clinical practice should be evidence based. Guidelines are a practical means of distilling results from clinical trials to help guide practice and thus serve a very useful role. We agree that conclusions from clinical trials may not always be generalizable and may simplify complex interactions.

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