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December 2010

Posterior Reversible Encephalopathy Syndrome: Imperative to Define

Author Affiliations

Author Affiliations: Departments of Neurology (Drs Zhang and Wu) and Radiology (Dr Zheng), the First Hospital of Jilin University, Changchun, China; Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden (Drs Zhang and Zheng); and the Department of Neurology, the Second Hospital of Jilin University, Changchun, China (Dr Mao).

Arch Neurol. 2010;67(12):1535. doi:10.1001/archneurol.2010.313

Posterior reversible encephalopathy syndrome (PRES) (also termed reversible posterior leukoencephalopathy syndrome) represents an entity with an underlying pathophysiological mechanism suggested to be vasogenic edema.1 Burrus and colleagues2 reported up to 48% PRES in patients with thrombotic thrombocytopenic purpura (TTP) and acute brain abnormalities. We agree that diffusion-weighted imaging and apparent diffusion coefficient mapping are indispensible to differentiation of vasogenic edema from cytotoxic edema in PRES. However, we have some concern regarding their definition of PRES.

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