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February 2011

Vascular Risk Scores for Dementia: Age Matters

Author Affiliations

Author Affiliations: Department of Neurology, University Medical Center Utrecht, Utrecht, The Netherlands.

Arch Neurol. 2011;68(2):264-271. doi:10.1001/archneurol.2011.2

Reitz et al1 presented published a summary risk score for prediction of Alzheimer disease (AD) in elderly individuals based on their vascular risk profiles. The risk score was developed using data from 1051 Medicare recipients aged 65 years and older who were followed up for an average period of 4 years. The risk score included the factors age, sex, education, ethnicity, APOE ε4 genotype, history of diabetes, hypertension, smoking, high-density lipoprotein levels, and waist to hip ratio. Based on the β coefficients of these factors, a weighted risk score was assigned to each factor and the dementia score was the sum of these scores. Using this approach, the risk of developing late-onset AD was 20 times higher for individuals with a summary score in the highest compared with the lowest quintile.

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