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Original Contributions
Feberuary 1973

Essential Hypernatremia: The Experimental Model

Author Affiliations

New York

From the Department of Anatomy, Albert Einstein College of Medicine, New York. Dr. Dorn is now with the University of Missouri Medical Center, Columbia, Mo. Dr. Rothballer is with the New York Medical College.

Arch Neurol. 1973;28(2):83-90. doi:10.1001/archneur.1973.00490200031003

A syndrome of sustained elevation of serum sodium and osmolality was produced in cats by injecting 5% silver nitrate (AgNO3) into the perichiasmatic subarachnoid cisterns. Metabolic balance studies showed no significant differences between preoperative and postoperative body weight, urine osmolality, water intake, or urine output. Injury to the supraoptic nucleus of the hypothalamus correlated well with the development of the hypernatremic, hyperosmotic state.

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