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Aug 2011

Effect of Pallidal Deep Brain Stimulation on Psychiatric Symptoms in Myoclonus-Dystonia due to ε-Sarcoglycan Mutations

Author Affiliations

Author Affiliations: Departments of Neurology (Drs Contarino, Foncke, Speelman, and Tijssen) and Neurosurgery (Dr Schuurman), Academic Medical Center; and the Department of Neurology (Dr Foncke), and Stichting GGZ Buitenamstel-de Geestgronden and Department of Psychiatry (Dr Cath), Free University, Amsterdam, the Netherlands.

Arch Neurol. 2011;68(8):1087-1089. doi:10.1001/archneurol.2011.180

In their article on deep brain stimulation (DBS) of the internal pallidum (GPi) for myoclonus-dystonia (M-D) due to ε-sarcoglycan (SGCE) mutations, Azoulay-Zyss and coauthors1 conclude that DBS’s effect on psychiatric comorbidity needs to be studied.

We describe 5 patients with SGCE –M-D (4 men; mean age, 37 years; range, 18-50 years) who underwent bilateral GPi-DBS for their invalidating motor symptoms.

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