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Sep 2011

The Th1/Th2 Paradigm in Guillain-Barré Syndrome

Author Affiliations

Author Affiliations: Department of Neurology, First Hospital of Jilin University, Changchun, China (Dr Zhang); and Department of Neurology, Affiliated Hospital of Medical College, Qingdao University, Qingdao, China (Dr Li).

Arch Neurol. 2011;68(9):1209-1210. doi:10.1001/archneurol.2011.214

Nyati and colleagues1 described a cohort of 65 patients with Guillain-Barré syndrome (GBS) with characteristic lymphocyte cytokine expression profiles in response to Campylobacter jejuni outer membrane protein stimulation. While their findings followed the T helper (Th) 1/Th2 paradigm, they should be interpreted with caution before robust conclusions are drawn.