The study by Landau et al1 reported that greater early-life and mid-life cognitive activity was associated with lower carbon 11–labeled Pittsburgh Compound B uptake and provided evidence supporting the direct link between cognitive activity and Alzheimer disease (AD)–related pathology. However, physical activity was not associated with the outcome. Indeed, a number of longitudinal studies have reported links between leisure activities and cognitive function or dementia. In line with the findings by Landau et al, the most consistently reported protective effect came from either mid-life or late-life cognitive activity. Nevertheless, most studies on physical activity also reported a beneficial effect, a finding that was supported by clinical trials.2,3
Wang H. Physical Activity and AD-Related Pathology. Arch Neurol. 2012;69(7):940–941. doi:10.1001/archneurol.2012.507
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