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January 2013

Blood-Based Biomarkers in Alzheimer Disease: Where Are We Now and Where Have We to Go?—Reply

Author Affiliations

Author Affiliations: Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical Sciences, Edith Cowan University, Joondalup (Drs Laws and Martins); Sir James McCusker Alzheimer's Disease Research Unit (Hollywood Private Hospital), Perth (Drs Laws and Martins); Co-operative Research Centre for Mental Health (Drs Laws and Martins), Western Australia; The Australian E-Health Research Centre, Royal Brisbane and Women's Hospital, Herston, Queensland (Dr Doecke); The Commonwealth Scientific and Industrial Research Organization (CSIRO) Preventative Health Flagship, CMSE, Parkville, Victoria (Dr Doecke); and CSIRO Mathematics and Information Sciences, Macquarie University, Macquarie Park (Dr Doecke), Australia.

JAMA Neurol. 2013;70(1):133-134. doi:10.1001/jamaneurol.2013.709

In reply

In his letter, Christoph Laske, MD, raises several pertinent points in reference to our recent article1 that are applicable to most, if not all, published blood-based biomarker studies in the field of Alzheimer disease (AD).

Laske correctly identifies that the perfect biomarker panel remains elusive, with very few candidates remaining consistent across studies. A study's final panel may lack extensive overlap, but this may simply be owing to the lack of analysis of a given protein rather than its lack of association, the case in point being the comparison of variables analyzed in both data sets in our study.1 Caution should be taken when discounting candidate biomarkers based on lack of overlap in most published panels.

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