In a retrospective clinicopathological analysis comparing 11 cases of frontotemporal lobar degeneration (FTLD) in elderly patients (mean [SD] age at onset, 73.5 [8.3] years) with 19 cases of presenile-onset FTLD (mean [SD] age, 49 [12.1] years), Baborie et al1 found some clinical and morphological differences between both groups (ie, more frequent anterograde memory loss and behavioral changes, and significantly more frequent hippocampal sclerosis but milder frontal atrophy in the elder group). Frontotemporal lobar degeneration should be considered in elderly patients presenting with an atypical Alzheimer disease phenotype. These data were confirmed by personal observations in 2 patients with FTLD who died at the ages of 85 and 88 years.
Jellinger KA. Elderly Individuals With FTLD. JAMA Neurol. 2013;70(3):412–413. doi:10.1001/2013.jamaneurol.552
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