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May 2013

Can Mild Cognitive Impairment in Parkinson Disease Predict the Development of Dementia?

JAMA Neurol. 2013;70(5):553-555. doi:10.1001/jamaneurol.2013.260

The term mild cognitive impairment (MCI) emerged in the 1990s, defining a transition state from normal cognitive function and forcing our appreciation of cognitive changes not attributable to age, education, sex, race, ethnicity, language, or culture, but rather to a well-defined disease process or related pathology.1 The acceptance of MCI as a precursor to dementia and its use in predicting progression to Alzheimer dementia, by identifying a profile of cognitive dysfunction unique to Alzheimer dementia and attributable to the disease process and related pathology, is well substantiated. Recently, subtypes of MCI have been described that may have individual predilections for various dementia types.2

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