As noted by William G. Lennox in 1960 in the opening sentence of the introduction to his legendary book Epilepsy and Related Disorders: “No disease is more intriguing, more protean, more pressing for solution than epilepsy and conditions related to it.”1 This statement remains true more than 50 years later. The great diversity of the clinical presentations of epilepsy and the responses to therapy provides challenges but also exciting opportunities for insights into how the brain functions when healthy and when diseased.